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Select item 101224051.

A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer

Li Xiong, Hua-shan Liu, Chi Zhou, Xin Yang, Liang Huang, Hai-qing Jie, Zi-wei Zeng, Xiao-bin Zheng, Wen-xin Li, Zhan-zhen Liu, Liang Kang, Zhen-xing Liang

Mol Cancer. 2023; 22: 72. Published online 2023 Apr 22. doi: 10.1186/s12943-023-01773-3

PMCID:: PMC10122405

Article PDF–12M

Select item 76084312.

Erratum: Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner

E Theusch, K Kim, K Stevens, J D Smith, Y-DI Chen, J I Rotter, D A Nickerson, M W Medina

Pharmacogenomics J. 2016; 16(3): 301. Published online 2016 May 20. doi: 10.1038/tpj.2016.30

Corrects:: Pharmacogenomics J. 2017 Jun; 17(3): 222–229.

PMCID:: PMC7608431

Correction PDF–89K

Select item 68931653.

Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China

Jing Tao, Mayila Abudoukelimu, Xin Shen, Jun Liu, Feng-xia Wang, Jie Yuan, Pei-Pei Gu, Wei Zhu, Xiao-tian Zhang, Zhao Wang, Yi-tong Ma, Guo-qing Li

Biosci Rep. 2019 Dec 20; 39(12): BSR20190498. Published online 2019 Nov 28. doi: 10.1042/BSR20190498

PMCID:: PMC6893165

Article PDF–447K

Select item 50089974.

Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner

E Theusch, K Kim, K Stevens, J D Smith, Y -D I Chen, J I Rotter, D A Nickerson, M W Medina

Pharmacogenomics J. 2017 Jun; 17(3): 222–229. Published online 2016 Mar 1. doi: 10.1038/tpj.2016.12

Correction in:: Pharmacogenomics J. 2016; 16(3): 301.

PMCID:: PMC5008997

Article PDF–366K

Select item 28387075.

INSIG1 influences obesity-related hypertriglyceridemia in humans

E. M. Smith, Y. Zhang, T. M Baye, S. Gawrieh, R. Cole, J. Blangero, M. A. Carless, J. E. Curran, T. D. Dyer, L. J. Abraham, E. K. Moses, A. H. Kissebah, L. J. Martin, M. Olivier

J Lipid Res. 2010 Apr; 51(4): 701–708. doi: 10.1194/jlr.M001404

PMCID:: PMC2838707

Article PDF–915K

Select item 1968586.

Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

Christopher M. Adams, Joseph L. Goldstein, Michael S. Brown

Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19): 10647–10652. Published online 2003 Sep 8. doi: 10.1073/pnas.1534833100

PMCID:: PMC196858

Article PDF–629K

Select item 1305197.

The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP

Bethany A. Janowski

Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20): 12675–12680. Published online 2002 Sep 19. doi: 10.1073/pnas.202471599

PMCID:: PMC130519

Article PDF–349K

Select item 80949108.

Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

Vian Azzu, Michele Vacca, Ioannis Kamzolas, Zoe Hall, Jack Leslie, Stefania Carobbio, Samuel Virtue, Susan E. Davies, Agnes Lukasik, Martin Dale, Mohammad Bohlooly-Y, Animesh Acharjee, Daniel Lindén, Guillaume Bidault, Evangelia Petsalaki, Julian L. Griffin, Fiona Oakley, Michael E.D. Allison, Antonio Vidal-Puig

Mol Metab. 2021 Jun; 48: 101210. Published online 2021 Mar 17. doi: 10.1016/j.molmet.2021.101210

PMCID:: PMC8094910

Article PDF–3.1M

Select item 63384949.

Genome-wide CRISPR analysis identifies substrate-specific conjugation modules in ER-associated degradation

Dara E. Leto, David W. Morgens, Lichao Zhang, Christopher P. Walczak, Joshua E. Elias, Michael C. Bassik, Ron R. Kopito

Mol Cell. Author manuscript; available in PMC 2020 Jan 17.

Published in final edited form as: Mol Cell. 2019 Jan 17; 73(2): 377–389.e11. Published online 2018 Dec 20. doi: 10.1016/j.molcel.2018.11.015

PMCID:: PMC6338494

Article PDF–1.9M

Select item 568900810.

Precursor microRNA-122 inhibits synthesis of Insig1 isoform mRNA by modulating polyadenylation site usage

Kara L. Norman, Tzu-Chun Chen, Gusti Zeiner, Peter Sarnow

RNA. 2017 Dec; 23(12): 1886–1893. doi: 10.1261/rna.063099.117

PMCID:: PMC5689008

Article PDF–1.6M

Select item 365626311.

Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi

Yinxin Zhang, Massoud Motamed, Joachim Seemann, Michael S. Brown, Joseph L. Goldstein

J Biol Chem. 2013 May 17; 288(20): 14059–14067. Published online 2013 Apr 5. doi: 10.1074/jbc.M113.469528

PMCID:: PMC3656263

Article PDF–2.0M

Select item 278977912.

Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells

Peter C. W. Lee, Russell A. DeBose-Boyd

J Lipid Res. 2010 Jan; 51(1): 192–201. doi: 10.1194/jlr.M900336-JLR200

PMCID:: PMC2789779

Article PDF–1.3M

Select item 278536613.

Insig-mediated, Sterol-accelerated Degradation of the Membrane Domain of Hamster 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase in Insect Cells

Andrew D. Nguyen, Soo Hee Lee, Russell A. DeBose-Boyd

J Biol Chem. 2009 Sep 25; 284(39): 26778–26788. Published online 2009 Jul 28. doi: 10.1074/jbc.M109.032342

PMCID:: PMC2785366

Article PDF–1.5M

Select item 271083014.

Dislocation of HMG-CoA Reductase and Insig-1, Two Polytopic Endoplasmic Reticulum Proteins, En Route to Proteasomal Degradation

Gil S. Leichner, Rachel Avner, Dror Harats, Joseph Roitelman

Mol Biol Cell. 2009 Jul 15; 20(14): 3330–3341. doi: 10.1091/mbc.E08-09-0953

PMCID:: PMC2710830

Article PDF–1.3M

Select item 836383115.

Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK–eIF2α–ATF4 axis

Yuichi Watanabe, Takashi Sasaki, Shoko Miyoshi, Makoto Shimizu, Yoshio Yamauchi, Ryuichiro Sato

J Biol Chem. 2021 Aug; 297(2): 100989. Published online 2021 Jul 21. doi: 10.1016/j.jbc.2021.100989

PMCID:: PMC8363831

Article PDF–2.7M

Select item 835460916.

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

Zu-Guo Zheng, Si-Tong Zhu, Hui-Min Cheng, Xin Zhang, Gang Cheng, Pyone Myat Thu, Supeng Perry Wang, Hui-Jun Li, Ming Ding, Lei Qiang, Xiao-Wei Chen, Qing Zhong, Ping Li, Xiaojun Xu

Autophagy. 2021; 17(7): 1592–1613. Published online 2020 May 20. doi: 10.1080/15548627.2020.1757955

PMCID:: PMC8354609

Article PDF–14M

Select item 820097817.

The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity

Flaminia Ferri, Simone Carotti, Guido Carpino, Monica Mischitelli, Alfredo Cantafora, Antonio Molinaro, Maria Eva Argenziano, Simona Parisse, Alessandro Corsi, Mara Riminucci, Quirino Lai, Gianluca Mennini, Gustavo Spadetta, Francesco Pugliese, Massimo Rossi, Sergio Morini, Eugenio Gaudio, Stefano Ginanni Corradini

Int J Mol Sci. 2021 Jun; 22(11): 6100. Published online 2021 Jun 5. doi: 10.3390/ijms22116100

PMCID:: PMC8200978

Article PDF–1.3M

Select item 624780118.

HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages

Alexander N. Orekhov, Tatiana Pushkarsky, Yumiko Oishi, Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth, Igor A. Sobenin, Vasily N. Sukhorukov, Emile R. Zakiev, Anatol Kontush, Wilfried Le Goff, Michael Bukrinsky

Exp Mol Pathol. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: Exp Mol Pathol. 2018 Oct; 105(2): 202–207. Published online 2018 Aug 16. doi: 10.1016/j.yexmp.2018.08.003

PMCID:: PMC6247801

Article PDF–563K

Select item 464340519.

Glucose-mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

Chunming Cheng, Peng Ru, Feng Geng, Junfeng Liu, Ji Young Yoo, Xiaoning Wu, Xiang Cheng, Vanessa Euthine, Peng Hu, Jeffrey Yunhua Guo, Etienne Lefai, Balveen Kaur, Axel Nohturfft, Jianjie Ma, Arnab Chakravarti, Deliang Guo

Cancer Cell. Author manuscript; available in PMC 2016 Nov 9.

Published in final edited form as: Cancer Cell. 2015 Nov 9; 28(5): 569–581. doi: 10.1016/j.ccell.2015.09.021

PMCID:: PMC4643405

Article PDF–2.7M

Select item 380661520.

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity

Stefania Carobbio, Rachel M. Hagen, Christopher J. Lelliott, Marc Slawik, Gema Medina-Gomez, Chong-Yew Tan, Audrey Sicard, Helen J. Atherton, Nuria Barbarroja, Mikael Bjursell, Mohammad Bohlooly-Y, Sam Virtue, Antoinette Tuthill, Etienne Lefai, Martine Laville, Tingting Wu, Robert V. Considine, Hubert Vidal, Dominique Langin, Matej Oresic, Francisco J. Tinahones, Jose Manuel Fernandez-Real, Julian L. Griffin, Jaswinder K. Sethi, Miguel López, Antonio Vidal-Puig

Diabetes. 2013 Nov; 62(11): 3697–3708. Published online 2013 Oct 18. doi: 10.2337/db12-1748

PMCID:: PMC3806615

Article PDF–1.2M

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