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Select item 107787681.

Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1

Daria V. Kim, Evgeniia A. Diatlova, Timofey D. Zharkov, Vasily S. Melentyev, Anna V. Yudkina, Anton V. Endutkin, Dmitry O. Zharkov

Int J Mol Sci. 2024 Jan; 25(1): 64. Published online 2023 Dec 20. doi: 10.3390/ijms25010064

PMCID:: PMC10778768

Article PDF–2.0M

Select item 107492802.

In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer

M. Mijit, E. Kpenu, N.N. Chowdhury, S. Gampala, R. Wireman, S. Liu, O. Babb, M.M. Georgiadis, J. Wan, M.L. Fishel, M.R. Kelley

Redox Biol. 2024 Feb; 69: 102977. Published online 2023 Dec 1. doi: 10.1016/j.redox.2023.102977

PMCID:: PMC10749280

Article PDF–6.6M

Select item 105005013.

Expression of Apurinic/Apyrimidinic Endonuclease 1 in Colorectal Cancer and its Relation to Tumor Progression and Prognosis

JI-YUN HONG, HYUNG-HOON OH, SUN-YOUNG PARK, YOUNG-LAN PARK, SUNG-BUM CHO*, YOUNG-EUN JOO

In Vivo. 2023 Sep-Oct; 37(5): 2070–2077. Published online 2023 Sep 3. doi: 10.21873/invivo.13304

PMCID:: PMC10500501

Article PDF–2.2M

Select item 103781824.

Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons

Matilde Clarissa Malfatti, Alessia Bellina, Giulia Antoniali, Gianluca Tell

Cells. 2023 Jul; 12(14): 1895. Published online 2023 Jul 20. doi: 10.3390/cells12141895

PMCID:: PMC10378182

Article PDF–3.7M

Select item 103596155.

Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics

Nicole M Hoitsma, Jessica Norris, Thu H Khoang, Vikas Kaushik, Rahul Chadda, Edwin Antony, Mark Hedglin, Bret D Freudenthal

Nucleic Acids Res. 2023 Jul 21; 51(13): 6738–6753. Published online 2023 Jun 2. doi: 10.1093/nar/gkad481

PMCID:: PMC10359615

Article PDF–2.0M

Select item 94093656.

Dual Function of Secreted APE1/Ref-1 in TNBC Tumorigenesis: An Apoptotic Initiator and a Regulator of Chronic Inflammatory Signaling

Sunga Choi, Yu-Ran Lee, Ki-Mo Kim, Euna Choi, Byeong-Hwa Jeon

Int J Mol Sci. 2022 Aug; 23(16): 9021. Published online 2022 Aug 12. doi: 10.3390/ijms23169021

PMCID:: PMC9409365

Article PDF–3.8M

Select item 93241947.

Conformational Rearrangements Regulating the DNA Repair Protein APE1

Nina Komaniecka, Marta Porras, Louis Cairn, Jon Ander Santas, Nerea Ferreiro, Juan Carlos Penedo, Sonia Bañuelos

Int J Mol Sci. 2022 Jul; 23(14): 8015. Published online 2022 Jul 20. doi: 10.3390/ijms23148015

PMCID:: PMC9324194

Article PDF–1.4M

Select item 92507398.

APEX1 regulates alternative splicing of key tumorigenesis genes in non-small-cell lung cancer

Li Peng, Yuwei Liu, Jing Chen, Mengxin Cheng, Ying Wu, Min Chen, Ya Zhong, Dan Shen, Ling Chen, Xujun Ye

BMC Med Genomics. 2022; 15: 147. Published online 2022 Jul 2. doi: 10.1186/s12920-022-01290-0

PMCID:: PMC9250739

Article PDF–3.9M

Select item 88658979.

Histone H3 lysine 56 acetylation enhances AP endonuclease 1-mediated repair of AP sites in nucleosome core particles

Yesenia Rodriguez, Julie K. Horton, Samuel H. Wilson

Biochemistry. Author manuscript; available in PMC 2022 Feb 23.

Published in final edited form as: Biochemistry. 2019 Sep 3; 58(35): 3646–3655. Published online 2019 Aug 16. doi: 10.1021/acs.biochem.9b00433

PMCID:: PMC8865897

Article PDF–902K

Select item 862319110.

Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study

Yumin Jo, Yeojung Kim, Eunhye Park, Yuran Lee, Jiyeon Kim, Minwoong Kang, Jaesung Lim, Insang Song, Chaeseong Lim, Byeonghwa Jeon

Medicina (Kaunas) 2021 Nov; 57(11): 1280. Published online 2021 Nov 21. doi: 10.3390/medicina57111280

PMCID:: PMC8623191

Article PDF–1.5M

Select item 860134411.

Association between APE1 rs1760944 and rs1130409 polymorphism with prostate cancer risk: A systematic review and meta-analysis

Jinnian Liu, Jian Zheng, Yu Guo, Xia Sheng, Yongjian Yin, Shengqiang Qian, Bin Xu, Wei Xiong, Xiangrui Yin

Medicine (Baltimore) 2021 Nov 19; 100(46): e27630. Published online 2021 Nov 19. doi: 10.1097/MD.0000000000027630

PMCID:: PMC8601344

Article PDF–1.6M

Select item 844547412.

Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line

Daria V. Kim, Liliya M. Kulishova, Natalia A. Torgasheva, Vasily S. Melentyev, Grigory L. Dianov, Sergey P. Medvedev, Suren M. Zakian, Dmitry O. Zharkov

PLoS One. 2021; 16(9): e0257473. Published online 2021 Sep 16. doi: 10.1371/journal.pone.0257473

PMCID:: PMC8445474

Article PDF–1.8M

Select item 843402213.

When UDG and hAPE1 Meet Cyclopurines. How (5′R) and (5′S) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity?

Michał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski

Molecules. 2021 Sep; 26(17): 5177. Published online 2021 Aug 26. doi: 10.3390/molecules26175177

PMCID:: PMC8434022

Article PDF–2.9M

Select item 819525614.

Arginine methylation of APE1 promotes its mitochondrial translocation to protect cells from oxidative damage

Yilan Zhang, Qi Zhang, LuLu Li, Dan Mu, Ke Hua, Shusheng Ci, Lei Shen, Li Zheng, Binghui Shen, Zhigang Guo

Free Radic Biol Med. Author manuscript; available in PMC 2021 Jun 11.

Published in final edited form as: Free Radic Biol Med. 2020 Oct; 158: 60–73. Published online 2020 Jul 15. doi: 10.1016/j.freeradbiomed.2020.06.027

PMCID:: PMC8195256

Article PDF–2.2M

Select item 793731415.

APE1 may influence CD4+ naïve T cells on recurrence free survival in early stage NSCLC

Yanping Li, Xiaolong Zhao, He Xiao, Bo Yang, Jie Liu, Wen Rao, Xiaoyan Dai, Mengxia Li, Nan Dai, Yuxin Yang, Dong Wang

BMC Cancer. 2021; 21: 233. Published online 2021 Mar 6. doi: 10.1186/s12885-021-07950-1

PMCID:: PMC7937314

Article PDF–2.1M

Select item 765923816.

Human apurinic/apyrimidinic endonuclease 1 translocalizes to mitochondria after photodynamic therapy and protects cells from apoptosis

Meng‐Xia Li, Jin‐Lu Shan, Dong Wang, Yong He, Qian Zhou, Lei Xia, Lin‐Li Zeng, Zeng‐Peng Li, Ge Wang, Zhen‐Zhou Yang

Cancer Sci. 2012 May; 103(5): 882–888. Published online 2012 Apr 12. doi: 10.1111/j.1349-7006.2012.02239.x

PMCID:: PMC7659238

Article PDF–462K

Select item 757506217.

Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability

Suhas S. Kharat, Xia Ding, Divya Swaminathan, Akshey Suresh, Manish Singh, Satheesh K. Sengodan, Sandra Burkett, Hanna Marks, Chinmayi Pamala, Yafeng He, Stephen D. Fox, Eugen C. Buehler, Kathrin Muegge, Scott E. Martin, Shyam K. Sharan

Sci Signal. Author manuscript; available in PMC 2021 Feb 18.

Published in final edited form as: Sci Signal. 2020 Aug 18; 13(645): eaba8091. Published online 2020 Aug 18. doi: 10.1126/scisignal.aba8091