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Select item 74694891.

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

Gabriela Andrejeva, Sharon Gowan, Gigin Lin, Anne-Christine LF Wong Te Fong, Elham Shamsaei, Harry G. Parkes, James Mui, Florence I. Raynaud, Yasmin Asad, Gema Vizcay-Barrena, Joanna Nikitorowicz-Buniak, Melanie Valenti, Louise Howell, Roland A. Fleck, Lesley-Ann Martin, Vladimir Kirkin, Martin O. Leach, Yuen-Li Chung

Autophagy. 2020; 16(6): 1044–1060. Published online 2019 Sep 13. doi: 10.1080/15548627.2019.1659608

PMCID:: PMC7469489

Abstract Article PDF–7.6M

Select item 68025262.

Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix

Svetla G. Taneva, Jaeyong Lee, Daniel G. Knowles, Chanajai Tishyadhigama, Hongwen Chen, Rosemary B. Cornell

J Biol Chem. 2019 Oct 18; 294(42): 15517–15530. Published online 2019 Sep 4. doi: 10.1074/jbc.RA119.009849

PMCID:: PMC6802526

Abstract Article PDF–3.2M

Select item 68025243.

Remodeling of the interdomain allosteric linker upon membrane binding of CCTα pulls its active site close to the membrane surface

Daniel G. Knowles, Jaeyong Lee, Svetla G. Taneva, Rosemary B. Cornell

J Biol Chem. 2019 Oct 18; 294(42): 15531–15543. Published online 2019 Sep 4. doi: 10.1074/jbc.RA119.009850

PMCID:: PMC6802524

Abstract Article PDF–2.2M

Select item 63647794.

Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTα impair enzymatic activity and fold stability

Rosemary B. Cornell, Svetla G. Taneva, Melissa K. Dennis, Ronnie Tse, Randeep K. Dhillon, Jaeyong Lee

J Biol Chem. 2019 Feb 1; 294(5): 1490–1501. Published online 2018 Dec 17. doi: 10.1074/jbc.RA118.006457

PMCID:: PMC6364779

Abstract Article PDF–3.2M

Select item 53923605.

Mutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy

Francesco Testa, Mariaelena Filippelli, Raffaella Brunetti-Pierri, Giuseppina Di Fruscio, Valentina Di Iorio, Mariateresa Pizzo, Annalaura Torella, Maria Rosaria Barillari, Vincenzo Nigro, Nicola Brunetti-Pierri, Francesca Simonelli, Sandro Banfi

Eur J Hum Genet. 2017 May; 25(5): 651–655. Published online 2017 Mar 8. doi: 10.1038/ejhg.2017.23

PMCID:: PMC5392360

Abstract Article PDF–1.7M

Select item 40665276.

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease

Felicity Payne, Koini Lim, Amandine Girousse, Rebecca J. Brown, Nora Kory, Ann Robbins, Yali Xue, Alison Sleigh, Elaine Cochran, Claire Adams, Arundhati Dev Borman, David Russel-Jones, Phillip Gorden, Robert K. Semple, Vladimir Saudek, Stephen O’Rahilly, Tobias C. Walther, Inês Barroso, David B. Savage

Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24): 8901–8906. Published online 2014 Jun 2. doi: 10.1073/pnas.1408523111

PMCID:: PMC4066527

Abstract Article PDF–1.1M

Select item 38829137.

Mutations in PCYT1A Cause Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy

Guilherme L. Yamamoto, Wagner A.R. Baratela, Tatiana F. Almeida, Monize Lazar, Clara L. Afonso, Maria K. Oyamada, Lisa Suzuki, Luiz A.N. Oliveira, Ester S. Ramos, Chong A. Kim, Maria Rita Passos-Bueno, Débora R. Bertola

Am J Hum Genet. 2014 Jan 2; 94(1): 113–119. doi: 10.1016/j.ajhg.2013.11.022

PMCID:: PMC3882913

Abstract Article PDF–1.1M

Select item 38827278.

Mutations in PCYT1A, Encoding a Key Regulator of Phosphatidylcholine Metabolism, Cause Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy

Julie Hoover-Fong, Nara Sobreira, Julie Jurgens, Peggy Modaff, Carrie Blout, Ann Moser, Ok-Hwa Kim, Tae-Joon Cho, Sung Yoon Cho, Sang Jin Kim, Dong-Kyu Jin, Hiroshi Kitoh, Woong-Yang Park, Hua Ling, Kurt N. Hetrick, Kimberly F. Doheny, David Valle, Richard M. Pauli

Am J Hum Genet. 2014 Jan 2; 94(1): 105–112. doi: 10.1016/j.ajhg.2013.11.018

PMCID:: PMC3882727

Article PDF–547K

Select item 73467259.

Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets

Lambert Yue, Michael J. McPhee, Kevin Gonzalez, Mark Charman, Jonghwa Lee, Jordan Thompson, Dirk F. H. Winkler, Rosemary B. Cornell, Steven Pelech, Neale D. Ridgway

Mol Biol Cell. 2020 May 1; 31(10): 1047–1059. doi: 10.1091/mbc.E20-01-0014

PMCID:: PMC7346725

Abstract Article PDF–2.6M

Select item 177092810.

CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population

James O Ebot Enaw, Huiping Zhu, Wei Yang, Wei Lu, Gary M Shaw, Edward J Lammer, Richard H Finnell

BMC Med. 2006; 4: 36. Published online 2006 Dec 21. doi: 10.1186/1741-7015-4-36

PMCID:: PMC1770928

Abstract Article PDF–243K

Select item 121852511.

Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions.

J Yang, J Wang, I Tseu, M Kuliszewski, W Lee, M Post

Biochem J. 1997 Jul 1; 325(Pt 1): 29–38. doi: 10.1042/bj3250029

PMCID:: PMC1218525

Summary PDF–584K

Select item 13391312.

Caspase Processing and Nuclear Export of CTP:Phosphocholine Cytidylyltransferase α during Farnesol-Induced Apoptosis

Thomas A. Lagace, Jessica R. Miller, Neale D. Ridgway

Mol Cell Biol. 2002 Jul; 22(13): 4851–4862. doi: 10.1128/MCB.22.13.4851-4862.2002

PMCID:: PMC133913

Abstract Article PDF–644K

Select item 648399313.

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair

Steven E. Guard, Zachary C. Poss, Christopher C. Ebmeier, Maria Pagratis, Helen Simpson, Dylan J. Taatjes, William M. Old

Sci Rep. 2019; 9: 6539. Published online 2019 Apr 25. doi: 10.1038/s41598-019-42990-5

PMCID:: PMC6483993

Abstract Article PDF–2.2M

Select item 723200914.

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress

Jiaojiao Yu, Tao Li, Yu Liu, Xi Wang, Jianchao Zhang, Xi'e Wang, Guizhi Shi, Jizhong Lou, Likun Wang, Chih‐chen Wang, Lei Wang

EMBO J. 2020 May 18; 39(10): e103841. Published online 2020 Mar 9. doi: 10.15252/embj.2019103841

PMCID:: PMC7232009

Abstract Article PDF–5.5M

Select item 563877015.

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer

Namgyu Lee, Dae-Kyum Kim, Seung Hyun Han, Hye Guk Ryu, Sung Jin Park, Kyong-Tai Kim, Kwan Yong Choi

Mol Cells. 2017 Sep 30; 40(9): 621–631. Published online 2017 Sep 20. doi: 10.14348/molcells.2017.0108

PMCID:: PMC5638770

Abstract Article PDF–2.9M

Select item 773761016.

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

EMBO J. 2020 Dec 15; 39(24): e104948. Published online 2020 Nov 23. doi: 10.15252/embj.2020104948

PMCID:: PMC7737610

Abstract Article PDF–3.7M

Select item 729072117.

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation

Danielle G. May, Kelsey L. Scott, Alexandre R. Campos, Kyle J. Roux

Cells. 2020 May; 9(5): 1070. Published online 2020 Apr 25. doi: 10.3390/cells9051070

PMCID:: PMC7290721

Abstract Article PDF–9.2M

Select item 889438018.

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing

Alexandra Bergfort, Marco Preußner, Benno Kuropka, İbrahim Avşar Ilik, Tarek Hilal, Gert Weber, Christian Freund, Tuğçe Aktaş, Florian Heyd, Markus C. Wahl

Nat Commun. 2022; 13: 1132. Published online 2022 Mar 3. doi: 10.1038/s41467-022-28754-2