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Select item 94860521.

Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication

Ruo-Wen Xiao, Fang Wang, Tong-Min Wang, Jiang-Bo Zhang, Zi-Yi Wu, Chang-Mi Deng, Ying Liao, Ting Zhou, Da-Wei Yang, Si-Qi Dong, Wen-Qiong Xue, Yong-Qiao He, Xiao-Hui Zheng, Xi-Zhao Li, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Yu-Ying Liu, Yun-Fei Xia, Song Gao, Jian-Bing Mu, Lin Feng, Wei-Hua Jia

eBioMedicine. 2022 Oct; 84: 104267. Published online 2022 Sep 15. doi: 10.1016/j.ebiom.2022.104267

PMCID:: PMC9486052

Abstract Article PDF–3.4M

Select item 82017712.

Multiple deprotonation paths of the nucleophile 3′-OH in the DNA synthesis reaction

Mark T. Gregory, Yang Gao, Qiang Cui, Wei Yang

Proc Natl Acad Sci U S A. 2021 Jun 8; 118(23): e2103990118. Published online 2021 Jun 4. doi: 10.1073/pnas.2103990118

PMCID:: PMC8201771

Abstract Article PDF–1.5M

Select item 77461413.

Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η

Hummin Jung, Rayala Naveen Kumar, Seongmin Lee

Biochem J. Author manuscript; available in PMC 2020 Dec 17.

Published in final edited form as: Biochem J. 2020 Dec 11; 477(23): 4543–4558. doi: 10.1042/BCJ20200767

PMCID:: PMC7746141

Abstract Article PDF–2.2M

Select item 66578084.

Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η

Hala Ouzon-Shubeita, Meghan Baker, Myong-Chul Koag, Seongmin Lee

Biochem J. Author manuscript; available in PMC 2019 Jul 25.

Published in final edited form as: Biochem J. 2019 Feb 28; 476(4): 747–758. Published online 2019 Feb 28. doi: 10.1042/BCJ20180848

PMCID:: PMC6657808

Abstract Article PDF–1.1M

Select item 64636945.

Human DNA polymerase η has reverse transcriptase activity in cellular environments

Yan Su, Pratibha P. Ghodke, Martin Egli, Lin Li, Yinsheng Wang, F. Peter Guengerich

J Biol Chem. 2019 Apr 12; 294(15): 6073–6081. Published online 2019 Mar 6. doi: 10.1074/jbc.RA119.007925

PMCID:: PMC6463694

Abstract Article PDF–1.1M

Select item 63197596.

Crystallographic evidence for two‐metal‐ion catalysis in human pol η

Jimin Wang, Zachary B. Smithline

Protein Sci. 2019 Feb; 28(2): 439–447. Published online 2018 Dec 11. doi: 10.1002/pro.3541

PMCID:: PMC6319759

Abstract Article PDF–3.7M

Select item 51049507.

Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O⁶-Methyl-2′-deoxyguanosine by Human DNA Polymerase η

Amitraj Patra, Qianqian Zhang, F. Peter Guengerich, Martin Egli

J Biol Chem. 2016 Nov 11; 291(46): 24304–24313. Published online 2016 Sep 30. doi: 10.1074/jbc.M116.755462

PMCID:: PMC5104950

Abstract Article PDF–3.2M

Select item 49331728.

Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N⁶-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η

Amritraj Patra, Yan Su, Qianqian Zhang, Kevin M. Johnson, F. Peter Guengerich, Martin Egli

J Biol Chem. 2016 Jul 1; 291(27): 14134–14145. Published online 2016 May 16. doi: 10.1074/jbc.M116.732487

PMCID:: PMC4933172

Abstract Article PDF–3.9M

Select item 47591569.

Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η

Yan Su, Martin Egli, F. Peter Guengerich

J Biol Chem. 2016 Feb 19; 291(8): 3747–3756. Published online 2016 Jan 6. doi: 10.1074/jbc.M115.706226

PMCID:: PMC4759156

Abstract Article PDF–3.0M

Select item 448122810.

Human DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency

A. S. Prakasha Gowda, George-Lucian Moldovan, Thomas E. Spratt

J Biol Chem. 2015 Jun 26; 290(26): 16292–16303. Published online 2015 May 11. doi: 10.1074/jbc.M115.653287

PMCID:: PMC4481228

Abstract Article PDF–1007K

Select item 323595711.

Kinetic analysis of the unique error signature of human DNA polymerase ν

Mercedes E. Arana, Olga Potapova, Thomas A. Kunkel, Catherine M. Joyce

Biochemistry. Author manuscript; available in PMC 2012 Nov 22.

Published in final edited form as: Biochemistry. 2011 Nov 22; 50(46): 10126–10135. Published online 2011 Oct 31. doi: 10.1021/bi201197p

PMCID:: PMC3235957

Abstract Article PDF–1.2M

Select item 713599412.

The roles of polymerases ν and θ in replicative bypass of O⁶- and N²-alkyl-2′-deoxyguanosine lesions in human cells

Hua Du, Pengcheng Wang, Jun Wu, Xiaomei He, Yinsheng Wang

J Biol Chem. 2020 Apr 3; 295(14): 4556–4562. Published online 2020 Feb 25. doi: 10.1074/jbc.RA120.012830

PMCID:: PMC7135994

Abstract Article PDF–1.0M

Select item 351677413.

Enhancement of Human DNA Polymerase η Activity and Fidelity Is Dependent Upon a Bipartite Interaction with the Werner Syndrome Protein

Leena Maddukuri, Amit Ketkar, Sarah Eddy, Maroof K. Zafar, Wezley C. Griffin, Robert L. Eoff

J Biol Chem. 2012 Dec 7; 287(50): 42312–42323. Published online 2012 Oct 8. doi: 10.1074/jbc.M112.410332

PMCID:: PMC3516774

Abstract Article PDF–1.8M

Select item 342167414.

Epstein-Barr Virus BPLF1 Deubiquitinates PCNA and Attenuates Polymerase η Recruitment to DNA Damage Sites

Christopher B. Whitehurst, Cyrus Vaziri, Julia Shackelford, Joseph S. Pagano

J Virol. 2012 Aug; 86(15): 8097–8106. doi: 10.1128/JVI.00588-12

PMCID:: PMC3421674

Abstract Article PDF–1.4M

Select item 283840615.

Novel Enzymatic Function of DNA Polymerase ν in Translesion DNA Synthesis Past Major Groove DNA−Peptide and DNA−DNA Cross-Links

Kinrin Yamanaka, Irina G. Minko, Kei-ichi Takata, Alexander Kolbanovskiy, Ivan D. Kozekov, Richard D. Wood, Carmelo J. Rizzo, R. Stephen Lloyd

Chem Res Toxicol. 2010 Mar 15; 23(3): 689–695. Published online 2010 Jan 26. doi: 10.1021/tx900449u

PMCID:: PMC2838406

Abstract Article PDF–4.1M

Select item 279055816.

Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links

Laura Zietlow, Leigh Anne Smith, Mika Bessho, Tadayoshi Bessho

Biochemistry. Author manuscript; available in PMC 2010 Dec 15.

Published in final edited form as: Biochemistry. 2009 Dec 15; 48(49): 11817–11824. doi: 10.1021/bi9015346

PMCID:: PMC2790558

Abstract Article PDF–1.2M

Select item 195068217.

A unique error signature for human DNA polymerase ν

Mercedes E. Arana, Kei-ichi Takata, Miguel Garcia-Diaz, Richard D. Wood, Thomas A. Kunkel

DNA Repair (Amst) Author manuscript; available in PMC 2008 Feb 4.

Published in final edited form as: DNA Repair (Amst). 2007 Feb 4; 6(2): 213–223. Published online 2006 Nov 21. doi: 10.1016/j.dnarep.2006.09.012

PMCID:: PMC1950682

Abstract Article PDF–996K

Select item 846385318.

DNA polymerases η and κ bypass N²-guanine-O⁶-alkylguanine DNA alkyltransferase cross-linked DNA-peptides

Pratibha P. Ghodke, F. Peter Guengerich

J Biol Chem. 2021 Oct; 297(4): 101124. Published online 2021 Aug 28. doi: 10.1016/j.jbc.2021.101124

PMCID:: PMC8463853

Abstract Article PDF–1.9M

Select item 582744519.

Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

Jung-Hoon Yoon, Richard P. Hodge, Linda C. Hackfeld, Jeseong Park, Jayati Roy Choudhury, Satya Prakash, Louise Prakash

J Biol Chem. 2018 Feb 23; 293(8): 2949–2958. Published online 2018 Jan 12. doi: 10.1074/jbc.RA117.000962

PMCID:: PMC5827445

Abstract Article PDF–722K

Select item 331869120.

Preparation of Site-specific T=^mCG cis-syn Cyclobutane Dimer-containing Template and Its Error-free Bypass by Yeast and Human Polymerase η

Qian Song, Shanen M. Sherrer, Zucai Suo, John-Stephen Taylor

J Biol Chem. 2012 Mar 9; 287(11): 8021–8028. Published online 2012 Jan 19. doi: 10.1074/jbc.M111.333591

PMCID:: PMC3318691

Abstract Article PDF–1.0M

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