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Select item 99387491.

Analysis of ASS1 gene in ten unrelated middle eastern families with citrullinemia type 1 identifies rare and novel variants

Melissa Daou, Mirna Souaid, Tony Yammine, Issam Khneisser, Hicham Mansour, Nabiha Salem, Antony Nemr, Johnny Awwad, Adib Moukarzel, Chantal Farra

Mol Genet Genomic Med. 2023 Feb; 11(2): e2058. Published online 2023 Jan 20. doi: 10.1002/mgg3.2058

PMCID:: PMC9938749

Article PDF–985K

Select item 80357872.

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma

Sanghwa Kim, Minji Lee, Yeonhwa Song, Su-Yeon Lee, Inhee Choi, I-Seul Park, Jiho Kim, Jin-sun Kim, Kang mo Kim, Haeng Ran Seo

J Exp Clin Cancer Res. 2021; 40: 127. Published online 2021 Apr 10. doi: 10.1186/s13046-021-01912-y

PMCID:: PMC8035787

Article PDF–3.4M

Select item 74426493.

Arginine depletion therapy with ADI-PEG20 limits tumor growth in argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type

Jennifer X. Ji, Dawn R. Cochrane, Basile Tessier-Cloutier, Shary Chen, Germain Ho, Khyatiben V. Pathak, Isabel Alcazar, David Farnell, Samuel Leung, Angela Cheng, Christine Chow, Shane Colborne, Gian Luca Negri, Frieder Kommoss, Anthony N. Karnezis, Gregg B. Morin, Jessica N. McAlpine, C. Blake Gilks, Bernard E. Weissman, Jeffrey M. Trent, Lynn N. Hoang, Patrick Pirrotte, Yemin Wang, David G. Huntsman

Clin Cancer Res. Author manuscript; available in PMC 2021 Feb 15.

Published in final edited form as: Clin Cancer Res. 2020 Aug 15; 26(16): 4402–4413. Published online 2020 May 14. doi: 10.1158/1078-0432.CCR-19-1905

PMCID:: PMC7442649

Article PDF–2.0M

Select item 65804644.

Citrullinemia type I is associated with a novel splicing variant, c.773 + 4A > C, in ASS1: a case report and literature review

Yiming Lin, Hongzhi Gao, Bin Lu, Shuang Zhou, Tianwen Zheng, Weihua Lin, Lin Zhu, Mengyi Jiang, Qingliu Fu

BMC Med Genet. 2019; 20: 110. Published online 2019 Jun 17. doi: 10.1186/s12881-019-0836-5

PMCID:: PMC6580464

Article PDF–847K

Select item 62942485.

Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM

Justyna Magdalena Przystal, Nabil Hajji, Combiz Khozoie, Alexander Renziehausen, Qingyu Zeng, Fernando Abaitua, Amin Hajitou, Keittisak Suwan, Elizabeth Want, John Bomalaski, Peter Szlosarek, Kevin O’Neill, Tim Crook, Nelofer Syed

Cell Death Dis. 2018 Dec; 9(12): 1192. Published online 2018 Dec 13. doi: 10.1038/s41419-018-1195-4

PMCID:: PMC6294248

Article PDF–2.3M

Select item 53425926.

Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance

Youngji Kim, Eisuke Kobayashi, Daisuke Kubota, Yoshiyuki Suehara, Kenta Mukaihara, Keisuke Akaike, Ayumu Ito, Kazuo Kaneko, Hirokazu Chuman, Akira Kawai, Shigehisa Kitano

Oncotarget. 2016 Oct 25; 7(43): 70832–70844. Published online 2016 Sep 23. doi: 10.18632/oncotarget.12225

PMCID:: PMC5342592

Article PDF–4.7M

Select item 53027827.

Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma

Qingqing Liu, John Stewart, Hua Wang, Asif Rashid, Jun Zhao, Matthew H. Katz, Jeffrey E. Lee, Jason B. Fleming, Anirban Maitra, Robert A. Wolff, Gauri R. Varadhachary, Sunil Krishnan, Huamin Wang

PLoS One. 2017; 12(2): e0171985. Published online 2017 Feb 10. doi: 10.1371/journal.pone.0171985

PMCID:: PMC5302782

Article PDF–1.2M

Select item 47941858.

Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma

Dario Barbone, Loes Van Dam, Carlo Follo, Puthen V. Jithesh, Shu-Dong Zhang, William G. Richards, Raphael Bueno, Dean A. Fennell, V. Courtney Broaddus

PLoS One. 2016; 11(3): e0150044. Published online 2016 Mar 16. doi: 10.1371/journal.pone.0150044

PMCID:: PMC4794185

Article PDF–2.0M

Select item 47897369.

Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20)

Natalie Burrows, Gaelle Cane, Mathew Robson, Edoardo Gaude, William J. Howat, Peter W. Szlosarek, R. Barbara Pedley, Christian Frezza, Margaret Ashcroft, Patrick H. Maxwell

Sci Rep. 2016; 6: 22950. Published online 2016 Mar 14. doi: 10.1038/srep22950

PMCID:: PMC4789736

Article PDF–2.2M

Select item 465544710.

Diversion of aspartate in ASS1-deficient tumors fosters de novo pyrimidine synthesis

Shiran Rabinovich, Lital Adler, Keren Yizhak, Alona Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, Alexander Brandis, Daniel Helbling, Stanley Korman, Shalev Itzkovitz, David Dimmock, Igor Ulitsky, Sandesh CS Nagamani, Eytan Ruppin, Ayelet Erez

Nature. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Nature. 2015 Nov 19; 527(7578): 379–383. Published online 2015 Nov 11. doi: 10.1038/nature15529

PMCID:: PMC4655447

Article PDF–2.4M

Select item 425467111.

Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer

YAN-SHEN SHAN, HUI-PING HSU, MING-DERG LAI, MENG-CHI YEN, YI-PEY LUO, YI-LING CHEN

Oncol Rep. 2015 Jan; 33(1): 49–57. Published online 2014 Oct 20. doi: 10.3892/or.2014.3556

PMCID:: PMC4254671

Article PDF–550K

Select item 422903912.

Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells

Fuming Qiu, Yun-Ru Chen, Xiyong Liu, Cheng-Ying Chu, Li-Jiuan Shen, Jinghong Xu, Shikha Gaur, Henry Jay Forman, Hang Zhang, Shu Zheng, Yun Yen, Jian Huang, Hsing-Jien Kung, David K. Ann

Sci Signal. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Sci Signal. 2014 Apr 1; 7(319): ra31. Published online 2014 Apr 1. doi: 10.1126/scisignal.2004761

PMCID:: PMC4229039

Article PDF–2.2M

Select item 387074313.

Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection

Sarah L. Grady, John G. Purdy, Joshua D. Rabinowitz, Thomas Shenk

Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51): E5006–E5015. Published online 2013 Dec 2. doi: 10.1073/pnas.1321305110

PMCID:: PMC3870743

Article PDF–1.3M

Select item 262119514.

The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes

Eleonore S Köhler, Selvakumari Sankaranarayanan, Christa J van Ginneken, Paul van Dijk, Jacqueline LM Vermeulen, Jan M Ruijter, Wouter H Lamers, Elisabeth Bruder

BMC Dev Biol. 2008; 8: 107. Published online 2008 Nov 10. doi: 10.1186/1471-213X-8-107

PMCID:: PMC2621195

Article PDF–2.2M

Select item 173760015.

Type II (adult onset) citrullinaemia: clinical pictures and the therapeutic effect of liver transplantation

S Ikeda, M Yazaki, Y Takei, T Ikegami, Y Hashikura, S Kawasaki, M Iwai, K Kobayashi, T Saheki

J Neurol Neurosurg Psychiatry. 2001 Nov; 71(5): 663–670. doi: 10.1136/jnnp.71.5.663

PMCID:: PMC1737600

Summary PDF–256K

Select item 113078816.

Cellular and subcellular localization of enzymes of arginine metabolism in rat kidney.

S N Dhanakoti, M E Brosnan, G R Herzberg, J T Brosnan

Biochem J. 1992 Mar 1; 282(Pt 2): 369–375. doi: 10.1042/bj2820369

PMCID:: PMC1130788

Summary Page Browse PDF–1.3M

Select item 36901417.

Molecular structure of the human argininosuccinate synthetase gene: occurrence of alternative mRNA splicing.

S O Freytag, A L Beaudet, H G Bock, W E O'Brien

Mol Cell Biol. 1984 Oct; 4(10): 1978–1984. doi: 10.1128/mcb.4.10.1978

PMCID:: PMC369014

Summary Page Browse PDF–1.7M

Select item 32639018.

Sequence for human argininosuccinate synthetase cDNA.

H G Bock, T S Su, W E O'Brien, A L Beaudet

Nucleic Acids Res. 1983 Sep 24; 11(18): 6505–6512. doi: 10.1093/nar/11.18.6505

PMCID:: PMC326390

Summary Page Browse PDF–602K

Select item 1015024219.

BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification

Sarah E. Barnett, Jenna Kenyani, Martina Tripari, Zohra Butt, Rudi Grosman, Francesca Querques, Liam Shaw, Luisa C. Silva, Zoe Goate, Stefan J. Marciniak, Doris M. Rassl, Richard Jackson, Lu-Yun Lian, Peter W. Szlosarek, Joseph J. Sacco, Judy M. Coulson

Mol Cancer Res. 2023 May 1; 21(5): 411–427. Published online 2023 Jan 20. doi: 10.1158/1541-7786.MCR-22-0635

PMCID:: PMC10150242

Article PDF–16M

Select item 934859320.

PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway

Min Liu, Runmei Li, Min Wang, Ting Liu, Qiuru Zhou, Dong Zhang, Jian Wang, Meng Shen, Xiubao Ren, Qian Sun

Mol Oncol. 2022 Aug; 16(15): 2843–2860. Published online 2022 Jun 27. doi: 10.1002/1878-0261.13259

PMCID:: PMC9348593

Article PDF–18M

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