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Items: 1 to 20 of 320

1.
Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice
Chen Ling, Su-Su Liu, Yu-Ya Wang, Gui-Tao Huo, Yan-Wei Yang, Nan Xu, Hong Wang, Yong Wu, Yu-Fa Miao, Rui Fu, Yu-Wei Zhao, Chang-Fa Fan
Zool Res. 2024 May 18; 45(3): 551–566. doi: 10.24272/j.issn.2095-8137.2024.002
PMCID:
PMC11188599
AbstractArticlePDF–27M
2.
Lack of effect of human c‐Ha‐ras proto‐oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats
Naomi Hokaiwado, Makoto Asamoto, Young‐Man Cho, Hiroyuki Tsuda, Tomoyuki Shirai
Cancer Sci. 2003 Dec; 94(12): 1042–1045. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01398.x
PMCID:
PMC11160280
AbstractArticlePDF–1.0M
3.
Crystal Structure of an i-Motif from the HRAS Oncogene Promoter
Kevin S. Li, Deondre Jordan, Linda Y. Lin, Sawyer E. McCarthy, John S. Schneekloth, Jr., Liliya A. Yatsunyk
Angew Chem Int Ed Engl. Author manuscript; available in PMC 2024 Jun 26.
Published in final edited form as: Angew Chem Int Ed Engl. 2023 Jun 26; 62(26): e202301666. Published online 2023 Apr 25. doi: 10.1002/anie.202301666
PMCID:
PMC10330059
AbstractArticlePDF–1.3M
4.
Mutated HRAS activates YAP1-AXL signaling to drive metastasis of head and neck cancer
Sankar Jagadeeshan, Manu Prasad, Mai Badarni, Talal Ben Lulu, Vijayasteltar Belsamma Liju, Sooraj Mathukkada, Claire Saunders, Avital Beeri Shnerb, Jonathan Zorea, Ksenia M Yegodayev, Monica Wainer, Liza Vtorov, Irit Allon, Ofir Cohen, Gro Gausdal, Dinorah Friedmann-Morvinski, Sok Ching Cheong, Alan L Ho, Ari J Rosenberg, Linda Kessler, Francis Burrows, Dexin Kong, Jennifer R Grandis, J Silvio Gutkind, Moshe Elkabets
Cancer Res. Author manuscript; available in PMC 2023 Oct 4.
Published in final edited form as: Cancer Res. 2023 Apr 4; 83(7): 1031–1047. doi: 10.1158/0008-5472.CAN-22-2586
PMCID:
PMC10073343
AbstractArticlePDF–2.6M
5.
HRAS overexpression predicts response to Lenvatinib treatment in gastroenteropancreatic neuroendocrine tumors
Chiara Liverani, Chiara Spadazzi, Toni Ibrahim, Federica Pieri, Flavia Foca, Chiara Calabrese, Alessandro De Vita, Giacomo Miserocchi, Claudia Cocchi, Silvia Vanni, Giorgio Ercolani, Davide Cavaliere, Nicoletta Ranallo, Elisa Chiadini, Giovanna Prisinzano, Stefano Severi, Maddalena Sansovini, Giovanni Martinelli, Alberto Bongiovanni, Laura Mercatali
Front Endocrinol (Lausanne) 2022; 13: 1045038. Published online 2023 Jan 20. doi: 10.3389/fendo.2022.1045038
PMCID:
PMC9895371
AbstractArticlePDF–4.0M
6.
A novel HRAS c.466C>T p.(Phe156Leu) variant in two patients with attenuated features of Costello syndrome
Suzanna Lindsey-Temple, Matt Edwards, Verena Rickassel, Theresa Nauth, Georg Rosenberger
Eur J Hum Genet. 2022 Sep; 30(9): 1088–1093. Published online 2022 Jun 29. doi: 10.1038/s41431-022-01139-1
PMCID:
PMC9437031
AbstractArticlePDF–1.1M
7.
HRAS Q61L Mutation as a Possible Target for Non-Small Cell Lung Cancer: Case Series and Review of Literature
Laurent Mathiot, Guillaume Herbreteau, Siméon Robin, Charlotte Fenat, Jaafar Bennouna, Christophe Blanquart, Marc Denis, Elvire Pons-Tostivint
Curr Oncol. 2022 May; 29(5): 3748–3758. Published online 2022 May 20. doi: 10.3390/curroncol29050300
PMCID:
PMC9139372
AbstractArticlePDF–976K
8.
HRAS is a therapeutic target in malignant chemo-resistant adenomyoepithelioma of the breast
Ivan Bièche, Florence Coussy, Rania El-Botty, Sophie Vacher, Sophie Château-Joubert, Ahmed Dahmani, Elodie Montaudon, Cécile Reyes, David Gentien, Fabien Reyal, Francesco Ricci, André Nicolas, Caterina Marchio, Anne Vincent-Salomon, Marick Laé, Elisabetta Marangoni
J Hematol Oncol. 2021; 14: 143. Published online 2021 Sep 8. doi: 10.1186/s13045-021-01158-3
PMCID:
PMC8424935
AbstractArticlePDF–1.0M
9.
Expression of oncogenic HRAS in human Rh28 and RMS-YM rhabdomyosarcoma cells leads to oncogene-induced senescence
Jenny J. Li, Alexander R. Kovach, Margaret DeMonia, Katherine K. Slemmons, Kristianne M. Oristian, Candy Chen, Corinne M. Linardic
Sci Rep. 2021; 11: 16505. Published online 2021 Aug 13. doi: 10.1038/s41598-021-95355-2
PMCID:
PMC8363632
AbstractArticlePDF–2.0M
10.
Tipifarnib in Recurrent, Metastatic HRAS-Mutant Salivary Gland Cancer
Glenn J. Hanna, Jeffrey P. Guenette, Nicole G. Chau, Cyrus M. Sayehli, Christian Wilhelm, Robert Metcalf, Deborah J. Wong, Marcia Brose, Mohammad Razaq, Elisabeth Pérez-Ruiz, Ezra E. W. Cohen, Rahul Aggarwal, Catherine Scholz, Antonio Gualberto, Alan L. Ho
Cancer. Author manuscript; available in PMC 2021 Sep 1.
Published in final edited form as: Cancer. 2020 Sep 1; 126(17): 3972–3981. Published online 2020 Jun 18. doi: 10.1002/cncr.33036
PMCID:
PMC8266417
AbstractArticlePDF–1.0M
11.
Costello syndrome: Clinical phenotype, genotype, and management guidelines
Karen W. Gripp, Lindsey A. Morse, Marni Axelrad, Kathryn C. Chatfield, Aaron Chidekel, William Dobyns, Daniel Doyle, Bronwyn Kerr, Angela E. Lin, David D. Schwartz, Barbara J. Sibbles, Dawn Siegel, Suma P. Shankar, David A. Stevenson, Mihir M. Thacker, K. Nicole Weaver, Sue M. White, Katherine A. Rauen
Am J Med Genet A. Author manuscript; available in PMC 2021 Jun 28.
Published in final edited form as: Am J Med Genet A. 2019 Sep; 179(9): 1725–1744. Published online 2019 Jun 20. doi: 10.1002/ajmg.a.61270
PMCID:
PMC8238015
AbstractArticlePDF–953K
12.
Tipifarnib in Head and Neck Squamous Cell Carcinoma With HRAS Mutations
Alan L. Ho, Irene Brana, Robert Haddad, Jessica Bauman, Keith Bible, Sjoukje Oosting, Deborah J. Wong, Myung-Ju Ahn, Valentina Boni, Caroline Even, Jerome Fayette, Maria José Flor, Kevin Harrington, David S. Hong, Sung-Bae Kim, Lisa Licitra, Ioanna Nixon, Nabil F. Saba, Stephan Hackenberg, Pol Specenier, Francis Worden, Binaifer Balsara, Mollie Leoni, Bridget Martell, Catherine Scholz, Antonio Gualberto
J Clin Oncol. 2021 Jun 10; 39(17): 1856–1864. Published online 2021 May 14. doi: 10.1200/JCO.20.02903
PMCID:
PMC8189627
AbstractArticlePDF–427K
13.
Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus
Eduardo Cararo-Lopes, Matheus H. Dias, Marcelo S. da Silva, Julianna D. Zeidler, Alexandre T. Vessoni, Marcelo S. Reis, Enrique Boccardo, Hugo A. Armelin
Cell Death Dis. 2021 Feb; 12(2): 194. Published online 2021 Feb 18. doi: 10.1038/s41419-021-03476-3
Correction in:
Cell Death Dis. 2021 Apr; 12(4): 293.
PMCID:
PMC7892846
AbstractArticlePDF–3.0M
14.
Catalytically Competent Non-transforming H-RASG12P Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS
Metehan Ilter, Ozge Sensoy
Sci Rep. 2019; 9: 10967. Published online 2019 Jul 29. doi: 10.1038/s41598-019-47481-1
PMCID:
PMC6662853
AbstractArticlePDF–1.7M
15.
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
Felipe C. Geyer, Anqi Li, Anastasios D. Papanastasiou, Alison Smith, Pier Selenica, Kathleen A. Burke, Marcia Edelweiss, Huei-Chi Wen, Salvatore Piscuoglio, Anne M. Schultheis, Luciano G. Martelotto, Fresia Pareja, Rahul Kumar, Alissa Brandes, Dan Fan, Thais Basili, Arnaud Da Cruz Paula, John R. Lozada, Pedro Blecua, Simone Muenst, Achim A. Jungbluth, Maria P. Foschini, Hannah Y. Wen, Edi Brogi, Juan Palazzo, Brian P. Rubin, Charlotte K. Y. Ng, Larry Norton, Zsuzsanna Varga, Ian O. Ellis, Emad A. Rakha, Sarat Chandarlapaty, Britta Weigelt, Jorge S. Reis-Filho
Nat Commun. 2018; 9: 1816. Published online 2018 May 8. doi: 10.1038/s41467-018-04128-5
PMCID:
PMC5940840
AbstractArticlePDF–7.4M
16.
The role of K-Ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines
Ravi P. Sahu, Sanjay Batra, Prabodh K. Kandala, Thomas L. Brown, Sanjay K. Srivastava
Cancer Chemother Pharmacol. Author manuscript; available in PMC 2018 Mar 8.
Published in final edited form as: Cancer Chemother Pharmacol. 2011 Feb; 67(2): 481–487. Published online 2010 Sep 17. doi: 10.1007/s00280-010-1463-1
PMCID:
PMC5842667
AbstractArticlePDF–2.1M
17.
Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway
Elena Y. Kochetkova, Galina I. Blinova, Olga A. Bystrova, Marina G. Martynova, Valery A. Pospelov, Tatiana V. Pospelova
Aging (Albany NY) 2017 Nov; 9(11): 2352–2375. Published online 2017 Nov 14. doi: 10.18632/aging.101325
PMCID:
PMC5723691
AbstractArticlePDF–11M
18.
Respiratory System Involvement in Costello Syndrome
Natalia Gomez-Ospina, Christin Kuo, Amitha Lakshmi Ananth, Angela Myers, Marie-Luise Brennan, David A Stevenson, Jonathan A Bernstein, Louanne Hudgins
Am J Med Genet A. Author manuscript; available in PMC 2017 Jul 14.
Published in final edited form as: Am J Med Genet A. 2016 Jul; 170(7): 1849–1857. Published online 2016 Apr 22. doi: 10.1002/ajmg.a.37655
PMCID:
PMC5509842
AbstractArticlePDF–376K
19.
Phenotypic Spectrum of Costello Syndrome Individuals Harboring the Rare HRAS Mutation p.Gly13Asp
Débora Bertola, Michelle Buscarilli, Deborah L. Stabley, Laura Baker, Daniel Doyle, Dennis W. Bartholomew, Katia Sol-Church, Karen W. Gripp
Am J Med Genet A. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Am J Med Genet A. 2017 May; 173(5): 1309–1318. Published online 2017 Apr 3. doi: 10.1002/ajmg.a.38178
PMCID:
PMC5397353
AbstractArticlePDF–564K
20.
Local tumour progression after percutaneous ablation of colorectal liver metastases according to RAS mutation status
Bruno C. Odisio, Suguru Yamashita, Steven Y. Huang, Samer Harmoush, Scott E. Kopetz, Kamran Ahrar, Yun Shin Chun, Claudius Conrad, Thomas A. Aloia, Sanjay Gupta, Marshall E. Hicks, Jean-Nicolas Vauthey
Br J Surg. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Br J Surg. 2017 May; 104(6): 760–768. Published online 2017 Feb 27. doi: 10.1002/bjs.10490
PMCID:
PMC5391264
AbstractArticlePDF–778K

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