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Select item 65672801.

Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis

Eun-Ju Lee, Oh Chan Kwon, Byeongzu Ghang, Doo-Ho Lim, Do Hoon Kim, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim

Int J Mol Sci. 2019 May; 20(10): 2606. Published online 2019 May 27. doi: 10.3390/ijms20102606

PMCID:: PMC6567280

Abstract Article PDF–3.2M

Select item 37744022.

The MID1 E3 Ligase Catalyzes the Polyubiquitination of Alpha4 (α4), a Regulatory Subunit of Protein Phosphatase 2A (PP2A): NOVEL INSIGHTS INTO MID1-MEDIATED REGULATION of PP2A

Haijuan Du, Yongzhao Huang, Manar Zaghlula, Erica Walters, Timothy C. Cox, Michael A. Massiah

J Biol Chem. 2013 Jul 19; 288(29): 21341–21350. Published online 2013 Jun 5. doi: 10.1074/jbc.M113.481093

PMCID:: PMC3774402

Abstract Article PDF–1.7M

Select item 36440673.

Structural basis of protein phosphatase 2A stable latency

Li Jiang, Vitali Stanevich, Kenneth A Satyshur, Mei Kong, Guy R. Watkins, Brian E. Wadzinski, Rituparna Sengupta, Yongna Xing

Nat Commun. 2013 Apr 16; 4: 1699. Published online 2013 Apr 16. doi: 10.1038/ncomms2663

PMCID:: PMC3644067

Abstract Article PDF–1.7M

Select item 32375704.

NMR Studies of the C-Terminus of alpha4 Reveal Possible Mechanism of Its Interaction with MID1 and Protein Phosphatase 2A

Haijuan Du, Michael A. Massiah

PLoS One. 2011; 6(12): e28877. Published online 2011 Dec 14. doi: 10.1371/journal.pone.0028877

PMCID:: PMC3237570

Abstract Article PDF–1.0M

Select item 28327975.

Alpha4 is a Ubiquitin-Binding Protein that Regulates PP2A Ubiquitination

Jamie L. McConnell, Guy R. Watkins, Sarah E. Soss, Heidi S. Franz, Lisa R. McCorvey, Benjamin W. Spiller, Walter J. Chazin, Brian E. Wadzinski

Biochemistry. Author manuscript; available in PMC 2011 Mar 2.

Published in final edited form as: Biochemistry. 2010 Mar 2; 49(8): 1713–1718. doi: 10.1021/bi901837h

PMCID:: PMC2832797

Abstract Article PDF–722K

Select item 64848416.

The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4

Michele L. LeNoue-Newton, Brian E. Wadzinski, Benjamin W. Spiller

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Apr 26.

Published in final edited form as: Biochem Biophys Res Commun. 2016 Jun 17; 475(1): 64–69. Published online 2016 May 8. doi: 10.1016/j.bbrc.2016.05.036

PMCID:: PMC6484841

Abstract Article PDF–602K

Select item 59541907.

α4 Coordinates Small Intestinal Epithelium Homeostasis by Regulating Stability of HuR

Hee Kyoung Chung, Shelley R. Wang, Lan Xiao, Navneeta Rathor, Douglas J. Turner, Peixin Yang, Myriam Gorospe, Jaladanki N. Rao, Jian-Ying Wang

Mol Cell Biol. 2018 Jun 1; 38(11): e00631-17. Prepublished online 2018 Mar 19. Published online 2018 May 15. doi: 10.1128/MCB.00631-17

PMCID:: PMC5954190

Abstract Article PDF–2.1M

Select item 39297578.

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

Ummuhan Demir, Andrea Koehler, Rainer Schneider, Susann Schweiger, Helmut Klocker

BMC Cancer. 2014; 14: 52. Published online 2014 Jan 31. doi: 10.1186/1471-2407-14-52

PMCID:: PMC3929757

Abstract Article PDF–1.3M

Select item 25688039.

Active Transport of the Ubiquitin Ligase MID1 along the Microtubules Is Regulated by Protein Phosphatase 2A

Beatriz Aranda-Orgillés, Johanna Aigner, Melanie Kunath, Rudi Lurz, Rainer Schneider, Susann Schweiger

PLoS One. 2008; 3(10): e3507. Published online 2008 Oct 24. doi: 10.1371/journal.pone.0003507

PMCID:: PMC2568803

Abstract Article PDF–520K

Select item 339784710.

Monoubiquitination Promotes Calpain Cleavage of the Protein Phosphatase 2A (PP2A) Regulatory Subunit α4, Altering PP2A Stability and Microtubule-associated Protein Phosphorylation

Guy R. Watkins, Ning Wang, Matthew D. Mazalouskas, Rey J. Gomez, Chris R. Guthrie, Brian C. Kraemer, Susann Schweiger, Benjamin W. Spiller, Brian E. Wadzinski

J Biol Chem. 2012 Jul 13; 287(29): 24207–24215. Published online 2012 May 21. doi: 10.1074/jbc.M112.368613

PMCID:: PMC3397847

Abstract Article PDF–1.8M

Select item 309384211.

The E3 Ubiquitin Ligase- and Protein Phosphatase 2A (PP2A)-binding Domains of the Alpha4 Protein Are Both Required for Alpha4 to Inhibit PP2A Degradation

Michele LeNoue-Newton, Guy R. Watkins, Ping Zou, Katherine L. Germane, Lisa R. McCorvey, Brian E. Wadzinski, Benjamin W. Spiller

J Biol Chem. 2011 May 20; 286(20): 17665–17671. Published online 2011 Mar 29. doi: 10.1074/jbc.M111.222414

PMCID:: PMC3093842

Abstract Article PDF–1.4M

Select item 6477912.

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

Kieran M Short, Blair Hopwood, Zou Yi, Timothy C Cox

BMC Cell Biol. 2002; 3: 1. Published online 2002 Jan 4. doi: 10.1186/1471-2121-3-1

PMCID:: PMC64779

Abstract Article PDF–1.8M

Select item 3440813.

Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit α4

Jun Liu, Todd D. Prickett, Elizabeth Elliott, Germana Meroni, David L. Brautigan

Proc Natl Acad Sci U S A. 2001 Jun 5; 98(12): 6650–6655. Published online 2001 May 22. doi: 10.1073/pnas.111154698

PMCID:: PMC34408

Abstract Article PDF–1.0M

Select item 416025614.

MID1 Catalyzes the Ubiquitination of Protein Phosphatase 2A and Mutations within Its Bbox1 Domain Disrupt Polyubiquitination of Alpha4 but Not of PP2Ac

Haijuan Du, Kuanlin Wu, Alma Didoronkute, Marcus V. A. Levy, Nimish Todi, Anna Shchelokova, Michael A. Massiah

PLoS One. 2014; 9(9): e107428. Published online 2014 Sep 10. doi: 10.1371/journal.pone.0107428

PMCID:: PMC4160256

Abstract Article PDF–5.1M

Select item 324236915.

A PP4-phosphatase complex dephosphorylates γ-H2AX generated during DNA replication

Dipanjan Chowdhury, Xingzhi Xu, Xueyan Zhong, Fariyal Ahmed, Jianing Zhong, Ji Liao, Derek M. Dykxhoorn, David M. Weinstock, Gerd P. Pfeifer, Judy Lieberman

Mol Cell. Author manuscript; available in PMC 2011 Dec 19.

Published in final edited form as: Mol Cell. 2008 Jul 11; 31(1): 33–46. doi: 10.1016/j.molcel.2008.05.016

PMCID:: PMC3242369

Abstract Article PDF–4.6M

Select item 278202716.

Inactivation of Mammalian Target of Rapamycin Increases STAT1 Nuclear Content and Transcriptional Activity in α4- and Protein Phosphatase 2A-dependent Fashion

Jill A. Fielhaber, Ying-Shan Han, Jason Tan, Shuo Xing, Catherine M. Biggs, Kwang-Bo Joung, Arnold S. Kristof

J Biol Chem. 2009 Sep 4; 284(36): 24341–24353. Published online 2009 Jun 24. doi: 10.1074/jbc.M109.033530

PMCID:: PMC2782027

Abstract Article PDF–4.1M

Select item 190003617.

Cytokine Activation of p38 Mitogen-Activated Protein Kinase and Apoptosis Is Opposed by alpha-4 Targeting of Protein Phosphatase 2A for Site-Specific Dephosphorylation of MEK3

Todd D. Prickett, David L. Brautigan

Mol Cell Biol. 2007 Jun; 27(12): 4217–4227. Published online 2007 Apr 16. doi: 10.1128/MCB.00067-07

PMCID:: PMC1900036

Abstract Article PDF–399K

Select item 266201718.

PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4

Ginny I. Chen, Sally Tisayakorn, Claus Jorgensen, Lisa M. D'Ambrosio, Marilyn Goudreault, Anne-Claude Gingras

J Biol Chem. 2008 Oct 24; 283(43): 29273–29284. doi: 10.1074/jbc.M803443200

PMCID:: PMC2662017

Abstract Article PDF–759K

Select item 267689919.

A Targeted Proteomic Analysis of the Ubiquitin-Like Modifier Nedd8 and Associated Proteins

Jeffrey Jones, Kenneth Wu, Yingying Yang, Cortnie Guerrero, Nadinath Nillegoda, Zhen-Qiang Pan, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2009 May 4.

Published in final edited form as: J Proteome Res. 2008 Mar; 7(3): 1274–1287. Published online 2008 Feb 5. doi: 10.1021/pr700749v

PMCID:: PMC2676899

Abstract Article PDF–2.6M

Select item 262100420.

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

Marilyn Goudreault, Lisa M. D’Ambrosio, Michelle J. Kean, Michael J. Mullin, Brett G. Larsen, Amy Sanchez, Sidharth Chaudhry, Ginny I. Chen, Frank Sicheri, Alexey I. Nesvizhskii, Ruedi Aebersold, Brian Raught, Anne-Claude Gingras

Mol Cell Proteomics. 2009 Jan; 8(1): 157–171. doi: 10.1074/mcp.M800266-MCP200

PMCID:: PMC2621004

Abstract Article PDF–641K

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PMC Links for Gene (Select 3476) (61)
PMC
PREDICTED: Homo sapiens solute carrier family 47 member 2 (SLC47A2), transcript ...
PREDICTED: Homo sapiens solute carrier family 47 member 2 (SLC47A2), transcript variant X4, mRNA
gi|2217310158|ref|XM_047435434.1|

Nucleotide
cardiolipin synthase (CMP-forming) isoform X3 [Homo sapiens]
cardiolipin synthase (CMP-forming) isoform X3 [Homo sapiens]
gi|530425767|ref|XP_005260795.1|

Protein
Homo sapiens cardiolipin synthase 1 (CRLS1), transcript variant 5, mRNA
Homo sapiens cardiolipin synthase 1 (CRLS1), transcript variant 5, mRNA
gi|1676319095|ref|NM_001323563.2|

Nucleotide
Mpv17l2 MPV17 mitochondrial inner membrane protein like 2 [Rattus norvegicus]
Mpv17l2 MPV17 mitochondrial inner membrane protein like 2 [Rattus norvegicus]
Gene ID:290645

Gene

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