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Select item 75087991.

Mutations in GET4 disrupt the transmembrane domain recognition complex pathway

Mitali A. Tambe, Bobby G. Ng, Shino Shimada, Lynne A. Wolfe, David R. Adams, Undiagnosed Diseases Network, William A. Gahl, Michael J. Bamshad, Deborah A. Nickerson, University of Washington Centre for Mendelian Genomics, May C.V. Malicdan, Hudson H. Freeze

J Inherit Metab Dis. Author manuscript; available in PMC 2020 Sep 23.

Published in final edited form as: J Inherit Metab Dis. 2020 Sep; 43(5): 1037–1045. Published online 2020 Jun 3. doi: 10.1002/jimd.12249

PMCID:: PMC7508799

Abstract Article PDF–1.0M

Select item 87482262.

GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein

Kensuke Koike, Takaaki Masuda, Kuniaki Sato, Atsushi Fujii, Hiroaki Wakiyama, Taro Tobo, Junichi Takahashi, Yushi Motomura, Takafumi Nakano, Hideyuki Saito, Yoshihiro Matsumoto, Hajime Otsu, Kazuki Takeishi, Yusuke Yonemura, Koshi Mimori, Takashi Nakagawa

Cancer Sci. 2022 Jan; 113(1): 156–169. Published online 2021 Nov 10. doi: 10.1111/cas.15174

PMCID:: PMC8748226

Abstract Article PDF–2.3M

Select item 37113193.

Nuclear BAG6-UBL4A-GET4 Complex Mediates DNA Damage Signaling and Cell Death

Giedre Krenciute, Shangfeng Liu, Nur Yucer, Yi Shi, Priscilla Ortiz, Qiongming Liu, Beom-Jun Kim, Abiola Ore Odejimi, Mei Leng, Jun Qin, Yi Wang

J Biol Chem. 2013 Jul 12; 288(28): 20547–20557. Published online 2013 May 30. doi: 10.1074/jbc.M112.443416

PMCID:: PMC3711319

Abstract Article PDF–2.3M

Select item 43868984.

Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4

Harry B. Gristick, Meera Rao, Justin W. Chartron, Michael E. Rome, Shu-ou Shan, William M. Clemons, Jr

Nat Struct Mol Biol. Author manuscript; available in PMC 2015 Apr 6.

Published in final edited form as: Nat Struct Mol Biol. 2014 May; 21(5): 437–442. Published online 2014 Apr 13. doi: 10.1038/nsmb.2813

PMCID:: PMC4386898

Abstract Article PDF–2.1M

Select item 56768755.

Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35

Jee-Young Mock, Yue Xu, Yihong Ye, William M. Clemons, Jr.

Proc Natl Acad Sci U S A. 2017 Oct 31; 114(44): 11679–11684. Published online 2017 Oct 17. doi: 10.1073/pnas.1702940114

PMCID:: PMC5676875

Abstract Article PDF–1.1M

Select item 90791726.

BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43

Yasar Arfat T. Kasu, Akshaya Arva, Jess Johnson, Christin Sajan, Jasmin Manzano, Andrew Hennes, Jacy Haynes, Christopher S. Brower

iScience. 2022 May 20; 25(5): 104273. Published online 2022 Apr 20. doi: 10.1016/j.isci.2022.104273

PMCID:: PMC9079172

Abstract Article PDF–2.8M

Select item 28432427.

Crystal Structure of Get4-Get5 Complex and Its Interactions with Sgt2, Get3, and Ydj1

Yi-Wei Chang, Yu-Chien Chuang, Yu-Chi Ho, Ming-Yuan Cheng, Yuh-Ju Sun, Chwan-Deng Hsiao, Chung Wang

J Biol Chem. 2010 Mar 26; 285(13): 9962–9970. Published online 2010 Jan 27. doi: 10.1074/jbc.M109.087098

PMCID:: PMC2843242

Abstract Article PDF–2.2M

Select item 36899518.

A Ubiquitin-like Domain Recruits an Oligomeric Chaperone to a Retrotranslocation Complex in Endoplasmic Reticulum-associated Degradation

Yue Xu, Yanfen Liu, Jin-gu Lee, Yihong Ye

J Biol Chem. 2013 Jun 21; 288(25): 18068–18076. Published online 2013 May 12. doi: 10.1074/jbc.M112.449199

PMCID:: PMC3689951

Abstract Article PDF–1.8M

Select item 60026979.

The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex

Rakesh Ganji, Sirisha Mukkavalli, Flavio Somanji, Malavika Raman

Mol Cell Biol. 2018 Jul 1; 38(13): e00154-18. Prepublished online 2018 Apr 23. Published online 2018 Jun 14. doi: 10.1128/MCB.00154-18

PMCID:: PMC6002697

Abstract Article PDF–3.8M

Select item 947756410.

Structural insights into metazoan pre-targeting GET complexes

Alexander F.A. Keszei, Matthew C.J. Yip, Ta-Chien Hsieh, Sichen Shao

Nat Struct Mol Biol. Author manuscript; available in PMC 2022 Sep 15.

Published in final edited form as: Nat Struct Mol Biol. 2021 Dec; 28(12): 1029–1037. Published online 2021 Dec 9. doi: 10.1038/s41594-021-00690-7

PMCID:: PMC9477564

Abstract Article PDF–4.7M

Select item 292886111.

A Ribosome-Associating Factor Chaperones Tail-Anchored Membrane Proteins

Malaiyalam Mariappan, Xingzhe Li, Sandra Stefanovic, Ajay Sharma, Agnieszka Mateja, Robert J. Keenan, Ramanujan S. Hegde

Nature. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: Nature. 2010 Aug 26; 466(7310): 1120–1124. Published online 2010 Aug 1. doi: 10.1038/nature09296

PMCID:: PMC2928861

Abstract Article PDF–617K

Select item 429165112.

Bag6 complex contains a minimal tail-anchor–targeting module and a mock BAG domain

Jee-Young Mock, Justin William Chartron, Ma’ayan Zaslaver, Yue Xu, Yihong Ye, William Melvon Clemons, Jr.

Proc Natl Acad Sci U S A. 2015 Jan 6; 112(1): 106–111. Published online 2014 Dec 22. doi: 10.1073/pnas.1402745112

PMCID:: PMC4291651

Abstract Article PDF–1.3M

Select item 388940213.

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Yanfen Liu, Nia Soetandyo, Jin-gu Lee, Liping Liu, Yue Xu, William M Clemons, Jr, Yihong Ye

eLife. 2014; 3: e01369. Published online 2014 Jan 14. doi: 10.7554/eLife.01369

PMCID:: PMC3889402

Abstract Article PDF–5.2M

Select item 313849914.

A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation

Qiuyan Wang, Yanfen Liu, Nia Soetandyo, Kheewoong Baek, Ramanujan Hegde, Yihong Ye

Mol Cell. Author manuscript; available in PMC 2012 Jun 24.

Published in final edited form as: Mol Cell. 2011 Jun 24; 42(6): 758–770. doi: 10.1016/j.molcel.2011.05.010

PMCID:: PMC3138499

Abstract Article PDF–2.9M

Select item 926436315.

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex

Peristera Roboti, Craig Lawless, Stephen High

J Cell Sci. 2022 May 1; 135(9): jcs259596. Published online 2022 May 11. doi: 10.1242/jcs.259596

PMCID:: PMC9264363

Abstract Article

Select item 410402716.

Cytosolic Quality Control of Mislocalized Proteins Requires RNF126 Recruitment to Bag6

Monica C. Rodrigo-Brenni, Erik Gutierrez, Ramanujan S. Hegde

Mol Cell. 2014 Jul 17; 55(2): 227–237. doi: 10.1016/j.molcel.2014.05.025

PMCID:: PMC4104027

Abstract Article

Select item 406815817.

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase

Yorann Baron, Patrick G Pedrioli, Kshitiz Tyagi, Clare Johnson, Nicola T Wood, Daniel Fountaine, Melanie Wightman, Gabriela Alexandru

BMC Biol. 2014; 12: 39. Published online 2014 May 29. doi: 10.1186/1741-7007-12-39

PMCID:: PMC4068158

Abstract Article PDF–2.8M

Select item 772476018.

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies

Jonathan P. Davies, Katherine M. Almasy, Eli F. McDonald, Lars Plate

ACS Infect Dis. Author manuscript; available in PMC 2024 Mar 5.

Published in final edited form as: ACS Infect Dis. 2020 Dec 11; 6(12): 3174–3189. Published online 2020 Dec 2. doi: 10.1021/acsinfecdis.0c00500

PMCID:: PMC7724760

Abstract Article PDF–2.1M

Select item 562506019.

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

Xiaorong Wang, Ilan E. Chemmama, Clinton Yu, Alexander Huszagh, Yue Xu, Rosa Viner, Sarah A. Block, Peter Cimermancic, Scott D. Rychnovsky, Yihong Ye, Andrej Sali, Lan Huang

J Biol Chem. 2017 Sep 29; 292(39): 16310–16320. Published online 2017 Aug 15. doi: 10.1074/jbc.M117.803619

PMCID:: PMC5625060

Abstract Article PDF–2.5M

Select item 561217320.

The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex

Meraj H. Khan, Siiri I. Salomaa, Guillaume Jacquemet, Umar Butt, Mitro Miihkinen, Takahiro Deguchi, Elena Kremneva, Pekka Lappalainen, Martin J. Humphries, Jeroen Pouwels

J Cell Sci. 2017 Sep 15; 130(18): 3094–3107. doi: 10.1242/jcs.200329

Correction in:: J Cell Sci. 2023 Oct 1; 136(19): jcs261581.

PMCID:: PMC5612173

Abstract Article

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PMC Links for Gene (Select 51608) (75)
PMC
Homo sapiens chromosome 16 clone RP11-504I2, complete sequence
Homo sapiens chromosome 16 clone RP11-504I2, complete sequence
gi|27356676|gnl|lanlchgs|504I2|gb|A 33.7|

Nucleotide
Structure Links for Protein (Select 4504659) (5)
Structure
putative antitoxin of a toxin / antitoxin system; putative transcriptional regul...
putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator [Bacillus subtilis subsp. subtilis str. 168]
gi|16078934|ref|NP_389755.1|

Protein
suppressor APC domain-containing protein 1 [Bos taurus]
suppressor APC domain-containing protein 1 [Bos taurus]
gi|126723451|ref|NP_001075936.1|

Protein

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