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Select item 111092161.

In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene

Md. Mostafa Kamal, Md. Sohel Mia, Md. Omar Faruque, Md. Golam Rabby, Md. Numan Islam, Md. Enamul Kabir Talukder, Tanveer A. Wani, M. Atikur Rahman, Md. Mahmudul Hasan

Sci Rep. 2024; 14: 11607. Published online 2024 May 21. doi: 10.1038/s41598-024-62299-2

PMCID:: PMC11109216

Abstract Article PDF–3.7M

Select item 103296002.

De novo MCM6 variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues

Daphne J. Smits, Rachel Schot, Cristiana A. Popescu, Kerith-Rae Dias, Lesley Ades, Lauren C. Briere, David A. Sweetser, Itaru Kushima, Branko Aleksic, Suliman Khan, Vasiliki Karageorgou, Natalia Ordonez, Frank J. G. T. Sleutels, Daniëlle C. M. van der Kaay, Christine Van Mol, Hilde Van Esch, Aida M. Bertoli-Avella, Tony Roscioli, Grazia M. S. Mancini

Hum Genet. 2023; 142(7): 949–964. Published online 2023 May 17. doi: 10.1007/s00439-023-02569-7

PMCID:: PMC10329600

Abstract Article PDF–3.6M

Select item 95162353.

MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target

Yifei Wang, Huarong Chen, Weixin Liu, Huan Yan, Yihan Zhang, Alvin H.K. Cheung, Jinglin Zhang, Bonan Chen, Li Liang, Zhaocai Zhou, Chi Chun Wong, William K.K. Wu, Michael W.Y. Chan, Alfred S.L. Cheng, Brigette B.Y. Ma, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang

Theranostics. 2022; 12(15): 6509–6526. Published online 2022 Sep 6. doi: 10.7150/thno.75431

PMCID:: PMC9516235

Abstract Article PDF–4.3M

Select item 78807374.

High MCM6 Expression as a Potential Prognostic Marker in Clear-cell Renal Cell Carcinoma

NU-RI JANG, JINA BAEK, YOUNGHWII KO, PHIL HYUN SONG, MI-JIN GU

In Vivo. 2021 Jan-Feb; 35(1): 299–306. Published online 2021 Jan 3. doi: 10.21873/invivo.12259

PMCID:: PMC7880737

Abstract Article PDF–1.5M

Select item 73885365.

Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma

Xuebing Li, Zhenzhen Ren, Chao Xiong, Jie Geng, Yuqing Li, Cong Liu, Chunfeng Ren, Hongchun Liu

Oncol Rep. 2020 Sep; 44(3): 987–1002. Published online 2020 Jun 23. doi: 10.3892/or.2020.7658

PMCID:: PMC7388536

Abstract Article PDF–2.2M

Select item 62953556.

Comparison of Lactase Variant MCM6 – 13910 C>T Testing and Self-Report of Dairy Sensitivity in Patients with Irritable Bowel Syndrome

Ann E Almazar, Joseph Y Chang, Joseph J Larson, Elizabeth J Atkinson, G. Richard Locke, Nicholas J Talley, Yuri A Saito

J Clin Gastroenterol. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: J Clin Gastroenterol. 2019 Jul; 53(6): e227–e231. doi: 10.1097/MCG.0000000000001065

PMCID:: PMC6295355

Abstract Article PDF–325K

Select item 57786937.

MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence

Mingyu Liu, Qiaoting Hu, Mengxian Tu, Xinyi Wang, Zike Yang, Guoxiong Yang, Rongcheng Luo

J Exp Clin Cancer Res. 2018; 37: 10. Published online 2018 Jan 22. doi: 10.1186/s13046-017-0669-z

PMCID:: PMC5778693

Abstract Article PDF–7.9M

Select item 50219988.

Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization

Caren E. Smith, Oscar Coltell, Jose V. Sorlí, Ramón Estruch, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Montserrat Fitó, Fernando Arós, Hassan S. Dashti, Chao Q. Lai, Leticia Miró, Lluís Serra-Majem, Enrique Gómez-Gracia, Miquel Fiol, Emilio Ros, Stella Aslibekyan, Bertha Hidalgo, Marian L. Neuhouser, Chongzhi Di, Katherine L. Tucker, Donna K. Arnett, José M. Ordovás, Dolores Corella

Sci Rep. 2016; 6: 33188. Published online 2016 Sep 14. doi: 10.1038/srep33188

PMCID:: PMC5021998

Abstract Article PDF–1.3M

Select item 41411439.

Can a genotype for lactase persistence be used as a tool to assess the relationship between renal cell carcinoma and milk drinking? Pitfalls in the application of Mendelian randomization

Nic Timpson, Paul Brennan, Valérie Gaborieau, Lee Moore, David Zaridze, Vsevolod Matveev, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Wong-Ho Chow, Nathaniel Rothman, Paolo Boffetta, Roger Harbord, George Davey Smith

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2014 Aug 22.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 May; 19(5): 1341–1348. doi: 10.1158/1055-9965.EPI-09-1019

PMCID:: PMC4141143

Abstract Article PDF–193K

Select item 298616610.

Lactase persistence-related genetic variant: population substructure and health outcomes

George Davey Smith, Debbie A Lawlor, Nic J Timpson, Jamil Baban, Matt Kiessling, Ian N M Day, Shah Ebrahim

Eur J Hum Genet. 2009 Mar; 17(3): 357–367. Published online 2008 Sep 17. doi: 10.1038/ejhg.2008.156

PMCID:: PMC2986166

Abstract Article PDF–177K

Select item 842114311.

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes

Vivek M Shastri, Veena Subramanian, Kristina H Schmidt

Nucleic Acids Res. 2021 Sep 7; 49(15): 8699–8713. Published online 2021 Aug 9. doi: 10.1093/nar/gkab663

PMCID:: PMC8421143

Abstract Article PDF–3.5M

Select item 650717912.

Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer

A. Hendricks, F. Gieseler, S. Nazzal, J. H. Bräsen, R. Lucius, B. Sipos, J. H. Claasen, Th. Becker, S. Hinz, G. Burmeister, C. Schafmayer, C. Schrader

BMC Cancer. 2019; 19: 429. Published online 2019 May 9. doi: 10.1186/s12885-019-5631-3

PMCID:: PMC6507179

Abstract Article PDF–998K

Select item 285712413.

Characterization and Structure Determination of the Cdt1 Binding Domain of Human Minichromosome Maintenance (Mcm) 6

Zhun Wei, Changdong Liu, Xing Wu, Naining Xu, Bo Zhou, Chun Liang, Guang Zhu

J Biol Chem. 2010 Apr 23; 285(17): 12469–12473. Published online 2010 Mar 4. doi: 10.1074/jbc.C109.094599

PMCID:: PMC2857124

Abstract Article PDF–775K

Select item 267215314.

Convergent adaptation of human lactase persistence in Africa and Europe

Sarah A Tishkoff, Floyd A Reed, Alessia Ranciaro, Benjamin F Voight, Courtney C Babbitt, Jesse S Silverman, Kweli Powell, Holly M Mortensen, Jibril B Hirbo, Maha Osman, Muntaser Ibrahim, Sabah A Omar, Godfrey Lema, Thomas B Nyambo, Jilur Ghori, Suzannah Bumpstead, Jonathan K Pritchard, Gregory A Wray, Panos Deloukas

Nat Genet. Author manuscript; available in PMC 2009 Apr 23.

Published in final edited form as: Nat Genet. 2007 Jan; 39(1): 31–40. Published online 2006 Dec 10. doi: 10.1038/ng1946

PMCID:: PMC2672153

Abstract Article PDF–1.5M

Select item 259797115.

The T/G−13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population

F Imtiaz, E Savilahti, A Sarnesto, D Trabzuni, K Al‐Kahtani, I Kagevi, MS Rashed, BF Meyer, I Järvelä

J Med Genet. 2007 Oct; 44(10): e89. doi: 10.1136/jmg.2007.051631

PMCID:: PMC2597971

Abstract Article PDF–210K

Select item 672692516.

MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis

Marianne Samir Makboul Issac, Einas Yousef, Muhammad Ramzan Tahir, Louis A. Gaboury

Neoplasia. 2019 Oct; 21(10): 1015–1035. Published online 2019 Aug 30. doi: 10.1016/j.neo.2019.07.011

PMCID:: PMC6726925

Abstract Article PDF–8.0M

Select item 292351417.

Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability

Isabel M. Pires, Zuzana Bencokova, Manuela Milani, Lisa K. Folkes, Ji-Liang Li, Mike R. Stratford, Adrian L. Harris, Ester M. Hammond

Cancer Res. Author manuscript; available in PMC 2010 Aug 18.

Published in final edited form as: Cancer Res. 2010 Feb 1; 70(3): 925–935. Published online 2010 Jan 26. doi: 10.1158/0008-5472.CAN-09-2715

PMCID:: PMC2923514

Abstract Article PDF–616K

Select item 1047656118.

UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells

Yanyan Luo, Yun Yang, Cong Yang, Chuanyin Li, Ronggui Hu, Wujun Geng, Xianhui Kang, Hai Lin

FEBS Open Bio. 2023 Sep; 13(9): 1756–1771. Published online 2023 Jul 28. doi: 10.1002/2211-5463.13675

PMCID:: PMC10476561

Abstract Article PDF–5.1M

Select item 701221019.

GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer

Yongchang Zheng, Yue Shi, Si Yu, Yuanyuan Han, Kai Kang, Haifeng Xu, Huajian Gu, Xinting Sang, Yang Chen, Jingyu Wang

Anal Cell Pathol (Amst) 2019; 2019: 1038069. Published online 2019 Dec 30. doi: 10.1155/2019/1038069

PMCID:: PMC7012210

Abstract Article PDF–1.2M

Select item 332629820.

Structural insights into the Cdt1-mediated MCM2–7 chromatin loading

Changdong Liu, Rentian Wu, Bo Zhou, Jiafeng Wang, Zhun Wei, Bik K. Tye, Chun Liang, Guang Zhu

Nucleic Acids Res. 2012 Apr; 40(7): 3208–3217. Published online 2011 Dec 2. doi: 10.1093/nar/gkr1118

PMCID:: PMC3326298

Abstract Article PDF–7.6M

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PMC Links for Gene (Select 4175) (171)
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Homo sapiens chromosome 2, GRCh38.p14 Primary Assembly
Homo sapiens chromosome 2, GRCh38.p14 Primary Assembly
gi|568815596|gnl|ASM:GCF_000001305| |NC_000002.12||gpp|GPC_000001294.1||gnl|NCBI_GENOMES|2

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