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Select item 108384401.

Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer

Yuting Huang, Szehoi Chan, Shuna Chen, Xueqi Liu, Miao Li, Liyuan Zheng, Zhaoxia Dong, Ziyi Yang, Zixuan Liu, Disheng Zhou, Xingding Zhang, Bo Zhang

J Transl Med. 2024; 22: 133. Published online 2024 Feb 3. doi: 10.1186/s12967-024-04934-0

PMCID:: PMC10838440

Abstract Article PDF–11M

Select item 104074312.

Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation

Audrey G. O’Neill, Anika L. Burrell, Michael Zech, Orly Elpeleg, Tamar Harel, Simon Edvardson, Hagar Mor-Shaked, Alyssa L. Rippert, Tomoki Nomakuchi, Kosuke Izumi, Justin M. Kollman

J Biol Chem. 2023 Aug; 299(8): 105012. Published online 2023 Jul 4. doi: 10.1016/j.jbc.2023.105012

PMCID:: PMC10407431

Abstract Article PDF–3.9M

Select item 86331843.

IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder

Anna Kuukasjärvi, Juan C. Landoni, Jyrki Kaukonen, Mika Juhakoski, Mari Auranen, Tommi Torkkeli, Vidya Velagapudi, Anu Suomalainen

Eur J Hum Genet. 2021 Dec; 29(12): 1833–1837. Published online 2021 Jul 26. doi: 10.1038/s41431-021-00939-1

PMCID:: PMC8633184

Abstract Article PDF–1.3M

Select item 81496914.

IMPDH2 and HPRT expression and a prognostic significance in preoperative and postoperative patients with osteosarcoma

Parunya Chaiyawat, Areerak Phanphaisarn, Nutnicha Sirikaew, Jeerawan Klangjorhor, Viraporn Thepbundit, Pimpisa Teeyakasem, Phichayut Phinyo, Dumnoensun Pruksakorn, Jongkolnee Settakorn

Sci Rep. 2021; 11: 10887. Published online 2021 May 25. doi: 10.1038/s41598-021-90456-4

PMCID:: PMC8149691

Abstract Article PDF–5.1M

Select item 70185145.

Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation

Matthew C Johnson, Justin M Kollman

eLife. 2020; 9: e53243. Published online 2020 Jan 30. doi: 10.7554/eLife.53243

PMCID:: PMC7018514

Abstract Article PDF–7.4M

Select item 66868846.

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, Risa Kawaguchi, Yuki Sugiura, Oltea Sampetrean, Yoshiki Ikeda, Mikako Warren, Naoya Sakamoto, Shuji Kitahara, Hirofumi Yoshino, Daisuke Yamashita, Kazutaka Sumita, Kara Wolfe, Lisa Lange, Satsuki Ikeda, Hiroko Shimada, Noriaki Minami, Akshiv Malhotra, Shin Morioka, Yuki Ban, Maya Asano, Victoria L Flanary, Annmarie Ramkissoon, Lionel M.L. Chow, Juri Kiyokawa, Tomoyuki Mashimo, Greg Lucey, Sergey Mareninov, Tatsuya Ozawa, Nobuyuki Onishi, Koichi Okumura, Jumpei Terakawa, Takiko Daikoku, Trisha Wise-Draper, Nazanin Majd, Kaori Kofuji, Mika Sasaki, Masaru Mori, Yonehiro Kanemura, Eric P. Smith, Dimitrios Anastasiou, Hiroaki Wakimoto, Eric C. Holland, William H. Yong, Craig Horbinski, Ichiro Nakano, Ralph J. DeBerardinis, Robert M. Bachoo, Paul S. Mischel, Wataru Yasui, Makoto Suematsu, Hideyuki Saya, Tomoyoshi Soga, Ingrid Grummt, Holger Bierhoff, Atsuo T. Sasaki

Nat Cell Biol. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Nat Cell Biol. 2019 Aug; 21(8): 1003–1014. Published online 2019 Aug 1. doi: 10.1038/s41556-019-0363-9

PMCID:: PMC6686884

Abstract Article PDF–2.8M

Select item 62823297.

IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

Shiyu Duan, Wenqing Huang, Xiaoting Liu, Xuming Liu, Nana Chen, Qiong Xu, Yukun Hu, Wen Song, Jun Zhou

J Exp Clin Cancer Res. 2018; 37: 304. Published online 2018 Dec 5. doi: 10.1186/s13046-018-0980-3

PMCID:: PMC6282329

Abstract Article PDF–13M

Select item 54297258.

High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma

Yi Xu, Zhousan Zheng, Ying Gao, Shiyu Duan, Cui Chen, Jian Rong, Kebing Wang, Miao Yun, Huiwen Weng, Sheng Ye, Jiaxing Zhang

Sci Rep. 2017; 7: 745. Published online 2017 Apr 7. doi: 10.1038/s41598-017-00887-1

PMCID:: PMC5429725

Abstract Article PDF–2.3M

Select item 40827949.

Effect of Diabetes Mellitus on Mycophenolate Sodium Pharmacokinetics and Inosine Monophosphate Dehydrogenase Activity in Stable Kidney Transplant Recipients

Chirag G. Patel, Katherine Richman, Dongfang Yang, Bingfang Yan, Reginald Y. Gohh, Fatemeh Akhlaghi

Ther Drug Monit. Author manuscript; available in PMC 2014 Jul 6.

Published in final edited form as: Ther Drug Monit. 2007 Dec; 29(6): 735–742. doi: 10.1097/FTD.0b013e31815d8ace

PMCID:: PMC4082794

Abstract Article PDF–308K

Select item 292233910.

Overexpression of Inosine 5′-Monophosphate Dehydrogenase Type II Mediates Chemoresistance to Human Osteosarcoma Cells

Jörg Fellenberg, Pierre Kunz, Heiner Sähr, Daniela Depeweg

PLoS One. 2010; 5(8): e12179. Published online 2010 Aug 16. doi: 10.1371/journal.pone.0012179

PMCID:: PMC2922339

Abstract Article PDF–487K

Select item 2232711.

Crystal structure of human type II inosine monophosphate dehydrogenase: Implications for ligand binding and drug design

Thomas D. Colby, Kristen Vanderveen, Michael D. Strickler, George D. Markham, Barry M. Goldstein

Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7): 3531–3536. doi: 10.1073/pnas.96.7.3531

PMCID:: PMC22327

Abstract Article PDF–465K

Select item 1111331112.

Glutamine deprivation initiates reversible assembly of mammalian rods and rings

S. John Calise, Wendy C. Carcamo, Claire Krueger, Joyce D. Yin, Daniel L. Purich, Edward K. L. Chan

Cell Mol Life Sci. 2014 Aug; 71(15): 2963–2973. Published online 2014 Jan 30. doi: 10.1007/s00018-014-1567-6

PMCID:: PMC11113311

Abstract Article PDF–1.4M

Select item 951337413.

SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling

Tai-Wei Li, Adam D. Kenney, Jun-Gyu Park, Guillaume N. Fiches, Helu Liu, Dawei Zhou, Ayan Biswas, Weiqiang Zhao, Jianwen Que, Netty Santoso, Luis Martinez-Sobrido, Jacob S. Yount, Jian Zhu

Front Immunol. 2022; 13: 1007089. Published online 2022 Sep 13. doi: 10.3389/fimmu.2022.1007089

PMCID:: PMC9513374

Abstract Article PDF–6.1M

Select item 676864014.

ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly

Dawn Hayward, Valentina L. Kouznetsova, Hannah E. Pierson, Nesrin M. Hasan, Estefany R. Guzman, Igor F. Tsigelny, Svetlana Lutsenko

J Biol Chem. 2019 Sep 27; 294(39): 14454–14466. Published online 2019 Jul 23. doi: 10.1074/jbc.RA119.008231

PMCID:: PMC6768640

Abstract Article PDF–3.6M

Select item 410120415.

Expression of IMPDH mRNA after Mycophenolate Administration in Male Volunteers

Sollip Kim, Woochang Lee, Sail Chun, Tae Hyun Um, Won-Ki Min

Biomed Res Int. 2014; 2014: 870209. Published online 2014 Jul 1. doi: 10.1155/2014/870209

PMCID:: PMC4101204

Abstract Article PDF–687K

Select item 323508416.

Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil

Olivier Gensburger, Ron H. N. Van Schaik, Nicolas Picard, Yannick Le Meur, Annick Rousseau, Jean-Baptiste Woillard, Teun Van Gelder, Pierre Marquet

Pharmacogenet Genomics. Author manuscript; available in PMC 2011 Dec 12.

Published in final edited form as: Pharmacogenet Genomics. 2010 Sep; 20(9): 537–543. doi: 10.1097/FPC.0b013e32833d8cf5

PMCID:: PMC3235084

Abstract Article

Select item 312309717.

IMPDHII Protein Inhibits Toll-like Receptor 2-mediated Activation of NF-κB

Julie Toubiana, Anne-Lise Rossi, David Grimaldi, Nadia Belaidouni, Philippe Chafey, Guilhem Clary, Emilie Courtine, Frederic Pene, Jean-Paul Mira, Yann-Erick Claessens, Jean-Daniel Chiche

J Biol Chem. 2011 Jul 1; 286(26): 23319–23333. Published online 2011 Apr 1. doi: 10.1074/jbc.M110.201210

PMCID:: PMC3123097

Abstract Article PDF–2.7M

Select item 301056918.

Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics

T-Y Wu, Y Peng, LL Pelleymounter, I Moon, BW Eckloff, ED Wieben, VC Yee, RM Weinshilboum

Br J Pharmacol. 2010 Dec; 161(7): 1584–1598. doi: 10.1111/j.1476-5381.2010.00987.x

PMCID:: PMC3010569

Abstract Article PDF–1.7M

Select item 983242519.

c‐Myc–IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming

Qiang Zhang, Kaisa Cui, Xiaoya Yang, Qilang He, Jing Yu, Li Yang, Gang Yao, Weiwei Guo, Zhanhao Luo, Yugeng Liu, Yuan Chen, Zhen He, Ping Lan

Clin Transl Med. 2023 Jan; 13(1): e1164. Published online 2023 Jan 11. doi: 10.1002/ctm2.1164

PMCID:: PMC9832425

Abstract Article PDF–5.4M

Select item 374489520.

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

Sudha Mannava, Vladimir Grachtchouk, Linda J. Wheeler, Michael Im, Dazhong Zhuang, Elena G. Slavina, Christopher K. Mathews, Donna S. Shewach, Mikhail A. Nikiforov

Cell Cycle. Author manuscript; available in PMC 2013 Aug 16.

Published in final edited form as: Cell Cycle. 2008 Aug; 7(15): 2392–2400. Published online 2008 Jun 3. doi: 10.4161/cc.6390

PMCID:: PMC3744895

Abstract Article PDF–2.7M

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