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Select item 97196471.

The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma

Suhjung Janet Lee, Aric F. Logsdon, Mayumi Yagi, Britahny M. Baskin, Elaine. R. Peskind, Murray M. Raskind, David G. Cook, Abigail. G. Schindler

J Neuroinflammation. 2022; 19: 288. Published online 2022 Dec 3. doi: 10.1186/s12974-022-02643-3

PMCID:: PMC9719647

Abstract Article PDF–3.5M

Select item 86747012.

Opioids in cancer: The κ-opioid receptor

Qier Zhou, Zhiwei Zhang, Songkai Long, Wanjun Li, Baiyun Wang, Na Liang

Mol Med Rep. 2022 Feb; 25(2): 44. Published online 2021 Dec 8. doi: 10.3892/mmr.2021.12560

PMCID:: PMC8674701

Abstract Article PDF–903K

Select item 86275093.

Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography

Kelly Smart, Ashley Yttredahl, Maria A. Oquendo, J. John Mann, Ansel T. Hillmer, Richard E. Carson, Jeffrey M. Miller

Transl Psychiatry. 2021; 11: 602. Published online 2021 Nov 27. doi: 10.1038/s41398-021-01729-5

PMCID:: PMC8627509

Abstract Article PDF–1.5M

Select item 68513174.

Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation

Selena S. Schattauer, Andrea Bedini, Floyd Summers, Aiden Reilly-Treat, Mackenzie M. Andrews, Benjamin B. Land, Charles Chavkin

J Biol Chem. 2019 Nov 8; 294(45): 16884–16896. Published online 2019 Oct 1. doi: 10.1074/jbc.RA119.009592

PMCID:: PMC6851317

Abstract Article PDF–3.1M

Select item 67851445.

Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers

David Matuskey, Mark Dias, Mika Naganawa, Brian Pittman, Shannan Henry, Songye Li, Hong Gao, Jim Ropchan, Nabeel Nabulsi, Richard E. Carson, Yiyun Huang

Neuropsychopharmacology. 2019 Sep; 44(10): 1714–1719. Published online 2019 Mar 30. doi: 10.1038/s41386-019-0379-7

PMCID:: PMC6785144

Abstract Article PDF–531K

Select item 67850046.

Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study

Diana Martinez, Mark Slifstein, David Matuskey, Nabeel Nabulsi, Ming-Qiang Zheng, Shu-fei Lin, Jim Ropchan, Nina Urban, Alexander Grassetti, Dinnisa Chang, Michael Salling, Richard Foltin, Richard E. Carson, Yiyun Huang

Neuropsychopharmacology. 2019 Sep; 44(10): 1720–1727. Published online 2019 Apr 26. doi: 10.1038/s41386-019-0398-4

PMCID:: PMC6785004

Abstract Article PDF–997K

Select item 62245337.

PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age

Aishwarya Vijay, Dana Cavallo, Alissa Goldberg, Bart de Laat, Nabeel Nabulsi, Yiyun Huang, Suchitra Krishnan-Sarin, Evan D. Morris

Neuropsychopharmacology. 2018 Dec; 43(13): 2539–2547. Published online 2018 Sep 6. doi: 10.1038/s41386-018-0199-1

PMCID:: PMC6224533

Abstract Article PDF–1.3M

Select item 61410198.

Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction

Vadim Yuferov, David Fussell, K. Steven LaForge, David A. Nielsen, Derek Gordon, Ann Ho, Suzanne M. Leal, Jurg Ott, Mary Jeanne Kreek

Pharmacogenetics. Author manuscript; available in PMC 2018 Sep 17.

Published in final edited form as: Pharmacogenetics. 2004 Dec; 14(12): 793–804. doi: 10.1097/00008571-200412000-00002

PMCID:: PMC6141019

Abstract Article PDF–813K

Select item 55629869.

Down-regulation of the tumour suppressor κ-opioid receptor predicts poor prognosis in hepatocellular carcinoma patients

Dongtai Chen, Yonghua Chen, Yan Yan, Jiahao Pan, Wei Xing, Qiang Li, Weian Zeng

BMC Cancer. 2017; 17: 553. Published online 2017 Aug 18. doi: 10.1186/s12885-017-3541-9

PMCID:: PMC5562986

Abstract Article PDF–3.3M

Select item 470551310.

Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI

Jianxin Cheng, Xianqiang Sun, Weihua Li, Guixia Liu, Yaoquan Tu, Yun Tang

Sci Rep. 2016; 6: 18913. Published online 2016 Jan 8. doi: 10.1038/srep18913

PMCID:: PMC4705513

Abstract Article PDF–1.8M

Select item 458684011.

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

Casey O’Connor, Kate L. White, Nathalie Doncescu, Tatiana Didenko, Bryan L. Roth, Georges Czaplicki, Raymond C. Stevens, Kurt Wüthrich, Alain Milon

Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38): 11852–11857. Published online 2015 Sep 8. doi: 10.1073/pnas.1510117112

PMCID:: PMC4586840

Abstract Article PDF–1.5M

Select item 416115112.

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profile

Chad M. Kormos, Moses G. Gichinga, Rangan Maitra, Scott P. Runyon, James B. Thomas, Lawrence E. Brieaddy, S. Wayne Mascarella, Hernán A. Navarro, F. Ivy Carroll

J Med Chem. 2014 Sep 11; 57(17): 7367–7381. Published online 2014 Aug 18. doi: 10.1021/jm5008177

PMCID:: PMC4161151

Abstract Article PDF–2.1M

Select item 397323213.

Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor

J Ma, J Wan, J Meng, S Banerjee, S Ramakrishnan, S Roy

Cell Death Dis. 2014 Mar; 5(3): e1099. Published online 2014 Mar 6. doi: 10.1038/cddis.2014.64

PMCID:: PMC3973232

Abstract Article PDF–2.4M

Select item 388587314.

κ-opioid Receptor Gene as a Predictor of Response in a Cocaine Vaccine Clinical Trial

D.A. Nielsen, S.C. Hamon, T.R. Kosten

Psychiatr Genet. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Psychiatr Genet. 2013 Dec; 23(6): 10.1097/YPG.0000000000000008. doi: 10.1097/YPG.0000000000000008

PMCID:: PMC3885873

Abstract Article PDF–462K

Select item 384306215.

Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists

Eyal Vardy, Philip D. Mosier, Kevin J. Frankowski, Huixian Wu, Vsevolod Katritch, Richard B. Westkaemper, Jeffrey Aubé, Raymond C. Stevens, Bryan L. Roth

J Biol Chem. 2013 Nov 29; 288(48): 34470–34483. Published online 2013 Oct 11. doi: 10.1074/jbc.M113.515668

PMCID:: PMC3843062

Abstract Article PDF–3.7M

Select item 375629016.

A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk

K Xu, D Seo, C Hodgkinson, Y Hu, D Goldman, R Sinha

Transl Psychiatry. 2013 Aug; 3(8): e292. Published online 2013 Aug 20. doi: 10.1038/tp.2013.62

PMCID:: PMC3756290

Abstract Article PDF–1.0M

Select item 278767317.

Kappa-opioid receptor signaling and brain reward function

Adrie W. Bruijnzeel

Brain Res Rev. Author manuscript; available in PMC 2010 Dec 11.

Published in final edited form as: Brain Res Rev. 2009 Dec 11; 62(1): 127–146. Published online 2009 Oct 2. doi: 10.1016/j.brainresrev.2009.09.008

PMCID:: PMC2787673

Abstract Article PDF–231K

Select item 240590418.

A regulatory variation in OPRK1, the gene encoding the κ-opioid receptor, is associated with alcohol dependence

Howard J. Edenberg, Jun Wang, Huijun Tian, Sirisha Pochareddy, Xiaoling Xuei, Leah Wetherill, Alison Goate, Tony Hinrichs, Samuel Kuperman, John I. Nurnberger, Jr, Marc Schuckit, Jay A. Tischfield, Tatiana Foroud

Hum Mol Genet. 2008 Jun 15; 17(12): 1783–1789. Published online 2008 Mar 4. doi: 10.1093/hmg/ddn068

PMCID:: PMC2405904

Abstract Article PDF–240K

Select item 1087536119.

κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway: KOR regulates OA synovitis via NF-κB

Yi Shi, Huaqiang Tao, Xueyan Li, Liyuan Zhang, Chunhui Li, Wen Sun, Miao Chu, Kai Chen, Pengfei Zhu, Qiang Wang, Chengyong Gu, Liangliang Wang, Xing Yang, Yuefeng Hao

Acta Biochim Biophys Sin (Shanghai) 2024 Jan 25; 56(1): 82–95. Published online 2023 Nov 28. doi: 10.3724/abbs.2023223

PMCID:: PMC10875361

Abstract Article PDF–4.1M

Select item 606116120.

Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics

Igor Bazov, Daniil Sarkisyan, Olga Kononenko, Hiroyuki Watanabe, Tatiana Yakovleva, Anita C. Hansson, Wolfgang H. Sommer, Rainer Spanagel, Georgy Bakalkin

Mol Neurobiol. 2018; 55(8): 7049–7061. Published online 2018 Jan 30. doi: 10.1007/s12035-017-0844-4