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Items: 1 to 20 of 108

1.
PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are Essential for Thrombin-Induced Morphological Changes in MEG-01 Cells
Yunkyung Heo, Hyejin Jeon, Wan Namkung
Int J Mol Sci. 2022 Jan; 23(2): 776. Published online 2022 Jan 11. doi: 10.3390/ijms23020776
PMCID:
PMC8775998
AbstractArticlePDF–3.7M
2.
PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153
Xu Han, Lukas Hofmann, Maria de la Fuente, Nathan Alexander, Krzysztof Palczewski, the INVENT Consortium, Marvin T. Nieman
Blood. 2020 Nov 5; 136(19): 2217–2228. Prepublished online 2020 Jun 23. doi: 10.1182/blood.2019004634
PMCID:
PMC7645988
AbstractArticle
3.
A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling
Benjamin A.T. Rodriguez, Arunoday Bhan, Andrew Beswick, Peter C. Elwood, Teemu J. Niiranen, Veikko Salomaa, FinnGen Study, David-Alexandre Trégouët, Pierre-Emmanuel Morange, Mete Civelek, Yoav Ben-Shlomo, Thorsten Schlaeger, Ming-Huei Chen, Andrew D. Johnson
Am J Hum Genet. 2020 Aug 6; 107(2): 211–221. Published online 2020 Jul 9. doi: 10.1016/j.ajhg.2020.06.008
PMCID:
PMC7413854
AbstractArticlePDF–1.7M
4.
Par-4 overexpression impedes leukemogenesis in the Eµ-TCL1 leukemia model through downregulation of NF-κB signaling
J. T. Greene, Rajeswaran Mani, Rahul Ramaswamy, Frank Frissora, Max Yano, Kevan Zapolnik, Bonnie Harrington, Ronni Wasmuth, Minh Tran, Xiaokui Mo, Mary McKenna, Vivek M. Rangnekar, John C. Byrd, Subbarao Bondada, Natarajan Muthusamy
Blood Adv. 2019 Apr 23; 3(8): 1255–1266. Published online 2019 Apr 15. doi: 10.1182/bloodadvances.2018025973
PMCID:
PMC6482354
AbstractArticlePDF–2.0M
5.
Protease-activated receptor 4 (PAR4) activity promotes platelet granule release and platelet-leukocyte interactions
Rachel A. Rigg, Laura D. Healy, Tiffany T. Chu, Anh T. P. Ngo, Annachiara Mitrugno, Jevgenia Zilberman-Rudenko, Joseph E. Aslan, Monica T. Hinds, Lisa Dirling Vecchiarelli, Terry K. Morgan, András Gruber, Kayla J. Temple, Craig W. Lindsley, Matthew T. Duvernay, Heidi E. Hamm, Owen J. T. McCarty
Platelets. Author manuscript; available in PMC 2020 Jan 1.
Published in final edited form as: Platelets. 2019; 30(1): 126–135. Published online 2018 Dec 18. doi: 10.1080/09537104.2017.1406076
PMCID:
PMC6397092
AbstractArticlePDF–2.0M
6.
pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain
Andrea M. Clark, Komala Ponniah, Meghan S. Warden, Emily M. Raitt, Andrea C. Yawn, Steven M. Pascal
Biomolecules. 2018 Dec; 8(4): 162. Published online 2018 Dec 4. doi: 10.3390/biom8040162
PMCID:
PMC6316887
AbstractArticlePDF–1.5M
7.
Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells
Ming Wang, Shuhong An, Diyi Wang, Haizhen Ji, Xingjing Guo, Zhaojin Wang
J Immunol Res. 2018; 2018: 4735752. Published online 2018 Sep 30. doi: 10.1155/2018/4735752
PMCID:
PMC6186345
AbstractArticlePDF–2.5M
8.
Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer
Nathaniel W. Mabe, Douglas B. Fox, Ryan Lupo, Amy E. Decker, Stephanie N. Phelps, J. Will Thompson, James V. Alvarez
J Clin Invest. 2018 Oct 1; 128(10): 4413–4428. Published online 2018 Aug 27. doi: 10.1172/JCI99481
PMCID:
PMC6159989
AbstractArticlePDF–7.3M
9.
Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition
Jeffrey S. Damrauer, Stephanie N. Phelps, Katie Amuchastegui, Ryan Lupo, Nathaniel W. Mabe, Andrea Walens, Benjamin R. Kroger, James V. Alvarez
Mol Cancer Res. Author manuscript; available in PMC 2019 Apr 1.
Published in final edited form as: Mol Cancer Res. 2018 Apr; 16(4): 599–609. Published online 2018 Jan 12. doi: 10.1158/1541-7786.MCR-17-0492
PMCID:
PMC5882527
AbstractArticlePDF–1.2M
10.
Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity
Simone Aparecida De Bessa Garcia, Ana Carolina Pavanelli, Natália Cruz E Melo, Maria Aparecida Nagai
Int J Mol Med. 2017 Apr; 39(4): 809–818. Published online 2017 Feb 21. doi: 10.3892/ijmm.2017.2900
PMCID:
PMC5360433
AbstractArticlePDF–1.3M
11.
Post-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells
Kevin Brasseur, François Fabi, Pascal Adam, Sophie Parent, Laurent Lessard, Eric Asselin
Oncotarget. 2016 Jun 14; 7(24): 36971–36987. Published online 2016 May 9. doi: 10.18632/oncotarget.9235
PMCID:
PMC5095052
AbstractArticlePDF–5.8M
12.
Role of PAR-4 in ovarian cancer
Sonia Meynier, Marianne Kramer, Pascale Ribaux, Jean-Christophe Tille, Florence Delie, Patrick Petignat, Marie Cohen
Oncotarget. 2015 Sep 8; 6(26): 22641–22652. Published online 2015 May 27. doi: 10.18632/oncotarget.4010
PMCID:
PMC4673188
AbstractArticlePDF–2.5M
13.
PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells
Bilal Rah, Reyaz ur Rasool, Debasis Nayak, Syed Khalid Yousuf, Debaraj Mukherjee, Lekha Dinesh Kumar, Anindya Goswami
Autophagy. 2015 Feb; 11(2): 314–331. Published online 2015 Mar 24. doi: 10.1080/15548627.2015.1017182
PMCID:
PMC4502794
AbstractArticlePDF–1.5M
14.
Cloning, expression, purification, crystallization and preliminary crystallographic analysis of the C-terminal domain of Par-4 (PAWR)
Udaya Kumar Tiruttani Subhramanyam, Jan Kubicek, Ulf B. Eidhoff, Joerg Labahn
Acta Crystallogr F Struct Biol Commun. 2014 Sep 1; 70(Pt 9): 1224–1227. Published online 2014 Aug 27. doi: 10.1107/S2053230X14014691
PMCID:
PMC4157423
AbstractArticlePDF–313K
15.
Prostate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cells
MICHELLY C. PEREIRA, SIMONE A. DE BESSA-GARCIA, RAVSHAN BURIKHANOV, ANA CAROLINA PAVANELLI, LOURIVAL ANTUNES, VIVEK M. RANGNEKAR, MARIA A. NAGAI
Int J Oncol. 2013 Aug; 43(2): 531–538. Published online 2013 Jun 12. doi: 10.3892/ijo.2013.1983
PMCID:
PMC4035780
AbstractArticlePDF–747K
16.
Expression and Regulation of Prostate Apoptosis Response-4 (Par-4) in Human Glioma Stem Cells in Drug-Induced Apoptosis
Jayashree C. Jagtap, Parveen Dawood, Reecha D. Shah, Goparaju Chandrika, Kumar Natesh, Anjali Shiras, Amba S. Hegde, Deepak Ranade, Padma Shastry
PLoS One. 2014; 9(2): e88505. Published online 2014 Feb 11. doi: 10.1371/journal.pone.0088505
Correction in:
PLoS One. 2014; 9(4): e95817.
PMCID:
PMC3921173
AbstractArticlePDF–2.7M
17.
Role of Prostate Apoptosis Response 4 in Translocation of GRP78 from the Endoplasmic Reticulum to the Cell Surface of Trophoblastic Cells
Marie Cohen, Pascale Ribaux, Manuella Epiney, Olivier Irion
PLoS One. 2013; 8(11): e80231. Published online 2013 Nov 25. doi: 10.1371/journal.pone.0080231
PMCID:
PMC3839917
AbstractArticlePDF–658K
18.
Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by upregulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells
Yun Wang, Michelle Moreland, James G Wagner, Bruce N. Ames, Beate Illek, David B. Peden, Qing Jiang
J Nutr Biochem. Author manuscript; available in PMC 2013 Jun 1.
Published in final edited form as: J Nutr Biochem. 2012 Jun; 23(6): 602–608. Published online 2011 Jul 20. doi: 10.1016/j.jnutbio.2011.03.003
PMCID:
PMC3201713
AbstractArticlePDF–1.1M
19.
The Akt inhibitor ISC-4 activates Prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model
Arun K. Sharma, Christina L Kline, Arthur Berg, Shantu Amin, Rosalyn B. Irby
Clin Cancer Res. Author manuscript; available in PMC 2012 Jul 1.
Published in final edited form as: Clin Cancer Res. 2011 Jul 1; 17(13): 4474–4483. Published online 2011 May 9. doi: 10.1158/1078-0432.CCR-10-2370
PMCID:
PMC3131476
AbstractArticlePDF–2.4M
20.
Apoptosis and Tumor Resistance Conferred by Par-4
Yanming Zhao, Vivek M. Rangnekar
Cancer Biol Ther. Author manuscript; available in PMC 2009 Dec 1.
Published in final edited form as: Cancer Biol Ther. 2008 Dec; 7(12): 1867–1874. Published online 2008 Dec 8. doi: 10.4161/cbt.7.12.6945
PMCID:
PMC2683365
AbstractArticlePDF–512K

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