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Select item 69969241.

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Niko Amin-Wetzel, Lisa Neidhardt, Yahui Yan, Matthias P Mayer, David Ron

eLife. 2019; 8: e50793. Published online 2019 Dec 24. doi: 10.7554/eLife.50793

PMCID:: PMC6996924

Abstract Article PDF–4.5M

Select item 81066772.

DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1

Hye-Youn Kim, Young-Mi Kim, Suntaek Hong

Cell Death Dis. 2021 May; 12(5): 461. Published online 2021 May 8. doi: 10.1038/s41419-021-03757-x

PMCID:: PMC8106677

Abstract Article PDF–5.1M

Select item 18635633.

Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides

Tatsuya Hoshino, Tadashi Nakaya, Wataru Araki, Keitarou Suzuki, Toshiharu Suzuki, Tohru Mizushima

Biochem J. 2007 Mar 15; 402(Pt 3): 581–589. Prepublished online 2006 Nov 29. Published online 2007 Feb 26. doi: 10.1042/BJ20061318

PMCID:: PMC1863563

Abstract Article PDF–681K

Select item 66144494.

Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR

Yunjie Huang, Kavisha Arora, Kyu Shik Mun, Fanmuyi Yang, ChangSuk Moon, Sunitha Yarlagadda, Anil Jegga, Timothy Weaver, Anjaparavanda P. Naren

Sci Rep. 2019; 9: 9808. Published online 2019 Jul 8. doi: 10.1038/s41598-019-46161-4

PMCID:: PMC6614449

Abstract Article PDF–2.9M

Select item 57333945.

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

Niko Amin-Wetzel, Reuben A. Saunders, Maarten J. Kamphuis, Claudia Rato, Steffen Preissler, Heather P. Harding, David Ron

Cell. 2017 Dec 14; 171(7): 1625–1637.e13. doi: 10.1016/j.cell.2017.10.040

PMCID:: PMC5733394

Abstract Article PDF–4.8M

Select item 42627726.

Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53

H J Lee, J M Kim, K H Kim, J I Heo, S J Kwak, J A Han

Cell Death Differ. 2015 Jan; 22(1): 86–95. Published online 2014 Aug 22. doi: 10.1038/cdd.2014.116

PMCID:: PMC4262772

Abstract Article PDF–2.9M

Select item 2076437.

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

Ann-Hwee Lee, Neal N. Iwakoshi, Laurie H. Glimcher

Mol Cell Biol. 2003 Nov; 23(21): 7448–7459. doi: 10.1128/MCB.23.21.7448-7459.2003

PMCID:: PMC207643

Abstract Article PDF–358K

Select item 42755698.

Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence

Dankyu Yoon, Young-Jin Kim, Wen-Yan Cui, Andrew Van der Vaart, Yoon Shin Cho, Jong-Young Lee, Jennie Z. Ma, Thomas J. Payne, Ming D. Li, Taesung Park

Hum Genet. Author manuscript; available in PMC 2014 Dec 24.

Published in final edited form as: Hum Genet. 2012 Jun; 131(6): 1009–1021. Published online 2011 Oct 18. doi: 10.1007/s00439-011-1102-x

PMCID:: PMC4275569

Abstract Article PDF–1.1M

Select item 28441459.

Inhibition of Secretion of Interleukin (IL)-12/IL-23 Family Cytokines by 4-Trifluoromethyl-celecoxib Is Coupled to Degradation via the Endoplasmic Reticulum Stress Protein HERP

Martin McLaughlin, Iraide Alloza, Hung Pham Quoc, Christopher J. Scott, Yasuhiko Hirabayashi, Koen Vandenbroeck

J Biol Chem. 2010 Mar 5; 285(10): 6960–6969. Published online 2010 Jan 6. doi: 10.1074/jbc.M109.056614

PMCID:: PMC2844145

Abstract Article PDF–2.5M

Select item 291899910.

Coxsackievirus B3 Infection Activates the Unfolded Protein Response and Induces Apoptosis through Downregulation of p58^IPK and Activation of CHOP and SREBP1

Huifang M. Zhang, Xin Ye, Yue Su, Ji Yuan, Zhen Liu, David A. Stein, Decheng Yang

J Virol. 2010 Sep; 84(17): 8446–8459. Published online 2010 Jun 16. doi: 10.1128/JVI.01416-09

PMCID:: PMC2918999

Abstract Article PDF–2.0M

Select item 239730111.

ERdj4 and ERdj5 Are Required for Endoplasmic Reticulum-associated Protein Degradation of Misfolded Surfactant Protein C

Mei Dong, James P. Bridges, Karen Apsley, Yan Xu, Timothy E. Weaver

Mol Biol Cell. 2008 Jun; 19(6): 2620–2630. doi: 10.1091/mbc.E07-07-0674

PMCID:: PMC2397301

Abstract Article PDF–1.2M

Select item 278518112.

Meckel-Gruber Syndrome Protein MKS3 Is Required for Endoplasmic Reticulum-associated Degradation of Surfactant Protein C

Mei Wang, James P. Bridges, Cheng-Lun Na, Yan Xu, Timothy E. Weaver

J Biol Chem. 2009 Nov 27; 284(48): 33377–33383. Published online 2009 Oct 8. doi: 10.1074/jbc.M109.034371

PMCID:: PMC2785181

Abstract Article PDF–1.3M

Select item 792630713.

EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning

Georgiana Manica, Simona Ghenea, Cristian V. A. Munteanu, Eliza C. Martin, Cristian Butnaru, Marius Surleac, Gabriela N. Chiritoiu, Petruta R. Alexandru, Andrei-Jose Petrescu, Stefana M. Petrescu

Int J Mol Sci. 2021 Feb; 22(4): 2172. Published online 2021 Feb 22. doi: 10.3390/ijms22042172

PMCID:: PMC7926307

Abstract Article PDF–4.2M

Select item 51788414.

The WW Domain-Containing Proteins Interact with the Early Spliceosome and Participate in Pre-mRNA Splicing In Vivo

Kai-Ti Lin, Ruei-Min Lu, Woan-Yuh Tarn

Mol Cell Biol. 2004 Oct; 24(20): 9176–9185. doi: 10.1128/MCB.24.20.9176-9185.2004

PMCID:: PMC517884

Abstract Article PDF–369K

Select item 31289615.

Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature

Kenzo Ohtsuka, Mami Hata

Cell Stress Chaperones. 2000 Apr; 5(2): 98–112. doi: 10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2

PMCID:: PMC312896

Abstract Article PDF–743K

Select item 295123516.

A Protein Interaction Network for Ecm29 Links the 26 S Proteasome to Molecular Motors and Endosomal Components

Carlos Gorbea, Gregory Pratt, Vicença Ustrell, Russell Bell, Sudhir Sahasrabudhe, Robert E. Hughes, Martin Rechsteiner

J Biol Chem. 2010 Oct 8; 285(41): 31616–31633. Published online 2010 Aug 3. doi: 10.1074/jbc.M110.154120

PMCID:: PMC2951235

Abstract Article PDF–6.3M

Select item 727904917.

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired

Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu

Int J Mol Sci. 2020 May; 21(10): 3468. Published online 2020 May 14. doi: 10.3390/ijms21103468

PMCID:: PMC7279049

Abstract Article PDF–12M

Select item 381740418.

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O’Brien, Brenda Andrews, Charles Boone, Jason Moffat

Mol Syst Biol. 2013; 9: 696. Published online 2013 Oct 8. doi: 10.1038/msb.2013.54

PMCID:: PMC3817404

Abstract Article PDF–13M

Select item 31093419.

Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells

Qing-Hua Zhang, Min Ye, Xin-Yan Wu, Shuang-Xi Ren, Meng Zhao, Chun-Jun Zhao, Gang Fu, Yu Shen, Hui-Yong Fan, Gang Lu, Ming Zhong, Xiang-Ru Xu, Ze-Guang Han, Ji-Wang Zhang, Jiong Tao, Qiu-Hua Huang, Jun Zhou, Geng-Xi Hu, Jian Gu, Sai-Juan Chen, Zhu Chen

Genome Res. 2000 Oct; 10(10): 1546–1560. doi: 10.1101/gr.140200

PMCID:: PMC310934

Abstract Article PDF–1.3M

Select item 340884720.

Interpreting cancer genomes using systematic host perturbations by tumour virus proteins

Orit Rozenblatt-Rosen, Rahul C. Deo, Megha Padi, Guillaume Adelmant, Michael A. Calderwood, Thomas Rolland, Miranda Grace, Amélie Dricot, Manor Askenazi, Maria Tavares, Sam Pevzner, Fieda Abderazzaq, Danielle Byrdsong, Anne-Ruxandra Carvunis, Alyce A. Chen, Jingwei Cheng, Mick Correll, Melissa Duarte, Changyu Fan, Mariet C. Feltkamp, Scott B. Ficarro, Rachel Franchi, Brijesh K. Garg, Natali Gulbahce, Tong Hao, Amy M. Holthaus, Robert James, Anna Korkhin, Larisa Litovchick, Jessica C. Mar, Theodore R. Pak, Sabrina Rabello, Renee Rubio, Yun Shen, Saurav Singh, Jennifer M. Spangle, Murat Tasan, Shelly Wanamaker, James T. Webber, Jennifer Roecklein-Canfield, Eric Johannsen, Albert-László Barabási, Rameen Beroukhim, Elliott Kieff, Michael E. Cusick, David E. Hill, Karl Münger, Jarrod A. Marto, John Quackenbush, Frederick P. Roth, James A. DeCaprio, Marc Vidal

Nature. Author manuscript; available in PMC 2013 Jan 26.

Published in final edited form as: Nature. 2012 Jul 26; 487(7408): 491–495. doi: 10.1038/nature11288

PMCID:: PMC3408847

Abstract Article PDF–937K

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