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Items: 1 to 20 of 71

1.
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator
Adrian L Sanborn, Benjamin T Yeh, Jordan T Feigerle, Cynthia V Hao, Raphael JL Townshend, Erez Lieberman Aiden, Ron O Dror, Roger D Kornberg
eLife. 2021; 10: e68068. Published online 2021 Apr 27. doi: 10.7554/eLife.68068
PMCID:
PMC8137143
AbstractArticlePDF–2.6M
2.
MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation
Cristina Batlle, Isabel Calvo, Valentin Iglesias, Cian J. Lynch, Marcos Gil-Garcia, Manuel Serrano, Salvador Ventura
Commun Biol. 2021; 4: 414. Published online 2021 Mar 26. doi: 10.1038/s42003-021-01930-8
PMCID:
PMC7997880
AbstractArticlePDF–2.9M
3.
Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors
Niklas Klümper, Isabella Syring, Anne Offermann, David Adler, Wenzel Vogel, Stefan C. Müller, Jörg Ellinger, Arne Strauß, Heinz Joachim Radzun, Philipp Ströbel, Johannes Brägelmann, Sven Perner, Felix Bremmer
Diagn Pathol. 2015; 10: 165. Published online 2015 Sep 17. doi: 10.1186/s13000-015-0398-6
PMCID:
PMC4573996
AbstractArticlePDF–1.5M
4.
A Rare Partner of TFE3 in the Xp11 Translocation Renal Cell Carcinoma: Clinicopathological Analyses and Detection of MED15-TFE3 Fusion
Hong Ye, Shuming Qin, Ning Li, Min Lin, Yanmei Xu, Xiaomei Li
Biomed Res Int. 2019; 2019: 5974089. Published online 2019 Nov 11. doi: 10.1155/2019/5974089
PMCID:
PMC6881588
AbstractArticlePDF–4.4M
5.
MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling
Anne Offermann, Ignacija Vlasic, Isabella Syring, Wenzel Vogel, Christian Ruiz, Tobias Zellweger, Cyrill A Rentsch, Susanne Hagedorn, Jochen Behrends, Michael Nowak, Axel Merseburger, Lukas Bubendorf, Jutta Kirfel, Stefan Duensing, David Adler, Sven Perner
Oncotarget. 2017 Jan 31; 8(5): 7964–7976. Published online 2016 Dec 10. doi: 10.18632/oncotarget.13860
PMCID:
PMC5352374
AbstractArticlePDF–3.3M
6.
MODULATION OF PLAGL2 TRANSACTIVATION BY POSITIVE COFACTOR 2 (PC2), A COMPONENT OF THE ARC/MEDIATOR COMPLEX
Sara J. Wezensky, Tracey S. Hanks, Michelle J. Wilkison, Mary Cloud Ammons, Daniel W. Siemsen, Katherine A. Gauss
Gene. Author manuscript; available in PMC 2011 Feb 15.
Published in final edited form as: Gene. 2010 Feb 15; 452(1): 22. Published online 2009 Dec 16. doi: 10.1016/j.gene.2009.12.003
PMCID:
PMC2815083
AbstractArticlePDF–2.4M
7.
MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma
Maryam Elahi, Vahid Rakhshan
Sci Rep. 2020; 10: 8475. Published online 2020 May 21. doi: 10.1038/s41598-020-65145-3
PMCID:
PMC7242386
AbstractArticlePDF–2.0M
8.
Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1
Spyros Petrakis, Tamás Raskó, Jenny Russ, Ralf P. Friedrich, Martin Stroedicke, Sean-Patrick Riechers, Katja Muehlenberg, Angeli Möller, Anita Reinhardt, Arunachalam Vinayagam, Martin H. Schaefer, Michael Boutros, Hervé Tricoire, Miguel A. Andrade-Navarro, Erich E. Wanker
PLoS Genet. 2012 Aug; 8(8): e1002897. Published online 2012 Aug 16. doi: 10.1371/journal.pgen.1002897
PMCID:
PMC3420947
AbstractArticlePDF–2.3M
9.
TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple
Runa Zhang, Si-Wei Li, Lijuan Liu, Jun Yang, Guofu Huang, Yi Sang
Oncogenesis. 2020 May; 9(5): 45. Published online 2020 May 7. doi: 10.1038/s41389-020-0229-9
Correction in:
Oncogenesis. 2024 Dec; 13(1): 5.
PMCID:
PMC7206012
AbstractArticlePDF–7.5M
10.
The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator
Fajun Yang, Rosalie DeBeaumont, Sharleen Zhou, Anders M. Näär
Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8): 2339–2344. Published online 2004 Feb 12. doi: 10.1073/pnas.0308676100
PMCID:
PMC356952
AbstractArticlePDF–597K
11.
Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes
Taiki Tsutsui, Rikiya Fukasawa, Kaori Shinmyouzu, Reiko Nakagawa, Kazuyuki Tobe, Aki Tanaka, Yoshiaki Ohkuma
J Biol Chem. 2013 Jul 19; 288(29): 20955–20965. Published online 2013 Jun 9. doi: 10.1074/jbc.M113.486746
PMCID:
PMC3774365
AbstractArticlePDF–1.5M
12.
HIF1A employs CDK8-Mediator to stimulate RNAPII elongation
Matthew D. Galbraith, Mary A. Allen, Claire L. Bensard, Xiaoxing Wang, Marie K. Schwinn, Bo Qin, Henry W. Long, Danette L. Daniels, William C. Hahn, Robin D. Dowell, Joaquín M. Espinosa
Cell. Author manuscript; available in PMC 2014 Jun 6.
Published in final edited form as: Cell. 2013 Jun 6; 153(6): 1327–1339. doi: 10.1016/j.cell.2013.04.048
PMCID:
PMC3681429
AbstractArticlePDF–2.7M
13.
Activator-Mediator binding regulates Mediator-cofactor interactions
Christopher C. Ebmeier, Dylan J. Taatjes
Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25): 11283–11288. Published online 2010 Jun 4. doi: 10.1073/pnas.0914215107
PMCID:
PMC2895140
AbstractArticlePDF–941K
14.
CDK8 is a positive regulator of transcriptional elongation within the serum response network
Aaron J. Donner, Christopher C. Ebmeier, Dylan J. Taatjes, Joaquín M. Espinosa
Nat Struct Mol Biol. Author manuscript; available in PMC 2010 Aug 11.
Published in final edited form as: Nat Struct Mol Biol. 2010 Feb; 17(2): 194–201. Published online 2010 Jan 24. doi: 10.1038/nsmb.1752
PMCID:
PMC2920286
AbstractArticlePDF–2.1M
15.
A novel docking site on Mediator is critical for activation by VP16 in mammalian cells
Gerhard Mittler, Thomas Stühler, Lisa Santolin, Thomas Uhlmann, Elisabeth Kremmer, F. Lottspeich, Lucia Berti, Michael Meisterernst
EMBO J. 2003 Dec 15; 22(24): 6494–6504. doi: 10.1093/emboj/cdg619
PMCID:
PMC291814
AbstractArticlePDF–382K
16.
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3
Krista D Meyer, Aaron J Donner, Matthew T Knuesel, Autumn G York, Joaquín M Espinosa, Dylan J Taatjes
EMBO J. 2008 May 21; 27(10): 1447–1457. Published online 2008 Apr 17. doi: 10.1038/emboj.2008.78
PMCID:
PMC2396395
AbstractArticlePDF–303K
17.
TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
Liang Chen, Guixin Zhu, Eleanor M. Johns, Xiaolu Yang
Nat Commun. 2018; 9: 1223. Published online 2018 Mar 26. doi: 10.1038/s41467-018-03499-z
PMCID:
PMC5964324
AbstractArticlePDF–3.1M
18.
The SCF–Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator
Michael A. Davis, Elizabeth A. Larimore, Brian M. Fissel, Jherek Swanger, Dylan J. Taatjes, Bruce E. Clurman
Genes Dev. 2013 Jan 15; 27(2): 151–156. doi: 10.1101/gad.207720.112
PMCID:
PMC3566307
AbstractArticlePDF–1.2M
19.
Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin
Roy Baas, Ayestha Sijm, Hetty A. A. M. van Teeffelen, Robert van Es, Harmjan R. Vos, H. Th. Marc Timmers
J Biol Chem. 2016 Nov 11; 291(46): 24121–24132. Published online 2016 Oct 4. doi: 10.1074/jbc.M116.748582
PMCID:
PMC5104937
AbstractArticlePDF–4.4M
20.
Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
Gerhard Mittler, Elisabeth Kremmer, H. Th. Marc Timmers, Michael Meisterernst
EMBO Rep. 2001 Sep 15; 2(9): 808–813. doi: 10.1093/embo-reports/kve186
PMCID:
PMC1084041
AbstractArticlePDF–413K

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