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Select item 110792161.

Identification of molecular subtypes based on chromatin regulator-related genes and experimental verification of the role of ASCL1 in conferring chemotherapy resistance to breast cancer

Yilun Li, Xiaolu Yang, Cuizhi Geng, Yunjiang Liu, Tiantian Tang, Lina Zhang, Fei Liu, Meng Zhang, Jun Hao, Li Ma

Front Immunol. 2024; 15: 1390261. Published online 2024 Apr 25. doi: 10.3389/fimmu.2024.1390261

PMCID:: PMC11079216

Abstract Article PDF–10M

Select item 107242322.

ASCL1 induces neurogenesis in human Müller glia

Juliette Wohlschlegel, Connor Finkbeiner, Dawn Hoffer, Faith Kierney, Aric Prieve, Alexandria D. Murry, Alexandra K. Haugan, Isabel Ortuño-Lizarán, Fred Rieke, Sam A. Golden, Thomas A. Reh

Stem Cell Reports. 2023 Dec 12; 18(12): 2400–2417. Published online 2023 Nov 30. doi: 10.1016/j.stemcr.2023.10.021

PMCID:: PMC10724232

Abstract Article PDF–8.5M

Select item 106482103.

ASCL1 Is Involved in the Pathogenesis of Schizophrenia by Regulation of Genes Related to Cell Proliferation, Neuronal Signature Formation, and Neuroplasticity

Dmitrii A. Abashkin, Dmitry S. Karpov, Artemii O. Kurishev, Ekaterina V. Marilovtseva, Vera E. Golimbet

Int J Mol Sci. 2023 Nov; 24(21): 15746. Published online 2023 Oct 30. doi: 10.3390/ijms242115746

PMCID:: PMC10648210

Abstract Article PDF–4.7M

Select item 96332984.

ASCL1 regulates super‐enhancer‐associated miRNAs to define molecular subtypes of small cell lung cancer

Kazuko Miyakawa, Naoya Miyashita, Masafumi Horie, Yasuhiro Terasaki, Hidenori Tanaka, Hirokazu Urushiyama, Kensuke Fukuda, Yugo Okabe, Takashi Ishii, Naomi Kuwahara, Hiroshi I. Suzuki, Takahide Nagase, Akira Saito

Cancer Sci. 2022 Nov; 113(11): 3932–3946. Published online 2022 Aug 30. doi: 10.1111/cas.15481

PMCID:: PMC9633298

Abstract Article PDF–5.3M

Select item 90462805.

ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

Shaghayegh Nouruzi, Dwaipayan Ganguli, Nakisa Tabrizian, Maxim Kobelev, Olena Sivak, Takeshi Namekawa, Daksh Thaper, Sylvan C. Baca, Matthew L. Freedman, Adeleke Aguda, Alastair Davies, Amina Zoubeidi

Nat Commun. 2022; 13: 2282. Published online 2022 Apr 27. doi: 10.1038/s41467-022-29963-5

PMCID:: PMC9046280

Abstract Article PDF–4.0M

Select item 89936896.

Therapeutic targeting of BAP1/ASXL3 sub-complex in ASCL1-dependent small cell lung cancer

Natsumi Tsuboyama, Ru Wang, Aileen Patricia Szczepanski, Huanhuan Chen, Zibo Zhao, Lei Shi, Lu Wang

Oncogene. 2022; 41(15): 2152–2162. Published online 2022 Feb 22. doi: 10.1038/s41388-022-02240-x

PMCID:: PMC8993689

Abstract Article PDF–4.5M

Select item 85616427.

Developmental programming and lineage branching of early human telencephalon

Lin Ma, Yanhua Du, Yi Hui, Nan Li, Beibei Fan, Xiaojie Zhang, Xiaocui Li, Wei Hong, Zhiping Wu, Shuwei Zhang, Shanshan Zhou, Xiangjie Xu, Zhongshu Zhou, Cizhong Jiang, Ling Liu, Xiaoqing Zhang

EMBO J. 2021 Nov 2; 40(21): e107277. Published online 2021 Sep 24. doi: 10.15252/embj.2020107277

PMCID:: PMC8561642

Abstract Article PDF–20M

Select item 77792028.

Clinicopathological features and prognostic implications of ASCL1 expression in surgically resected small cell lung cancer

Jiacong Wei, Li Liu, Yiying Guo, Jinyao Zhang, Xin Wang, Jiyan Dong, Puyuan Xing, Jianming Ying, Lin Yang, Junling Li

Thorac Cancer. 2021 Jan; 12(1): 40–47. Published online 2020 Nov 15. doi: 10.1111/1759-7714.13705

PMCID:: PMC7779202

Abstract Article PDF–1.1M

Select item 69110839.

hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen

Jennifer A. Fraser, Joseph E. Sutton, Saba Tazayoni, Isla Bruce, Amy V. Poole

Sci Rep. 2019; 9: 19076. Published online 2019 Dec 13. doi: 10.1038/s41598-019-55665-y

PMCID:: PMC6911083

Abstract Article PDF–5.2M

Select item 673326910.

Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids

Saurabh V. Laddha, Edaise M. da Silva, Kenneth Robzyk, Brian R. Untch, Hua Ke, Natasha Rekhtman, John T. Poirier, William D. Travis, Laura H. Tang, Chang S. Chan

Cancer Res. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Cancer Res. 2019 Sep 1; 79(17): 4339–4347. Published online 2019 Jul 12. doi: 10.1158/0008-5472.CAN-19-0214

PMCID:: PMC6733269

Abstract Article PDF–2.1M

Select item 600043711.

hASH1在肺神经内分泌肿瘤中的表达及其临床意义

李菲, 钟志永, 李锐, 黄鹤宇, 王丽君, 郑东晗, 张道荣

Zhongguo Fei Ai Za Zhi. 2010 Apr 20; 13(4): 317–321. Chinese. doi: 10.3779/j.issn.1009-3419.2010.04.09

PMCID:: PMC6000437

Abstract Article PDF–2.0M

Select item 539004712.

Fragment-Based NMR Study of the Conformational Dynamics in the bHLH Transcription Factor Ascl1

Lorenzo Baronti, Tomáš Hošek, Sergio Gil-Caballero, Hadas Raveh-Amit, Eduardo O. Calçada, Isabel Ayala, András Dinnyés, Isabella C. Felli, Roberta Pierattelli, Bernhard Brutscher

Biophys J. 2017 Apr 11; 112(7): 1366–1373. Published online 2017 Apr 11. doi: 10.1016/j.bpj.2017.02.025

PMCID:: PMC5390047

Abstract Article PDF–1.2M

Select item 420560313.

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

Alexander Augustyn, Mark Borromeo, Tao Wang, Junya Fujimoto, Chunli Shao, Patrick D. Dospoy, Victoria Lee, Christopher Tan, James P. Sullivan, Jill E. Larsen, Luc Girard, Carmen Behrens, Ignacio I. Wistuba, Yang Xie, Melanie H. Cobb, Adi F. Gazdar, Jane E. Johnson, John D. Minna

Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41): 14788–14793. Published online 2014 Sep 29. doi: 10.1073/pnas.1410419111

PMCID:: PMC4205603

Abstract Article PDF–1.4M

Select item 377430114.

An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma

Esther Rheinbay, Mario L. Suvà, Shawn M. Gillespie, Hiroaki Wakimoto, Anoop P. Patel, Mohammad Shahid, Ozgur Oksuz, Samuel D. Rabkin, Robert L. Martuza, Miguel N. Rivera, David N. Louis, Simon Kasif, Andrew S. Chi, Bradley E. Bernstein

Cell Rep. Author manuscript; available in PMC 2013 Nov 30.

Published in final edited form as: Cell Rep. 2013 May 30; 3(5): 1567–1579. Published online 2013 May 23. doi: 10.1016/j.celrep.2013.04.021

PMCID:: PMC3774301

Abstract Article PDF–2.1M

Select item 312724515.

Regulation of Prenatal Human Retinal Neurosphere Growth and Cell Fate Potential by Retinal Pigment Epithelium and Mash1

David M. Gamm, Lynda S. Wright, Elizabeth Capowski, Rebecca L. Shearer, Jason S. Meyer, Hyun-Jung Kim, Bernard L. Schneider, J. Nicholas Melvan, Clive N. Svendsen

Stem Cells. Author manuscript; available in PMC 2011 Jun 30.

Published in final edited form as: Stem Cells. 2008 Dec; 26(12): 3182–3193. Published online 2008 Sep 18. doi: 10.1634/stemcells.2008-0300

PMCID:: PMC3127245

Abstract Article PDF–4.9M

Select item 291931716.

Achaete-Scute Complex Homolog 1 Regulates Tumor-Initiating Capacity in Human Small Cell Lung Cancer

Tianyun Jiang, Brendan J. Collins, Ning Jin, David N. Watkins, Malcolm V. Brock, William Matsui, Barry D. Nelkin, Douglas W. Ball

Cancer Res. Author manuscript; available in PMC 2010 Aug 10.

Published in final edited form as: Cancer Res. 2009 Feb 1; 69(3): 845–854. Published online 2009 Jan 27. doi: 10.1158/0008-5472.CAN-08-2762

PMCID:: PMC2919317

Abstract Article PDF–1.5M

Select item 4677817.

Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors.

D W Ball, C G Azzoli, S B Baylin, D Chi, S Dou, H Donis-Keller, A Cumaraswamy, M Borges, B D Nelkin

Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12): 5648–5652. doi: 10.1073/pnas.90.12.5648

PMCID:: PMC46778

Summary Page Browse PDF–1.3M

Select item 1056783518.

Ubiquitination of ASCL1 mediates CD47 transcriptional activation of the AKT signaling pathway, and glycolysis promotes osteogenic differentiation of hBMSCs

Jimei Zhang, Ling Zhu, Jianping Zhou, Qunying Yu, Guangyuan Yang, Ke Zhao, Chaoli Luo, Jianguo Meng, Jing Liu, Xuming Yang

In Vitro Cell Dev Biol Anim. 2023; 59(8): 636–648. Published online 2023 Oct 2. doi: 10.1007/s11626-023-00811-0

PMCID:: PMC10567835

Abstract Article PDF–11M

Select item 1023661719.

An integrative epigenomic approach identifies ELF3 as an oncogenic regulator in ASCL1‐positive neuroendocrine carcinoma

Masafumi Horie, Hidenori Tanaka, Masami Suzuki, Yoshihiko Sato, So Takata, Erina Takai, Naoya Miyashita, Akira Saito, Yoichiro Nakatani, Shinichi Yachida

Cancer Sci. 2023 Jun; 114(6): 2596–2608. Published online 2023 Mar 15. doi: 10.1111/cas.15764

PMCID:: PMC10236617

Abstract Article PDF–3.5M

Select item 990755520.

Validation of ASCL1 and LHX8 Methylation Analysis as Primary Cervical Cancer Screening Strategy in South African Women with Human Immunodeficiency Virus

Frederique J Vink, Chris J L M Meijer, Birgit I Lissenberg-Witte, Cathy Visser, Sylvia Duin, Leon C Snyman, Karin L Richter, Frederick H van der Merwe, Matthys H Botha, Renske D M Steenbergen, Greta Dreyer

Clin Infect Dis. 2023 Feb 1; 76(3): 416–423. Published online 2022 Nov 11. doi: 10.1093/cid/ciac801

PMCID:: PMC9907555

Abstract Article PDF–716K

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PMC Links for Gene (Select 429) (63)
PMC
Homo sapiens gamma-glutamyltransferase 5 (GGT5), transcript variant 2, mRNA
Homo sapiens gamma-glutamyltransferase 5 (GGT5), transcript variant 2, mRNA
gi|1887096800|ref|NM_004121.5|

Nucleotide
achaete-scute homolog 1 [Homo sapiens]
achaete-scute homolog 1 [Homo sapiens]
gi|55743094|ref|NP_004307.2|

Protein
LOC100506331 [Homo sapiens]
LOC100506331 [Homo sapiens]
Gene ID:100506331

Gene

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