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Select item 107633691.

Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities

Eduardo Durán-Jara, Matías del Campo, Valentina Gutiérrez, Ignacio Wichmann, César Trigo, Marcelo Ezquer, Lorena Lobos-González

Biol Res. 2024; 57: 1. Published online 2024 Jan 3. doi: 10.1186/s40659-023-00477-8

PMCID:: PMC10763369

Abstract Article PDF–5.7M

Select item 106204122.

Transcriptomic analyses reveal proinflammatory activation of human brain microvascular endothelial cells by aging-associated peptide medin and reversal by nanoliposomes

Yining Zhang, Nina Karamanova, Kaleb T. Morrow, Jillian Madine, Seth Truran, Maria Lozoya, Volkmar Weissig, Ming Li, Mehdi Nikkhah, Jin G. Park, Raymond Q. Migrino

Sci Rep. 2023; 13: 18802. Published online 2023 Nov 1. doi: 10.1038/s41598-023-45959-7

PMCID:: PMC10620412

Abstract Article PDF–2.1M

Select item 105896443.

Targeting MFGE8 secreted by cancer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma

Beilei Liu, Baifeng Zhang, Jiali Qi, Hongyu Zhou, Licheng Tan, Jinlin Huang, Jiao Huang, Xiaona Fang, Lanqi Gong, Jie Luo, Shan Liu, Li Fu, Fei Ling, Stephianie Ma, Dora Lai-wan Kwong, Xin Wang, Xin-Yuan Guan

Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2307914120. Published online 2023 Oct 10. doi: 10.1073/pnas.2307914120

PMCID:: PMC10589644

Abstract Article PDF–6.8M

Select item 105186334.

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

Makis Tzioras, Michael J.D. Daniels, Caitlin Davies, Paul Baxter, Declan King, Sean McKay, Balazs Varga, Karla Popovic, Madison Hernandez, Anna J. Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K. Holloway, Jane Tulloch, Jonathan Moss, Clare Latta, Jothy Kandasamy, Drahoslav Sokol, Colin Smith, Veronique E. Miron, Ragnhildur Thóra Káradóttir, Giles E. Hardingham, Christopher M. Henstridge, Paul M. Brennan, Barry W. McColl, Tara L. Spires-Jones

Cell Rep Med. 2023 Sep 19; 4(9): 101175. Published online 2023 Aug 30. doi: 10.1016/j.xcrm.2023.101175

PMCID:: PMC10518633

Abstract Article PDF–7.3M

Select item 105029385.

A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects

Bishwa R. Sapkota, Dharambir K. Sanghera

Acta Diabetol. Author manuscript; available in PMC 2023 Sep 15.

Published in final edited form as: Acta Diabetol. 2020 Jun; 57(6): 733–741. Published online 2020 Feb 6. doi: 10.1007/s00592-019-01463-x

Correction in:: Acta Diabetol. 2022 Jun 1

PMCID:: PMC10502938

Abstract Article PDF–485K

Select item 87413626.

DCI after Aneurysmal Subarachnoid Hemorrhage Is Related to the Expression of MFG-E8

Xianjun Chen, Yong'an Jiang, Jiayu Liu, Changfeng Wang, Dengfeng Wan, Ai'jun Liang, Jingxing Leng, Yu Yang, Hui Xiang, Ru'en Liu

Biomed Res Int. 2021; 2021: 6568477. Published online 2021 Dec 31. doi: 10.1155/2021/6568477

PMCID:: PMC8741362

Abstract Article PDF–785K

Select item 83326337.

Mfge8 attenuates human gastric antrum smooth muscle contractions

Wen Li, Ashley Olseen, Yeming Xie, Cristina Alexandru, Andrew Outland, Angela F. Herrera, Andrew J. Syder, Jill Wykosky, Brian A. Perrino

J Muscle Res Cell Motil. 2021; 42(2): 219–231. Published online 2021 Jun 3. doi: 10.1007/s10974-021-09604-y

PMCID:: PMC8332633

Abstract Article PDF–1.3M

Select item 76898528.

Absence of the MFG‐E8 gene prevents hypoxia‐induced pulmonary hypertension in mice

Jun Wang, Jixing Wu, Xianying Zhu, Jinkun Chen, Jianping Zhao, Yongjian Xu, Jungang Xie

J Cell Physiol. 2021 Jan; 236(1): 587–600. Published online 2020 Jun 27. doi: 10.1002/jcp.29885

PMCID:: PMC7689852

Abstract Article PDF–6.5M

Select item 69013359.

An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

Chung Park, John H Kehrl

eLife. 2019; 8: e47776. Published online 2019 Dec 6. doi: 10.7554/eLife.47776

PMCID:: PMC6901335

Abstract Article PDF–7.7M

Select item 689791510.

Polymorphisms of MFGE8 are associated with susceptibility and clinical manifestations through gene expression modulation in Koreans with systemic lupus erythematosus

Wook-Young Baek, Ji-Min Woo, Hyoun-Ah Kim, Ju-Yang Jung, Chang-Hee Suh

Sci Rep. 2019; 9: 18565. Published online 2019 Dec 6. doi: 10.1038/s41598-019-55061-6

PMCID:: PMC6897915

Abstract Article PDF–1.0M

Select item 682349411.

Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

Tomonari Shimagaki, Sachiyo Yoshio, Hironari Kawai, Yuzuru Sakamoto, Hiroyoshi Doi, Michitaka Matsuda, Taizo Mori, Yosuke Osawa, Moto Fukai, Takeshi Yoshida, Yunfei Ma, Tomoyuki Akita, Junko Tanaka, Akinobu Taketomi, Rikinari Hanayama, Tomoharu Yoshizumi, Masaki Mori, Tatsuya Kanto

Sci Rep. 2019; 9: 15788. Published online 2019 Oct 31. doi: 10.1038/s41598-019-52356-6

PMCID:: PMC6823494

Abstract Article PDF–1.7M

Select item 675357012.

Synovial fluid and plasma levels of milk fat globule–epidermal growth factor 8 are inversely correlated with radiographic severity of knee osteoarthritis

Feihu Chen, Hao Liu, Jie Xia, Xiaomin Ding, Jianbo Fan, Xinhui Zhu, Shengyu Cui, Hong Yi, Rufeng Gao, Wei Liu

J Int Med Res. 2019 Sep; 47(9): 4422–4430. Published online 2019 Jul 25. doi: 10.1177/0300060519862460

PMCID:: PMC6753570

Abstract Article PDF–333K

Select item 621589213.

Immunoregulatory influence of abundant MFG‐E8 expression by esophageal cancer treated with chemotherapy

Takashi Kanemura, Hiroshi Miyata, Tomoki Makino, Koji Tanaka, Keijiro Sugimura, Mika Hamada‐Uematsu, Yu Mizote, Hiroaki Uchida, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Hisashi Wada, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki, Hideaki Tahara

Cancer Sci. 2018 Nov; 109(11): 3393–3402. Published online 2018 Sep 22. doi: 10.1111/cas.13785