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Items: 1 to 20 of 106

1.
NEK2通过抵抗肝癌细胞衰老促进肝癌进展
雷 倩, 夏 机良, 冯 湘玲, 郭 姣姣, 李 官成, 周 文
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Feb 28; 47(2): 153–164. Chinese. doi: 10.11817/j.issn.1672-7347.2022.210058
PMCID:
PMC10930516
AbstractArticlePDF–2.9M
2.
NEK2 enhances malignancies of glioblastoma via NIK/NF-κB pathway
Jianyang Xiang, Wahafu Alafate, Wei Wu, Yichang Wang, Xiaodong Li, Wanfu Xie, Xiaobin Bai, Ruichun Li, Maode Wang, Jia Wang
Cell Death Dis. 2022 Jan; 13(1): 58. Published online 2022 Jan 14. doi: 10.1038/s41419-022-04512-6
PMCID:
PMC8760305
AbstractArticlePDF–5.5M
3.
The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells
Yainyrette Rivera-Rivera, Mihaela Marina, Shirley Jusino, Miyoung Lee, Jaleisha Vélez Velázquez, Camille Chardón-Colón, Geraldine Vargas, Jaya Padmanabhan, Srikumar P. Chellappan, Harold I. Saavedra
Sci Rep. 2021; 11: 9016. Published online 2021 Apr 27. doi: 10.1038/s41598-021-88512-0
PMCID:
PMC8079711
AbstractArticlePDF–2.0M
4.
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer
Tie Xu, Yulan Zeng, Linli Shi, Qin Yang, Yeshan Chen, Gang Wu, Guiling Li, Shuangbing Xu
J Exp Clin Cancer Res. 2020; 39: 183. Published online 2020 Sep 10. doi: 10.1186/s13046-020-01659-y
PMCID:
PMC7488040
AbstractArticlePDF–5.6M
5.
Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis
Linda Viol, Shoji Hata, Ana Pastor-Peidro, Annett Neuner, Florian Murke, Patrick Wuchter, Anthony D. Ho, Bernd Giebel, Gislene Pereira
J Cell Biol. 2020 Mar 2; 219(3): e201907136. Published online 2020 Feb 14. doi: 10.1083/jcb.201907136
PMCID:
PMC7055001
AbstractArticlePDF–7.2M
6.
High NEK2 confers to poor prognosis and contributes to cisplatin‐based chemotherapy resistance in nasopharyngeal carcinoma
He Xu, Liang Zeng, Yongjun Guan, Xiangling Feng, Yinghong Zhu, Yichen Lu, Chen Shi, Shilian Chen, Jiliang Xia, Jiaojiao Guo, Chunmei Kuang, Wei Li, Fengyan Jin, Wen Zhou
J Cell Biochem. 2019 Mar; 120(3): 3547–3558. Published online 2018 Oct 8. doi: 10.1002/jcb.27632
PMCID:
PMC6704366
AbstractArticlePDF–1012K
7.
NIMA related kinase 2 promotes gastric cancer cell proliferation via ERK/MAPK signaling
Wei-Dong Fan, Tao Chen, Peng-Jun Liu
World J Gastroenterol. 2019 Jun 21; 25(23): 2898–2910. Published online 2019 Jun 21. doi: 10.3748/wjg.v25.i23.2898
PMCID:
PMC6589739
AbstractArticlePDF–11M
8.
Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-catenin
Honghong Shen, Wenpeng Yan, Jinyang Yuan, Ziyue Wang, Chen Wang
J Exp Clin Cancer Res. 2019; 38: 243. Published online 2019 Jun 7. doi: 10.1186/s13046-019-1231-y
PMCID:
PMC6556028
AbstractArticlePDF–7.4M
9.
Controlling the dynamics of the Nek2 leucine zipper by engineering of “kinetic” disulphide bonds
Daniel S. Gutmans, Sara B-M Whittaker, Karishma Asiani, R. Andrew Atkinson, Alain Oregioni, Mark Pfuhl
PLoS One. 2019; 14(2): e0210352. Published online 2019 Feb 1. doi: 10.1371/journal.pone.0210352
PMCID:
PMC6358272
AbstractArticlePDF–3.5M
10.
NEK2 promotes hepatocellular carcinoma migration and invasion through modulation of the epithelial-mesenchymal transition
Yi Zhang, Wei Wang, Yifei Wang, Xiaohui Huang, Zhaohui Zhang, Bin Chen, Wenxuan Xie, Shaoqiang Li, Shunli Shen, Baogang Peng
Oncol Rep. 2018 Mar; 39(3): 1023–1033. Published online 2018 Jan 22. doi: 10.3892/or.2018.6224
PMCID:
PMC5802024
AbstractArticlePDF–1.1M
11.
NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma
M Hao, R Franqui-Machin, H Xu, J Shaughnessy, Jr, B Barlogie, D Roodman, D E Quelle, S Janz, M H Tomasson, R D Sanderson, L Qiu, I Frech, G Tricot, F Zhan
Leukemia. 2017 Jul; 31(7): 1648–1650. Prepublished online 2017 Apr 12. Published online 2017 Apr 25. doi: 10.1038/leu.2017.115
PMCID:
PMC5508075
ArticlePDF–359K
12.
NEK2 serves as a prognostic biomarker for hepatocellular carcinoma
Gang Li, Yanping Zhong, Qingrong Shen, Yi Zhou, Xiaofang Deng, Cuiping Li, Jiagui Chen, Ying Zhou, Min He
Int J Oncol. 2017 Feb; 50(2): 405–413. Published online 2017 Jan 3. doi: 10.3892/ijo.2017.3837
PMCID:
PMC5238800
AbstractArticlePDF–781K
13.
Targeting NEK2 as a promising therapeutic approach for cancer treatment
Yanfen Fang, Xiongwen Zhang
Cell Cycle. 2016; 15(7): 895–907. Published online 2016 Mar 28. doi: 10.1080/15384101.2016.1152430
PMCID:
PMC4889274
AbstractArticlePDF–914K
14.
Clinical significance and prognostic value of Nek2 protein expression in colon cancer
Lei Lu, Xiaofeng Zhai, Ronghua Yuan
Int J Clin Exp Pathol. 2015; 8(11): 15467–15473. Published online 2015 Nov 1.
PMCID:
PMC4713702
AbstractArticlePDF–744K
15.
Role of NEK2A in Human Cancer and Its Therapeutic Potentials
Jiliang Xia, Reinaldo Franqui Machin, Zhimin Gu, Fenghuang Zhan
Biomed Res Int. 2015; 2015: 862461. Published online 2015 Feb 1. doi: 10.1155/2015/862461
PMCID:
PMC4330945
AbstractArticlePDF–650K
16.
Inhibition of Nek2 by Small Molecules Affects Proteasome Activity
Lingyao Meng, Kent Carpenter, Alexis Mollard, Hariprasad Vankayalapati, Steven L. Warner, Sunil Sharma, Guido Tricot, Fenghuang Zhan, David J. Bearss
Biomed Res Int. 2014; 2014: 273180. Published online 2014 Sep 17. doi: 10.1155/2014/273180
PMCID:
PMC4182079
AbstractArticlePDF–1.8M
17.
Abnormal expression of Nek2 in pancreatic ductal adenocarcinoma: a novel marker for prognosis
Zhen Ning, Aman Wang, Jinxiao Liang, Jiwei Liu, Tao Zhou, Qiu Yan, Zhongyu Wang
Int J Clin Exp Pathol. 2014; 7(5): 2462–2469. Published online 2014 Apr 15.
PMCID:
PMC4069945
AbstractArticlePDF–960K
18.
Nek2-targeted ASO or siRNA pretreatment enhances anticancer drug sensitivity in triple-negative breast cancer cells
JAEHYUNG LEE, LAUREN GOLLAHON
Int J Oncol. 2013 Mar; 42(3): 839–847. Published online 2013 Jan 22. doi: 10.3892/ijo.2013.1788
PMCID:
PMC3597451
AbstractArticlePDF–795K
19.
An Undecided Coiled Coil: THE LEUCINE ZIPPER OF Nek2 KINASE EXHIBITS ATYPICAL CONFORMATIONAL EXCHANGE DYNAMICS
Rebecca Croasdale, Frank J. Ivins, Fred Muskett, Tina Daviter, David J. Scott, Tara Hardy, Steven J. Smerdon, Andrew M. Fry, Mark Pfuhl
J Biol Chem. 2011 Aug 5; 286(31): 27537–27547. Published online 2011 Jun 13. doi: 10.1074/jbc.M110.196972
PMCID:
PMC3149346
AbstractArticlePDF–3.1M
20.
Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis.
Rebecca S Hames, Andrew M Fry
Biochem J. 2002 Jan 1; 361(Pt 1): 77–85. doi: 10.1042/0264-6021:3610077
PMCID:
PMC1222281
SummaryPDF–309K

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