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Select item 108856171.

Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin

Mol Metab. 2024 Mar; 81: 101900. Published online 2024 Feb 13. doi: 10.1016/j.molmet.2024.101900

PMCID:: PMC10885617

Abstract Article PDF–3.5M

Select item 74397882.

MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin

Guang-Ang Tian, Chun-Jie Xu, Kai-Xia Zhou, Zhi-Gang Zhang, Jian-Ren Gu, Xue-Li Zhang, Ya-Hui Wang

J Immunol Res. 2020; 2020: 8340329. Published online 2020 Aug 19. doi: 10.1155/2020/8340329

PMCID:: PMC7439788

Abstract Article PDF–3.0M

Select item 64479543.

Mitochondrial pyruvate carrier 1 expression controls cancer epithelial‐mesenchymal transition and radioresistance

Yuji Takaoka, Masamitsu Konno, Jun Koseki, Hugh Colvin, Ayumu Asai, Keisuke Tamari, Taroh Satoh, Masaki Mori, Yuichiro Doki, Kazuhiko Ogawa, Hideshi Ishii

Cancer Sci. 2019 Apr; 110(4): 1331–1339. Published online 2019 Apr 4. doi: 10.1111/cas.13980

PMCID:: PMC6447954

Abstract Article PDF–1.0M

Select item 63776394.

MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway

Hongbo Zou, Qian Chen, Anmei Zhang, Songtao Wang, Hong Wu, Ye Yuan, Shuang Wang, Jing Yu, Mao Luo, Xianmei Wen, Wei Cui, Wenjuan Fu, Ruilian Yu, Lin Chen, Ming Zhang, Haitao Lan, Xia Zhang, Qichao Xie, Guoxiang Jin, Chuan Xu

Cell Death Dis. 2019 Mar; 10(3): 148. Published online 2019 Feb 15. doi: 10.1038/s41419-019-1324-8

PMCID:: PMC6377639

Abstract Article PDF–4.7M

Select item 89006675.

Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes

Liang Xu, Clyde F. Phelix, Liao Y. Chen

J Chem Inf Model. Author manuscript; available in PMC 2022 Nov 22.

Published in final edited form as: J Chem Inf Model. 2021 Nov 22; 61(11): 5614–5625. Published online 2021 Oct 19. doi: 10.1021/acs.jcim.1c00879

PMCID:: PMC8900667

Abstract Article PDF–2.2M

Select item 74078326.

The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier

Joséphine Zangari, Francesco Petrelli, Benoît Maillot, Jean-Claude Martinou

Biomolecules. 2020 Jul; 10(7): 1068. Published online 2020 Jul 17. doi: 10.3390/biom10071068

PMCID:: PMC7407832

Abstract Article PDF–991K

Select item 73624447.

Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy

Huanhuan Zhu, Huiting Wan, Lin Wu, Qing Li, Simeng Liu, Suyan Duan, Zhimin Huang, Chengning Zhang, Bo Zhang, Changying Xing, Yanggang Yuan

BMC Nephrol. 2020; 21: 274. Published online 2020 Jul 14. doi: 10.1186/s12882-020-01931-5

PMCID:: PMC7362444

Abstract Article PDF–11M

Select item 72469998.

Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases

Jinyi Lee, Zeyu Jin, Donghan Lee, Ji-Hye Yun, Weontae Lee

Int J Mol Sci. 2020 May; 21(9): 3403. Published online 2020 May 11. doi: 10.3390/ijms21093403

PMCID:: PMC7246999

Abstract Article PDF–3.0M

Select item 66292389.

Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction

Lalita Oonthonpan, Adam J. Rauckhorst, Lawrence R. Gray, Audrey C. Boutron, Eric B. Taylor

JCI Insight. 2019 Jul 11; 4(13): e126132. Published online 2019 Jul 11. doi: 10.1172/jci.insight.126132

PMCID:: PMC6629238

Abstract Article PDF–1.6M

Select item 639759310.

Loss of MPC1 reprograms retinal metabolism to impair visual function

Allison Grenell, Yekai Wang, Michelle Yam, Aditi Swarup, Tanya L. Dilan, Allison Hauer, Jonathan D. Linton, Nancy J. Philp, Elizabeth Gregor, Siyan Zhu, Quan Shi, Joseph Murphy, Tongju Guan, Daniel Lohner, Saravanan Kolandaivelu, Visvanathan Ramamurthy, Andrew F. X. Goldberg, James B. Hurley, Jianhai Du

Proc Natl Acad Sci U S A. 2019 Feb 26; 116(9): 3530–3535. Published online 2019 Feb 11. doi: 10.1073/pnas.1812941116

PMCID:: PMC6397593

Abstract Article PDF–1.4M

Select item 582390811.

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter

Raghavendra Sashi Krishna Nagampalli, José Edwin Neciosup Quesñay, Douglas Adamoski, Zeyaul Islam, James Birch, Heitor Gobbi Sebinelli, Richard Marcel Bruno Moreira Girard, Carolline Fernanda Rodrigues Ascenção, Angela Maria Fala, Bianca Alves Pauletti, Sílvio Roberto Consonni, Juliana Ferreira de Oliveira, Amanda Cristina Teixeira Silva, Kleber Gomes Franchini, Adriana Franco Paes Leme, Ariel Mariano Silber, Pietro Ciancaglini, Isabel Moraes, Sandra Martha Gomes Dias, Andre Luis Berteli Ambrosio

Sci Rep. 2018; 8: 3510. Published online 2018 Feb 22. doi: 10.1038/s41598-018-21740-z

PMCID:: PMC5823908

Abstract Article PDF–3.6M

Select item 492474312.

MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer

Leiming Wang, Mafei Xu, Jun Qin, Shih-Chieh Lin, Hui-Ju Lee, Sophia Y. Tsai, Ming-Jer Tsai

Oncotarget. 2016 Mar 22; 7(12): 14673–14683. Published online 2016 Feb 15. doi: 10.18632/oncotarget.7405

PMCID:: PMC4924743

Abstract Article PDF–5.4M

Select item 426841613.

A role for the mitochondrial pyruvate carrier as a repressor of the Warburg Effect and colon cancer cell growth

John C. Schell, Kristofor A. Olson, Lei Jiang, Amy J. Hawkins, Jonathan G. Van Vranken, Jianxin Xie, Robert A. Egnatchik, Espen G. Earl, Ralph J. Deberardinis, Jared Rutter

Mol Cell. Author manuscript; available in PMC 2015 Nov 6.

Published in final edited form as: Mol Cell. 2014 Nov 6; 56(3): 400–413. Published online 2014 Oct 21. doi: 10.1016/j.molcel.2014.09.026

PMCID:: PMC4268416

Abstract Article PDF–2.4M

Select item 896806314.

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji

Mol Metab. 2022 Jun; 60: 101469. Published online 2022 Mar 10. doi: 10.1016/j.molmet.2022.101469

PMCID:: PMC8968063

Abstract Article PDF–3.0M

Select item 621382415.

C-Terminal Binding Protein 1 Modulates Cellular Redox via Feedback Regulation of MPC1 and MPC2 in Melanoma Cells

Yu Deng, Hong Li, Xinyi Yin, Hongbin Liu, Jing Liu, Dongjie Guo, Zheng Shi

Med Sci Monit. 2018; 24: 7614–7624. Published online 2018 Oct 25. doi: 10.12659/MSM.912735

PMCID:: PMC6213824

Abstract Article PDF–1.1M

Select item 591993216.

PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

Dan Li, Chaoqun Wang, Panfei Ma, Qingan Yu, Mingqi Gu, Liqian Dong, Wenjing Jiang, Shangha Pan, Changming Xie, Jihua Han, Yaliang Lan, Jing Sun, Ping Sheng, Kunpeng Liu, Yaohua Wu, Lianxin Liu, Yong Ma, Hongchi Jiang

Cell Death Dis. 2018 May; 9(5): 466. Published online 2018 Apr 27. doi: 10.1038/s41419-018-0494-0

PMCID:: PMC5919932

Abstract Article PDF–5.5M

Select item 497436017.

MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells

Benoît Vanderperre, Kristina Cermakova, Jessica Escoffier, Mayis Kaba, Tom Bender, Serge Nef, Jean-Claude Martinou

J Biol Chem. 2016 Aug 5; 291(32): 16448–16461. Published online 2016 Jun 17. doi: 10.1074/jbc.M116.733840

PMCID:: PMC4974360

Abstract Article PDF–3.7M

Select item 467171918.

Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier

Ana Martínez-Zamora, Salvador Meseguer, Juan M. Esteve, Magda Villarroya, Carmen Aguado, J. Antonio Enríquez, Erwin Knecht, M.-Eugenia Armengod

PLoS One. 2015; 10(12): e0144273. Published online 2015 Dec 7. doi: 10.1371/journal.pone.0144273

PMCID:: PMC4671719

Abstract Article PDF–3.3M

Select item 993818919.

KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer

Gang Quan, Jian Xu, Jie Wang, Xinyuan Liu, Jichuan Xu, Jianxin Jiang

Cell Death Dis. 2023 Feb; 14(2): 137. Published online 2023 Feb 17. doi: 10.1038/s41419-023-05679-2

PMCID:: PMC9938189

Abstract Article PDF–8.4M

Select item 369081820.

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

Daniel K. Bricker, Eric B. Taylor, John C. Schell, Thomas Orsak, Audrey Boutron, Yu-Chan Chen, James E. Cox, Caleb M. Cardon, Jonathan G. Van Vranken, Noah Dephoure, Claire Redin, Sihem Boudina, Steven P. Gygi, Michèle Brivet, Carl S. Thummel, Jared Rutter

Science. Author manuscript; available in PMC 2013 Jun 24.

Published in final edited form as: Science. 2012 Jul 6; 337(6090): 96–100. Published online 2012 May 24. doi: 10.1126/science.1218099

PMCID:: PMC3690818

Abstract Article PDF–2.1M

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