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Select item 73434811.

miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity

Yu Zhuang, Shouguo Wang, Haodong Fei, Feng Ji, Peng Sun

Aging (Albany NY) 2020 Jun 30; 12(12): 11754–11767. Published online 2020 Jun 11. doi: 10.18632/aging.103341

PMCID:: PMC7343481

Abstract Article PDF–2.3M

Select item 70545332.

MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39

Yu Liang, Danxi Zhu, Lidan Hou, Yu Wang, Xin Huang, Cui Zhou, Liming Zhu, Yingying Wang, Lei Li, Yan Gu, Meng Luo, Jianhua Wang, Xiangjun Meng

Br J Cancer. 2020 Mar 3; 122(5): 705–714. Published online 2020 Jan 10. doi: 10.1038/s41416-019-0703-3

PMCID:: PMC7054533

Abstract Article PDF–3.1M

Select item 37254193.

Structural insights into the activation of MST3 by MO25

Youcef Mehellou, Dario R. Alessi, Thomas J. Macartney, Marta Szklarz, Stefan Knapp, Jonathan M. Elkins

Biochem Biophys Res Commun. 2013 Feb 15; 431(3): 604–609. doi: 10.1016/j.bbrc.2012.12.113

PMCID:: PMC3725419

Abstract Article

Select item 35845784.

MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma

YUAN TIAN, YANG NAN, LEI HAN, ANLING ZHANG, GUANGXIU WANG, ZHIFAN JIA, JIANWEI HAO, PEIYU PU, YUE ZHONG, CHUNSHENG KANG

Int J Oncol. 2012 Apr; 40(4): 1105–1112. Published online 2011 Dec 15. doi: 10.3892/ijo.2011.1306

PMCID:: PMC3584578

Abstract Article PDF–779K

Select item 26862655.

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Elton Zeqiraj, Beatrice Maria Filippi, Simon Goldie, Iva Navratilova, Jérôme Boudeau, Maria Deak, Dario R. Alessi, Daan M. F. van Aalten

PLoS Biol. 2009 Jun; 7(6): e1000126. Published online 2009 Jun 9. doi: 10.1371/journal.pbio.1000126

PMCID:: PMC2686265

Abstract Article PDF–3.2M

Select item 46285606.

6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling

Ruiting Lin, Shannon Elf, Changliang Shan, Hee-Bum Kang, Quanjiang Ji, Lu Zhou, Taro Hitosugi, Liang Zhang, Shuai Zhang, Jae Ho Seo, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Jessica Sudderth, Lei Jiang, Matthew Mitsche, Ralph J. DeBerardinis, Shaoxiong Wu, Yuancheng Li, Hui Mao, Peng R. Chen, Dongsheng Wang, Georgia Zhuo Chen, Selwyn J. Hurwitz, Sagar Lonial, Hanna J. Khoury, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Qunying Lei, Daniel J. Brat, Keqiang Ye, Titus J. Boggon, Chuan He, Sumin Kang, Jun Fan, Jing Chen

Nat Cell Biol. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Nat Cell Biol. 2015 Nov; 17(11): 1484–1496. Published online 2015 Oct 19. doi: 10.1038/ncb3255

PMCID:: PMC4628560

Abstract Article PDF–2.4M

Select item 26105107.

C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest

Sarah Fogarty, D. Grahame Hardie

J Biol Chem. 2009 Jan 2; 284(1): 77–84. doi: 10.1074/jbc.M806152200

PMCID:: PMC2610510

Abstract Article PDF–534K

Select item 2044738.

MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Jérôme Boudeau, Annette F. Baas, Maria Deak, Nick A. Morrice, Agnieszka Kieloch, Mike Schutkowski, Alan R. Prescott, Hans C. Clevers, Dario R. Alessi

EMBO J. 2003 Oct 1; 22(19): 5102–5114. doi: 10.1093/emboj/cdg490

PMCID:: PMC204473

Abstract Article PDF–663K

Select item 35182689.

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

Elton Zeqiraj, Beatrice Maria Filippi, Maria Deak, Dario R. Alessi, Daan M. F. van Aalten

Science. Author manuscript; available in PMC 2012 Dec 10.

Published in final edited form as: Science. 2009 Dec 18; 326(5960): 1707–1711. Published online 2009 Nov 5. doi: 10.1126/science.1178377

PMCID:: PMC3518268

Abstract Article PDF–2.3M

Select item 310198910.

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Beatrice M Filippi, Paola de los Heros, Youcef Mehellou, Iva Navratilova, Robert Gourlay, Maria Deak, Lorna Plater, Rachel Toth, Elton Zeqiraj, Dario R Alessi

EMBO J. 2011 May 4; 30(9): 1730–1741. Published online 2011 Mar 18. doi: 10.1038/emboj.2011.78

PMCID:: PMC3101989

Abstract Article PDF–740K

Select item 676120511.

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling

Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen, Steven H. Lin

Nat Commun. 2019; 10: 4363. Published online 2019 Sep 25. doi: 10.1038/s41467-019-12377-1

PMCID:: PMC6761205

Abstract Article PDF–2.2M

Select item 658468912.

FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growth

Xiao-Na Zhu, Ping He, Liang Zhang, Shuo Yang, Hui-Lin Zhang, Di Zhu, Meng-Di Liu, Yun Yu

Cell Death Dis. 2019 Jul; 10(7): 486. Published online 2019 Jun 19. doi: 10.1038/s41419-019-1732-9

PMCID:: PMC6584689

Abstract Article PDF–1.8M

Select item 533712013.

Skp2-dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

Szu-Wei Lee, Chien-Feng Li, Guoxiang Jin, Zhen Cai, Fei Han, Chia-Hsin Chan, Wei-Lei Yang, Bin-Kui Li, Abdol Hossein Rezaeian, Hong-Yu Li, Hsuan-Ying Huang, Hui-Kuan Lin

Mol Cell. Author manuscript; available in PMC 2017 Mar 4.

Published in final edited form as: Mol Cell. 2015 Mar 19; 57(6): 1022–1033. Published online 2015 Feb 26. doi: 10.1016/j.molcel.2015.01.015

PMCID:: PMC5337120

Abstract Article PDF–3.2M

Select item 1011932214.

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Lei Chen, Wenjing Zhang, Dan Chen, Quan Yang, Siwen Sun, Zhenwei Dai, Zhengzheng Li, Xuemei Liang, Chaoqun Chen, Yuexia Jiao, Lili Zhi, Lianmei Zhao, Jinrui Zhang, Xuefeng Liu, Jinyao Zhao, Man Li, Yang Wang, Yangfan Qi

Signal Transduct Target Ther. 2023; 8: 159. Published online 2023 Apr 21. doi: 10.1038/s41392-023-01367-x

PMCID:: PMC10119322

Abstract Article PDF–7.7M

Select item 394004015.

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K⁺–Cl⁻ co-transporters

Paola delos Heros, Dario R. Alessi, Robert Gourlay, David G. Campbell, Maria Deak, Thomas J. Macartney, Kristopher T. Kahle, Jinwei Zhang

Biochem J. 2014 Mar 15; 458(Pt 3): 559–573. Prepublished online 2014 Jan 7. Published online 2014 Feb 28. doi: 10.1042/BJ20131478

PMCID:: PMC3940040

Abstract Article PDF–1.7M

Select item 38101416.

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Jose M Lizcano, Olga Göransson, Rachel Toth, Maria Deak, Nick A Morrice, Jérôme Boudeau, Simon A Hawley, Lina Udd, Tomi P Mäkelä, D Grahame Hardie, Dario R Alessi

EMBO J. 2004 Feb 25; 23(4): 833–843. Published online 2004 Feb 19. doi: 10.1038/sj.emboj.7600110

PMCID:: PMC381014

Abstract Article PDF–586K

Select item 31087617.

Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics

Chun-Hung Lai, Chang-Yuan Chou, Lan-Yang Ch'ang, Chung-Shyan Liu, Wen-chang Lin

Genome Res. 2000 May; 10(5): 703–713. doi: 10.1101/gr.10.5.703

PMCID:: PMC310876

Abstract Article PDF–1.2M

Select item 356134318.

VCP Phosphorylation-Dependent Interaction Partners Prevent Apoptosis in Helicobacter pylori-Infected Gastric Epithelial Cells

Cheng-Chou Yu, Jyh-Chin Yang, Yen-Ching Chang, Jiing-Guang Chuang, Chung-Wu Lin, Ming-Shiang Wu, Lu-Ping Chow

PLoS One. 2013; 8(1): e55724. Published online 2013 Jan 31. doi: 10.1371/journal.pone.0055724

PMCID:: PMC3561343

Abstract Article PDF–1.9M

Select item 910630319.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 290199820.

Network organization of the human autophagy system

Christian Behrends, Mathew E. Sowa, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Nature. 2010 Jul 1; 466(7302): 68–76. Published online 2010 Jun 20. doi: 10.1038/nature09204

PMCID:: PMC2901998

Abstract Article PDF–1.4M

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