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Select item 110229871.

Soluble uric acid inhibits β₂ integrin–mediated neutrophil recruitment in innate immunity

Qiuyue Ma, Roland Immler, Monika Pruenster, Markus Sellmayr, Chenyu Li, Albrecht von Brunn, Brigitte von Brunn, Rosina Ehmann, Roman Wölfel, Matteo Napoli, Qiubo Li, Paola Romagnani, Ralph Thomas Böttcher, Markus Sperandio, Hans-Joachim Anders, Stefanie Steiger

Blood. 2022 Jun 9; 139(23): 3402–3417. Published online 2022 Mar 22. doi: 10.1182/blood.2021011234

PMCID:: PMC11022987

Abstract Article

Select item 109929272.

ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas

Houshi Xu, Anke Zhang, Xiaying Han, Yanning Li, Zeyu Zhang, Liying Song, Wei Wang, Meiqing Lou

Cancer Immunol Immunother. 2022 Mar; 71(3): 645–660. Published online 2021 Jul 27. doi: 10.1007/s00262-021-03022-2

PMCID:: PMC10992927

Abstract Article PDF–8.3M

Select item 104636743.

Association of integrin-β2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients

Aliaa M. Selim, Yumn A. Elsabagh, Maha M. El-Sawalhi, Nabila A. Ismail, Mahmoud A. Senousy

BMC Med Genomics. 2023; 16: 204. Published online 2023 Aug 29. doi: 10.1186/s12920-023-01635-3

PMCID:: PMC10463674

Abstract Article PDF–2.0M

Select item 102960284.

Targeting Neutrophil β₂-Integrins: A Review of Relevant Resources, Tools, and Methods

Haleigh E. Conley, M. Katie Sheats

Biomolecules. 2023 Jun; 13(6): 892. Published online 2023 May 26. doi: 10.3390/biom13060892

PMCID:: PMC10296028

Abstract Article PDF–445K

Select item 98801575.

Correlation between ITGB2 expression and clinical characterization of glioma and the prognostic significance of its methylation in low-grade glioma(LGG)

He Liu, Jiao Wang, Tao Luo, Zhiming Zhen, Li Liu, Yalan Zheng, Chaobin Zhang, Xiaofei Hu

Front Endocrinol (Lausanne) 2022; 13: 1106120. Published online 2023 Jan 13. doi: 10.3389/fendo.2022.1106120

PMCID:: PMC9880157

Abstract Article PDF–3.5M

Select item 85086326.

Integrin β1 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-β Receptor-2

Md Saimon Mia, Yagna Jarajapu, Reena Rao, Sijo Mathew

Int J Mol Sci. 2021 Oct; 22(19): 10599. Published online 2021 Sep 30. doi: 10.3390/ijms221910599

PMCID:: PMC8508632

Abstract Article PDF–1.9M

Select item 82142187.

Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin

Carlos Angel Espinosa-Vinals, Jiri Masin, Jana Holubova, Ondrej Stanek, David Jurnecka, Radim Osicka, Peter Sebo, Ladislav Bumba

J Biol Chem. 2021 Jul; 297(1): 100833. Published online 2021 May 26. doi: 10.1016/j.jbc.2021.100833

PMCID:: PMC8214218

Abstract Article PDF–1.8M

Select item 81011758.

Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses

Kotaro Matsumoto, Takahiko Kurasawa, Keiko Yoshimoto, Katsuya Suzuki, Tsutomu Takeuchi

Arthritis Res Ther. 2021; 23: 136. Published online 2021 May 6. doi: 10.1186/s13075-021-02510-1

PMCID:: PMC8101175

Abstract Article PDF–1.5M

Select item 76676939.

ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system

Xiaoxin Zhang, Yingchun Dong, Mengxiang Zhao, Liang Ding, Xihu Yang, Yue Jing, Yuxian Song, Sheng Chen, Qingang Hu, Yanhong Ni

Theranostics. 2020; 10(26): 12044–12059. Published online 2020 Oct 26. doi: 10.7150/thno.47901

PMCID:: PMC7667693

Abstract Article PDF–3.7M

Select item 740685710.

β₂-integrin LFA1 mediates airway damage following neutrophil transepithelial migration during respiratory syncytial virus infection

Jenny Amanda Herbert, Yu Deng, Pia Hardelid, Elisabeth Robinson, Luo Ren, Dale Moulding, Rosalind Louise Smyth, Claire Mary Smith

Eur Respir J. 2020 Aug; 56(2): 1902216. Published online 2020 Aug 6. doi: 10.1183/13993003.02216-2019

PMCID:: PMC7406857

Abstract Article PDF–1.2M

Select item 693540311.

Increased adhesive potential of antiphospholipid syndrome neutrophils mediated by beta-2 integrin Mac-1

Gautam Sule, William J. Kelley, Kelsey Gockman, Srilakshmi Yalavarthi, Andrew P. Vreede, Alison L. Banka, Paula L. Bockenstedt, Omolola Eniola-Adefeso, Jason S. Knight

Arthritis Rheumatol. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Arthritis Rheumatol. 2020 Jan; 72(1): 114–124. doi: 10.1002/art.41057

PMCID:: PMC6935403

Abstract Article PDF–1.5M

Select item 674772012.

The Extracellular Domain of the β₂ Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity

Laura C. Ristow, Vy Tran, Kevin J. Schwartz, Lillie Pankratz, Andrew Mehle, John-Demian Sauer, Rodney A. Welch

mBio. 2019 Jul-Aug; 10(4): e01459-19. Published online 2019 Jul 9. doi: 10.1128/mBio.01459-19

PMCID:: PMC6747720

Abstract Article PDF–1.6M

Select item 617993513.

LFA-1 Ligation by High Density ICAM-1 is Sufficient to Activate IFN-γ Release by Innate T lymphocytes

Akshat Sharma, Stephanie M. Lawry, Bruce S. Klein, Xiaohua Wang, Nathan M. Sherer, Nicholas A. Zumwalde, Jenny E. Gumperz

J Immunol. Author manuscript; available in PMC 2019 Oct 15.

Published in final edited form as: J Immunol. 2018 Oct 15; 201(8): 2452–2461. Published online 2018 Aug 31. doi: 10.4049/jimmunol.1800537

PMCID:: PMC6179935

Abstract Article PDF–1.8M

Select item 592580214.

Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1

Mehmet Sen, Adem C. Koksal, Koichi Yuki, Jianchuan Wang, Timothy A. Springer

J Biol Chem. 2018 Apr 27; 293(17): 6565–6577. Published online 2018 Mar 5. doi: 10.1074/jbc.RA117.000710

PMCID:: PMC5925802

Abstract Article PDF–2.3M

Select item 581372415.

Evaluating a CLL susceptibility variant in ITGB2 in families with multiple subtypes of hematological malignancies

Nicholas B. Blackburn, James R. Marthick, Annette Banks, Jac C. Charlesworth, Katherine A. Marsden, Ray M. Lowenthal, John Blangero, Joanne L. Dickinson

Blood. 2017 Jul 6; 130(1): 86–88. doi: 10.1182/blood-2017-03-774232

PMCID:: PMC5813724

Article

Select item 562943016.

Altered levels of soluble CD18 may associate immune mechanisms with outcome in sepsis

T. W. Kragstrup, K. Juul‐Madsen, S. H. Christiansen, X. Zhang, J. Krog, T. Vorup‐Jensen, A. G. Kjærgaard

Clin Exp Immunol. 2017 Nov; 190(2): 258–267. Published online 2017 Aug 7. doi: 10.1111/cei.13016

PMCID:: PMC5629430

Abstract Article PDF–618K

Select item 506255917.

Coordinated integrin activation by actin-dependent force during T-cell migration

Pontus Nordenfelt, Hunter L. Elliott, Timothy A. Springer

Nat Commun. 2016; 7: 13119. Published online 2016 Oct 10. doi: 10.1038/ncomms13119

PMCID:: PMC5062559

Abstract Article PDF–5.9M

Select item 501610218.

Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3

Maria Risager Jensen, Goran Bajic, Xianwei Zhang, Anne Kjær Laustsen, Heidi Koldsø, Katrine Kirkeby Skeby, Birgit Schiøtt, Gregers R. Andersen, Thomas Vorup-Jensen

J Biol Chem. 2016 Aug 12; 291(33): 16963–16976. Published online 2016 Jun 23. doi: 10.1074/jbc.M116.732222

PMCID:: PMC5016102

Abstract Article PDF–2.1M

Select item 496184519.

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Anne-Elisabeth Petit, Nathalie Demotte, Benoît Scheid, Claude Wildmann, René Bigirimana, Monica Gordon-Alonso, Javier Carrasco, Salvatore Valitutti, Danièle Godelaine, Pierre van der Bruggen

Nat Commun. 2016; 7: 12242. Published online 2016 Jul 22. doi: 10.1038/ncomms12242