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Select item 104192441.

Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology

Ángel Juan García-Yagüe, Antonio Cuadrado

Int J Mol Sci. 2023 Aug; 24(15): 12280. Published online 2023 Jul 31. doi: 10.3390/ijms241512280

PMCID:: PMC10419244

Abstract Article PDF–1.9M

Select item 92959712.

Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells

Fengchun Ye, David Alvarez-Carbonell, Kien Nguyen, Konstantin Leskov, Yoelvis Garcia-Mesa, Sheetal Sreeram, Saba Valadkhan, Jonathan Karn

PLoS Pathog. 2022 Jul; 18(7): e1010110. Published online 2022 Jul 7. doi: 10.1371/journal.ppat.1010110

PMCID:: PMC9295971

Abstract Article PDF–6.3M

Select item 92824323.

NURR1 expression regulates retinal pigment epithelial–mesenchymal transition and age-related macular degeneration phenotypes

Pei-Li Yao, Vipul M. Parmar, Mayur Choudhary, Goldis Malek

Proc Natl Acad Sci U S A. 2022 Jul 12; 119(28): e2202256119. Published online 2022 Jul 8. doi: 10.1073/pnas.2202256119

PMCID:: PMC9282432

Abstract Article PDF–4.3M

Select item 92352364.

The role of NURR1 in metabolic abnormalities of Parkinson’s disease

Murad Al-Nusaif, Yuting Yang, Song Li, Cheng Cheng, Weidong Le

Mol Neurodegener. 2022; 17: 46. Published online 2022 Jun 27. doi: 10.1186/s13024-022-00544-w

PMCID:: PMC9235236

Abstract Article PDF–1.1M

Select item 91098285.

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma

Mehrdad Zarei, Rupesh Shrestha, Sneha Johnson, Zuhua Yu, Keshav Karki, Ali Vaziri-Gohar, Jessica Epps, Heng Du, Larry Suva, Mahsa Zarei, Stephen Safe

Cancer Res Commun. 2021 Nov; 1(2): 65–78. Published online 2021 Nov 3. doi: 10.1158/2767-9764.CRC-21-0073

PMCID:: PMC9109828

Abstract Article PDF–6.5M

Select item 85265886.

NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast

Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Owen Stock, Katie M. Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Natalie J. Hannan

Sci Rep. 2021; 11: 20670. Published online 2021 Oct 19. doi: 10.1038/s41598-021-00192-y

PMCID:: PMC8526588

Abstract Article PDF–1.5M

Select item 78715657.

Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study

Elizabeth Ruiz-Sánchez, Janet Jiménez-Genchi, Yessica M. Alcántara-Flores, Carlos J. Castañeda-González, Carlos L. Aviña-Cervantes, Petra Yescas, María del Socorro González-Valadez, Nancy Martínez-Rodríguez, Antonio Ríos-Ortiz, Martha González-González, María E. López-Navarro, Patricia Rojas

BMC Psychiatry. 2021; 21: 86. Published online 2021 Feb 9. doi: 10.1186/s12888-021-03081-w

PMCID:: PMC7871565

Abstract Article PDF–950K

Select item 73948798.

De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy

Sakshi Singh, Aditi Gupta, Michael Zech, Ashley N. Sigafoos, Karl J. Clark, Yasemin Dincer, Matias Wagner, Jennifer B. Humberson, Sarah Green, Koen van Gassen, Tracy Brandt, Rhonda E. Schnur, Francisca Millan, Yue Si, Volker Mall, Juliane Winkelmann, Ralitza H. Gavrilova, Eric W. Klee, Kendra Engleman, Nicole P. Safina, Rachel Slaugh, Emily M. Bryant, Wen-Hann Tan, Jorge Granadillo, Sunita N. Misra, G. Bradley Schaefer, Shelley Towner, Eva H. Brilstra, Bobby P. C. Koeleman

Genet Med. 2020; 22(8): 1413–1417. Published online 2020 May 5. doi: 10.1038/s41436-020-0815-4

PMCID:: PMC7394879

Abstract Article PDF–489K

Select item 73323579.

Genome-Wide Analysis Identifies NURR1-Controlled Network of New Synapse Formation and Cell Cycle Arrest in Human Neural Stem Cells

Soo Min Kim, Soo Young Cho, Min Woong Kim, Seung Ryul Roh, Hee Sun Shin, Young Ho Suh, Dongho Geum, Myung Ae Lee

Mol Cells. 2020 Jun 30; 43(6): 551–571. Published online 2020 Jun 10. doi: 10.14348/molcells.2020.0071

PMCID:: PMC7332357

Abstract Article PDF–2.6M

Select item 692645610.

Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements

Longying Jiang, Shuyan Dai, Jun Li, Xujun Liang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Zhuchu Chen, Lin Chen, Hudie Wei, Yongheng Chen

J Biol Chem. 2019 Dec 20; 294(51): 19795–19803. Published online 2019 Nov 13. doi: 10.1074/jbc.RA119.010730

PMCID:: PMC6926456

Abstract Article PDF–1.8M

Select item 669304911.

Heterozygous loss of function of NR4A2 is associated with intellectual deficiency, rolandic epilepsy, and language impairment

Luiza L. P. Ramos, Fabiola P. Monteiro, Leticia P. B. Sampaio, Larissa A. Costa, Mara D. O. Ribeiro, Erika L. Freitas, Joao P. Kitajima, Fernando Kok

Clin Case Rep. 2019 Aug; 7(8): 1582–1584. Published online 2019 Jul 11. doi: 10.1002/ccr3.2260

PMCID:: PMC6693049

Abstract Article PDF–157K

Select item 667310412.

Heroin Abuse Is Characterized by Discrete Mesolimbic Dopamine and Opioid Abnormalities and Exaggerated Nuclear Receptor-Related 1 Transcriptional Decline with Age

Monika Cs. Horvath, Gabor G. Kovacs, Viktor Kovari, Katalin Majtenyi, Yasmin L. Hurd, Eva Keller

J Neurosci. 2007 Dec 5; 27(49): 13371–13375. doi: 10.1523/JNEUROSCI.2398-07.2007

PMCID:: PMC6673104

Abstract Article PDF–169K

Select item 558875913.

cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren's syndrome

H. Takahashi, H. Tsuboi, H. Asashima, T. Hirota, Y. Kondo, M. Moriyama, I. Matsumoto, S. Nakamura, T. Sumida

Clin Exp Immunol. 2017 Oct; 190(1): 96–109. Published online 2017 Jul 21. doi: 10.1111/cei.13000

PMCID:: PMC5588759

Abstract Article PDF–888K

Select item 494699914.

Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1

Ian Mitchelle S. de Vera, Pankaj K. Giri, Paola Munoz-Tello, Richard Brust, Jakob Fuhrmann, Edna Matta-Camacho, Jinsai Shang, Sean Campbell, Henry D. Wilson, Juan Granados, William J. Gardner, Jr, Trevor P. Creamer, Laura. A. Solt, Douglas J. Kojetin

ACS Chem Biol. Author manuscript; available in PMC 2017 Jul 15.

Published in final edited form as: ACS Chem Biol. 2016 Jul 15; 11(7): 1795–1799. Published online 2016 Apr 29. doi: 10.1021/acschembio.6b00037

PMCID:: PMC4946999

Abstract Article PDF–1.2M

Select item 451309115.

Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis

Sahil Mahajan, Ankita Saini, Vemika Chandra, Ravikanth Nanduri, Rashi Kalra, Ella Bhagyaraj, Neeraj Khatri, Pawan Gupta

J Biol Chem. 2015 Jul 24; 290(30): 18304–18314. Published online 2015 May 7. doi: 10.1074/jbc.M115.638064

PMCID:: PMC4513091

Abstract Article PDF–2.0M

Select item 381933216.

The NR4A2 Nuclear Receptor Is Recruited to Novel Nuclear Foci in Response to UV Irradiation and Participates in Nucleotide Excision Repair

Kasturee Jagirdar, Kelvin Yin, Matthew Harrison, Wen Lim, George E. O. Muscat, Richard A. Sturm, Aaron G. Smith

PLoS One. 2013; 8(11): e78075. Published online 2013 Nov 6. doi: 10.1371/journal.pone.0078075

PMCID:: PMC3819332

Abstract Article PDF–1.8M

Select item 373722017.

Chemoprevention of Skin Cancer with 1,1-Bis (3′-Indolyl)-1-(Aromatic) Methane Analog through Induction of the Orphan Nuclear Receptor, NR4A2 (Nurr1)

Cedar H. A. Boakye, Ravi Doddapaneni, Punit P. Shah, Apurva R. Patel, Chandraiah Godugu, Stephen Safe, Santosh K. Katiyar, Mandip Singh

PLoS One. 2013; 8(8): e69519. Published online 2013 Aug 7. doi: 10.1371/journal.pone.0069519

PMCID:: PMC3737220

Abstract Article PDF–974K

Select item 362775218.

NR4A2: Effects of an “Orphan” Receptor on Sustained Attention in a Schizophrenic Population

Inés Ancín, José A. Cabranes, Blanca Vázquez-Álvarez, José Luis Santos, Eva Sánchez-Morla, Maaike Alaerts, Jurgen Del-Favero, Ana Barabash

Schizophr Bull. 2013 May; 39(3): 555–563. Published online 2012 Jan 31. doi: 10.1093/schbul/sbr176

PMCID:: PMC3627752

Abstract Article PDF–761K

Select item 361789819.

Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer

Shawn Llopis, Brittany Singleton, Tamika Duplessis, Latonya Carrier, Brian Rowan, Christopher Williams

BMC Cancer. 2013; 13: 139. Published online 2013 Mar 21. doi: 10.1186/1471-2407-13-139

PMCID:: PMC3617898

Abstract Article PDF–6.3M

Select item 346886120.

Ya-Ming Wei, Yan-Lei Du, Yu-Qiang Nie, Yu-Yuan Li, Yu-Jui Wan

World J Gastroenterol. 2012 Oct 7; 18(37): 5276–5282. Published online 2012 Oct 7. doi: 10.3748/wjg.v18.i37.5276

PMCID:: PMC3468861

Abstract Article PDF–802K

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