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Select item 77540381.

Functional genetic variant of HSD17B12 in the fatty acid biosynthesis pathway predicts the outcome of colorectal cancer

Yu Lin, Yixuan Meng, Jinying Zhang, Ling Ma, Lu Jiang, Yi Zhang, Ming Yuan, Anjing Ren, Weiyou Zhu, Shuwei Li, Yongqian Shu, Mulong Du, Lingjun Zhu

J Cell Mol Med. 2020 Dec; 24(24): 14160–14170. Published online 2020 Oct 28. doi: 10.1111/jcmm.16026

PMCID:: PMC7754038

Abstract Article PDF–1.0M

Select item 72306042.

An Integrative Phenotype–Genotype Approach Using Phenotypic Characteristics from the UAE National Diabetes Study Identifies HSD17B12 as a Candidate Gene for Obesity and Type 2 Diabetes

Mahmood Y. Hachim, Hayat Aljaibeji, Rifat A. Hamoudi, Ibrahim Y. Hachim, Noha M. Elemam, Abdul Khader Mohammed, Albert Salehi, Jalal Taneera, Nabil Sulaiman

Genes (Basel) 2020 Apr; 11(4): 461. Published online 2020 Apr 23. doi: 10.3390/genes11040461

PMCID:: PMC7230604

Abstract Article PDF–3.2M

Select item 71092003.

Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration

Maria Tsachaki, Pirmin Strauss, Anja Dunkel, Hana Navrátilová, Natasa Mladenovic, Alex Odermatt

Cell Mol Life Sci. 2020 Mar; 77(6): 1153–1175. Published online 2019 Jul 13. doi: 10.1007/s00018-019-03227-w

PMCID:: PMC7109200

Abstract Article PDF–6.6M

Select item 70553534.

Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses

Bassim Mohamed, Clément Mazeaud, Martin Baril, Donald Poirier, Aïssatou Aïcha Sow, Laurent Chatel-Chaix, Vladimir Titorenko, Daniel Lamarre

Sci Rep. 2020; 10: 4040. Published online 2020 Mar 4. doi: 10.1038/s41598-020-61051-w

PMCID:: PMC7055353

Abstract Article PDF–2.0M

Select item 60671285.

Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung

Joseph H Ashmore, Shaman Luo, Christy J W Watson, Philip Lazarus

Carcinogenesis. 2018 Jul; 39(8): 1079–1088. Published online 2018 May 17. doi: 10.1093/carcin/bgy065

PMCID:: PMC6067128

Abstract Article PDF–1.1M

Select item 36074336.

17β hydroxysteroid dehydrogenase type 12 (HSD17B12) is a marker of poor prognosis in ovarian carcinoma

Marta Szajnik, Miroslaw J. Szczepanski, Esther Elishaev, Carmen Visus, Diana Lenzner, Maciej Zabel, Marta Glura, Albert B. DeLeo, Theresa L. Whiteside

Gynecol Oncol. Author manuscript; available in PMC 2013 Dec 1.

Published in final edited form as: Gynecol Oncol. 2012 Dec; 127(3): 587–594. Published online 2012 Aug 17. doi: 10.1016/j.ygyno.2012.08.010

PMCID:: PMC3607433

Abstract Article PDF–1.7M

Select item 34088917.

Identification of Hydroxysteroid (17β) dehydrogenase type 12 (HSD17B12) as a CD8⁺ T-cell-defined human tumor antigen of human carcinomas

Carmen Visus, Diasuke Ito, Rajiv Dhir, Miroslaw J. Szczepanski, Yoo Jung Chang, Jean J. Latimer, Stephen G. Grant, Albert B. DeLeo

Cancer Immunol Immunother. 2011 Jul; 60(7): 919–929. Published online 2011 Mar 16. doi: 10.1007/s00262-011-1001-y

PMCID:: PMC3408891

Abstract Article PDF–1.0M

Select item 92039428.

Genetic variants in CYP2B6 and HSD17B12 associated with the risk of squamous cell carcinoma of the head and neck

Hongliang Liu, Guojun Li, Erich M. Sturgis, Sanjay Shete, Kristina R. Dahlstrom, Mulong Du, Christopher I. Amos, David C. Christiani, Philip Lazarus, Qingyi Wei

Int J Cancer. Author manuscript; available in PMC 2023 Aug 15.

Published in final edited form as: Int J Cancer. 2022 Aug 15; 151(4): 553–564. Published online 2022 May 7. doi: 10.1002/ijc.34023

PMCID:: PMC9203942

Abstract Article PDF–1.2M

Select item 68247219.

Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival

Wei Dai, Hongliang Liu, Xinyuan Xu, Ge Jie, Sheng Luo, Dakai Zhu, Christopher I. Amos, Shenying Fang, Jeffrey E. Lee, Xin Li, Hongmei Nan, Chunying Li, Qingyi Wei

Int J Cancer. Author manuscript; available in PMC 2019 Nov 15.

Published in final edited form as: Int J Cancer. 2019 Nov 15; 145(10): 2619–2628. Published online 2019 Feb 20. doi: 10.1002/ijc.32194

PMCID:: PMC6824721

Abstract Article PDF–508K

Select item 408693710.

Two Modes of Regulation of the Fatty Acid Elongase ELOVL6 by the 3-Ketoacyl-CoA Reductase KAR in the Fatty Acid Elongation Cycle

Tatsuro Naganuma, Akio Kihara

PLoS One. 2014; 9(7): e101823. Published online 2014 Jul 8. doi: 10.1371/journal.pone.0101823

PMCID:: PMC4086937

Abstract Article PDF–1.5M

Select item 377280411.

Genetic Effects on DNA Methylation and Its Potential Relevance for Obesity in Mexican Americans

Melanie A. Carless, Hemant Kulkarni, Mark Z. Kos, Jac Charlesworth, Juan M. Peralta, Harald H. H. Göring, Joanne E. Curran, Laura Almasy, Thomas D. Dyer, Anthony G. Comuzzie, Michael C. Mahaney, John Blangero

PLoS One. 2013; 8(9): e73950. Published online 2013 Sep 13. doi: 10.1371/journal.pone.0073950

PMCID:: PMC3772804

Abstract Article PDF–218K

Select item 414009312.

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Daan W. Loth, María Soler Artigas, Sina A. Gharib, Louise V. Wain, Nora Franceschini, Beate Koch, Tess Pottinger, Albert Vernon Smith, Qing Duan, Chris Oldmeadow, Mi Kyeong Lee, David P. Strachan, Alan L. James, Jennifer E. Huffman, Veronique Vitart, Adaikalavan Ramasamy, Nicholas J. Wareham, Jaakko Kaprio, Xin-Qun Wang, Holly Trochet, Mika Kähönen, Claudia Flexeder, Eva Albrecht, Lorna M. Lopez, Kim de Jong, Bharat Thyagarajan, Alexessander Couto Alves, Stefan Enroth, Ernst Omenaas, Peter K. Joshi, Tove Fall, Ana Viňuela, Lenore J. Launer, Laura R. Loehr, Myriam Fornage, Guo Li, Jemma B. Wilk, Wenbo Tang, Ani Manichaikul, Lies Lahousse, Tamara B. Harris, Kari E. North, Alicja R. Rudnicka, Jennie Hui, Xiangjun Gu, Thomas Lumley, Alan F. Wright, Nicholas D. Hastie, Susan Campbell, Rajesh Kumar, Isabelle Pin, Robert A. Scott, Kirsi H. Pietiläinen, Ida Surakka, Yongmei Liu, Elizabeth G. Holliday, Holger Schulz, Joachim Heinrich, Gail Davies, Judith M. Vonk, Mary Wojczynski, Anneli Pouta, Åsa Johansson, Sarah H. Wild, Erik Ingelsson, Fernando Rivadeneira, Henry Völzke, Pirro G. Hysi, Gudny Eiriksdottir, Alanna C. Morrison, Jerome I. Rotter, Wei Gao, Dirkje S. Postma, Wendy B. White, Stephen S. Rich, Albert Hofman, Thor Aspelund, David Couper, Lewis J. Smith, Bruce M. Psaty, Kurt Lohman, Esteban G. Burchard, André G. Uitterlinden, Melissa Garcia, Bonnie R. Joubert, Wendy L. McArdle, A. Bill Musk, Nadia Hansel, Susan R. Heckbert, Lina Zgaga, Joyce B.J. van Meurs, Pau Navarro, Igor Rudan, Yeon-Mok Oh, Susan Redline, Deborah Jarvis, Jing Hua Zhao, Taina Rantanen, George T. O’Connor, Samuli Ripatti, Rodney J. Scott, Stefan Karrasch, Harald Grallert, Nathan C. Gaddis, John M. Starr, Cisca Wijmenga, Ryan L. Minster, David J. Lederer, Juha Pekkanen, Ulf Gyllensten, Harry Campbell, Andrew P. Morris, Sven Gläser, Christopher J. Hammond, Kristin M. Burkart, John Beilby, Stephen B. Kritchevsky, Vilmundur Gudnason, Dana B. Hancock, O. Dale Williams, Ozren Polasek, Tatijana Zemunik, Ivana Kolcic, Marcy F. Petrini, Matthias Wjst, Woo Jin Kim, David J. Porteous, Generation Scotland, Blair H. Smith, Anne Viljanen, Markku Heliövaara, John R. Attia, Ian Sayers, Regina Hampel, Christian Gieger, Ian J. Deary, H. Marike Boezen, Anne Newman, Marjo-Riitta Jarvelin, James F. Wilson, Lars Lind, Bruno H. Stricker, Alexander Teumer, Timothy D. Spector, Erik Melén, Marjolein J. Peters, Leslie A. Lange, R. Graham Barr, Ken R. Bracke, Fien M. Verhamme, Joohon Sung, Pieter S. Hiemstra, Patricia A. Cassano, Akshay Sood, Caroline Hayward, Josée Dupuis, Ian P. Hall, Guy G. Brusselle, Martin D. Tobin, Stephanie J. London

Nat Genet. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Nat Genet. 2014 Jul; 46(7): 669–677. Published online 2014 Jun 15. doi: 10.1038/ng.3011

PMCID:: PMC4140093

Abstract Article PDF–826K

Select item 345929213.

Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma

Sharon J Diskin, Mario Capasso, Robert W Schnepp, Kristina A Cole, Edward F Attiyeh, Cuiping Hou, Maura Diamond, Erica L Carpenter, Cynthia Winter, Hanna Lee, Jayanti Jagannathan, Valeria Latorre, Achille Iolascon, Hakon Hakonarson, Marcella Devoto, John M Maris

Nat Genet. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: Nat Genet. 2012 Oct; 44(10): 1126–1130. Published online 2012 Sep 2. doi: 10.1038/ng.2387

PMCID:: PMC3459292

Abstract Article PDF–787K

Select item 387961414.

Elucidating Novel Hepatitis C Virus–Host Interactions Using Combined Mass Spectrometry and Functional Genomics Approaches

Marie-Anne Germain, Laurent Chatel-Chaix, Bridget Gagné, Éric Bonneil, Pierre Thibault, Fabrine Pradezynski, Benoît de Chassey, Laurène Meyniel-Schicklin, Vincent Lotteau, Martin Baril, Daniel Lamarre

Mol Cell Proteomics. 2014 Jan; 13(1): 184–203. Published online 2013 Oct 29. doi: 10.1074/mcp.M113.030155

PMCID:: PMC3879614

Abstract Article PDF–4.7M

Select item 444778615.

A novel common variant in DCST2 is associated with length in early life and height in adulthood

Ralf J.P. van der Valk, Eskil Kreiner-Møller, Marjolein N. Kooijman, Mònica Guxens, Evangelia Stergiakouli, Annika Sääf, Jonathan P. Bradfield, Frank Geller, M. Geoffrey Hayes, Diana L. Cousminer, Antje Körner, Elisabeth Thiering, John A. Curtin, Ronny Myhre, Ville Huikari, Raimo Joro, Marjan Kerkhof, Nicole M. Warrington, Niina Pitkänen, Ioanna Ntalla, Momoko Horikoshi, Riitta Veijola, Rachel M. Freathy, Yik-Ying Teo, Sheila J. Barton, David M. Evans, John P. Kemp, Beate St Pourcain, Susan M. Ring, George Davey Smith, Anna Bergström, Inger Kull, Hakon Hakonarson, Frank D. Mentch, Hans Bisgaard, Bo Chawes, Jakob Stokholm, Johannes Waage, Patrick Eriksen, Astrid Sevelsted, Mads Melbye, Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Cornelia M. van Duijn, Carolina Medina-Gomez, Albert Hofman, Johan C. de Jongste, H. Rob Taal, André G. Uitterlinden, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Loren L. Armstrong, Johan Eriksson, Aarno Palotie, Mariona Bustamante, Xavier Estivill, Juan R. Gonzalez, Sabrina Llop, Wieland Kiess, Anubha Mahajan, Claudia Flexeder, Carla M.T. Tiesler, Clare S. Murray, Angela Simpson, Per Magnus, Verena Sengpiel, Anna-Liisa Hartikainen, Sirkka Keinanen-Kiukaanniemi, Alexandra Lewin, Alexessander Da Silva Couto Alves, Alexandra I. Blakemore, Jessica L. Buxton, Marika Kaakinen, Alina Rodriguez, Sylvain Sebert, Marja Vaarasmaki, Timo Lakka, Virpi Lindi, Ulrike Gehring, Dirkje S. Postma, Wei Ang, John P. Newnham, Leo-Pekka Lyytikäinen, Katja Pahkala, Olli T. Raitakari, Kalliope Panoutsopoulou, Eleftheria Zeggini, Dorret I. Boomsma, Maria Groen-Blokhuis, Jorma Ilonen, Lude Franke, Joel N. Hirschhorn, Tune H. Pers, Liming Liang, Jinyan Huang, Berthold Hocher, Mikael Knip, Seang-Mei Saw, John W. Holloway, Erik Melén, Struan F.A. Grant, Bjarke Feenstra, William L. Lowe, Elisabeth Widén, Elena Sergeyev, Harald Grallert, Adnan Custovic, Bo Jacobsson, Marjo-Riitta Jarvelin, Mustafa Atalay, Gerard H. Koppelman, Craig E. Pennell, Harri Niinikoski, George V. Dedoussis, Mark I. Mccarthy, Timothy M. Frayling, Jordi Sunyer, Nicholas J. Timpson, Fernando Rivadeneira, Klaus Bønnelykke, Vincent W.V. Jaddoe

Hum Mol Genet. 2015 Feb 15; 24(4): 1155–1168. Published online 2014 Oct 3. doi: 10.1093/hmg/ddu510

PMCID:: PMC4447786

Abstract Article PDF–539K

Select item 297300216.

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Yusuke Ohno, Shota Suto, Masao Yamanaka, Yukiko Mizutani, Susumu Mitsutake, Yasuyuki Igarashi, Takayuki Sassa, Akio Kihara

Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43): 18439–18444. Published online 2010 Oct 11. doi: 10.1073/pnas.1005572107

PMCID:: PMC2973002

Abstract Article PDF–1.2M

Select item 558282717.

Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle

Taner Dogan, Florian Gnad, Jocelyn Chan, Lilian Phu, Amy Young, Mark J. Chen, Sophia Doll, Matthew P. Stokes, Marcia Belvin, Lori S. Friedman, Donald S. Kirkpatrick, Klaus P. Hoeflich, Georgia Hatzivassiliou

J Biol Chem. 2017 Sep 1; 292(35): 14311–14324. Published online 2017 Jun 27. doi: 10.1074/jbc.M117.792754

PMCID:: PMC5582827

Abstract Article PDF–2.0M

Select item 713853718.

Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism

Johanna Hietamäki, Louise C Gregory, Sandy Ayoub, Anna-Pauliina Iivonen, Kirsi Vaaralahti, Xiaonan Liu, Nina Brandstack, Andrew J Buckton, Tiina Laine, Johanna Känsäkoski, Matti Hero, Päivi J Miettinen, Markku Varjosalo, Emma Wakeling, Mehul T Dattani, Taneli Raivio

J Clin Endocrinol Metab. 2020 Jun; 105(6): 1748–1758. Published online 2020 Feb 15. doi: 10.1210/clinem/dgaa078

PMCID:: PMC7138537

Abstract Article

Select item 676379119.

Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome

Ahmed Sharaf, Leonore Mensching, Christina Keller, Sebastian Rading, Marina Scheffold, Lysann Palkowitsch, Nevena Djogo, Meriem Rezgaoui, Hans A. Kestler, Barbara Moepps, Antonio Virgilio Failla, Meliha Karsak

Front Mol Neurosci. 2019; 12: 224. Published online 2019 Sep 20. doi: 10.3389/fnmol.2019.00224

PMCID:: PMC6763791

Abstract Article PDF–3.6M

Select item 979335920.

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen

Signal Transduct Target Ther. 2022; 7: 400. Published online 2022 Dec 27. doi: 10.1038/s41392-022-01239-w

PMCID:: PMC9793359

Abstract Article PDF–3.7M

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