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Select item 100698161.

ASIC1a Involves the Acid-Mediated Activation of Pancreatic Stellate Cells Associated With Autophagy Induction

Tao WANG, Qianqian WANG, Guixia PAN, Guorong JIA, Xiao LI, Chao WANG, Liming ZHANG, Changjing ZUO

Physiol Res. 2023 Feb; 72(1): 49–57. Published online 2022 Dec 22. doi: 10.33549/physiolres.934950

PMCID:: PMC10069816

Abstract Article PDF–1.1M

Select item 90978442.

ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3β/Snail pathway driven by TGFβ/Smad signals

Yinci Zhang, Niandie Cao, Jiafeng Gao, Jiaojiao Liang, Yong Liang, Yinghai Xie, Shuping Zhou, Xiaolong Tang

J Cell Mol Med. 2022 May; 26(10): 2777–2792. Published online 2022 Apr 14. doi: 10.1111/jcmm.17288

PMCID:: PMC9097844

Abstract Article PDF–54M

Select item 84485443.

Regulation of gliomagenesis and stemness through acid sensor ASIC1a

Pendelton King, Jingwei Wan, Alyssa Aihui Guo, Shanchun Guo, Yugang Jiang, Mingli Liu

Int J Oncol. 2021 Oct; 59(4): 82. Published online 2021 Sep 10. doi: 10.3892/ijo.2021.5262

PMCID:: PMC8448544

Abstract Article PDF–2.4M

Select item 83185894.

Structure and analysis of nanobody binding to the human ASIC1a ion channel

Yangyu Wu, Zhuyuan Chen, Fred J Sigworth, Cecilia M Canessa

eLife. 2021; 10: e67115. Published online 2021 Jul 28. doi: 10.7554/eLife.67115

PMCID:: PMC8318589

Abstract Article PDF–5.7M

Select item 80096795.

Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

Sabrina Vullo, Nicolas Ambrosio, Jan P Kucera, Olivier Bignucolo, Stephan Kellenberger

eLife. 2021; 10: e66488. Published online 2021 Mar 17. doi: 10.7554/eLife.66488

PMCID:: PMC8009679

Abstract Article PDF–6.0M

Select item 78763226.

Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis

Yayun Xu, Feihu Chen

Front Immunol. 2020; 11: 580936. Published online 2021 Jan 28. doi: 10.3389/fimmu.2020.580936

PMCID:: PMC7876322

Abstract Article PDF–937K

Select item 78707427.

Postsynaptic Targeting and Mobility of Membrane Surface-Localized hASIC1a

Xing-Lei Song, Di-Shi Liu, Min Qiang, Qian Li, Ming-Gang Liu, Wei-Guang Li, Xin Qi, Nan-Jie Xu, Guang Yang, Michael Xi Zhu, Tian-Le Xu

Neurosci Bull. 2021 Feb; 37(2): 145–165. Published online 2020 Sep 30. doi: 10.1007/s12264-020-00581-9

PMCID:: PMC7870742

Abstract Article PDF–4.6M

Select item 75537798.

Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Demeng Sun, Sanling Liu, Siyu Li, Mengge Zhang, Fan Yang, Ming Wen, Pan Shi, Tao Wang, Man Pan, Shenghai Chang, Xing Zhang, Longhua Zhang, Changlin Tian, Lei Liu

eLife. 2020; 9: e57096. Published online 2020 Sep 11. doi: 10.7554/eLife.57096

PMCID:: PMC7553779

Abstract Article PDF–3.1M

Select item 68515079.

ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc

Feng Cai, Xin Hong, Xiang Tang, Nai-Cheng Liu, Feng Wang, Lei Zhu, Xin-Hui Xie, Zhi-Yang Xie, Xiao-Tao Wu

Biosci Rep. 2019 Nov 29; 39(11): BSR20192708. Published online 2019 Nov 13. doi: 10.1042/BSR20192708

PMCID:: PMC6851507

Abstract Article PDF–2.9M

Select item 649744110.

A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

Yangyu Wu, Zhuyuan Chen, Cecilia M Canessa

eLife. 2019; 8: e45851. Published online 2019 May 2. doi: 10.7554/eLife.45851

PMCID:: PMC6497441

Abstract Article PDF–3.7M

Select item 645040411.

Regulation of breast tumorigenesis through acid sensors

Subash C. Gupta, Ramesh Singh, Mathew Asters, Jianghua Liu, Xu Zhang, Mallikarjuna R. Pabbidi, Kounosuke Watabe, Yin-Yuan Mo

Oncogene. Author manuscript; available in PMC 2019 Apr 5.

Published in final edited form as: Oncogene. 2016 Aug 4; 35(31): 4102–4111. Published online 2015 Dec 21. doi: 10.1038/onc.2015.477

PMCID:: PMC6450404

Abstract Article PDF–1.5M

Select item 543223112.

Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer

Cheng Jin, Feng-Lai Yuan, Yuan-Long Gu, Xia Li, Min-Feng Liu, Xiao-Min Shen, Bo Liu, Mao-Qun Zhu

Oncotarget. 2017 Apr 18; 8(16): 25977–25988. Published online 2016 Jul 22. doi: 10.18632/oncotarget.10774

PMCID:: PMC5432231

Abstract Article PDF–11M

Select item 538929013.

Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating

Sabrina Vullo, Gaetano Bonifacio, Sophie Roy, Niklaus Johner, Simon Bernèche, Stephan Kellenberger

Proc Natl Acad Sci U S A. 2017 Apr 4; 114(14): 3768–3773. Published online 2017 Mar 20. doi: 10.1073/pnas.1620560114

PMCID:: PMC5389290

Abstract Article PDF–3.2M

Select item 537339514.

Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive

David M. MacLean, Vasanthi Jayaraman

Proc Natl Acad Sci U S A. 2017 Mar 21; 114(12): E2504–E2513. Published online 2017 Mar 6. doi: 10.1073/pnas.1620508114

PMCID:: PMC5373395

Abstract Article PDF–6.2M

Select item 530957815.

Bile acids potentiate proton‐activated currents in Xenopus laevis oocytes expressing human acid‐sensing ion channel (ASIC1a)

Alexandr V. Ilyaskin, Alexei Diakov, Christoph Korbmacher, Silke Haerteis

Physiol Rep. 2017 Feb; 5(3): e13132. Published online 2017 Feb 13. doi: 10.14814/phy2.13132

PMCID:: PMC5309578

Abstract Article PDF–1.1M

Select item 455689416.

Physical and functional interactions between a glioma cation channel and integrin-β₁ require α-actinin

Arun K. Rooj, Zhiyong Liu, Carmel M. McNicholas, Catherine M. Fuller

Am J Physiol Cell Physiol. 2015 Sep 1; 309(5): C308–C319. Published online 2015 Jun 24. doi: 10.1152/ajpcell.00036.2015

PMCID:: PMC4556894

Abstract Article

Select item 452923517.

The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface

Miguel Xavier van Bemmelen, Delphine Huser, Ivan Gautschi, Laurent Schild

PLoS One. 2015; 10(8): e0135191. Published online 2015 Aug 7. doi: 10.1371/journal.pone.0135191

PMCID:: PMC4529235

Abstract Article PDF–2.7M

Select item 451664218.

Validation of Candidate Anxiety Disorder Genes Using a Carbon Dioxide Challenge Task

Jeanne E. Savage, Omari McMichael, Eugenia I. Gorlin, Jessica R. Beadel, Bethany Teachman, Vladimir I. Vladimirov, John M. Hettema, Roxann Roberson-Nay

Biol Psychol. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Biol Psychol. 2015 Jul; 109: 61–66. Published online 2015 Apr 22. doi: 10.1016/j.biopsycho.2015.04.006

PMCID:: PMC4516642

Abstract Article PDF–357K

Select item 450504319.

Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a

Karolina Gwiazda, Gaetano Bonifacio, Sabrina Vullo, Stephan Kellenberger

J Biol Chem. 2015 Jul 17; 290(29): 17956–17966. Published online 2015 Jun 12. doi: 10.1074/jbc.M115.641688

PMCID:: PMC4505043

Abstract Article PDF–3.0M

Select item 410397220.

The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder And Amygdala Structure And Function

Jordan W. Smoller, Patience J. Gallagher, Laramie E. Duncan, Lauren M. McGrath, Stephen A. Haddad, Avram. Holmes, Aaron B. Wolf, Sidney Hilker, Stefanie R. Block, Sydney Weill, Sarah Young, Eun Young Choi, Jerrold F. Rosenbaum, Joseph Biederman, Stephen V. Faraone, Joshua Roffman, Gisele G. Manfro, Carolina Blaya, Dina R. Hirshfeld-Becker, Murray B. Stein, Michael Van Ameringen, David F. Tolin, Michael W. Otto, Mark H. Pollack, Naomi M. Simon, Randy L. Buckner, Dost Ongur, Bruce M. Cohen

Biol Psychiatry. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Biol Psychiatry. 2014 Dec 1; 76(11): 902–910. Published online 2014 Jan 18. doi: 10.1016/j.biopsych.2013.12.018

PMCID:: PMC4103972

Abstract Article PDF–1.1M

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