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Select item 39310761.

Crystal Structures of Leukotriene C₄ Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM

Damian Niegowski, Thea Kleinschmidt, Ulrika Olsson, Shabbir Ahmad, Agnes Rinaldo-Matthis, Jesper Z. Haeggström

J Biol Chem. 2014 Feb 21; 289(8): 5199–5207. Published online 2013 Dec 23. doi: 10.1074/jbc.M113.534628

PMCID:: PMC3931076

Abstract Article PDF–1.8M

Select item 37287072.

Elevated levels of leukotriene C₄ synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients

Willem S. Lexmond, Michael Pardo, Katharine Rooney, Jeremy A. Goettel, Scott B. Snapper, Elizabeth H. Yen, Eleonora Dehlink, Samuel Nurko, Edda Fiebiger

Clin Exp Allergy. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: Clin Exp Allergy. 2013 Aug; 43(8): 902–913. doi: 10.1111/cea.12146

PMCID:: PMC3728707

Abstract Article PDF–1.9M

Select item 32321663.

Seleno-detergent MAD phasing of leukotriene C₄ synthase in complex with dodecyl-β-d-selenomaltoside

Hiromichi Saino, Hideo Ago, Yoko Ukita, Masashi Miyano

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1; 67(Pt 12): 1666–1673. Published online 2011 Nov 29. doi: 10.1107/S1744309111042345

PMCID:: PMC3232166

Abstract Article PDF–1.5M

Select item 30912454.

The Catalytic Architecture of Leukotriene C₄ Synthase with Two Arginine Residues

Hiromichi Saino, Yoko Ukita, Hideo Ago, Daisuke Irikura, Atsushi Nisawa, Go Ueno, Masaki Yamamoto, Yoshihide Kanaoka, Bing K. Lam, K. Frank Austen, Masashi Miyano

J Biol Chem. 2011 May 6; 286(18): 16392–16401. Published online 2011 Mar 16. doi: 10.1074/jbc.M110.150177

PMCID:: PMC3091245

Abstract Article PDF–1.8M

Select item 30033775.

Arginine 104 Is a Key Catalytic Residue in Leukotriene C₄ Synthase

Agnes Rinaldo-Matthis, Anders Wetterholm, Daniel Martinez Molina, Johanna Holm, Damian Niegowski, Eva Ohlson, Pär Nordlund, Ralf Morgenstern, Jesper Z. Haeggström

J Biol Chem. 2010 Dec 24; 285(52): 40771–40776. Published online 2010 Oct 27. doi: 10.1074/jbc.M110.105940

PMCID:: PMC3003377

Abstract Article PDF–617K

Select item 30002616.

Increased expression of leukotriene C₄ synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm

Antonio Di Gennaro, Dick Wågsäter, Mikko I. Mäyränpää, Anders Gabrielsen, Jesper Swedenborg, Anders Hamsten, Bengt Samuelsson, Per Eriksson, Jesper Z. Haeggström

Proc Natl Acad Sci U S A. 2010 Dec 7; 107(49): 21093–21097. Published online 2010 Nov 15. doi: 10.1073/pnas.1015166107

PMCID:: PMC3000261

Abstract Article PDF–363K

Select item 22302007.

Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35.

T. D. Bigby, C. R. Hodulik, K. C. Arden, L. Fu

Mol Med. 1996 Sep; 2(5): 637–646.

PMCID:: PMC2230200

Summary Page Browse PDF–1.8M

Select item 18843718.

Leukotriene C₄ synthase polymorphisms and responsiveness to leukotriene antagonists in asthma

Graeme P Currie, John J Lima, Jim E Sylvester, Daniel K C Lee, Wendy J R Cockburn, Brian J Lipworth

Br J Clin Pharmacol. 2003 Oct; 56(4): 422–426. doi: 10.1046/j.1365-2125.2003.01952.x

PMCID:: PMC1884371

Abstract Article PDF–104K

Select item 17466609.

Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma

I Sayers, S Barton, S Rorke, B Beghe, B Hayward, P Van Eerdewegh, T Keith, J Clough, S Ye, J Holloway, A Sampson, S Holgate

Thorax. 2003 May; 58(5): 417–424. doi: 10.1136/thorax.58.5.417

PMCID:: PMC1746660

Summary PDF–193K

Select item 5060110.

Purification of human leukotriene C4 synthase.

J F Penrose, L Gagnon, M Goppelt-Struebe, P Myers, B K Lam, R M Jack, K F Austen, R J Soberman

Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23): 11603–11606. doi: 10.1073/pnas.89.23.11603

PMCID:: PMC50601

Summary Page Browse PDF–981K

Select item 4601111.

Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

D W Nicholson, A Ali, J P Vaillancourt, J R Calaycay, R A Mumford, R J Zamboni, A W Ford-Hutchinson

Proc Natl Acad Sci U S A. 1993 Mar 1; 90(5): 2015–2019. doi: 10.1073/pnas.90.5.2015

PMCID:: PMC46011

Summary Page Browse PDF–1.2M

Select item 4489312.

Molecular cloning and expression of human leukotriene-C4 synthase.

D J Welsch, D P Creely, S D Hauser, K J Mathis, G G Krivi, P C Isakson

Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21): 9745–9749. doi: 10.1073/pnas.91.21.9745

PMCID:: PMC44893

Summary Page Browse PDF–1.0M

Select item 4446213.

Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.

B K Lam, J F Penrose, G J Freeman, K F Austen

Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16): 7663–7667. doi: 10.1073/pnas.91.16.7663

PMCID:: PMC44462

Summary Page Browse PDF–1.2M

Select item 838943014.

Effect of TGF-β1 on eosinophils to induce cysteinyl leukotriene E₄ production in aspirin-exacerbated respiratory disease

Youngwoo Choi, Soyoon Sim, Dong-Hyun Lee, Hee-Ra Lee, Ga-Young Ban, Yoo Seob Shin, Yoon-Keun Kim, Hae-Sim Park

PLoS One. 2021; 16(8): e0256237. Published online 2021 Aug 26. doi: 10.1371/journal.pone.0256237

PMCID:: PMC8389430

Abstract Article PDF–1.2M

Select item 500008615.

Phosphorylation of Leukotriene C₄ Synthase at Serine 36 Impairs Catalytic Activity

Shabbir Ahmad, A. Jimmy Ytterberg, Madhuranayaki Thulasingam, Fredrik Tholander, Tomas Bergman, Roman Zubarev, Anders Wetterholm, Agnes Rinaldo-Matthis, Jesper Z. Haeggström

J Biol Chem. 2016 Aug 26; 291(35): 18410–18418. Published online 2016 Jun 30. doi: 10.1074/jbc.M116.735647

PMCID:: PMC5000086

Abstract Article PDF–1.3M

Select item 1847716.

5-Lipoxygenase expression in Langerhans cells of normal human epidermis

Rainer Spanbroek, Hans-Jürgen Stark, Uwe Janßen-Timmen, Stefan Kraft, Markus Hildner, Thomas Andl, Franz-Xaver Bosch, Norbert E. Fusenig, Thomas Bieber, Olof Rådmark, Bengt Samuelsson, Andreas J. R. Habenicht

Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2): 663–668. doi: 10.1073/pnas.95.2.663

PMCID:: PMC18477

Abstract Article PDF–316K

Select item 508705217.

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Jesmond Dalli, Iliyan Vlasakov, Ian R. Riley, Ana R. Rodriguez, Bernd W. Spur, Nicos A. Petasis, Nan Chiang, Charles N. Serhan

Proc Natl Acad Sci U S A. 2016 Oct 25; 113(43): 12232–12237. Published online 2016 Oct 6. doi: 10.1073/pnas.1607003113

PMCID:: PMC5087052

Abstract Article PDF–1.0M

Select item 273168818.

5-lipoxygenase Pharmacogenetics in Asthma: Overlap with CystLTR1 Loci

K.G. Tantisira, J. Lima, J. Sylvia, B. Klanderman, S.T. Weiss

Pharmacogenet Genomics. Author manuscript; available in PMC 2010 Mar 1.

Published in final edited form as: Pharmacogenet Genomics. 2009 Mar; 19(3): 244–247. doi: 10.1097/FPC.0b013e328326e0b1

PMCID:: PMC2731688

Abstract Article PDF–438K

Select item 266293919.

Influence of Leukotriene Pathway Polymorphisms on Response to Montelukast in Asthma

John J. Lima, Shu Zhang, Audrey Grant, Lianhe Shao, Kelan G. Tantisira, Hooman Allayee, Jianwei Wang, James Sylvester, Janet Holbrook, Robert Wise, Scott T. Weiss, Kathleen Barnes

Am J Respir Crit Care Med. 2006 Feb 15; 173(4): 379–385. Published online 2005 Nov 17. doi: 10.1164/rccm.200509-1412OC