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Select item 41884151.

Ebola virus VP24 targets a unique NLS-binding site on karyopherin5 to selectively compete with nuclear import of phosphorylated STAT1

Wei Xu, Megan R. Edwards, Dominika M. Borek, Alicia R. Feagins, Anuradha Mittal, Joshua B. Alinger, Kayla N. Berry, Benjamin Yen, Jennifer Hamilton, Tom J. Brett, Rohit V. Pappu, Daisy W. Leung, Christopher F. Basler, Gaya K. Amarasinghe

Cell Host Microbe. Author manuscript; available in PMC 2015 Aug 13.

Published in final edited form as: Cell Host Microbe. 2014 Aug 13; 16(2): 187–200. doi: 10.1016/j.chom.2014.07.008

PMCID:: PMC4188415

Abstract Article PDF–1.0M

Select item 28884052.

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-α Using Oriented Peptide Library Screening

Sundy N. Y. Yang, Agnes A. S. Takeda, Marcos R. M. Fontes, Jonathan M. Harris, David A. Jans, Boštjan Kobe

J Biol Chem. 2010 Jun 25; 285(26): 19935–19946. Published online 2010 Apr 20. doi: 10.1074/jbc.M109.079574

PMCID:: PMC2888405

Abstract Article PDF–2.1M

Select item 1495053.

A Nonconventional Nuclear Localization Signal within the UL84 Protein of Human Cytomegalovirus Mediates Nuclear Import via the Importin α/β Pathway

Peter Lischka, Gabriele Sorg, Michael Kann, Michael Winkler, Thomas Stamminger

J Virol. 2003 Mar; 77(6): 3734–3748. doi: 10.1128/JVI.77.6.3734-3748.2003

PMCID:: PMC149505

Abstract Article PDF–2.5M

Select item 55229644.

Degradation of the Transcription Factor Twist, an Oncoprotein that Promotes Cancer Metastasis

Jiateng Zhong, Kohei Ogura, Zhiwei Wang, Hiroyuki Inuzuka

Discov Med. Author manuscript; available in PMC 2017 Jul 24.

Published in final edited form as: Discov Med. 2013 Jan; 15(80): 7–15.

PMCID:: PMC5522964

Abstract Article PDF–784K

Select item 38145995.

Viral and Cellular Requirements for the Nuclear Entry of Retroviral Preintegration Nucleoprotein Complexes

Kenneth A. Matreyek, Alan Engelman

Viruses. 2013 Oct; 5(10): 2483–2511. Published online 2013 Oct 7. doi: 10.3390/v5102483

PMCID:: PMC3814599

Abstract Article PDF–878K

Select item 30761286.

A Genome-wide Association Study Identifies a Locus on Chromosome 14q21 as a Predictor of Leukocyte Telomere Length and as a Marker of Susceptibility for Bladder Cancer

Jian Gu, Meng Chen, Sanjay Shete, Christopher I. Amos, Ashish Kamat, Yuanqing Ye, Jie Lin, Colin P. Dinney, Xifeng Wu

Cancer Prev Res (Phila) Author manuscript; available in PMC 2012 Apr 2.

Published in final edited form as: Cancer Prev Res (Phila). 2011 Apr; 4(4): 514–521. Published online 2011 Apr 2. doi: 10.1158/1940-6207.CAPR-11-0063

PMCID:: PMC3076128

Abstract Article PDF–404K

Select item 47059417.

Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence

Akira Tsujii, Yoichi Miyamoto, Tetsuji Moriyama, Yuko Tsuchiya, Chikashi Obuse, Kenji Mizuguchi, Masahiro Oka, Yoshihiro Yoneda

J Biol Chem. 2015 Dec 4; 290(49): 29375–29388. Published online 2015 Oct 21. doi: 10.1074/jbc.M115.681908

PMCID:: PMC4705941

Abstract Article PDF–3.8M

Select item 32249478.

Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal

Aviad Levin, Ayelet Armon-Omer, Joseph Rosenbluh, Naomi Melamed-Book, Adolf Graessmann, Elisabeth Waigmann, Abraham Loyter

Retrovirology. 2009; 6: 112. Published online 2009 Dec 5. doi: 10.1186/1742-4690-6-112

PMCID:: PMC3224947

Abstract Article PDF–2.9M

Select item 22299449.

Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.

L. Dubrovsky, P. Ulrich, G. J. Nuovo, K. R. Manogue, A. Cerami, M. Bukrinsky

Mol Med. 1995 Jan; 1(2): 217–230.

PMCID:: PMC2229944

Summary Page Browse PDF–2.8M

Select item 117007910.

HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.

R A Fouchier, B E Meyer, J H Simon, U Fischer, M H Malim

EMBO J. 1997 Aug 1; 16(15): 4531–4539. doi: 10.1093/emboj/16.15.4531

PMCID:: PMC1170079

Summary PDF–392K

Select item 18990811.

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.

P Gallay, V Stitt, C Mundy, M Oettinger, D Trono

J Virol. 1996 Feb; 70(2): 1027–1032. doi: 10.1128/jvi.70.2.1027-1032.1996

PMCID:: PMC189908

Summary PDF–526K

Select item 18912412.

Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.

E O Freed, G Englund, M A Martin

J Virol. 1995 Jun; 69(6): 3949–3954. doi: 10.1128/jvi.69.6.3949-3954.1995

PMCID:: PMC189124

Summary PDF–421K

Select item 10964013.

The Putative Alpha Helix 2 of Human Immunodeficiency Virus Type 1 Vpr Contains a Determinant Which Is Responsible for the Nuclear Translocation of Proviral DNA in Growth-Arrested Cells

Zilin Nie, Dominique Bergeron, Ramu A. Subbramanian, Xiao-Jian Yao, Florent Checroune, Nicole Rougeau, Eric A. Cohen

J Virol. 1998 May; 72(5): 4104–4115. doi: 10.1128/jvi.72.5.4104-4115.1998

PMCID:: PMC109640

Abstract Article PDF–461K

Select item 10575814.

CNI-H0294, a Nuclear Importation Inhibitor of the Human Immunodeficiency Virus Type 1 Genome, Abrogates Virus Replication in Infected Activated Peripheral Blood Mononuclear Cells

Omar K. Haffar, Molly D. Smithgall, Serguei Popov, Peter Ulrich, A. Gregory Bruce, Steven G. Nadler, Anthony Cerami, Michael I. Bukrinsky

Antimicrob Agents Chemother. 1998 May; 42(5): 1133–1138. doi: 10.1128/aac.42.5.1133

PMCID:: PMC105758

Abstract Article PDF–526K

Select item 4438915.

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

N K Heinzinger, M I Bukinsky, S A Haggerty, A M Ragland, V Kewalramani, M A Lee, H E Gendelman, L Ratner, M Stevenson, M Emerman

Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15): 7311–7315. doi: 10.1073/pnas.91.15.7311

PMCID:: PMC44389

Summary Page Browse PDF–1.2M

Select item 4432416.

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.

U von Schwedler, R S Kornbluth, D Trono

Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15): 6992–6996. doi: 10.1073/pnas.91.15.6992

PMCID:: PMC44324

Summary Page Browse PDF–907K

Select item 3814917.

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.

S Popov, L Dubrovsky, M A Lee, S Pennathur, O Haffar, Y aL-Abed, P Tonge, P Ulrich, M Rexach, G Blobel, A Cerami, M Bukrinsky

Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21): 11859–11864. doi: 10.1073/pnas.93.21.11859

PMCID:: PMC38149

Summary Page Browse PDF–1.6M

Select item 446002518.

BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells

Nam-Hee Kim, Tetsuro Yoshimaru, Yi-An Chen, Taisuke Matsuo, Masato Komatsu, Yasuo Miyoshi, Eiji Tanaka, Mitsunori Sasa, Kenji Mizuguchi, Toyomasa Katagiri

PLoS One. 2015; 10(6): e0127707. Published online 2015 Jun 8. doi: 10.1371/journal.pone.0127707