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Items: 1 to 20 of 49

1.
Copper coordination states affect the flexibility of copper Metallochaperone Atox1: Insights from molecular dynamics simulations
Renana Schwartz, Sharon Ruthstein, Dan Thomas Major
Protein Sci. 2022 Dec; 31(12): e4464. doi: 10.1002/pro.4464
PMCID:
PMC9667823
AbstractArticlePDF–2.0M
2.
Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion
Vincenzo Mangini, Benny Danilo Belviso, Maria Incoronata Nardella, Giovanni Natile, Fabio Arnesano, Rocco Caliandro
Biomolecules. 2022 Oct; 12(10): 1494. Published online 2022 Oct 16. doi: 10.3390/biom12101494
PMCID:
PMC9599288
AbstractArticlePDF–2.0M
3.
Cu(I) Controls Conformational States in Human Atox1 Metallochaperone: An EPR and Multiscale Simulation Study
Ortal Perkal, Zena Qasem, Meital Turgeman, Renana Schwartz, Lada Gevorkyan-Airapetov, Matic Pavlin, Alessandra Magistrato, Dan Thomas Major, Sharon Ruthstein
J Phys Chem B. 2020 Jun 4; 124(22): 4399–4411. Published online 2020 May 12. doi: 10.1021/acs.jpcb.0c01744
PMCID:
PMC7294806
AbstractArticlePDF–5.3M
4.
Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer
Stéphanie Blockhuys, Donita C. Brady, Pernilla Wittung-Stafshede
Breast Cancer. 2020; 27(3): 505–509. Published online 2020 Jan 2. doi: 10.1007/s12282-019-01044-4
PMCID:
PMC7196078
AbstractArticlePDF–662K
5.
Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer
Arundhati Jana, Archita Das, Nancy L. Krett, Grace Guzman, Alexandra Thomas, Georgina Mancinelli, Jessica Bauer, Masuko Ushio-Fukai, Tohru Fukai, Barbara Jung
PLoS One. 2020; 15(1): e0227916. Published online 2020 Jan 21. doi: 10.1371/journal.pone.0227916
PMCID:
PMC6974162
AbstractArticlePDF–4.2M
6.
The structural flexibility of the human copper chaperone Atox1: Insights from combined pulsed EPR studies and computations
Ariel R. Levy, Meital Turgeman, Lada Gevorkyan‐Aiapetov, Sharon Ruthstein
Protein Sci. 2017 Aug; 26(8): 1609–1618. Published online 2017 May 31. doi: 10.1002/pro.3197
PMCID:
PMC5521546
AbstractArticlePDF–2.4M
7.
Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?
Helena Öhrvik, Pernilla Wittung-Stafshede
Int J Mol Sci. 2015 Aug; 16(8): 16728–16739. Published online 2015 Jul 23. doi: 10.3390/ijms160816728
PMCID:
PMC4581165
AbstractArticlePDF–1.2M
8.
Atox1 Contains Positive Residues That Mediate Membrane Association and Aid Subsequent Copper Loading
Adrian G. Flores, Vinzenz M. Unger
J Membr Biol. Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: J Membr Biol. 2013 Dec; 246(12): 10.1007/s00232-013-9592-1. Published online 2013 Sep 15. doi: 10.1007/s00232-013-9592-1
PMCID:
PMC3827972
AbstractArticlePDF–2.3M
9.
Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells
HUAWEI CAI, FANGYU PENG
Oncol Rep. 2013 Jul; 30(1): 269–275. Published online 2013 Apr 29. doi: 10.3892/or.2013.2436
PMCID:
PMC3729205
AbstractArticlePDF–419K
10.
Functional Partnership of the Copper Export Machinery and Glutathione Balance in Human Cells
Yuta Hatori, Sara Clasen, Nesrin M. Hasan, Amanda N. Barry, Svetlana Lutsenko
J Biol Chem. 2012 Aug 3; 287(32): 26678–26687. Published online 2012 May 30. doi: 10.1074/jbc.M112.381178
PMCID:
PMC3411007
AbstractArticlePDF–2.2M
11.
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
Maria E. Palm, Christoph F. Weise, Christina Lundin, Gunnar Wingsle, Yvonne Nygren, Erik Björn, Peter Naredi, Magnus Wolf-Watz, Pernilla Wittung-Stafshede
Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17): 6951–6956. Published online 2011 Apr 11. doi: 10.1073/pnas.1012899108
PMCID:
PMC3084073
AbstractArticlePDF–606K
12.
Unification of the Copper(I) Binding Affinities of the Metallo-chaperones Atx1, Atox1, and Related Proteins: DETECTION PROBES AND AFFINITY STANDARDS
Zhiguang Xiao, Jens Brose, Sonja Schimo, Susan M. Ackland, Sharon La Fontaine, Anthony G. Wedd
J Biol Chem. 2011 Apr 1; 286(13): 11047–11055. Published online 2011 Jan 22. doi: 10.1074/jbc.M110.213074
PMCID:
PMC3064159
AbstractArticlePDF–797K
13.
Analysis of the human Atox 1 homologue in Wilson patients
Isabel Simon, Mark Schaefer, Jürgen Reichert, Wolfgang Stremmel
World J Gastroenterol. 2008 Apr 21; 14(15): 2383–2387. Published online 2008 Apr 21. doi: 10.3748/wjg.14.2383
PMCID:
PMC2705094
AbstractArticlePDF–898K
14.
Insights into Cu(I) Exchange in HAH1 using Quantum Mechanical and Molecular Simulations
Bryan T. Op’t Holt, Kenneth M. Merz, Jr.
Biochemistry. Author manuscript; available in PMC 2008 Sep 1.
Published in final edited form as: Biochemistry. 2007 Jul 31; 46(30): 8816–8826. Published online 2007 Jul 6. doi: 10.1021/bi7007195
PMCID:
PMC2527583
AbstractArticlePDF–2.2M
15.
Conserved residues modulate copper release in human copper chaperone Atox1
Faiza Hussain, John S. Olson, Pernilla Wittung-Stafshede
Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32): 11158–11163. Published online 2008 Aug 6. doi: 10.1073/pnas.0802928105
PMCID:
PMC2516206
AbstractArticlePDF–1.2M
16.
Cuproptosis-related gene LIPT1 as a prognostic indicator in non-small cell lung cancer: Functional involvement and regulation of ATOX1 expression
Ruiyun Deng, Lili Zhu, Jun Jiang, Jing Chen, Hua Li
Biomol Biomed. 2024 Jun 1; 24(3): 647–658. Published online 2024 Jun 1. doi: 10.17305/bb.2023.9931
PMCID:
PMC11088889
AbstractArticlePDF–3.8M
17.
Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro
Xiaolu Zhang, Gulshan R. Walke, Istvan Horvath, Ranjeet Kumar, Stéphanie Blockhuys, Stellan Holgersson, Paul H. Walton, Pernilla Wittung-Stafshede
Proc Natl Acad Sci U S A. 2022 Sep 13; 119(37): e2206905119. Published online 2022 Sep 6. doi: 10.1073/pnas.2206905119
PMCID:
PMC9477392
AbstractArticlePDF–1.2M
18.
An EPR Study on the Interaction between the Cu(I) Metal Binding Domains of ATP7B and the Atox1 Metallochaperone
Michael Zaccak, Zena Qasem, Lada Gevorkyan-Airapetov, Sharon Ruthstein
Int J Mol Sci. 2020 Aug; 21(15): 5536. Published online 2020 Aug 2. doi: 10.3390/ijms21155536
PMCID:
PMC7432781
AbstractArticlePDF–2.4M
19.
Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma
Ye-Jin Kim, Gavin J. Bond, Tiffany Tsang, Jessica M. Posimo, Luca Busino, Donita C. Brady
Metallomics. Author manuscript; available in PMC 2019 Aug 14.
Published in final edited form as: Metallomics. 2019 Aug 1; 11(8): 1430–1440. Published online 2019 Jul 18. doi: 10.1039/c9mt00042a
PMCID:
PMC6693990
AbstractArticlePDF–1.6M
20.
The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics
Corey H. Yu, Nan Yang, Jameson Bothe, Marco Tonelli, Sergiy Nokhrin, Natalia V. Dolgova, Lelita Braiterman, Svetlana Lutsenko, Oleg Y. Dmitriev
J Biol Chem. 2017 Nov 3; 292(44): 18169–18177. Published online 2017 Sep 12. doi: 10.1074/jbc.M117.811752
PMCID:
PMC5672040
AbstractArticlePDF–1.5M

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