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Select item 108534421.

Molecular mechanisms of pancreatic cancer liver metastasis: the role of PAK2

Hao Yang, Zhongyi Li, Shiqi Zhu, Wenxia Wang, Jing Zhang, Dongxu Zhao, Man Zhang, Wenxin Zhu, Wei Xu, Chunfang Xu

Front Immunol. 2024; 15: 1347683. Published online 2024 Jan 26. doi: 10.3389/fimmu.2024.1347683

PMCID:: PMC10853442

Abstract Article PDF–22M

Select item 108508052.

A novel pipeline for prioritizing cancer type‐specific therapeutic vulnerabilities using DepMap identifies PAK2 as a target in head and neck squamous cell carcinomas

Malay K. Sannigrahi, Austin C. Cao, Pavithra Rajagopalan, Lova Sun, Robert M. Brody, Lovely Raghav, Phyllis A. Gimotty, Devraj Basu

Mol Oncol. 2024 Feb; 18(2): 336–349. Published online 2023 Dec 13. doi: 10.1002/1878-0261.13558

PMCID:: PMC10850805

Abstract Article PDF–1.7M

Select item 56557923.

Expansion of BCR/ABL1⁺ cells requires PAK2 but not PAK1

Leo Edlinger, Angelika Berger‐Becvar, Ingeborg Menzl, Gregor Hoermann, Georg Greiner, Eva Grundschober, Zsuzsanna Bago‐Horvath, Wael Al‐Zoughbi, Gerald Hoefler, Christine Brostjan, Lars Gille, Richard Moriggl, Andreas Spittler, Veronika Sexl, Andrea Hoelbl‐Kovacic

Br J Haematol. 2017 Oct; 179(2): 229–241. Published online 2017 Jul 14. doi: 10.1111/bjh.14833

PMCID:: PMC5655792

Abstract Article PDF–1.0M

Select item 41518044.

Motility of select ovarian cancer cell lines: Effect of extracellular matrix proteins and the involvement of PAK2

ELIZABETH FLATE, JOHN R.D. STALVEY

Int J Oncol. 2014 Oct; 45(4): 1401–1411. Published online 2014 Jul 22. doi: 10.3892/ijo.2014.2553

PMCID:: PMC4151804

Abstract Article PDF–818K

Select item 39751795.

Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer

Chengcheng Gao, Tianheng Ma, Liqun Pang, Rui Xie

Diagn Pathol. 2014; 9: 55. Published online 2014 Mar 12. doi: 10.1186/1746-1596-9-55

PMCID:: PMC3975179

Abstract Article PDF–470K

Select item 30866986.

P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation

Tingting Li, Jishuai Zhang, Feng Zhu, Weihong Wen, Tatyana Zykova, Xiang Li, Kangdong Liu, Cong Peng, Weiya Ma, Guozheng Shi, Ziming Dong, Ann M. Bode, Zigang Dong

Carcinogenesis. 2011 May; 32(5): 659–666. Published online 2010 Dec 22. doi: 10.1093/carcin/bgq271

PMCID:: PMC3086698

Abstract Article PDF–696K

Select item 30247657.

Mechanistic Studies of the Autoactivation of PAK2: A TWO-STEP MODEL OF CIS INITIATION FOLLOWED BY TRANS AMPLIFICATION

Jue Wang, Jia-Wei Wu, Zhi-Xin Wang

J Biol Chem. 2011 Jan 28; 286(4): 2689–2695. Published online 2010 Nov 22. doi: 10.1074/jbc.M110.156505

PMCID:: PMC3024765

Abstract Article PDF–1.0M

Select item 26477318.

Elevated p21-Activated Kinase 2 Activity Results in Anchorage-Independent Growth and Resistance to Anticancer Drug-Induced Cell Death

Jerry W Marlin, Andrew Eaton, Gerald T Montano, Yu-Wen E Chang, Rolf Jakobi

Neoplasia. 2009 Mar; 11(3): 286–297. doi: 10.1593/neo.81446

PMCID:: PMC2647731

Abstract Article PDF–1.3M

Select item 14589209.

Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events

Gonzalo L. Vilas, Maria M. Corvi, Greg J. Plummer, Andrea M. Seime, Gareth R. Lambkin, Luc G. Berthiaume

Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17): 6542–6547. Published online 2006 Apr 14. doi: 10.1073/pnas.0600824103

PMCID:: PMC1458920

Abstract Article PDF–1.9M

Select item 39452310.

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

G A Martin, G Bollag, F McCormick, A Abo

EMBO J. 1995 Sep 1; 14(17): 4385. doi: 10.1002/j.1460-2075.1995.tb00113.x

Corrects:: EMBO J. 1995 May 1; 14(9): 1970–1978.

PMCID:: PMC394523

Correction PDF–135K

Select item 990116211.

Circular RNA 0001789 sponges miR-140-3p and regulates PAK2 to promote the progression of gastric cancer

Jun You, Yinan Chen, Donghan Chen, Yongwen Li, Tinghao Wang, Jingtao Zhu, Qingqi Hong, Qiyuan Li

J Transl Med. 2023; 21: 83. Published online 2023 Feb 5. doi: 10.1186/s12967-022-03853-2

PMCID:: PMC9901162

Abstract Article PDF–12M

Select item 963794712.

Quantitative Phosphoproteomics Analysis Uncovers PAK2- and CDK1-Mediated Malignant Signaling Pathways in Clear Cell Renal Cell Carcinoma

Aydanur Senturk, Ayse T. Sahin, Ayse Armutlu, Murat Can Kiremit, Omer Acar, Selcuk Erdem, Sidar Bagbudar, Tarik Esen, Nurhan Ozlu

Mol Cell Proteomics. 2022 Nov; 21(11): 100417. Published online 2022 Sep 21. doi: 10.1016/j.mcpro.2022.100417

PMCID:: PMC9637947

Abstract Article PDF–3.5M

Select item 916192513.

Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer

Huimin Wang, Zhiqin Tang, Jihui Duan, Chunlei Zhou, Ke Xu, Hong Mu

Bioengineered. 2022; 13(4): 8937–8949. Published online 2022 Mar 25. doi: 10.1080/21655979.2022.2056822

PMCID:: PMC9161925

Abstract Article PDF–3.4M

Select item 909785114.

LncRNA FAF attenuates hypoxia/ischaemia‐induced pyroptosis via the miR‐185‐5p/PAK2 axis in cardiomyocytes

Jie Gu, Jian‐Zhou Shi, Ya‐Xing Wang, Liu Liu, Si‐Bo Wang, Jia‐Teng Sun, Tian‐Kai Shan, Hao Wang, Qi‐Ming Wang, Lian‐Sheng Wang

J Cell Mol Med. 2022 May; 26(10): 2895–2907. Published online 2022 Apr 3. doi: 10.1111/jcmm.17304

PMCID:: PMC9097851

Abstract Article PDF–15M

Select item 908125815.

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling

Eleonora Sementino, Yuwaraj Kadariya, Mitchell Cheung, Craig W. Menges, Yinfei Tan, Anna-Mariya Kukuyan, Ujjawal Shrestha, Sofiia Karchugina, Kathy Q. Cai, Suraj Peri, James S. Duncan, Jonathan Chernoff, Joseph R. Testa

Mol Cancer Res. Author manuscript; available in PMC 2022 Nov 4.

Published in final edited form as: Mol Cancer Res. 2022 May 4; 20(5): 699–711. doi: 10.1158/1541-7786.MCR-21-0837