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Items: 1 to 20 of 82

1.
MPL S505C enhances driver mutations at W515 in essential thrombocythemia
Leila N. Varghese, Gonzalo Carreño-Tarragona, Gabriel Levy, Xabier Gutiérrez-López de Ocáriz, Inmaculada Rapado, Joaquín Martínez-López, Rosa Ayala, Stefan N. Constantinescu
Blood Cancer J. 2021 Nov; 11(11): 188. Published online 2021 Nov 29. doi: 10.1038/s41408-021-00583-4
PMCID:
PMC8630145
ArticlePDF–817K
2.
CAMT-MPL: congenital amegakaryocytic thrombocytopenia caused by MPL mutations - heterogeneity of a monogenic disorder - a comprehensive analysis of 56 patients
Manuela Germeshausen, Matthias Ballmaier
Haematologica. 2021 Sep 1; 106(9): 2439–2448. Published online 2020 Jul 23. doi: 10.3324/haematol.2020.257972
PMCID:
PMC8409039
AbstractArticlePDF–2.8M
3.
Thrombopoietin Contributes to Enhanced Platelet Activation in Patients with Type 1 Diabetes Mellitus
Ornella Bosco, Barbara Vizio, Gabriella Gruden, Martina Schiavello, Bartolomeo Lorenzati, Paolo Cavallo-Perin, Isabella Russo, Giuseppe Montrucchio, Enrico Lupia
Int J Mol Sci. 2021 Jul; 22(13): 7032. Published online 2021 Jun 29. doi: 10.3390/ijms22137032
PMCID:
PMC8269076
AbstractArticlePDF–1.6M
4.
An Asian-specific MPL genetic variant alters JAK–STAT signaling and influences platelet count in the population
Pengfei Sun, Wei Zhou, Yi Fu, Chloe Y Y Cheung, Yujun Dong, Min-Lee Yang, He Zhang, Jia Jia, Yong Huo, Cristen J Willer, Y Eugene Chen, Clara S Tang, Hung-Fat Tse, Karen S L Lam, Wei Gao, Ming Xu, Haiyi Yu, Pak Chung Sham, Yan Zhang, Santhi K Ganesh
Hum Mol Genet. 2021 May 1; 30(9): 836–842. Published online 2021 Mar 9. doi: 10.1093/hmg/ddab062
PMCID:
PMC8161516
AbstractArticlePDF–273K
5.
MPL mutations and palpable splenomegaly are independent risk factors for fibrotic progression in essential thrombocythemia
M Haider, Y C Elala, N Gangat, C A Hanson, A Tefferi
Blood Cancer J. 2016 Oct; 6(10): e487. Published online 2016 Oct 21. doi: 10.1038/bcj.2016.98
PMCID:
PMC5098266
ArticlePDF–216K
6.
Flow cytometric detection of MPL (CD110) as a diagnostic tool for differentiation of congenital thrombocytopenias
Matthias Ballmaier, Wolfgang Holter, Manuela Germeshausen
Haematologica. 2015 Sep; 100(9): e341–e344. doi: 10.3324/haematol.2015.125963
PMCID:
PMC4800683
ArticlePDF–583K
7.
His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor
Emilie Leroy, Jean-Philippe Defour, Takeshi Sato, Sharmila Dass, Vitalina Gryshkova, Myat M. Shwe, Judith Staerk, Stefan N. Constantinescu, Steven O. Smith
J Biol Chem. 2016 Feb 5; 291(6): 2974–2987. Published online 2015 Dec 1. doi: 10.1074/jbc.M115.696534
PMCID:
PMC4742759
AbstractArticlePDF–831K
8.
Severe Clinical Course in a Patient with Congenital Amegakaryocytic Thrombocytopenia Due to a Missense Mutation of the c-MPL Gene
İkbal Ok Bozkaya, Neşe Yaralı, Pamir Işık, Rukiye Ünsal Saç, Betül Tavil, Bahattin Tunç
Turk J Haematol. 2015 Jun; 32(2): 172–174. Published online 2015 May 8. doi: 10.4274/tjh.2013.0191
PMCID:
PMC4451487
AbstractArticlePDF–178K
9.
A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor
Eyayu Belay, Chris P. Miller, Amanda N. Kortum, Beverly Torok-Storb, C. Anthony Blau, David W. Emery
Blood. 2015 Feb 5; 125(6): 1025–1033. Prepublished online 2014 Oct 24. doi: 10.1182/blood-2014-02-555318
PMCID:
PMC4319233
AbstractArticle
10.
Novel Pathways to Erythropoiesis Induced by Dimerization of Intracellular c-Mpl in Human Hematopoietic Progenitors
CHINTAN PAREKH, ARINEH SAHAGHIAN, WILLIAM KIM, JESSICA SCHOLES, SHUNDI GE, YUHUA ZHU, SHAHAB ASGHARZADEH, ROGER HOLLIS, DONALD KOHN, LINGYUN JI, JEMILY MALVAR, XIAOYAN WANG, GAY CROOKS
Stem Cells. Author manuscript; available in PMC 2014 Apr 2.
Published in final edited form as: Stem Cells. 2012 Apr; 30(4): 697–708. doi: 10.1002/stem.1046
PMCID:
PMC3973153
AbstractArticlePDF–1.8M
11.
Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling
Shinji Hirata, Naoya Takayama, Ryoko Jono-Ohnishi, Hiroshi Endo, Sou Nakamura, Takeaki Dohda, Masanori Nishi, Yuhei Hamazaki, Ei-ichi Ishii, Shin Kaneko, Makoto Otsu, Hiromitsu Nakauchi, Shinji Kunishima, Koji Eto
J Clin Invest. 2013 Sep 3; 123(9): 3802–3814. Published online 2013 Aug 1. doi: 10.1172/JCI64721
PMCID:
PMC3754238
AbstractArticlePDF–2.2M
12.
Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in MPL-mutated myeloproliferative neoplasms
Elisa Rumi, Daniela Pietra, Paola Guglielmelli, Roberta Bordoni, Ilaria Casetti, Chiara Milanesi, Emanuela Sant’Antonio, Virginia Ferretti, Alessandro Pancrazzi, Giada Rotunno, Marco Severgnini, Alessandro Pietrelli, Cesare Astori, Elena Fugazza, Cristiana Pascutto, Emanuela Boveri, Francesco Passamonti, Gianluca De Bellis, Alessandro Vannucchi, Mario Cazzola
Blood. 2013 May 23; 121(21): 4388–4395. Prepublished online 2013 Apr 10. doi: 10.1182/blood-2013-02-486050
PMCID:
PMC3663431
AbstractArticle
13.
Different mutations of the human c-mpl gene indicate distinct haematopoietic diseases
Xin He, Zhigang Chen, Yangyan Jiang, Xi Qiu, Xiaoying Zhao
J Hematol Oncol. 2013; 6: 11. Published online 2013 Jan 25. doi: 10.1186/1756-8722-6-11
PMCID:
PMC3563459
AbstractArticlePDF–734K
14.
Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling
John Anto Pulikkan, Dmitri Madera, Liting Xue, Paul Bradley, Sean Francis Landrette, Ya-Huei Kuo, Saman Abbas, Lihua Julie Zhu, Peter Valk, Lucio Hernán Castilla
Blood. 2012 Jul 26; 120(4): 868–879. Prepublished online 2012 May 21. doi: 10.1182/blood-2012-03-414649
PMCID:
PMC3412349
AbstractArticle
15.
The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO
Fu-Sheng Chou, Andrea Griesinger, Mark Wunderlich, Shan Lin, Kevin A. Link, Mahesh Shrestha, Susumu Goyama, Benjamin Mizukawa, Shuhong Shen, Guido Marcucci, James C. Mulloy
Blood. 2012 Jul 26; 120(4): 709–719. Prepublished online 2012 Feb 14. doi: 10.1182/blood-2012-01-403212
PMCID:
PMC3412344
AbstractArticle
16.
Exome sequencing identifies MPL as a causative gene in familial aplastic anemia
Amanda J. Walne, Arran Dokal, Vincent Plagnol, Richard Beswick, Michael Kirwan, Josu de la Fuente, Tom Vulliamy, Inderjeet Dokal
Haematologica. 2012 Apr; 97(4): 524–528. doi: 10.3324/haematol.2011.052787
PMCID:
PMC3347658
AbstractArticlePDF–962K
17.
Effects of Clinically Relevant MPL Mutations in the Transmembrane Domain Revealed at the Atomic Level through Computational Modeling
Tai-Sung Lee, Hagop Kantarjian, Wanlong Ma, Chen-Hsiung Yeh, Francis Giles, Maher Albitar
PLoS One. 2011; 6(8): e23396. Published online 2011 Aug 17. doi: 10.1371/journal.pone.0023396
PMCID:
PMC3157383
AbstractArticlePDF–1.3M
18.
Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation
Erin E. Matthews, Damien Thévenin, Julia M. Rogers, Lisa Gotow, Paul D. Lira, Lawrence A. Reiter, William H. Brissette, Donald M. Engelman
FASEB J. 2011 Jul; 25(7): 2234–2244. doi: 10.1096/fj.10-178673
PMCID:
PMC3114528
AbstractArticle
19.
Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms
Daniela Pietra, Angela Brisci, Elisa Rumi, Sabrina Boggi, Chiara Elena, Alessandro Pietrelli, Roberta Bordoni, Maurizio Ferrari, Francesco Passamonti, Gianluca De Bellis, Laura Cremonesi, Mario Cazzola
Haematologica. 2011 Apr; 96(4): 607–611. Published online 2011 Jan 12. doi: 10.3324/haematol.2010.034793
PMCID:
PMC3069239
AbstractArticlePDF–859K
20.
Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms
Philip A. Beer, Christina A. Ortmann, Frank Stegelmann, Paola Guglielmelli, John T. Reilly, Thomas S. Larsen, Hans C. Hasselbalch, Alessandro M. Vannucchi, Peter Möller, Konstanze Döhner, Anthony R. Green
Haematologica. 2010 Dec; 95(12): 2153–2156. Published online 2010 Sep 7. doi: 10.3324/haematol.2010.029306
PMCID:
PMC2995575
AbstractArticlePDF–2.7M

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