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Select item 109014351.

Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors

Channing J. Paller, Hanna Tukachinsky, Alexandra Maertens, Brennan Decker, Julian R. Sampson, Jeremy P. Cheadle, Emmanuel S. Antonarakis

JCO Precis Oncol. 2024; 8: e2300251. Published online 2024 Feb 23. doi: 10.1200/PO.23.00251

PMCID:: PMC10901435

Article PDF–1.1M

Select item 104366652.

Summary of the experiences, knowledge, medical management, and family communication of monoallelic MUTYH carriers

Danielle B. McKenna, Pauleen Sanchez, Jacquelyn Powers, Jamie Brower, Louise Wang, Rebecca Mueller, Heather Symecko, Jada G. Hamilton, Temima Wildman, Susan M. Domchek, Fergus J. Couch, Judy E. Garber, Kenneth Offit, Mark E. Robson, Bryson W. Katona

J Genet Couns. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: J Genet Couns. 2023 Apr; 32(2): 342–350. Published online 2022 Oct 17. doi: 10.1002/jgc4.1641

PMCID:: PMC10436665

Article PDF–258K

Select item 100468173.

Evolutionary Origin of MUTYH Germline Pathogenic Variations in Modern Humans

Fengxia Xiao, Jiaheng Li, Philip Naderev Panuringan Lagniton, Si Hoi Kou, Huijun Lei, Benjamin Tam, San Ming Wang

Biomolecules. 2023 Mar; 13(3): 429. Published online 2023 Feb 24. doi: 10.3390/biom13030429

PMCID:: PMC10046817

Article PDF–6.7M

Select item 99436634.

Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism

Merve Demir, L Peyton Russelburg, Wen-Jen Lin, Carlos H Trasviña-Arenas, Beili Huang, Philip K Yuen, Martin P Horvath, Sheila S David

Nucleic Acids Res. 2023 Feb 22; 51(3): 1034–1049. Published online 2023 Jan 12. doi: 10.1093/nar/gkac1246

PMCID:: PMC9943663

Article PDF–5.5M

Select item 95413775.

Germline MUTYH mutations and high‐grade gliomas: Novel evidence for a potential association

Gábor Bedics, Lili Kotmayer, Erik Zajta, Lajos László Hegyi, Edit Ágota Brückner, Hajnalka Rajnai, Lilla Reiniger, Csaba Bödör, Miklós Garami, Bálint Scheich

Genes Chromosomes Cancer. 2022 Oct; 61(10): 622–628. Published online 2022 May 21. doi: 10.1002/gcc.23054

PMCID:: PMC9541377

Article PDF–5.7M

Select item 92704276.

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

Philip S. Robinson, Laura E. Thomas, Federico Abascal, Hyunchul Jung, Luke M. R. Harvey, Hannah D. West, Sigurgeir Olafsson, Bernard C. H. Lee, Tim H. H. Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A. Sanders, Stefanie V. Lensing, Simon J. A. Buczacki, Rogier ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J. Campbell, Iñigo Martincorena, Julian R. Sampson, Michael R. Stratton

Nat Commun. 2022; 13: 3949. Published online 2022 Jul 8. doi: 10.1038/s41467-022-31341-0

PMCID:: PMC9270427

Article PDF–1.6M

Select item 90803867.

Intronic Variant of MUTYH Gene Exhibits A Strong Association with Early Onset of Breast Cancer Susceptibility in Indonesian Women Population

Sonar Soni Panigoro, Erlin Listiyaningsih, Ika Nurlaila, Bharuno Mahesworo, Alam Ahmad Hidayat, Arif Budiarto, Digdo Sudigyo, Dian Amirullah, Simon Simon, James Baurley, Bens Pardamean

Asian Pac J Cancer Prev. 2021 Dec; 22(12): 3985–3991. doi: 10.31557/APJCP.2021.22.12.3985

PMCID:: PMC9080386

Article PDF–424K

Select item 86836338.

Filling the gap: A thorough investigation for the genetic diagnosis of unsolved polyposis patients with monoallelic MUTYH pathogenic variants

Anastasia Dell’Elice, Giulia Cini, Mara Fornasarig, Franco Armelao, Daniela Barana, Francesca Bianchi, Guido Claudio Casalis Cavalchini, Antonella Maffè, Isabella Mammi, Monica Pedroni, Antonio Percesepe, Italo Sorrentini, Mariagrazia Tibiletti, Roberta Maestro, Michele Quaia, Alessandra Viel

Mol Genet Genomic Med. 2021 Dec; 9(12): e1831. Published online 2021 Oct 26. doi: 10.1002/mgg3.1831

PMCID:: PMC8683633

Article PDF–1.1M

Select item 75938289.

Detection of OG:A lesion mispairs by MutY relies on interactions of a single His residue with the 2-amino group of 8-oxoguanine

Andrea J. Lee, Chandrima Majumdar, Scott D. Kathe, Robert P. Van Ostrand, Holly R. Vickery, April M. Averill, Shane R. Nelson, Amelia H. Manlove, Morgan A. McCord, Sheila S. David

J Am Chem Soc. Author manuscript; available in PMC 2021 Aug 5.

Published in final edited form as: J Am Chem Soc. 2020 Aug 5; 142(31): 13283–13287. Published online 2020 Jul 23. doi: 10.1021/jacs.0c04284

PMCID:: PMC7593828

Article PDF–642K

Select item 683137210.

Association of the MUTYH Gln324His (CAG/CAC) variant with cervical carcinoma and HR-HPV infection in a Chinese population

Huaizeng Chen, Hanzhi Wang, Jia Liu, Qi Cheng, Xiaojing Chen, Feng Ye

Medicine (Baltimore) 2019 Apr; 98(17): e15359. Published online 2019 Apr 26. doi: 10.1097/MD.0000000000015359

PMCID:: PMC6831372

Article PDF–219K

Select item 681267111.

When you’re strange: Unusual features of the MUTYH glycosylase and implications in cancer

Alan G. Raetz, Sheila S. David

DNA Repair (Amst) Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: DNA Repair (Amst). 2019 Aug; 80: 16–25. Published online 2019 Jun 8. doi: 10.1016/j.dnarep.2019.05.005

PMCID:: PMC6812671

Article PDF–1.3M

Select item 680053812.

Association of a New Germline Variant in the MUTYH DNA Glycosylase Gene with Colorectal Adenoma Transformation into Malignancy

Amjad Mahasneh, Fawaz N. Al-Shaheri, Mohammed N. BaniHani

Iran Biomed J. 2019 Nov; 23(6): 412–422. doi: 10.29252/ibj.23.6.412

PMCID:: PMC6800538

Article PDF–1.4M

Select item 664900013.

Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer

Karim Bougatef, Raja Marrakchi, Nadia Kourda, Yannick Blondeau Lahely, Sarra Baltagi Ben Jileni, Houssein K. El Khil, Florent Soubrier, Amel Ben Ammar Elgaaied

J Clin Lab Anal. 2007; 21(6): 372–374. Published online 2007 Nov 16. doi: 10.1002/jcla.20198

PMCID:: PMC6649000

Article PDF–181K

Select item 638242114.

AluYb8 insertion polymorphism in the MUTYH gene impairs mitochondrial DNA maintenance and affects the age of onset of IPF

Wei Zhou, Jiapeng Sun, Wenwen Guo, Yi Zhuang, Lizhi Xu, Yaping Wang

Aging (Albany NY) 2019 Feb 15; 11(3): 933–949. Published online 2019 Feb 4. doi: 10.18632/aging.101793

PMCID:: PMC6382421

Article PDF–2.0M

Select item 606002515.

A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]²⁺ cluster

Kevin J. McDonnell, Joseph A. Chemler, Phillip L. Bartels, Elizabeth O’Brien, Monica L. Marvin, Janice Ortega, Ralph H. Stern, Leon Raskin, GuoMin Li, David H. Sherman, Jacqueline K. Barton, Stephen B. Gruber

Nat Chem. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Chem. 2018 Aug; 10(8): 873–880. Published online 2018 Jun 18. doi: 10.1038/s41557-018-0068-x

PMCID:: PMC6060025

Article PDF–545K

Select item 552737316.

A MUTYH germline mutation is associated with small intestinal neuroendocrine tumors

Jan P Dumanski, Chiara Rasi, Peyman Björklund, Hanna Davies, Abir S Ali, Malin Grönberg, Staffan Welin, Halfdan Sorbye, Henning Grønbæk, Janet L Cunningham, Lars A Forsberg, Lars Lind, Erik Ingelsson, Peter Stålberg, Per Hellman, Eva Tiensuu Janson

Endocr Relat Cancer. 2017 Aug; 24(8): 427–443. Published online 2017 Jun 20. doi: 10.1530/ERC-17-0196

PMCID:: PMC5527373

Article PDF–2.2M

Select item 545771117.

Repair of 8-oxoG:A Mismatches by the MUTYH Glycosylase: Mechanism, Metals & Medicine

Douglas M. Banda, Nicole N. Nuñez, Michael A. Burnside, Katie M. Bradshaw, Sheila S. David

Free Radic Biol Med. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Free Radic Biol Med. 2017 Jun; 107: 202–215. Published online 2017 Jan 10. doi: 10.1016/j.freeradbiomed.2017.01.008

PMCID:: PMC5457711

Article PDF–1.2M

Select item 535472618.

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity

George Sharbeen, Janet Youkhana, Amanda Mawson, Joshua McCarroll, Andrea Nunez, Andrew Biankin, Amber Johns, David Goldstein, Phoebe Phillips

Oncotarget. 2017 Feb 7; 8(6): 9216–9229. Published online 2016 Dec 16. doi: 10.18632/oncotarget.13985

PMCID:: PMC5354726

Article PDF–5.4M

Select item 529715619.

Polymorphism and protein expression of MUTYH gene for risk of rheumatoid arthritis

Shih-Yin Chen, Hsin-Han Chen, Yu-Chuen Huang, Shih-Ping Liu, Ying-Ju Lin, Sui-Foon Lo, Yuan-Yen Chang, Hui-Wen Lin, Chung-Ming Huang, Fuu-Jen Tsai

BMC Musculoskelet Disord. 2017; 18: 69. Published online 2017 Feb 7. doi: 10.1186/s12891-017-1437-0

PMCID:: PMC5297156

Article PDF–468K

Select item 509481020.

Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH

Aung Ko Win, Jeanette C. Reece, James G. Dowty, Daniel D. Buchanan, Mark Clendenning, Christophe Rosty, Melissa C. Southey, Joanne P. Young, Sean P. Cleary, Hyeja Kim, Michelle Cotterchio, Finlay A. Macrae, Katherine M. Tucker, John A. Baron, Terrilea Burnett, Loïc Le Marchand, Graham Casey, Robert W. Haile, Polly A. Newcomb, Stephen N. Thibodeau, John L. Hopper, Steven Gallinger, Ingrid M. Winship, Noralane M. Lindor, Mark A. Jenkins

Int J Cancer. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Int J Cancer. 2016 Oct 1; 139(7): 1557–1563. Published online 2016 Jun 2. doi: 10.1002/ijc.30197

Correction in:: Int J Cancer. 2017 Dec 15; 141(12): E7.

PMCID:: PMC5094810

Article PDF–235K

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