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Items: 1 to 20 of 64

1.
ENL: structure, function, and roles in hematopoiesis and acute myeloid leukemia
Jianbiao Zhou, Yvonne Ng, Wee-Joo Chng
Cell Mol Life Sci. 2018 Nov; 75(21): 3931–3941. Published online 2018 Jul 31. doi: 10.1007/s00018-018-2895-8
PMCID:
PMC11105289
AbstractArticlePDF–953K
2.
MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours
Elizabeth J. Perlman, Samantha Gadd, Stefan T. Arold, Anand Radhakrishnan, Daniela S. Gerhard, Lawrence Jennings, Vicki Huff, Jaime M. Guidry Auvil, Tanja M. Davidsen, Jeffrey S. Dome, Daoud Meerzaman, Chih Hao Hsu, Cu Nguyen, James Anderson, Yussanne Ma, Andrew J. Mungall, Richard A. Moore, Marco A. Marra, Charles G. Mullighan, Jing Ma, David A. Wheeler, Oliver A. Hampton, Julie M. Gastier-Foster, Nicole Ross, Malcolm A. Smith
Nat Commun. 2015; 6: 10013. Published online 2015 Dec 4. doi: 10.1038/ncomms10013
PMCID:
PMC4686660
AbstractArticlePDF–1.3M
3.
MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells
Emanuel Maethner, Maria-Paz Garcia-Cuellar, Constanze Breitinger, Sylvia Takacova, Vladimir Divoky, Jay L. Hess, Robert K. Slany
Cell Rep. Author manuscript; available in PMC 2014 Aug 7.
Published in final edited form as: Cell Rep. 2013 May 30; 3(5): 1553–1566. Published online 2013 Apr 25. doi: 10.1016/j.celrep.2013.03.038
PMCID:
PMC4124133
AbstractArticlePDF–1.2M
4.
Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia
Javier G. Blanco, Thierry Dervieux, Mathew J. Edick, Perdeep K. Mehta, Jeffrey E. Rubnitz, Sheila Shurtleff, Susana C. Raimondi, Frederick G. Behm, Ching-Hon Pui, Mary V. Relling
Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18): 10338–10343. doi: 10.1073/pnas.181199898
PMCID:
PMC56962
AbstractArticlePDF–232K
5.
The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia
Hsiangyu Hu, Nirmalya Saha, Yuting Yang, Ejaz Ahmad, Lauren Lachowski, Uttar Shrestha, Vidhya Premkumar, James Ropa, Lili Chen, Blaine Teahan, Sierrah Grigsby, Rolf Marschalek, Zaneta Nikolovska-Coleska, Andrew G. Muntean
Leukemia. Author manuscript; available in PMC 2024 Jul 14.
Published in final edited form as: Leukemia. 2023 Jan; 37(1): 190–201. Published online 2022 Nov 26. doi: 10.1038/s41375-022-01765-0
PMCID:
PMC11246743
AbstractArticlePDF–2.2M
6.
KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene expression programs
Fangxue Yan, Jinyang Li, Jelena Milosevic, Ricardo Petroni, Suying Liu, Zhennan Shi, Salina Yuan, Janice M. Reynaga, Yuwei Qi, Joshua Rico, Sixiang Yu, Yiman Liu, Susumu Rokudai, Neil Palmisiano, Sara E. Meyer, Pamela J Sung, Liling Wan, Fei Lan, Benjamin A. Garcia, Ben Z. Stanger, David B. Sykes, M. Andrés Blanco
Cancer Discov. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Cancer Discov. 2022 Mar 1; 12(3): 792–811. doi: 10.1158/2159-8290.CD-20-1459
PMCID:
PMC8916037
AbstractArticlePDF–2.6M
7.
The intrinsically disordered proteins MLLT3 (AF9) and MLLT1 (ENL) – multimodal transcriptional switches with roles in normal hematopoiesis, MLL fusion leukemia, and kidney cancer
Ashish Kabra, John Bushweller
J Mol Biol. Author manuscript; available in PMC 2023 Jan 15.
Published in final edited form as: J Mol Biol. 2022 Jan 15; 434(1): 167117. Published online 2021 Jun 23. doi: 10.1016/j.jmb.2021.167117
PMCID:
PMC8695629
AbstractArticlePDF–1.3M
8.
ENL links histone acetylation to oncogenic gene expression in AML
Liling Wan, Hong Wen, Yuanyuan Li, Jie Lyu, Yuanxin Xi, Takayuki Hoshii, Julia Joseph, Xiaolu Wang, Yong-Hwee E. Loh, Michael A. Erb, Amanda L. Souza, James E. Bradner, Li Shen, Wei Li, Haitao Li, C. David Allis, Scott A. Armstrong, Xiaobing Shi
Nature. Author manuscript; available in PMC 2017 Sep 1.
Published in final edited form as: Nature. 2017 Mar 9; 543(7644): 265–269. Published online 2017 Mar 1. doi: 10.1038/nature21687
PMCID:
PMC5372383
AbstractArticlePDF–2.1M
9.
An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias
Nisha N. Barretto, Dean S. Karahalios, Dewen You, Charles S. Hemenway
J Exp Ther Oncol. Author manuscript; available in PMC 2016 Dec 20.
Published in final edited form as: J Exp Ther Oncol. 2014; 10(4): 293–300.
PMCID:
PMC5172450
AbstractArticlePDF–730K
10.
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
Mark A. Dawson, Rab K. Prinjha, Antje Dittman, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M. Savitski, Carola Huthmacher, Emma Gudgin, Dave Lugo, Soren Beinke, Trevor D. Chapman, Emma J. Roberts, Peter E Soden, Kurt R. Auger, Olivier Mirguet, Konstanze Doehner, Ruud Delwel, Alan K. Burnett, Phillip Jeffrey, Gerard Drewes, Kevin Lee, Brian J.P Huntly, Tony Kouzarides
Nature. Author manuscript; available in PMC 2013 Jun 12.
Published in final edited form as: Nature. 2011 Oct 2; 478(7370): 529–533. Published online 2011 Oct 2. doi: 10.1038/nature10509
PMCID:
PMC3679520
AbstractArticlePDF–4.2M
11.
Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.
M J Thirman, D A Levitan, H Kobayashi, M C Simon, J D Rowley
Proc Natl Acad Sci U S A. 1994 Dec 6; 91(25): 12110–12114. doi: 10.1073/pnas.91.25.12110
PMCID:
PMC45386
SummaryPage BrowsePDF–1.4M
12.
Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited
Michaël Gué, Jian-Sheng Sun, Thomas Boudier
BMC Cancer. 2006; 6: 20. Published online 2006 Jan 24. doi: 10.1186/1471-2407-6-20
PMCID:
PMC1388228
AbstractArticlePDF–372K
13.
Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
Catherine Lavau, Roger T. Luo, Changchun Du, Michael J. Thirman
Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20): 10984–10989. Published online 2000 Sep 19. doi: 10.1073/pnas.190167297
PMCID:
PMC27135
AbstractArticlePDF–243K
14.
The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development
Theresa Okeyo-Owuor, Yanan Li, Riddhi M. Patel, Wei Yang, Emily B. Casey, Andrew S. Cluster, Shaina N. Porter, David Bryder, Jeffrey A. Magee
Blood Adv. 2019 Aug 13; 3(15): 2388–2399. Published online 2019 Aug 12. doi: 10.1182/bloodadvances.2019000554
PMCID:
PMC6693010
AbstractArticlePDF–1.7M
15.
HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold
Seemay Chou, Heather Upton, Katherine Bao, Ursula Schulze-Gahmen, Avi J. Samelson, Nanhai He, Anna Nowak, Huasong Lu, Nevan J. Krogan, Qiang Zhou, Tom Alber
Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2): E123–E131. Published online 2012 Dec 18. doi: 10.1073/pnas.1216971110
PMCID:
PMC3545800
AbstractArticlePDF–1.6M
16.
The ubiquitin ligase Siah1 controls ELL2 stability and formation of Super Elongation Complexes (SECs) to modulate gene transcription
Min Liu, Joanne Hsu, Caleb Chan, Zichong Li, Qiang Zhou
Mol Cell. Author manuscript; available in PMC 2013 May 11.
Published in final edited form as: Mol Cell. 2012 May 11; 46(3): 325–334. Published online 2012 Apr 5. doi: 10.1016/j.molcel.2012.03.007
PMCID:
PMC3360964
AbstractArticlePDF–4.1M
17.
Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia
Dorothee Mueller, María-Paz García-Cuéllar, Christian Bach, Sebastian Buhl, Emanuel Maethner, Robert K. Slany
PLoS Biol. 2009 Nov; 7(11): e1000249. Published online 2009 Nov 24. doi: 10.1371/journal.pbio.1000249
PMCID:
PMC2774266
AbstractArticlePDF–764K
18.
Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin
Nanhai He, Caleb K. Chan, Bijan Sobhian, Seemay Chou, Yuhua Xue, Min Liu, Tom Alber, Monsef Benkirane, Qiang Zhou
Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36): E636-E645. Published online 2011 Aug 22. doi: 10.1073/pnas.1107107108
PMCID:
PMC3169135
AbstractArticlePDF–1.1M
19.
Human ALKBH4 Interacts with Proteins Associated with Transcription
Linn G. Bjørnstad, Trine J. Meza, Marit Otterlei, Solveig M. Olafsrud, Leonardo A. Meza-Zepeda, Pål Ø. Falnes
PLoS One. 2012; 7(11): e49045. Published online 2012 Nov 8. doi: 10.1371/journal.pone.0049045
PMCID:
PMC3493508
AbstractArticlePDF–679K
20.
A higher-order complex containing AF4- and ENL-family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription
Akihiko Yokoyama, Min Lin, Alpana Naresh, Issay Kitabayashi, Michael L. Cleary
Cancer Cell. Author manuscript; available in PMC 2011 Feb 17.
Published in final edited form as: Cancer Cell. 2010 Feb 17; 17(2): 198–212. doi: 10.1016/j.ccr.2009.12.040
PMCID:
PMC2824033
AbstractArticlePDF–1.8M

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