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Select item 100869991.

IL1RAP expression and the enrichment of IL‐33 activation signatures in severe neutrophilic asthma

Yusef Eamon Badi, Barbora Salcman, Adam Taylor, Batika Rana, Nazanin Zounemat Kermani, John H. Riley, Sally Worsley, Sharon Mumby, Sven‐Eric Dahlen, David Cousins, Silvia Bulfone‐Paus, Karen Affleck, Kian Fan Chung, Stewart Bates, Ian M. Adcock

Allergy. 2023 Jan; 78(1): 156–167. Published online 2022 Aug 28. doi: 10.1111/all.15487

PMCID:: PMC10086999

Abstract Article PDF–9.3M

Select item 98900102.

IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1-positive leukemia cells in preclinical models

Helena Ågerstam, Henrik Lilljebjörn, Marianne Rissler, Carl Sandén1, Thoas Fioretos

Haematologica. 2023 Feb 1; 108(2): 599–604. Published online 2022 Oct 13. doi: 10.3324/haematol.2022.281059

PMCID:: PMC9890010

Article PDF–1.0M

Select item 92721233.

Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia

Rim Trad, Walid Warda, Vincent Alcazer, Mathieu Neto da Rocha, Ana Berceanu, Clémentine Nicod, Rafik Haderbache, Xavier Roussel, Yohan Desbrosses, Etienne Daguindau, Florain Renosi, Christophe Roumier, Lucie Bouquet, Sabeha Biichle, Melanie Guiot, Evan Seffar, Denis Caillot, Stephane Depil, Eric Robinet, Yahya Salma, Eric Deconinck, Marina Deschamps, Christophe Ferrand

J Immunother Cancer. 2022; 10(7): e004222. Published online 2022 Jul 8. doi: 10.1136/jitc-2021-004222

PMCID:: PMC9272123

Abstract Article PDF–7.4M

Select item 91281184.

Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer

Yang Zhang, Xiaoyi Chen, Huamin Wang, Shanisha Gordon-Mitchell, Srabani Sahu, Tushar D. Bhagat, Gaurav Choudhary, Srinivas Aluri, Kith Pradhan, Plabani Sahu, Milagros Carbajal, Hui Zhang, Beamon Agarwal, Aditi Shastri, Robert Martell, Daniel Starczynowski, Ulrich Steidl, Anirban Maitra, Amit Verma

J Hematol Oncol. 2022; 15: 70. Published online 2022 May 23. doi: 10.1186/s13045-022-01286-4

Correction in:: J Hematol Oncol. 2022; 15: 100.

PMCID:: PMC9128118

Abstract Article PDF–3.6M

Select item 85633745.

Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma

Hai-Feng Zhang, Christopher S. Hughes, Wei Li, Jian-Zhong He, Didier Surdez, Amal M. El-Naggar, Hongwei Cheng, Anna Prudova, Alberto Delaidelli, Gian Luca Negri, Xiaojun Li, Maj Sofie Ørum-Madsen, Michael M. Lizardo, Htoo Zarni Oo, Shane Colborne, Taras Shyp, Renata Scopim-Ribeiro, Colin A. Hammond, Anne-Chloe Dhez, Sofya Langman, Jonathan K.M. Lim, Sonia H.Y. Kung, Amy Li, Anne Steino, Mads Daugaard, Seth J. Parker, Ramon I. Klein Geltink, Rimas J. Orentas, Li-Yan Xu, Gregg B. Morin, Olivier Delattre, Dimiter S. Dimitrov, Poul H. Sorensen

Cancer Discov. 2021 Nov 1; 11(11): 2884–2903. Published online 2021 May 25. doi: 10.1158/2159-8290.CD-20-1690

PMCID:: PMC8563374

Abstract Article PDF–8.9M

Select item 78978086.

The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma

Qing Lv, Qinghua Xia, Anshu Li, Zhiyong Wang

Technol Cancer Res Treat. 2021; 20: 1533033821995282. Published online 2021 Feb 19. doi: 10.1177/1533033821995282

PMCID:: PMC7897808

Abstract Article PDF–1.6M

Select item 67078547.

IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

Jesper Falkesgaard Højen, Marie Louise Vindvad Kristensen, Amy S. McKee, Megan Taylor Wade, Tania Azam, Lars P. Lunding, Dennis M. de Graaf, Benjamin J. Swartzwelter, Michael Wegmann, Martin Tolstrup, Karsten Beckman, Mayumi Fujita, Stephan Fischer, Charles A. Dinarello

Nat Immunol. Author manuscript; available in PMC 2020 Feb 19.

Published in final edited form as: Nat Immunol. 2019 Sep; 20(9): 1138–1149. Published online 2019 Aug 19. doi: 10.1038/s41590-019-0467-1

PMCID:: PMC6707854

Abstract Article PDF–1.7M

Select item 46714798.

GWAS of longitudinal amyloid accumulation on ¹⁸F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP

Vijay K Ramanan, Shannon L. Risacher, Kwangsik Nho, Sungeun Kim, Li Shen, Brenna C. McDonald, Karmen K. Yoder, Gary D. Hutchins, John D. West, Eileen F. Tallman, Sujuan Gao, Tatiana M. Foroud, Martin R. Farlow, Philip L. De Jager, David A. Bennett, Paul S. Aisen, Ronald C. Petersen, Clifford R. Jack, Jr., Arthur W. Toga, Robert C. Green, William J. Jagust, Michael W. Weiner, Andrew J. Saykin, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Brain. 2015 Oct; 138(10): 3076–3088. Published online 2015 Aug 12. doi: 10.1093/brain/awv231

PMCID:: PMC4671479

Abstract Article PDF–708K

Select item 41540959.

Plasma Levels of Soluble Interleukin 1 Receptor Accessory Protein Are Reduced in Obesity

Kiymet Bozaoglu, Chantal Attard, Hemant Kulkarni, Nik Cummings, Vincent P. Diego, Melanie A. Carless, Katherine A. Shields, Matthew P. Johnson, Sudhir Kowlessur, Thomas D. Dyer, Anthony G. Comuzzie, Laura Almasy, Paul Zimmet, Eric K. Moses, Harald H. H. Göring, Joanne E. Curran, John Blangero, Jeremy B. M. Jowett

J Clin Endocrinol Metab. 2014 Sep; 99(9): 3435–3443. Published online 2014 Jun 10. doi: 10.1210/jc.2013-4475

PMCID:: PMC4154095

Abstract Article

Select item 407247810.

Blood soluble interleukin 1 receptor accessory protein levels are consistently low throughout the menstrual cycle of women with endometriosis

Nadège Michaud, Mahera Al-Akoum, Ali Akoum

Reprod Biol Endocrinol. 2014; 12: 51. Published online 2014 Jun 16. doi: 10.1186/1477-7827-12-51

PMCID:: PMC4072478

Abstract Article PDF–369K

Select item 341872211.

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

Laura Barreyro, Britta Will, Boris Bartholdy, Li Zhou, Tihomira I. Todorova, Robert F. Stanley, Susana Ben-Neriah, Cristina Montagna, Samir Parekh, Andrea Pellagatti, Jacqueline Boultwood, Elisabeth Paietta, Rhett P. Ketterling, Larry Cripe, Hugo F. Fernandez, Peter L. Greenberg, Martin S. Tallman, Christian Steidl, Constantine S. Mitsiades, Amit Verma, Ulrich Steidl

Blood. 2012 Aug 9; 120(6): 1290–1298. Prepublished online 2012 Jun 21. doi: 10.1182/blood-2012-01-404699

PMCID:: PMC3418722

Abstract Article

Select item 294134112.

Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein

Marcus Järås, Petra Johnels, Nils Hansen, Helena Ågerstam, Panagiotis Tsapogas, Marianne Rissler, Carin Lassen, Tor Olofsson, Ole Weis Bjerrum, Johan Richter, Thoas Fioretos

Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37): 16280–16285. Published online 2010 Aug 30. doi: 10.1073/pnas.1004408107

PMCID:: PMC2941341

Abstract Article PDF–713K

Select item 765244913.

The Role of SNPs in IL1RL1 and IL1RAP Genes in Age-related Macular Degeneration Development and Treatment Efficacy

ALVITA VILKEVICIUTE, NERINGA BASTIKAITYTE, RUTA MOCKUTE, DZASTINA CEBATORIENE, LORESA KRIAUCIUNIENE, JURATE BALCIUNIENE, REDA ZEMAITIENE, RASA LIUTKEVICIENE

In Vivo. 2020 Sep-Oct; 34(5): 2443–2451. Published online 2020 Sep 3. doi: 10.21873/invivo.12059

PMCID:: PMC7652449

Abstract Article PDF–155K

Select item 638525214.

Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein

Anna Zettergren, Kina Höglund, Silke Kern, Valgeir Thorvaldsson, Msc Johan Skoog, Oskar Hansson, Niels Andreasen, Nenad Bogdanovic, Kaj Blennow, Ingmar Skoog, Henrik Zetterberg

Sci Rep. 2019; 9: 2460. Published online 2019 Feb 21. doi: 10.1038/s41598-018-36650-3

PMCID:: PMC6385252

Abstract Article PDF–1.0M

Select item 598792615.

IL1RAP potentiates multiple oncogenic signaling pathways in AML

Kelly Mitchell, Laura Barreyro, Tihomira I. Todorova, Samuel J. Taylor, Iléana Antony-Debré, Swathi-Rao Narayanagari, Luis A. Carvajal, Joana Leite, Zubair Piperdi, Gopichand Pendurti, Ioannis Mantzaris, Elisabeth Paietta, Amit Verma, Kira Gritsman, Ulrich Steidl

J Exp Med. 2018 Jun 4; 215(6): 1709–1727. doi: 10.1084/jem.20180147

PMCID:: PMC5987926

Abstract Article PDF–2.6M

Select item 410374616.

A Novel CNS-Restricted Isoform of the IL-1R Accessory Protein Modulates Neuronal Responses to IL-1

Dirk E. Smith, Brian P. Lipsky, Chris Russell, Randal R. Ketchem, Jacqueline Kirchner, Kelly Hensley, Vincent Boissonneault, Marie-Michèle Plante, Serge Rivest, Yangyang Huang, Wilma Friedman, John E. Sims

Immunity. Author manuscript; available in PMC 2014 Jul 18.

Published in final edited form as: Immunity. 2009 Jun 19; 30(6): 817–831. Published online 2009 May 28. doi: 10.1016/j.immuni.2009.03.020

PMCID:: PMC4103746

Abstract Article PDF–2.2M

Select item 340977617.

Interleukin-1R3 mediates interleukin-1–induced potassium current increase through fast activation of Akt kinase

Jiang Qian, Ling Zhu, Qiming Li, Natalya Belevych, Qun Chen, Fangli Zhao, Scott Herness, Ning Quan

Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30): 12189–12194. Published online 2012 Jul 9. doi: 10.1073/pnas.1205207109

PMCID:: PMC3409776

Abstract Article PDF–980K

Select item 1107479618.

Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation

Megan Mulholland, Marie A C Depuydt, Gabriel Jakobsson, Irena Ljungcrantz, Andrietta Grentzmann, Fong To, Eva Bengtsson, Elin Jaensson Gyllenbäck, Caitríona Grönberg, Sara Rattik, David Liberg, Alexandru Schiopu, Harry Björkbacka, Johan Kuiper, Ilze Bot, Bram Slütter, Daniel Engelbertsen

Cardiovasc Res. 2024 Apr; 120(6): 581–595. Published online 2024 Apr 2. doi: 10.1093/cvr/cvae046

PMCID:: PMC11074796

Abstract Article PDF–4.6M

Select item 634917419.

Potential regulatory network in the PSG10P/miR‐19a‐3p/IL1RAP pathway is possibly involved in preeclampsia pathogenesis

Nan Wang, Ruizhen Li, Min Xue

J Cell Mol Med. 2019 Feb; 23(2): 852–864. Published online 2018 Oct 28. doi: 10.1111/jcmm.13985

PMCID:: PMC6349174

Abstract Article PDF–2.4M

Select item 497437520.

Structural and Functional Attributes of the Interleukin-36 Receptor

Guanghui Yi, Joel A. Ybe, Siddhartha S. Saha, Gary Caviness, Ernest Raymond, Rajkumar Ganesan, M. Lamine Mbow, C. Cheng Kao

J Biol Chem. 2016 Aug 5; 291(32): 16597–16609. Published online 2016 Jun 15. doi: 10.1074/jbc.M116.723064

PMCID:: PMC4974375

Abstract Article PDF–3.5M

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