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Select item 111215261.

Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations

Frode Selheim, Elise Aasebø, Håkon Reikvam, Øystein Bruserud, Maria Hernandez-Valladares

Int J Mol Sci. 2024 May; 25(10): 5080. Published online 2024 May 7. doi: 10.3390/ijms25105080

PMCID:: PMC11121526

Abstract Article PDF–2.7M

Select item 110117762.

Comprehensive Molecular Profiling of NPM1-Mutated Acute Myeloid Leukemia Using RNAseq Approach

Jessica Petiti, Ymera Pignochino, Aurora Schiavon, Emilia Giugliano, Enrico Berrino, Giorgia Giordano, Federico Itri, Matteo Dragani, Daniela Cilloni, Marco Lo Iacono

Int J Mol Sci. 2024 Apr; 25(7): 3631. Published online 2024 Mar 24. doi: 10.3390/ijms25073631

PMCID:: PMC11011776

Abstract Article PDF–785K

Select item 109073893.

Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML

Onyee Chan, Najla Al Ali, Hammad Tashkandi, Austin Ellis, Somedeb Ball, Justin Grenet, Caroline Hana, Yehuda Deutsch, Ling Zhang, Mohammad Hussaini, Jinming Song, Seongseok Yun, Chetasi Talati, Andrew Kuykendall, Eric Padron, Alison Walker, Gail Roboz, Pinkal Desai, David Sallman, Kendra Sweet, Rami Komrokji, Jeffrey Lancet

Blood Adv. 2024 Mar 12; 8(5): 1075–1083. Published online 2024 Jan 5. doi: 10.1182/bloodadvances.2023011173

PMCID:: PMC10907389

Abstract Article PDF–1.7M

Select item 108578044.

NPM1-Mutated Acute Myeloid Leukemia: Recent Developments and Open Questions

Sanjay S. Patel

Pathobiology. 2024 Feb; 91(1): 18–29. Published online 2023 Mar 21. doi: 10.1159/000530253

PMCID:: PMC10857804

Abstract Article

Select item 100275075.

Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML

Ghayas C. Issa, Aram Bidikian, Sangeetha Venugopal, Marina Konopleva, Courtney D. DiNardo, Tapan M. Kadia, Gautam Borthakur, Elias Jabbour, Naveen Pemmaraju, Musa Yilmaz, Nicholas J. Short, Abhishek Maiti, Koji Sasaki, Lucia Masarova, Sherry Pierce, Koichi Takahashi, Guilin Tang, Sanam Loghavi, Keyur Patel, Michael Andreeff, Kapil Bhalla, Guillermo Garcia-Manero, Farhad Ravandi, Hagop Kantarjian, Naval Daver

Blood Adv. 2023 Mar 28; 7(6): 933–942. Published online 2022 Nov 4. doi: 10.1182/bloodadvances.2022008316

PMCID:: PMC10027507

Abstract Article PDF–554K

Select item 99672836.

Positive Linear Relationship between Nucleophosmin Protein Expression and the Viral Load in HPV-Associated Oropharyngeal Squamous Cell Carcinoma: A Possible Tool for Stratification of Patients

Marco D’Agostino, Marco Di Cecco, Carla Marani, Maurizio Giovanni Vigili, Sara Sileno, Chiara Costanza Volpi, Annunziata Gloghini, Daniele Avitabile, Alessandra Magenta, Siavash Rahimi

Int J Mol Sci. 2023 Feb; 24(4): 3482. Published online 2023 Feb 9. doi: 10.3390/ijms24043482

PMCID:: PMC9967283

Abstract Article PDF–1.3M

Select item 99585847.

Targeting and Monitoring Acute Myeloid Leukaemia with Nucleophosmin-1 (NPM1) Mutation

Lynn Chin, Chantelle Ye Gwen Wong, Harinder Gill

Int J Mol Sci. 2023 Feb; 24(4): 3161. Published online 2023 Feb 5. doi: 10.3390/ijms24043161

PMCID:: PMC9958584

Abstract Article PDF–2.7M

Select item 97363288.

Insights into Network of Hot Spots of Aggregation in Nucleophosmin 1

Daniele Florio, Sara La Manna, Concetta Di Natale, Marilisa Leone, Flavia Anna Mercurio, Fabiana Napolitano, Anna Maria Malfitano, Daniela Marasco

Int J Mol Sci. 2022 Dec; 23(23): 14704. Published online 2022 Nov 25. doi: 10.3390/ijms232314704

PMCID:: PMC9736328

Abstract Article PDF–41M

Select item 92782929.

The antagonistic duality of NPM1 mutations in AML

Irum Khan, Andrei L. Gartel

Blood Adv. 2022 Jul 12; 6(13): 4028–4030. Published online 2022 Jul 11. doi: 10.1182/bloodadvances.2022007420

PMCID:: PMC9278292

Article PDF–684K

Select item 915303810.

Clinical impact of NPM1-mutant molecular persistence after chemotherapy for acute myeloid leukemia

Ing S. Tiong, Richard Dillon, Adam Ivey, James A. Kuzich, Nisha Thiagarajah, Kirsty M. Sharplin, Chung Hoow Kok, Aditya Tedjaseputra, James P. Rowland, Carolyn S. Grove, Emad Abro, Jake Shortt, Devendra K. Hiwase, Ashish Bajel, Nicola E. Potter, Matthew L. Smith, Claire J. Hemmaway, Abin Thomas, Amanda F. Gilkes, Nigel H. Russell, Andrew H. Wei

Blood Adv. 2021 Dec 14; 5(23): 5107–5111. Published online 2021 Dec 6. doi: 10.1182/bloodadvances.2021005455

Correction in:: Blood Adv. 2022 Mar 8; 6(5): 1489.

PMCID:: PMC9153038

Abstract Article PDF–790K

Select item 903775611.

Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML

Maria Paola Martelli, Roberta Rossi, Alessandra Venanzi, Manja Meggendorfer, Vincenzo Maria Perriello, Giovanni Martino, Orietta Spinelli, Raffaella Ciurnelli, Emanuela Varasano, Lorenzo Brunetti, Stefano Ascani, Corinne Quadalti, Valeria Cardinali, Federica Mezzasoma, Ilaria Gionfriddo, Francesca Milano, Roberta Pacini, Alessia Tabarrini, Barbara Bigerna, Francesco Albano, Giorgina Specchia, Calogero Vetro, Francesco Di Raimondo, Ombretta Annibali, Giuseppe Avvisati, Alessandro Rambaldi, Franca Falzetti, Enrico Tiacci, Paolo Sportoletti, Torsten Haferlach, Claudia Haferlach, Brunangelo Falini

Blood. 2021 Dec 23; 138(25): 2696–2701. doi: 10.1182/blood.2021012732

PMCID:: PMC9037756

Abstract Article

Select item 894419612.

Flow Cytometric Immunophenotypic Alterations of Persistent Clonal Hematopoiesis in Remission Bone Marrows of Patients with NPM1-Mutated Acute Myeloid Leukemia

Sanam Loghavi, Courtney DiNardo, Ken Furudate, Koichi Takahashi, Tomoyuki Tanaka, Nicholas J. Short, Tapan Kadia, Marina Konopleva, Rashmi Kanagal-Shamanna, Noushin R. Farnoud, Sherry Pierce, Joseph D. Khoury, Jeffrey L. Jorgensen, Keyur P. Patel, Naval Daver, Musa Yilmaz, L. Jeffrey Medeiros, Hagop Kantarjian, Farhad Ravandi, Sa A. Wang

Br J Haematol. Author manuscript; available in PMC 2022 Mar 24.

Published in final edited form as: Br J Haematol. 2021 Mar; 192(6): 1054–1063. Published online 2021 Feb 22. doi: 10.1111/bjh.17347

PMCID:: PMC8944196

Abstract Article PDF–1.0M

Select item 872729013.

Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears

Jan-Niklas Eckardt, Jan Moritz Middeke, Sebastian Riechert, Tim Schmittmann, Anas Shekh Sulaiman, Michael Kramer, Katja Sockel, Frank Kroschinsky, Ulrich Schuler, Johannes Schetelig, Christoph Röllig, Christian Thiede, Karsten Wendt, Martin Bornhäuser

Leukemia. 2022; 36(1): 111–118. Published online 2021 Sep 8. doi: 10.1038/s41375-021-01408-w

PMCID:: PMC8727290

Abstract Article PDF–1.7M

Select item 856824514.

Molecular study of Nucleophosmin 1(NPM1) gene in acute myeloid leukemia in Kurdish population

Galawezh Obaid Othman, Nawsherwan Sadiq Mohammad, Chiman Hameed Saeed

Afr Health Sci. 2021 Jun; 21(2): 687–692. doi: 10.4314/ahs.v21i2.26

PMCID:: PMC8568245

Abstract Article PDF–356K

Select item 847865815.

Integrated genomic-metabolic classification of acute myeloid leukemia defines a subgroup with NPM1 and cohesin/DNA damage mutations

Giorgia Simonetti, Carlo Mengucci, Antonella Padella, Eugenio Fonzi, Gianfranco Picone, Claudio Delpino, Jacopo Nanni, Rossella De Tommaso, Eugenia Franchini, Cristina Papayannidis, Giovanni Marconi, Martina Pazzaglia, Margherita Perricone, Emanuela Scarpi, Maria Chiara Fontana, Samantha Bruno, Michela Tebaldi, Anna Ferrari, Maria Teresa Bochicchio, Andrea Ghelli Luserna Di Rorà, Martina Ghetti, Roberta Napolitano, Annalisa Astolfi, Carmen Baldazzi, Viviana Guadagnuolo, Emanuela Ottaviani, Ilaria Iacobucci, Michele Cavo, Gastone Castellani, Torsten Haferlach, Daniel Remondini, Francesco Capozzi, Giovanni Martinelli

Leukemia. 2021; 35(10): 2813–2826. Published online 2021 Jun 30. doi: 10.1038/s41375-021-01318-x

PMCID:: PMC8478658

Abstract Article PDF–4.3M

Select item 846786116.

Significance of NPM1 Gene Mutations in AML

Andrew Hindley, Mark Alexander Catherwood, Mary Frances McMullin, Ken I. Mills

Int J Mol Sci. 2021 Sep; 22(18): 10040. Published online 2021 Sep 17. doi: 10.3390/ijms221810040

PMCID:: PMC8467861

Abstract Article PDF–1.8M

Select item 846252917.

Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts

Linus Angenendt, Christoph Röllig, Pau Montesinos, David Martínez-Cuadrón, Eva Barragan, Raimundo García, Carmen Botella, Pilar Martínez, Farhad Ravandi, Tapan Kadia, Hagop M. Kantarjian, Jorge Cortes, Gunnar Juliusson, Vladimir Lazarevic, Martin Höglund, Sören Lehmann, Christian Recher, Arnaud Pigneux, Sarah Bertoli, Pierre-Yves Dumas, Hervé Dombret, Claude Preudhomme, Jean-Baptiste Micol, Christine Terré, Zdeněk Ráčil, Jan Novák, Pavel Žák, Andrew H. Wei, Ing S. Tiong, Meaghan Wall, Elihu Estey, Carole Shaw, Rita Exeler, Lisa Wagenführ, Friedrich Stölzel, Christian Thiede, Matthias Stelljes, Georg Lenz, Jan-Henrik Mikesch, Hubert Serve, Gerhard Ehninger, Wolfgang E. Berdel, Michael Kramer, Utz Krug, Christoph Schliemann

J Clin Oncol. 2019 Oct 10; 37(29): 2632–2642. Published online 2019 Aug 20. doi: 10.1200/JCO.19.00416

PMCID:: PMC8462529

Abstract Article PDF–969K

Select item 835936218.

Radar plots facilitate differential diagnosis of acute promyelocytic leukemia and NPM1+ acute myeloid leukemia by flow cytometry

Monali Gupta, Katayoon Jafari, Amr Rajab, Cuihong Wei, Joanna Mazur, Anne Tierens, Elizabeth Hyjek, Rumina Musani, Anna Porwit

Cytometry B Clin Cytom. 2021 Jul; 100(4): 409–420. Published online 2020 Dec 10. doi: 10.1002/cyto.b.21979

PMCID:: PMC8359362

Abstract Article PDF–5.2M

Select item 826844419.

The correlation of next-generation sequencing-based genotypic profiles with clinicopathologic characteristics in NPM1-mutated acute myeloid leukemia

Biao Wang, Bin Yang, Wei Wu, Xuan Liu, Haiqian Li

BMC Cancer. 2021; 21: 788. Published online 2021 Jul 8. doi: 10.1186/s12885-021-08455-7

PMCID:: PMC8268444

Abstract Article PDF–1.5M

Select item 820520720.

A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA

Morgane Gourvest, Etienne De Clara, Hsin-Chieh Wu, Christian Touriol, Fabienne Meggetto, Hugues De Thé, Stéphane Pyronnet, Pierre Brousset, Marina Bousquet

Leukemia. 2021; 35(10): 2784–2798. Published online 2021 Jun 15. doi: 10.1038/s41375-021-01307-0

PMCID:: PMC8205207

Abstract Article PDF–1.6M

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