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Select item 91998721.

Population genetics of PDE4B (phosphodiesterase‐4B) in neglected Native Americans: Implications for cancer pharmacogenetics

Rennan Garcias Moreira, Julia Maria Saraiva‐Duarte, Alexandre Costa Pereira, Martha Sosa‐Macias, Carlos Galaviz‐Hernandez, Meddly Lesley Santolalla, Wagner C. S. Magalhães, Camila Zolini, Thiago Peixoto Leal, Zsolt Balázs, Adrián Llerena, Robert H. Gilman, José Geraldo Mill, Victor Borda, Heinner Guio, Timothy D. O’Connor, Eduardo Tarazona‐Santos, Fernanda Rodrigues‐Soares

Clin Transl Sci. 2022 Jun; 15(6): 1400–1405. Published online 2022 Mar 28. doi: 10.1111/cts.13266

PMCID:: PMC9199872

Abstract Article PDF–889K

Select item 68071822.

Expression of Phosphodiesterase 4B cAMP‐Specific Gene in Subjects With Cryptorchidism and Down's Syndrome

Michele Salemi, Rosita A. Condorelli, Sandro La Vignera, Roberto Castiglione, Maria Grazia Salluzzo, Carmela M. Bonaccorso, Mirella Vinci, Paolo Bosco, Carmelo Romano, Cristina Campagna, Corrado Romano, Aldo E. Calogero

J Clin Lab Anal. 2016 May; 30(3): 196–199. Published online 2014 Dec 26. doi: 10.1002/jcla.21835

PMCID:: PMC6807182

Abstract Article PDF–482K

Select item 66731243.

Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels

Hannah Murdoch, Shaun Mackie, Daniel M. Collins, Elaine V. Hill, Graeme B. Bolger, Enno Klussmann, David J. Porteous, J. Kirsty Millar, Miles D. Houslay

J Neurosci. 2007 Aug 29; 27(35): 9513–9524. doi: 10.1523/JNEUROSCI.1493-07.2007

PMCID:: PMC6673124

Abstract Article PDF–5.9M

Select item 65377924.

Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study

Sandra M. Meier, Kalevi Trontti, Kirstin L. Purves, Thomas Damm Als, Jakob Grove, Mikaela Laine, Marianne Giørtz Pedersen, Jonas Bybjerg-Grauholm, Marie Bækved-Hansen, Ewa Sokolowska, Preben B. Mortensen, David M. Hougaard, Thomas Werge, Merete Nordentoft, Gerome Breen, Anders D. Børglum, Thalia C. Eley, Iiris Hovatta, Manuel Mattheisen, Ole Mors

JAMA Psychiatry. 2019 Sep; 76(9): 924–932. Published online 2019 May 22. doi: 10.1001/jamapsychiatry.2019.1119

PMCID:: PMC6537792

Abstract Article

Select item 47105085.

Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies

Yanguo Feng, Dejun Cheng, Chaofeng Zhang, Yuchun Li, Zhiying Zhang, Juan Wang, Yuzhong Shi

PLoS One. 2016; 11(1): e0147092. Published online 2016 Jan 12. doi: 10.1371/journal.pone.0147092

PMCID:: PMC4710508

Abstract Article PDF–1.8M

Select item 46512106.

Gene Set Enrichment Analysis Unveils the Mechanism for the Phosphodiesterase 4B Control of Glucocorticoid Response in B-cell Lymphoma

Sang-Woo Kim, Deepak Rai, Ricardo C.T. Aguiar

Clin Cancer Res. Author manuscript; available in PMC 2015 Nov 18.

Published in final edited form as: Clin Cancer Res. 2011 Nov 1; 17(21): 6723–6732. Published online 2011 Jul 8. doi: 10.1158/1078-0432.CCR-11-0770

PMCID:: PMC4651210

Abstract Article PDF–986K

Select item 31286727.

Insight into the Phosphodiesterase Mechanism from Combined QM/MM Free Energy Simulations

Kin-Yiu Wong, Jiali Gao

FEBS J. Author manuscript; available in PMC 2012 Jul 1.

Published in final edited form as: FEBS J. 2011 Jul; 278(14): 2579–2595. Published online 2011 Jun 14. doi: 10.1111/j.1742-4658.2011.08187.x

PMCID:: PMC3128672

Abstract Article PDF–2.6M

Select item 29292398.

An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing

Keven R Johnson, Jessie Nicodemus-Johnson, Robert S Danziger

BMC Evol Biol. 2010; 10: 247. Published online 2010 Aug 11. doi: 10.1186/1471-2148-10-247

PMCID:: PMC2929239

Abstract Article PDF–1.8M

Select item 25759099.

Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease

Leila Gobejishvili, Shirish Barve, Swati Joshi-Barve, Craig McClain

Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4): G718–G724. Published online 2008 Aug 7. doi: 10.1152/ajpgi.90232.2008

PMCID:: PMC2575909

Abstract Article

Select item 237408810.

Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B

Wei Zhang, Hengming Ke, Anna P. Tretiakova, Bradford Jameson, Robert W. Colman

Protein Sci. 2001 Aug; 10(8): 1481–1489. doi: 10.1110/ps.6601

PMCID:: PMC2374088

Abstract Article PDF–457K

Select item 26236311.

Regulation of T-Cell Activation by Phosphodiesterase 4B2 Requires Its Dynamic Redistribution during Immunological Synapse Formation

Jacqueline Arp, Mark G. Kirchhof, Miren L. Baroja, Steven H. Nazarian, Thu A. Chau, Craig A. Strathdee, Eric H. Ball, Joaquín Madrenas

Mol Cell Biol. 2003 Nov; 23(22): 8042–8057. doi: 10.1128/MCB.23.22.8042-8057.2003

PMCID:: PMC262363

Abstract Article PDF–658K

Select item 226735312.

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

Huanchen Wang, Ming-Sheng Peng, Yi Chen, Jie Geng, Howard Robinson, Miles D. Houslay, Jiwen Cai, Hengming Ke

Biochem J. 2007 Dec 1; 408(Pt 2): 193–201. Prepublished online 2007 Aug 30. Published online 2007 Nov 14. doi: 10.1042/BJ20070970

PMCID:: PMC2267353

Abstract Article PDF–1023K

Select item 206452113.

PGE₁ stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

Anna Terrin, Giulietta Di Benedetto, Vanessa Pertegato, York-Fong Cheung, George Baillie, Martin J. Lynch, Nicola Elvassore, Anke Prinz, Friedrich W. Herberg, Miles D. Houslay, Manuela Zaccolo

J Cell Biol. 2006 Nov 6; 175(3): 441–451. doi: 10.1083/jcb.200605050

PMCID:: PMC2064521

Abstract Article PDF–2.2M

Select item 12430514.

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses

S.-L. Catherine Jin, Marco Conti

Proc Natl Acad Sci U S A. 2002 May 28; 99(11): 7628–7633. Published online 2002 May 21. doi: 10.1073/pnas.122041599

PMCID:: PMC124305

Abstract Article PDF–233K

Select item 880624515.

Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson’s disease

Ming-Yu Chen, Kai Fan, Lian-Jiang Zhao, Jie-Mei Wei, Ji-Xu Gao, Zhen-Fu Li

Bioengineered. 2021; 12(1): 708–719. Published online 2021 Feb 22. doi: 10.1080/21655979.2021.1883279

PMCID:: PMC8806245

Abstract Article PDF–2.2M

Select item 876163416.

qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus

Waseem Raza, Jinlei Guo, Muhammad Imran Qadir, Baogang Bai, Syed Aun Muhammad

Front Endocrinol (Lausanne) 2021; 12: 774696. Published online 2022 Jan 3. doi: 10.3389/fendo.2021.774696

PMCID:: PMC8761634

Abstract Article PDF–7.2M

Select item 614327017.

The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer

Jennifer K. Pleiman, Amy A. Irving, Zhishi Wang, Erik Toraason, Linda Clipson, William F. Dove, Dustin A. Deming, Michael A. Newton

PLoS Genet. 2018 Sep; 14(9): e1007611. Published online 2018 Sep 6. doi: 10.1371/journal.pgen.1007611

PMCID:: PMC6143270

Abstract Article PDF–8.4M

Select item 537388918.

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease

Motomasa Tanaka, Koko Ishizuka, Yoko Nekooki-Machida, Ryo Endo, Noriko Takashima, Hideyuki Sasaki, Yusuke Komi, Amy Gathercole, Elaine Huston, Kazuhiro Ishii, Kelvin Kai-Wan Hui, Masaru Kurosawa, Sun-Hong Kim, Nobuyuki Nukina, Eiki Takimoto, Miles D. Houslay, Akira Sawa

J Clin Invest. 2017 Apr 3; 127(4): 1438–1450. Published online 2017 Mar 6. doi: 10.1172/JCI85594