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Items: 1 to 20 of 153

1.
Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells
Lucia Cappabianca, Marianna Ruggieri, Michela Sebastiano, Maddalena Sbaffone, Ilaria Martelli, Pierdomenico Ruggeri, Monica Di Padova, Antonietta Rosella Farina, Andrew Reay Mackay
Int J Mol Sci. 2024 May; 25(10): 5475. Published online 2024 May 17. doi: 10.3390/ijms25105475
PMCID:
PMC11122047
AbstractArticlePDF–14M
2.
Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors
Yoichi Naito, Saori Mishima, Kiwamu Akagi, Naomi Hayashi, Akira Hirasawa, Tomoro Hishiki, Ataru Igarashi, Masafumi Ikeda, Shigenori Kadowaki, Hiroaki Kajiyama, Motohiro Kato, Hirotsugu Kenmotsu, Yasuhiro Kodera, Keigo Komine, Takafumi Koyama, Osamu Maeda, Mitsuru Miyachi, Hiroshi Nishihara, Hiroyuki Nishiyama, Shouichi Ohga, Wataru Okamoto, Eiji Oki, Shigeru Ono, Masashi Sanada, Ikuo Sekine, Tadao Takano, Kayoko Tao, Keita Terashima, Katsuya Tsuchihara, Yasushi Yatabe, Takayuki Yoshino, Eishi Baba
Int J Clin Oncol. 2023; 28(7): 827–840. Published online 2023 May 22. doi: 10.1007/s10147-023-02345-7
PMCID:
PMC10310565
AbstractArticlePDF–779K
3.
Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines
Bo Jiao, Mi Zhang, Caixia Zhang, Xueqin Cao, Baowen Liu, Ningbo Li, Jiaoli Sun, Xianwei Zhang
PeerJ. 2023; 11: e15219. Published online 2023 Apr 12. doi: 10.7717/peerj.15219
PMCID:
PMC10105561
AbstractArticlePDF–8.4M
4.
Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1‐rearranged tumor cells
Chiaki Suzuki, Akihiro Nishiyama, Sachiko Arai, Shoichiro Tange, Atsushi Tajima, Azusa Tanimoto, Koji Fukuda, Yohei Takumi, Hiroshi Kotani, Shinji Takeuchi, Naohiro Yanagimura, Koushiro Ohtsubo, Norio Yamamoto, Koichi Omori, Seiji Yano
Cancer Sci. 2022 Jul; 113(7): 2323–2335. Published online 2022 May 11. doi: 10.1111/cas.15354
PMCID:
PMC9277414
AbstractArticlePDF–5.8M
5.
Efficacy and Safety of Larotrectinib in Patients With Tropomyosin Receptor Kinase Fusion–Positive Lung Cancers
Alexander Drilon, Daniel S. W. Tan, Ulrik N. Lassen, Serge Leyvraz, Yongmei Liu, Jyoti D. Patel, Lee Rosen, Benjamin Solomon, Ricarda Norenberg, Laura Dima, Nicoletta Brega, Lin Shen, Victor Moreno, Shivaani Kummar, Jessica J. Lin
JCO Precis Oncol. 2022; 6: e2100418. Published online 2022 Jan 27. doi: 10.1200/PO.21.00418
PMCID:
PMC8830513
AbstractArticlePDF–544K
6.
Identification of novel variations in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis
Shang Li, Hua‐ying Hu, Jun‐Jun Xu, Zhan‐ke Feng, Yong‐qing Sun, Xu Chen, Kai Yang, Ya‐zhou Li, Dong‐liang Zhang
Mol Genet Genomic Med. 2021 Nov; 9(11): e1839. Published online 2021 Oct 21. doi: 10.1002/mgg3.1839
PMCID:
PMC8606206
AbstractArticlePDF–1.2M
7.
Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer’s Disease
Erika Kropf, Margaret Fahnestock
Cells. 2021 Aug; 10(8): 1983. Published online 2021 Aug 4. doi: 10.3390/cells10081983
PMCID:
PMC8392605
AbstractArticlePDF–1.3M
8.
NTRK fusion in Japanese colorectal adenocarcinomas
Yuya Yamashiro, Taisei Kurihara, Takuo Hayashi, Yoshiyuki Suehara, Takashi Yao, Shunsuke Kato, Tsuyoshi Saito
Sci Rep. 2021; 11: 5635. Published online 2021 Mar 11. doi: 10.1038/s41598-021-85075-y
PMCID:
PMC7952565
AbstractArticlePDF–2.2M
9.
Clinicopathologic and molecular characterization of NTRK-rearranged thyroid carcinoma (NRTC)
Ying-Hsia Chu, Dora Dias-Santagata, Alexander A. Farahani, Baris Boyraz, William C. Faquin, Vânia Nosé, Peter M. Sadow
Mod Pathol. Author manuscript; available in PMC 2021 May 1.
Published in final edited form as: Mod Pathol. 2020 Nov; 33(11): 2186–2197. Published online 2020 May 26. doi: 10.1038/s41379-020-0574-4
PMCID:
PMC7584778
AbstractArticlePDF–1.8M
10.
The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer
Nathan Griffin, Mark Marsland, Severine Roselli, Christopher Oldmeadow, John Attia, Marjorie M. Walker, Hubert Hondermarck, Sam Faulkner
Biomolecules. 2020 Sep; 10(9): 1329. Published online 2020 Sep 17. doi: 10.3390/biom10091329
PMCID:
PMC7564775
AbstractArticlePDF–2.5M
11.
Structural basis of the transmembrane domain dimerization and rotation in the activation mechanism of the TRKA receptor by nerve growth factor
María L. Franco, Kirill D. Nadezhdin, Sergey A. Goncharuk, Konstantin S. Mineev, Alexander S. Arseniev, Marçal Vilar
J Biol Chem. 2020 Jan 3; 295(1): 275–286. Published online 2019 Dec 4. doi: 10.1074/jbc.RA119.011312
PMCID:
PMC6952603
AbstractArticlePDF–2.4M
12.
Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation
Emiliano Cocco, Alison M Schram, Amanda Kulick, Sandra Misale, Helen H Won, Rona Yaeger, Pedram Razavi, Ryan Ptashkin, Jaclyn F Hechtman, Eneda Toska, James Cownie, Romel Somwar, Sophie Shifman, Marissa Mattar, S Duygu Selçuklu, Aliaksandra Samoila, Sean Guzman, Brian B Tuch, Kevin Ebata, Elisa de Stanchina, Rebecca J Nagy, Richard B Lanman, Brian Houck-Loomis, Juber A Patel, Michael F Berger, Marc Ladanyi, David M Hyman, Alexander Drilon, Maurizio Scaltriti
Nat Med. Author manuscript; available in PMC 2020 Feb 12.
Published in final edited form as: Nat Med. 2019 Sep; 25(9): 1422–1427. Published online 2019 Aug 12. doi: 10.1038/s41591-019-0542-z
PMCID:
PMC6736691
ArticlePDF–2.9M
13.
Phenotypic and genotypic features of a pair of Chinese identical twins with congenital insensitivity to pain and anhidrosis: A case report
Ningbo Li, Jiaoli Sun, Shanna Guo, Yi Liu, Cong Wang, Changmao Zhu, Xianwei Zhang
Medicine (Baltimore) 2018 Nov; 97(47): e13209. Published online 2018 Nov 21. doi: 10.1097/MD.0000000000013209
PMCID:
PMC6392968
AbstractArticlePDF–892K
14.
Copper Binding Features of Tropomyosin-Receptor-Kinase-A Fragment: Clue for Neurotrophic Factors and Metals Link
Antonio Magrì, Diego La Mendola
Int J Mol Sci. 2018 Aug; 19(8): 2374. Published online 2018 Aug 12. doi: 10.3390/ijms19082374
PMCID:
PMC6121459
AbstractArticlePDF–2.1M
15.
Nerve Growth Factor (NGF)—Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma
József Dudás, Wolfgang Dietl, Angela Romani, Susanne Reinold, Rudolf Glueckert, Anneliese Schrott-Fischer, Daniel Dejaco, Lejo Johnson Chacko, Raphaela Tuertscher, Volker Hans Schartinger, Herbert Riechelmann
Int J Mol Sci. 2018 Jun; 19(6): 1771. Published online 2018 Jun 14. doi: 10.3390/ijms19061771
PMCID:
PMC6032238
AbstractArticlePDF–4.5M
16.
Novel NTRK1 mutations in Chinese patients with congenital insensitivity to pain with anhidrosis
Xingzhu Geng, Yanshan Liu, XiuZhi Ren, Yun Guan, Yanzhou Wang, Bin Mao, Xiuli Zhao, Xue Zhang
Mol Pain. 2018; 14: 1744806918781140. Published online 2018 May 17. doi: 10.1177/1744806918781140
PMCID:
PMC6009080
AbstractArticlePDF–811K
17.
Identification of a novel nonsense mutation of the neurotrophic tyrosine kinase receptor type 1 gene in two siblings with congenital insensitivity to pain with anhidrosis
Ting Wang, Haibo Li, Jingjing Xiang, Bin Wei, Qin Zhang, Qin Zhu, Minjuan Liu, Miao Sun, Hong Li
J Int Med Res. 2017 Apr; 45(2): 549–555. Published online 2017 Mar 27. doi: 10.1177/0300060517691699
PMCID:
PMC5536645
AbstractArticlePDF–653K
18.
A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV)
Samiha S. Shaikh, Ya‐Chun Chen, Sally‐Anne Halsall, Michael S. Nahorski, Kiyoyuki Omoto, Gareth T. Young, Anne Phelan, Christopher Geoffrey Woods
Hum Mutat. 2017 Jan; 38(1): 55–63. Published online 2016 Nov 26. doi: 10.1002/humu.23123
PMCID:
PMC5299464
AbstractArticlePDF–1003K
19.
Recurrent NTRK1 Gene Fusions Define A Novel Subset Of Locally Aggressive Lipofibromatosis-Like Neural Tumors
Narasimhan P. Agaram, Lei Zhang, Yun Shao Sung, Chun Liang Chen, Catherine T. Chung, Cristina R. Antonescu, Christopher D.M. Fletcher
Am J Surg Pathol. Author manuscript; available in PMC 2017 Oct 1.
Published in final edited form as: Am J Surg Pathol. 2016 Oct; 40(10): 1407–1416. doi: 10.1097/PAS.0000000000000675
PMCID:
PMC5023452
AbstractArticlePDF–897K
20.
NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer
Do Youn Park, Chan Choi, Eunji Shin, Jae Hyuk Lee, Chae Hwa Kwon, Hong-Jae Jo, Hyeong-Rok Kim, Hyun Sung Kim, Nahmgun Oh, Ji Shin Lee, Ok Ku Park, Eok Park, Jonghoon Park, Jong-Yeon Shin, Jong-Il Kim, Jeong-Sun Seo, Hee Dong Park, Joonghoon Park
Oncotarget. 2016 Feb 16; 7(7): 8399–8412. Published online 2015 Dec 22. doi: 10.18632/oncotarget.6724
PMCID:
PMC4885001
AbstractArticlePDF–7.3M

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