PMC Links for Gene (Select 4613) - PMC

Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E. Deubzer, Annette Künkele, Peter Lang, Jörg Fuchs, Anton G. Henssen, Angelika Eggert, Nikolaus Rajewsky, Falk Hertwig, Johannes H. Schulte

Nat Commun. 2023; 14: 3936. Published online 2023 Jul 4. doi: 10.1038/s41467-023-38747-4

PMCID:: PMC10319804

Article PDF–5.4M

Select item 101795534.

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma

Prasoon Agarwal, Aleksandra Glowacka, Loay Mahmoud, Wesam Bazzar, Lars-Gunnar Larsson, Mohammad Alzrigat

Int J Mol Sci. 2023 May; 24(9): 8141. Published online 2023 May 2. doi: 10.3390/ijms24098141

PMCID:: PMC10179553

Article PDF–3.4M

Select item 98173085.

Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome

Léa Guerrini-Rousseau, Arnault Tauziède-Espariat, David Castel, Etienne Rouleau, Philipp Sievers, Raphaël Saffroy, Kévin Beccaria, Thomas Blauwblomme, Lauren Hasty, Franck Bourdeaut, Jacques Grill, Pascale Varlet, Marie-Anne Debily

Acta Neuropathol Commun. 2023; 11: 3. Published online 2023 Jan 6. doi: 10.1186/s40478-022-01490-w

PMCID:: PMC9817308

Article PDF–695K

Select item 92822796.

An immature, dedifferentiated, and lineage-deconstrained cone precursor origin of N-Myc–initiated retinoblastoma

Hardeep P. Singh, Dominic W. H. Shayler, G. Esteban Fernandez, Matthew E. Thornton, Cheryl Mae Craft, Brendan H. Grubbs, David Cobrinik

Proc Natl Acad Sci U S A. 2022 Jul 12; 119(28): e2200721119. Published online 2022 Jul 8. doi: 10.1073/pnas.2200721119

PMCID:: PMC9282279

Article PDF–5.2M

Select item 92779557.

MYCN protein stability is a better prognostic indicator in neuroblastoma

Yi Yang, Jie Zhao, Yingwen Zhang, Tianyue Feng, Bo Yv, Jing Wang, Yijin Gao, Minzhi Yin, Jingyan Tang, Yanxin Li

BMC Pediatr. 2022; 22: 404. Published online 2022 Jul 11. doi: 10.1186/s12887-022-03449-1

PMCID:: PMC9277955

Article PDF–1.5M

Select item 91106588.

MYCN Directly Targets NeuroD1 to Promote Cellular Proliferation in Neuroblastoma

Fangjin Lu, Bin Mu, Ge Jin, Lin Zhu, Ping Mu

Oncol Res. 2021; 29(1): 1–10. Published online 2022 May 4. doi: 10.3727/096504021X16401852341873

PMCID:: PMC9110658

Article PDF–479K

Select item 90410689.

MYCN amplification plus 1p36 loss of heterozygosity predicts ultra high risk in bone marrow metastatic neuroblastoma

Zhi‐Xia Yue, Tian‐Yu Xing, Wen Zhao, Qian Zhao, Xi‐Si Wang, Yan Su, Chao Gao, Shu‐Guang Liu, Xiao‐Li Ma

Cancer Med. 2022 Apr; 11(8): 1837–1849. Published online 2022 Feb 9. doi: 10.1002/cam4.4583

PMCID:: PMC9041068

Article PDF–865K

Select item 883052210.

Urinary 3-Methoxytyramine Is a Biomarker for MYC Activity in Patients With Neuroblastoma

Iedan R. N. Verly, Yvette A. H. Matser, René Leen, Rutger Meinsma, Marta Fiocco, Jan Koster, Richard Volckmann, Dilara Savci-Heijink, Giuliana Cangemi, Sebastiano Barco, Linda J. Valentijn, Godelieve A. M. Tytgat, André B. P. van Kuilenburg

JCO Precis Oncol. 2022; 6: e2000447. Published online 2022 Jan 27. doi: 10.1200/PO.20.00447

PMCID:: PMC8830522

Article PDF–1.0M

Select item 837306811.

Targeting a noncanonical, hairpin-containing G-quadruplex structure from the MYCN gene

Mo Yang, Sakereh Carter, Shaifaly Parmar, Desta D Bume, David R Calabrese, Xiao Liang, Kamyar Yazdani, Man Xu, Zhihui Liu, Carol J Thiele, John S Schneekloth, Jr

Nucleic Acids Res. 2021 Aug 20; 49(14): 7856–7869. Published online 2021 Jul 21. doi: 10.1093/nar/gkab594

PMCID:: PMC8373068

Article PDF–4.6M

Select item 793839912.

MYCN gene polymorphisms and Wilms tumor susceptibility in Chinese children

Xiaokai Huang, Jie Zhao, Jinhong Zhu, Shanshan Chen, Wen Fu, Xiaoqian Tian, Susu Lou, Jichen Ruan, Jing He, Haixia Zhou

J Clin Lab Anal. 2019 Nov; 33(9): e22988. Published online 2019 Jul 25. doi: 10.1002/jcla.22988

PMCID:: PMC7938399

Article PDF–326K

Select item 766990613.

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche

Nat Commun. 2020; 11: 5823. Published online 2020 Nov 16. doi: 10.1038/s41467-020-19452-y

PMCID:: PMC7669906

Article PDF–2.8M

Select item 741588514.

MYCN Silencing by RNAi Induces Neurogenesis and Suppresses Proliferation in Models of Neuroblastoma with Resistance to Retinoic Acid

Ruhina Maeshima, Dale Moulding, Andrew W. Stoker, Stephen L. Hart

Nucleic Acid Ther. August 2020; 30(4): 237–248. Published online 2020 Aug 6. doi: 10.1089/nat.2019.0831

PMCID:: PMC7415885

Article PDF–733K

Select item 734635615.

High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma

Mark Raffeld, Zied Abdullaev, Svetlana D. Pack, Liqiang Xi, Sushma Nagaraj, Nicole Briceno, Elizabeth Vera, Stefania Pittaluga, Osorio Lopes Abath Neto, Martha Quezado, Kenneth Aldape, Terri S. Armstrong, Mark R. Gilbert

Acta Neuropathol Commun. 2020; 8: 101. Published online 2020 Jul 8. doi: 10.1186/s40478-020-00973-y

PMCID:: PMC7346356

Article PDF–5.2M

Select item 729566416.

Association of heterogeneous MYCN amplification with clinical features, biological characteristics, and outcomes in neuroblastoma: A report from the Children’s Oncology Group

Kevin Campbell, Arlene Naranjo, Emily Hibbitts, Julie M. Gastier-Foster, Rochelle Bagatell, Meredith S. Irwin, Hiroyuki Shimada, Michael Hogarty, Julie R. Park, Steven G. DuBois

Eur J Cancer. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Eur J Cancer. 2020 Jul; 133: 112–119. Published online 2020 May 31. doi: 10.1016/j.ejca.2020.04.007

PMCID:: PMC7295664

Article PDF–502K

Select item 685139417.

MYCN amplification drives an aggressive form of spinal ependymoma

David R. Ghasemi, Martin Sill, Konstantin Okonechnikov, Andrey Korshunov, Stephen Yip, Peter W. Schutz, David Scheie, Anders Kruse, Patrick N. Harter, Marina Kastelan, Marlies Wagner, Christian Hartmann, Julia Benzel, Kendra K. Maass, Mustafa Khasraw, Ronald Sträter, Christian Thomas, Werner Paulus, Christian P. Kratz, Hendrik Witt, Daisuke Kawauchi, Christel Herold-Mende, Felix Sahm, Sebastian Brandner, Marcel Kool, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, David E. Reuss, Kristian W. Pajtler

Acta Neuropathol. 2019; 138(6): 1075–1089. Published online 2019 Aug 14. doi: 10.1007/s00401-019-02056-2

PMCID:: PMC6851394

Article PDF–3.9M

Select item 682984318.

Chromosome band 11q23 deletion predicts poor prognosis in bone marrow metastatic neuroblastoma patients without MYCN amplification

Zhi-Xia Yue, Tian-Yu Xing, Chao Gao, Shu-Guang Liu, Wen Zhao, Qian Zhao, Xi-Si Wang, Mei Jin, Xiao-Li Ma

Cancer Commun (Lond) 2019; 39: 68. Published online 2019 Nov 4. doi: 10.1186/s40880-019-0409-1

PMCID:: PMC6829843

Article PDF–1.0M

Select item 675851419.

N-myc Promotes Survival and Induces S-Phase Entry of Postmitotic Sympathetic Neurons

Kirmo Wartiovaara, Fanie Barnabé-Heider, Freda D. Miller, David R. Kaplan

J Neurosci. 2002 Feb 1; 22(3): 815–824. doi: 10.1523/JNEUROSCI.22-03-00815.2002

PMCID:: PMC6758514

Article PDF–628K

Select item 671537020.

N-Myc–mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer

Adeline Berger, Nicholas J. Brady, Rohan Bareja, Brian Robinson, Vincenza Conteduca, Michael A. Augello, Loredana Puca, Adnan Ahmed, Etienne Dardenne, Xiaodong Lu, Inah Hwang, Alyssa M. Bagadion, Andrea Sboner, Olivier Elemento, Jihye Paik, Jindan Yu, Christopher E. Barbieri, Noah Dephoure, Himisha Beltran, David S. Rickman

J Clin Invest. 2019 Sep 3; 129(9): 3924–3940. Published online 2019 Aug 19. doi: 10.1172/JCI127961

PMCID:: PMC6715370

Article PDF–17M

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