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Select item 84883941.

MAT2A-Mediated S-Adenosylmethionine Level in CD4⁺ T Cells Regulates HIV-1 Latent Infection

Xiaofan Yang, Ting Huang, Tiantian Wang, Hongbo Gao, Haitao Zhang, Wen Peng, Jiacong Zhao, Shujing Hu, Panpan Lu, Zhongsi Hong, Bo Li, Kai Deng

Front Immunol. 2021; 12: 745784. Published online 2021 Sep 20. doi: 10.3389/fimmu.2021.745784

PMCID:: PMC8488394

Abstract Article PDF–5.3M

Select item 81612252.

MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients

Pei-Yi Chu, Hsing-Ju Wu, Shin-Mae Wang, Po-Ming Chen, Feng-Yao Tang, En-Pei Isabel Chiang

Int J Mol Sci. 2021 May; 22(10): 5382. Published online 2021 May 20. doi: 10.3390/ijms22105382

PMCID:: PMC8161225

Abstract Article PDF–1.2M

Select item 75161363.

Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes

Tyler D. Huber, Jonathan A. Clinger, Yang Liu, Weijun Xu, Mitchell D. Miller, George N. Phillips, Jr., Jon S. Thorson

ACS Chem Biol. Author manuscript; available in PMC 2020 Sep 25.

Published in final edited form as: ACS Chem Biol. 2020 Mar 20; 15(3): 695–705. Published online 2020 Mar 3. doi: 10.1021/acschembio.9b00943

PMCID:: PMC7516136

Abstract Article PDF–1.5M

Select item 47764774.

Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes

Ben Murray, Svetlana V. Antonyuk, Alberto Marina, Shelly C. Lu, Jose M. Mato, S. Samar Hasnain, Adriana L. Rojas

Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8): 2104–2109. Published online 2016 Feb 8. doi: 10.1073/pnas.1510959113

PMCID:: PMC4776477

Abstract Article PDF–1.7M

Select item 90493115.

Expression of vimentin, TPI and MAT2A in human dermal microvascular endothelial cells during angiogenesis in vitro

Christina Herre, Arpenik Nshdejan, Robert Klopfleisch, Giuliano Mario Corte, Mahtab Bahramsoltani

PLoS One. 2022; 17(4): e0266774. Published online 2022 Apr 28. doi: 10.1371/journal.pone.0266774

PMCID:: PMC9049311

Abstract Article PDF–1.8M

Select item 86382596.

Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B

Jonathan Bailey, Holly Douglas, Laura Masino, Luiz Pedro Sorio de Carvalho, Argyrides Argyrou

Biochemistry. 2021 Nov 30; 60(47): 3621–3632. Published online 2021 Nov 15. doi: 10.1021/acs.biochem.1c00672

PMCID:: PMC8638259

Abstract Article PDF–3.8M

Select item 81398297.

SAM homeostasis is regulated by CFI_m-mediated splicing of MAT2A

Anna M Scarborough, Juliana N Flaherty, Olga V Hunter, Kuanqing Liu, Ashwani Kumar, Chao Xing, Benjamin P Tu, Nicholas K Conrad

eLife. 2021; 10: e64930. Published online 2021 May 5. doi: 10.7554/eLife.64930

PMCID:: PMC8139829

Abstract Article PDF–3.1M

Select item 78883148.

Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer

Yan Zhang, Hui Yang, Jun Zhao, Ping Wan, Ye Hu, Kun Lv, YiRen Hu, Xi Yang, Mingzhe Ma

J Immunother Cancer. 2021; 9(2): e001364. Published online 2021 Feb 16. doi: 10.1136/jitc-2020-001364

Correction in:: J Immunother Cancer. 2021; 9(4): 1.

Correction in:: J Immunother Cancer. 2021; 9(10): e001364corr2.

PMCID:: PMC7888314

Abstract Article PDF–4.6M

Select item 68500149.

Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds

Jiraporn Panmanee, Jack Bradley‐Clarke, Jose M. Mato, Paul M. O'Neill, Svetlana V. Antonyuk, S. Samar Hasnain

FEBS J. 2019 Jun; 286(11): 2135–2154. Published online 2019 Mar 4. doi: 10.1111/febs.14790

PMCID:: PMC6850014

Abstract Article PDF–5.7M

Select item 483928610.

ROLE OF METHIONINE ADENOSYLTRANSFERASE α2 AND β PHOSPHORYLATION AND STABILIZATION IN HUMAN HEPATIC STELLATE CELL TRANS-DIFFERENTIATION

Komal Ramani, Shant Donoyan, Maria Lauda Tomasi, Sunhee Park

J Cell Physiol. Author manuscript; available in PMC 2016 Apr 21.

Published in final edited form as: J Cell Physiol. 2015 May; 230(5): 1075–1085. doi: 10.1002/jcp.24839

PMCID:: PMC4839286

Abstract Article PDF–1.5M

Select item 481473711.

S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells

Sonia Amelia Lozano-Sepulveda, Eduardo Bautista-Osorio, Jose Angel Merino-Mascorro, Marta Varela-Rey, Linda Elsa Muñoz-Espinosa, Paula Cordero-Perez, María Luz Martinez-Chantar, Ana Maria Rivas-Estilla

World J Gastroenterol. 2016 Apr 14; 22(14): 3746–3757. Published online 2016 Apr 14. doi: 10.3748/wjg.v22.i14.3746

PMCID:: PMC4814737

Abstract Article PDF–1.2M

Select item 442181712.

Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer

Hong-Bin Yang, Ying-Ying Xu, Xiang-Ning Zhao, Shao-Wu Zou, Ye Zhang, Min Zhang, Jin-Tao Li, Feng Ren, Li-Ying Wang, Qun-Ying Lei

Nat Commun. 2015 Apr 30; 6: 6973. Published online 2015 Apr 30. doi: 10.1038/ncomms7973

PMCID:: PMC4421817

Abstract Article PDF–1.4M

Select item 400382613.

Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis

Xuliang Wang, Xiaoqiang Guo, Wenshui Yu, Cailing Li, Yaoting Gui, Zhiming Cai

BMC Cancer. 2014; 14: 196. Published online 2014 Mar 17. doi: 10.1186/1471-2407-14-196

PMCID:: PMC4003826

Abstract Article PDF–1.4M

Select item 328544014.

Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells

Heping YANG, Tony W. H. LI, Jian PENG, José M. MATO, Shelly C. LU

Biochem J. Author manuscript; available in PMC 2012 Feb 23.

Published in final edited form as: Biochem J. 2011 Jun 1; 436(2): 507–516. doi: 10.1042/BJ20101754

PMCID:: PMC3285440

Abstract Article PDF–2.9M

Select item 308956015.

The X Protein of Hepatitis B Virus Inhibits Apoptosis in Hepatoma Cells through Enhancing the Methionine Adenosyltransferase 2A Gene Expression and Reducing S-Adenosylmethionine Production

Quanyan Liu, Jiwei Chen, Li Liu, Jun Zhang, Dongfeng Wang, Lu Ma, Yueming He, Yingle Liu, Zhisu Liu, Jianguo Wu

J Biol Chem. 2011 May 13; 286(19): 17168–17180. Published online 2011 Jan 19. doi: 10.1074/jbc.M110.167783

PMCID:: PMC3089560

Abstract Article PDF–2.1M

Select item 238712516.

Leptin’s Mitogenic Effect in Human Liver Cancer Cells Requires Induction of Both Methionine Adenosyltransferase 2A and 2β

Komal Ramani, Heping Yang, Meng Xia, Ainhoa Iglesias Ara, José M. Mato, Shelly C. Lu

Hepatology. Author manuscript; available in PMC 2008 May 19.

Published in final edited form as: Hepatology. 2008 Feb; 47(2): 521–531. doi: 10.1002/hep.22064

PMCID:: PMC2387125

Abstract Article PDF–957K

Select item 921344517.

Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

Jin-Tao Li, Hai Yang, Ming-Zhu Lei, Wei-Ping Zhu, Ying Su, Kai-Yue Li, Wen-Ying Zhu, Jian Wang, Lei Zhang, Jia Qu, Lei Lv, Hao-Jie Lu, Zheng-Jun Chen, Lu Wang, Miao Yin, Qun-Ying Lei

Signal Transduct Target Ther. 2022; 7: 192. Published online 2022 Jun 22. doi: 10.1038/s41392-022-01017-8

Correction in:: Signal Transduct Target Ther. 2022; 7: 401.

PMCID:: PMC9213445

Abstract Article PDF–4.2M

Select item 492468718.

Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells

Nguyen Thi Thuy Phuong, Sang Kyum Kim, Ji Hye Im, Jin Won Yang, Min Chang Choi, Sung Chul Lim, Kwang Yeol Lee, Young-Mi Kim, Jeong Hoon Yoon, Keon Wook Kang

Oncotarget. 2016 Mar 22; 7(12): 13902–13916. Published online 2015 Sep 18. doi: 10.18632/oncotarget.5298

PMCID:: PMC4924687

Abstract Article PDF–9.4M

Select item 474195919.

Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells

Maria Lauda Tomasi, Minjung Ryoo, Komal Ramani, Ivan Tomasi, Pasquale Giordano, José M. Mato, Shelly C. Lu

Oncotarget. 2015 Nov 10; 6(35): 37706–37723. Published online 2015 Sep 25. doi: 10.18632/oncotarget.5342

PMCID:: PMC4741959

Abstract Article PDF–8.9M

Select item 428968220.

MAT2A Mutations Predispose Individuals to Thoracic Aortic Aneurysms

Dong-chuan Guo, Limin Gong, Ellen S. Regalado, Regie L. Santos-Cortez, Ren Zhao, Bo Cai, Sudha Veeraraghavan, Siddharth K. Prakash, Ralph J. Johnson, Ann Muilenburg, Marcia Willing, Guillaume Jondeau, Catherine Boileau, Hariyadarshi Pannu, Rocio Moran, Julie Debacker, GenTAC Investigators, National Heart, Lung, and Blood Institute Go Exome Sequencing Project, Montalcino Aortic Consortium, Michael J. Bamshad, Jay Shendure, Deborah A. Nickerson, Suzanne M. Leal, C.S. Raman, Eric C. Swindell, Dianna M. Milewicz

Am J Hum Genet. 2015 Jan 8; 96(1): 170–177. doi: 10.1016/j.ajhg.2014.11.015

PMCID:: PMC4289682

Abstract Article PDF–1.5M

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PMC Links for Gene (Select 4144) (125)
PMC
Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F8...
Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830007I07 product:hypothetical Proline-rich region profile/Serine-rich region profile containing protein, full insert sequence
gi|74217690|dbj|AK156084.1|

Nucleotide
Mus musculus cDNA, clone:Y2G0147K22, strand:plus, reference:ENSEMBL:Mouse-Transc...
Mus musculus cDNA, clone:Y2G0147K22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000054850, based on BLAT search
gi|56043370|dbj|AK219193.1|

Nucleotide

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