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Select item 39385151.

Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target

Jing Li, Sufang Han, Ziliang Qian, Xinying Su, Shuqiong Fan, Jiangang Fu, Yuanjie Liu, Xiaolu Yin, Zeren Gao, Jingchuan Zhang, De-Hua Yu, Qunsheng Ji

Cancer Biol Ther. 2014 Jan 1; 15(1): 128–134. Published online 2013 Nov 19. doi: 10.4161/cbt.27146

PMCID:: PMC3938515

Abstract Article PDF–1.5M

Select item 46140682.

A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size

Xiaoyu Xia, Ankur Gholkar, Silvia Senese, Jorge Z Torres

Cell Cycle. 2015 Jun 15; 14(12): 1938–1947. Published online 2015 Apr 3. doi: 10.1080/15384101.2015.1026487

PMCID:: PMC4614068

Abstract Article PDF–1.0M

Select item 30840963.

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

Daniel A. Bachovchin, Justin T. Mohr, Anna E. Speers, Chu Wang, Jacob M. Berlin, Timothy P. Spicer, Virneliz Fernandez-Vega, Peter Chase, Peter S. Hodder, Stephan C. Schürer, Daniel K. Nomura, Hugh Rosen, Gregory C. Fu, Benjamin F. Cravatt

Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17): 6811–6816. Published online 2011 Mar 11. doi: 10.1073/pnas.1015248108

PMCID:: PMC3084096

Abstract Article PDF–2.2M

Select item 110989614.

The luciferase-based in vivo protein–protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction

Sana Ando, Keiko Tanaka, Maharu Matsumoto, Yuki Oyama, Yuri Tomabechi, Atsushi Yamagata, Mikako Shirouzu, Reiko Nakagawa, Noriaki Okimoto, Makoto Taiji, Koichi Sato, Takashi Ohama

J Biol Chem. 2024 May; 300(5): 107277. Published online 2024 Apr 6. doi: 10.1016/j.jbc.2024.107277

PMCID:: PMC11098961

Abstract Article PDF–1.2M

Select item 102574115.

PP2A methylesterase PME‐1 suppresses anoikis and is associated with therapy relapse of PTEN‐deficient prostate cancers

Anna Aakula, Aleksi Isomursu, Christian Rupp, Andrew Erickson, Nikhil Gupta, Otto Kauko, Pragya Shah, Artur Padzik, Yuba Raj Pokharel, Amanpreet Kaur, Song‐Ping Li, Lloyd Trotman, Pekka Taimen, Antti Rannikko, Jan Lammerding, Ilkka Paatero, Tuomas Mirtti, Johanna Ivaska, Jukka Westermarck

Mol Oncol. 2023 Jun; 17(6): 1007–1023. Published online 2023 Apr 18. doi: 10.1002/1878-0261.13353

PMCID:: PMC10257411

Abstract Article PDF–2.0M

Select item 71838676.

DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p

Tao Xu, Ting Lei, Si-Qiao Li, Er-Hui Mai, Fei-Hu Ding, Bin Niu

World J Gastroenterol. 2020 Apr 21; 26(15): 1745–1757. Published online 2020 Apr 21. doi: 10.3748/wjg.v26.i15.1745

PMCID:: PMC7183867

Abstract Article PDF–12M

Select item 68744737.

Glycogen synthase kinase-3β suppresses the expression of protein phosphatase methylesterase-1 through β-catenin

Nana Jin, Ruirui Shi, Yanli Jiang, Dandan Chu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu

Aging (Albany NY) 2019 Nov 15; 11(21): 9672–9688. Published online 2019 Nov 12. doi: 10.18632/aging.102413

PMCID:: PMC6874473

Abstract Article PDF–2.9M

Select item 54134028.

NNMT silencing activates tumor suppressor PP2A, inactivates oncogenic STKs and inhibits tumor forming ability

Kamalakannan Palanichamy, Suman Kanji, Nicolaus Gordon, Krishnan Thirumoorthy, John R. Jacob, Kevin T. Litzenberg, Disha Patel, Arnab Chakravarti

Clin Cancer Res. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Clin Cancer Res. 2017 May 1; 23(9): 2325–2334. Published online 2016 Nov 3. doi: 10.1158/1078-0432.CCR-16-1323

PMCID:: PMC5413402

Abstract Article PDF–2.1M

Select item 71053179.

Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1

Otto Kauko, Susumu Y. Imanishi, Evgeny Kulesskiy, Laxman Yetukuri, Teemu Daniel Laajala, Mukund Sharma, Karolina Pavic, Anna Aakula, Christian Rupp, Mikael Jumppanen, Pekka Haapaniemi, Luyao Ruan, Bhagwan Yadav, Veronika Suni, Taru Varila, Garry L. Corthals, Jüri Reimand, Krister Wennerberg, Tero Aittokallio, Jukka Westermarck

J Biol Chem. 2020 Mar 27; 295(13): 4194–4211. Published online 2020 Feb 18. doi: 10.1074/jbc.RA119.011265

PMCID:: PMC7105317

Abstract Article PDF–3.4M

Select item 328165610.

Identification and Characterization of an Alternatively Spliced Isoform of the Human Protein Phosphatase 2Aα Catalytic Subunit

Deivid L. S. Migueleti, Juliana H. C. Smetana, Hugo F. Nunes, Jörg Kobarg, Nilson I. T. Zanchin

J Biol Chem. 2012 Feb 10; 287(7): 4853–4862. Published online 2011 Dec 13. doi: 10.1074/jbc.M111.283341

PMCID:: PMC3281656

Abstract Article PDF–1.8M

Select item 281034711.

PME-1 protects ERK pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

Pietri Puustinen, Melissa R. Junttila, Sari Vanhatupa, Anna A. Sablina, Melissa E. Hector, Kaisa Teittinen, Olayinka Raheem, Kirsi Ketola, Shujun Lin, Juergen Kast, Hannu Haapasalo, William C. Hahn, Jukka Westermarck

Cancer Res. Author manuscript; available in PMC 2010 Apr 1.

Published in final edited form as: Cancer Res. 2009 Apr 1; 69(7): 2870–2877. Published online 2009 Mar 17. doi: 10.1158/0008-5472.CAN-08-2760

PMCID:: PMC2810347

Abstract Article PDF–1.0M

Select item 350331212.

A Protein Phosphatase Methylesterase (PME-1) Is One of Several Novel Proteins Stably Associating with Two Inactive Mutants of Protein Phosphatase 2A

Egon Ogris, Xianxing Du, Kasey C. Nelson, Elsa K. Mak, Xing Xian Yu, William S. Lane, David C. Pallas

J Biol Chem. Author manuscript; available in PMC 2012 Nov 21.

Published in final edited form as: J Biol Chem. 1999 May 14; 274(20): 14382–14391. doi: 10.1074/jbc.274.20.14382

PMCID:: PMC3503312

Abstract Article PDF–1.8M

Select item 411031413.

Interaction between Salt-inducible Kinase 2 and Protein Phosphatase 2A Regulates the Activity of Calcium/Calmodulin-dependent Protein Kinase I and Protein Phosphatase Methylesterase-1

Chia-Wei Lee, Fu-Chia Yang, Hsin-Yun Chang, Hanyi Chou, Bertrand Chin-Ming Tan, Sheng-Chung Lee

J Biol Chem. 2014 Jul 25; 289(30): 21108–21119. Published online 2014 May 19. doi: 10.1074/jbc.M113.540229

PMCID:: PMC4110314

Abstract Article PDF–2.3M

Select item 988565014.

Long non-coding RNA SLC25A21-AS1 inhibits the development of epithelial ovarian cancer by specifically inducing PTBP3 degradation

Sihui Li, Shizhen Shen, Wanzhong Ge, Yixuan Cen, Songfa Zhang, Xiaodong Cheng, Xinyu Wang, Xing Xie, Weiguo Lu

Biomark Res. 2023; 11: 12. Published online 2023 Jan 30. doi: 10.1186/s40364-022-00432-x

Correction in:: Biomark Res. 2024; 12: 108.

PMCID:: PMC9885650

Abstract Article PDF–11M

Select item 262100415.

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

Marilyn Goudreault, Lisa M. D’Ambrosio, Michelle J. Kean, Michael J. Mullin, Brett G. Larsen, Amy Sanchez, Sidharth Chaudhry, Ginny I. Chen, Frank Sicheri, Alexey I. Nesvizhskii, Ruedi Aebersold, Brian Raught, Anne-Claude Gingras

Mol Cell Proteomics. 2009 Jan; 8(1): 157–171. doi: 10.1074/mcp.M800266-MCP200

PMCID:: PMC2621004

Abstract Article PDF–641K

Select item 476262216.

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein–Protein Interaction Data

Yuba Raj Pokharel, Jani Saarela, Agnieszka Szwajda, Christian Rupp, Anne Rokka, Shibendra Kumar Lal Karna, Kaisa Teittinen, Garry Corthals, Olli Kallioniemi, Krister Wennerberg, Tero Aittokallio, Jukka Westermarck

Mol Cell Proteomics. 2015 Dec; 14(12): 3274–3283. Published online 2015 Oct 23. doi: 10.1074/mcp.M115.050773

PMCID:: PMC4762622

Abstract Article PDF–1.4M

Select item 562727517.

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

Zhen-Dong Xiao, Leng Han, Hyemin Lee, Li Zhuang, Yilei Zhang, Joelle Baddour, Deepak Nagrath, Christopher G. Wood, Jian Gu, Xifeng Wu, Han Liang, Boyi Gan

Nat Commun. 2017; 8: 783. Published online 2017 Oct 4. doi: 10.1038/s41467-017-00902-z

PMCID:: PMC5627275

Abstract Article PDF–1.1M

Select item 264417418.

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

Timo Glatter, Alexander Wepf, Ruedi Aebersold, Matthias Gstaiger

Mol Syst Biol. 2009; 5: 237. Published online 2009 Jan 20. doi: 10.1038/msb.2008.75

PMCID:: PMC2644174

Abstract Article PDF–4.5M

Select item 664638719.

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

Kerrie-Ann McMahon, Yeping Wu, Yann Gambin, Emma Sierecki, Vikas A. Tillu, Thomas Hall, Nick Martel, Satomi Okano, Shayli Varasteh Moradi, Jayde E. Ruelcke, Charles Ferguson, Alpha S. Yap, Kirill Alexandrov, Michelle M. Hill, Robert G. Parton

Nat Commun. 2019; 10: 3279. Published online 2019 Jul 22. doi: 10.1038/s41467-019-11111-1

PMCID:: PMC6646387

Abstract Article PDF–7.0M

Select item 122409120.

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.

Mercedes Pozuelo Rubio, Kathryn M Geraghty, Barry H C Wong, Nicola T Wood, David G Campbell, Nick Morrice, Carol Mackintosh

Biochem J. 2004 Apr 15; 379(Pt 2): 395–408. doi: 10.1042/BJ20031797

PMCID:: PMC1224091

Summary PDF–323K

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PMC Links for Gene (Select 51400) (54)
PMC
hypothetical protein HMPREF9981_00296 [Staphylococcus epidermidis NIHLM020]
hypothetical protein HMPREF9981_00296 [Staphylococcus epidermidis NIHLM020]
gi|394268551|gb|EJE13107.1||gnl|WGS |HMPREF9981_00296

Protein
Homo sapiens protein phosphatase methylesterase 1 (PPME1), transcript variant 2,...
Homo sapiens protein phosphatase methylesterase 1 (PPME1), transcript variant 2, mRNA
gi|1676319940|ref|NM_001271593.2|

Nucleotide
JR316_0002738 [Psilocybe cubensis]
JR316_0002738 [Psilocybe cubensis]
Gene ID:71969059

Gene

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