U.S. flag

An official website of the United States government

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Links from Gene

Items: 1 to 20 of 46

1.
Energy metabolism and mitochondrial defects in X-linked Charcot-Marie-Tooth (CMTX6) iPSC-derived motor neurons with the p.R158H PDK3 mutation
G. Perez-Siles, A. Cutrupi, M. Ellis, R. Screnci, D. Mao, M. Uesugi, Eppie M. Yiu, Monique M. Ryan, B. O. Choi, G. Nicholson, M. L. Kennerson
Sci Rep. 2020; 10: 9262. Published online 2020 Jun 5. doi: 10.1038/s41598-020-66266-5
PMCID:
PMC7275085
AbstractArticlePDF–11M
2.
A new locus for X-linked dominant Charcot–Marie–Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene
Marina L. Kennerson, Eppie M. Yiu, David T. Chuang, Aditi Kidambi, Shih-Chia Tso, Carolyn Ly, Rabia Chaudhry, Alexander P. Drew, Gary Rance, Martin B. Delatycki, Stephan Züchner, Monique M. Ryan, Garth A. Nicholson
Hum Mol Genet. 2013 Apr 1; 22(7): 1404–1416. Published online 2013 Jan 7. doi: 10.1093/hmg/dds557
PMCID:
PMC3596851
AbstractArticlePDF–459K
3.
Crystal Structure of an Asymmetric Complex of Pyruvate Dehydrogenase Kinase 3 with Lipoyl Domain 2 and its Biological Implications
Yancho Devedjiev, C. Nicklaus Steussy, Dmitry G. Vassylyev
J Mol Biol. Author manuscript; available in PMC 2008 Jul 13.
Published in final edited form as: J Mol Biol. 2007 Jul 13; 370(3): 407–416. Published online 2007 May 10. doi: 10.1016/j.jmb.2007.04.083
PMCID:
PMC1994203
AbstractArticlePDF–1.8M
4.
Charcot–Marie–tooth disease causing mutation (p.R158H) in pyruvate dehydrogenase kinase 3 (PDK3) affects synaptic transmission, ATP production and causes neurodegeneration in a CMTX6 C. elegans model
Ramesh K Narayanan, Megan H Brewer, Gonzalo Perez-Siles, Melina Ellis, Carolyn Ly, Andrew Burgess, Brent Neumann, Garth A Nicholson, Steve Vucic, Marina L Kennerson
Hum Mol Genet. 2022 Jan 1; 31(1): 133–145. Published online 2021 Aug 13. doi: 10.1093/hmg/ddab228
PMCID:
PMC8682796
AbstractArticlePDF–1.2M
5.
miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3
Lan Feng, Kai Cheng, Rongjia Zang, Qingdong Wang, Jianjie Wang
Biosci Rep. 2019 Sep 30; 39(9): BSR20190654. Prepublished online 2019 Aug 13. Published online 2019 Sep 6. doi: 10.1042/BSR20190654
PMCID:
PMC6732365
AbstractArticlePDF–1.6M
6.
Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming
Alessandro Prigione, Björn Lichtner, Heiner Kuhl, Eduard A. Struys, Mirjam Wamelink, Hans Lehrach, Markus Ralser, Bernd Timmermann, James Adjaye
Stem Cells. Author manuscript; available in PMC 2017 Dec 14.
Published in final edited form as: Stem Cells. 2014 Feb; 32(2): 364–376. doi: 10.1002/stem.1552
PMCID:
PMC5730046
AbstractArticlePDF–1.6M
7.
Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance
Chun-Wun Lu, Shih-Chieh Lin, Ko-Fan Chen, Yen-Yu Lai, Shaw-Jenq Tsai
J Biol Chem. 2008 Oct 17; 283(42): 28106–28114. doi: 10.1074/jbc.M803508200
PMCID:
PMC2661383
AbstractArticlePDF–524K
8.
KDM4A coactivates E2F1 to regulate PDK-dependent metabolic switch between mitochondrial oxidation and glycolysis
Ling-Yu Wang, Chiu-Lien Hung, Yun-Ru Chen, Joy C. Yang, Junjian Wang, Mel Campbell, Yoshihiro Izumiya, Hong-Wu Chen, Wen-Ching Wang, David K. Ann, Hsing-Jien Kung
Cell Rep. Author manuscript; available in PMC 2016 Sep 15.
Published in final edited form as: Cell Rep. 2016 Sep 13; 16(11): 3016–3027. doi: 10.1016/j.celrep.2016.08.018
PMCID:
PMC5024724
AbstractArticlePDF–2.7M
9.
Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol
Masato Kato, Jun Li, Jacinta L. Chuang, David T. Chuang
Structure. Author manuscript; available in PMC 2010 May 17.
Published in final edited form as: Structure. 2007 Aug; 15(8): 992–1004. Published online 2007 Aug 2. doi: 10.1016/j.str.2007.07.001
PMCID:
PMC2871385
AbstractArticlePDF–3.2M
10.
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
Masato Kato, Jacinta L Chuang, Shih-Chia Tso, R Max Wynn, David T Chuang
EMBO J. 2005 May 18; 24(10): 1763–1774. Published online 2005 Apr 28. doi: 10.1038/sj.emboj.7600663
PMCID:
PMC1142596
AbstractArticlePDF–479K
11.
Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance
Jinye Xu, Qiqi Shi, Wenxia Xu, Qiyin Zhou, Rongkai Shi, Yanning Ma, Dingwei Chen, Liyuan Zhu, Lifeng Feng, Alfred Sze-Lok Cheng, Helen Morrison, Xian Wang, Hongchuan Jin
Theranostics. 2019; 9(10): 2999–3013. Published online 2019 May 9. doi: 10.7150/thno.31301
PMCID:
PMC6568185
AbstractArticlePDF–2.3M
12.
Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.
Alina Tuganova, Igor Boulatnikov, Kirill M Popov
Biochem J. 2002 Aug 15; 366(Pt 1): 129–136. doi: 10.1042/BJ20020301
PMCID:
PMC1222743
SummaryPDF–237K
13.
Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.
E Kolobova, A Tuganova, I Boulatnikov, K M Popov
Biochem J. 2001 Aug 15; 358(Pt 1): 69–77. doi: 10.1042/0264-6021:3580069
PMCID:
PMC1222033
SummaryPDF–195K
14.
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leuekmia
Alicia Cole, Zezhou Wang, Etienne Coyaud, Veronique Voisin, Marcela Gronda, Yulia Jitkova, Rachel Mattson, Rose Hurren, Sonja Babovic, Neil Maclean, Ian Restall, Xiaoming Wang, Danny V. Jeyaraju, Mahadeo A. Sukhai, Swayam Prabha, Shaheena Bashir, Ashwin Ramakrishnan, Elisa Leung, Yi Hua Qia, Nianxian Zhang, Kevin R. Combes, Troy Ketela, Fengshu Lin, Walid A. Houry, Ahmed Aman, Rima Al-awar, Wei Zheng, Erno Wienholds, Chang Jiang Xu, John Dick, Jean C.Y. Wang, Jason Moffat, Mark D. Minden, Connie J. Eaves, Gary D. Bader, Zhenyue Hao, Steven M. Kornblau, Brian Raught, Aaron D. Schimmer
Cancer Cell. Author manuscript; available in PMC 2016 Jun 8.
Published in final edited form as: Cancer Cell. 2015 Jun 8; 27(6): 864–876. doi: 10.1016/j.ccell.2015.05.004
PMCID:
PMC4461837
AbstractArticlePDF–2.3M
15.
Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
Jo Ishizawa, Sarah F. Zarabi, R. Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St-Germain, Lauren E. Heese, Grace Egan, Vivian R. Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, John Man Chun Ma, Andrew B. Leber, Mark D. Minden, Walid Houry, Hagop Kantarjian, Martin Stogniew, Brian Raught, Emil F. Pai, Aaron D. Schimmer, Michael Andreeff
Cancer Cell. Author manuscript; available in PMC 2020 May 13.
Published in final edited form as: Cancer Cell. 2019 May 13; 35(5): 721–737.e9. Published online 2019 May 2. doi: 10.1016/j.ccell.2019.03.014
PMCID:
PMC6620028
AbstractArticlePDF–2.9M
16.
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome
Ricarda Richter, Joanna Rorbach, Aleksandra Pajak, Paul M Smith, Hans J Wessels, Martijn A Huynen, Jan A Smeitink, Robert N Lightowlers, Zofia M Chrzanowska-Lightowlers
EMBO J. 2010 Mar 17; 29(6): 1116–1125. Published online 2010 Feb 25. doi: 10.1038/emboj.2010.14
PMCID:
PMC2845271
AbstractArticlePDF–1.3M
17.
Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved
Tabish Hussain, Jaeho Lee, Martin C. Abba, Junjie Chen, C. Marcelo Aldaz
Front Oncol. 2018; 8: 591. Published online 2018 Dec 13. doi: 10.3389/fonc.2018.00591
PMCID:
PMC6300487
AbstractArticlePDF–1.8M
18.
A conserved acetylation switch enables pharmacological control of tubby-like protein stability
Evan M. Kerek, Kevin H. Yoon, Shu Y. Luo, Jerry Chen, Robert Valencia, Olivier Julien, Andrew J. Waskiewicz, Basil P. Hubbard
J Biol Chem. 2021 Jan-Jun; 296: 100073. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015839
PMCID:
PMC7948452
AbstractArticlePDF–3.6M
19.
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC
Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223
PMCID:
PMC6927754
AbstractArticlePDF–5.1M
20.
Mitochondrial protein interaction mapping identifies new regulators of respiratory chain function
Brendan J. Floyd, Emily M. Wilkerson, Mike T. Veling, Catie E. Minogue, Chuanwu Xia, Emily T. Beebe, Russell L. Wrobel, Holly Cho, Laura S. Kremer, Charlotte L. Alston, Katarzyna A. Gromek, Brendan K. Dolan, Arne Ulbrich, Jonathan A. Stefely, Sarah L. Bohl, Kelly M. Werner, Adam Jochem, Michael S. Westphall, Jarred W. Rensvold, Robert W. Taylor, Holger Prokisch, Jung-Ja P. Kim, Joshua J. Coon, David J. Pagliarini
Mol Cell. Author manuscript; available in PMC 2017 Aug 18.
Published in final edited form as: Mol Cell. 2016 Aug 18; 63(4): 621–632. Published online 2016 Aug 4. doi: 10.1016/j.molcel.2016.06.033
PMCID:
PMC4992456
AbstractArticlePDF–1.7M

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filter your results:

Find related data

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > Literature > PubMed Central (PMC)
Support Center