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Items: 1 to 20 of 45

1.
Ribosome collisions trigger general stress responses to regulate cell fate
Colin Chih-Chien Wu, Amy Peterson, Boris Zinshteyn, Sergi Regot, Rachel Green
Cell. Author manuscript; available in PMC 2021 Jul 23.
Published in final edited form as: Cell. 2020 Jul 23; 182(2): 404–416.e14. Published online 2020 Jun 30. doi: 10.1016/j.cell.2020.06.006
PMCID:
PMC7384957
AbstractArticlePDF–2.3M
2.
Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation
Chien-Yao Fu, Ing-Shiow Lay, Marthandam Asokan Shibu, Yan-Shen Tseng, Wei-Wen Kuo, Jaw-Ji Yang, Tso-Fu Wang, B. Mahalakshmi, Yu-Lan Yeh, Chih-Yang Huang
Int J Mol Sci. 2020 May; 21(9): 3366. Published online 2020 May 9. doi: 10.3390/ijms21093366
PMCID:
PMC7247666
AbstractArticlePDF–2.8M
3.
Novel Genetic Variants in the P38MAPK Pathway Gene ZAK and Susceptibility to Lung Cancer
Yun Feng, Yanru Wang, Hongliang Liu, Zhensheng Liu, Coleman Mills, Kouros Owzar, Jichun Xie, Younghun Han, David C. Qiang, Rayjean J. Hung RJ, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeböller, Albert Rosenberger, Richard S. Houlston, Neil Caporaso, Maria Teresa Landi, Irene Brüske, Angela Risch, Yuanqing Ye, Xifeng Wu, David C. Christiani, Christopher I. Amos, Wei Q
Mol Carcinog. Author manuscript; available in PMC 2018 Sep 7.
Published in final edited form as: Mol Carcinog. 2018 Feb; 57(2): 216–224. Published online 2017 Oct 31. doi: 10.1002/mc.22748
PMCID:
PMC6128286
AbstractArticlePDF–992K
4.
Mixed lineage kinase ZAK promotes epithelial–mesenchymal transition in cancer progression
Linna Li, Ning Su, Ting Zhou, Dayong Zheng, Zheng Wang, Haoyu Chen, Shoujun Yuan, Wenliang Li
Cell Death Dis. 2018 Feb; 9(2): 143. Published online 2018 Feb 2. doi: 10.1038/s41419-017-0161-x
PMCID:
PMC5833348
AbstractArticlePDF–4.4M
5.
Recessive mutations in the kinase ZAK cause a congenital myopathy with fibre type disproportion
Nasim Vasli, Elizabeth Harris, Jason Karamchandani, Eric Bareke, Jacek Majewski, Norma B. Romero, Tanya Stojkovic, Rita Barresi, Hichem Tasfaout, Richard Charlton, Edoardo Malfatti, Johann Bohm, Chiara Marini-Bettolo, Karine Choquet, Marie-Josée Dicaire, Yi-Hong Shao, Ana Topf, Erin O’Ferrall, Bruno Eymard, Volker Straub, Gonzalo Blanco, Hanns Lochmüller, Bernard Brais, Jocelyn Laporte, Martine Tétreault
Brain. 2017 Jan; 140(1): 37–48. Published online 2016 Nov 5. doi: 10.1093/brain/aww257
PMCID:
PMC5226058
AbstractArticlePDF–756K
6.
Long Non-coding RNA URHC Regulates Cell Proliferation and Apoptosis via ZAK through the ERK/MAPK Signaling Pathway in Hepatocellular Carcinoma
Wei-Hua Xu, Jian-Bin Zhang, Zheng Dang, Xiao Li, Ti Zhou, Jie Liu, De-Sheng Wang, Wen-Jie Song, Ke-Feng Dou
Int J Biol Sci. 2014; 10(7): 664–676. Published online 2014 Jun 10. doi: 10.7150/ijbs.8232
PMCID:
PMC4081602
AbstractArticlePDF–1.2M
7.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer
Jinfeng Liu, Mark McCleland, Eric W. Stawiski, Florian Gnad, Oleg Mayba, Peter M. Haverty, Steffen Durinck, Ying-Jiun Chen, Christiaan Klijn, Suchit Jhunjhunwala, Michael Lawrence, Hanbin Liu, Yinan Wan, Vivek Chopra, Murat B. Yaylaoglu, Wenlin Yuan, Connie Ha, Houston N. Gilbert, Jens Reeder, Gregoire Pau, Jeremy Stinson, Howard M. Stern, Gerard Manning, Thomas D. Wu, Richard M. Neve, Frederic J. de Sauvage, Zora Modrusan, Somasekar Seshagiri, Ron Firestein, Zemin Zhang
Nat Commun. 2014 May 8; 5: 3830. Published online 2014 May 8. doi: 10.1038/ncomms4830
PMCID:
PMC4024760
AbstractArticlePDF–580K
8.
ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells
Kristin AD Sauter, Eli A Magun, Mihail S Iordanov, Bruce E Magun
Cancer Biol Ther. 2010 Aug 1; 10(3): 258–266. Published online 2010 Aug 13. doi: 10.4161/cbt.10.3.12367
PMCID:
PMC3040836
AbstractArticlePDF–2.5M
9.
ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP‐1‐dependent manner
Jaw‐Ji Yang, Yi‐Ju Lee, Hsin‐Hung Hung, Wei‐Pu Tseng, Chuan‐Chou Tu, Huei Lee, Wen‐Jun Wu
Cancer Sci. 2010 Jun; 101(6): 1374–1381. Published online 2010 Feb 18. doi: 10.1111/j.1349-7006.2010.01537.x
PMCID:
PMC11159936
AbstractArticlePDF–637K
10.
Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK kinase
Harina Vin, Grace Ching, Sandra S. Ojeda, Charles H. Adelmann, Vida Chitsazzadeh, David W. Dwyer, Haiching Ma, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L. Curry, Ana M. Ciurea, Madeleine Duvic, Naifa L. Busaidy, Nizar M. Tannir, Kenneth Y. Tsai
Mol Cancer Ther. Author manuscript; available in PMC 2015 Mar 20.
Published in final edited form as: Mol Cancer Ther. 2014 Jan; 13(1): 221–229. Published online 2013 Oct 29. doi: 10.1158/1535-7163.MCT-13-0561
PMCID:
PMC4366425
AbstractArticlePDF–1.4M
11.
Myofibrillar myopathy hallmarks associated with ZAK deficiency
Amy Stonadge, Aitana V Genzor, Alex Russell, Mohamed F Hamed, Norma Romero, Gareth Evans, Mary Elizabeth Pownall, Simon Bekker-Jensen, Gonzalo Blanco
Hum Mol Genet. 2023 Sep 1; 32(17): 2751–2770. Published online 2023 Jul 10. doi: 10.1093/hmg/ddad113
Correction in:
Hum Mol Genet. 2023 Dec 15; 32(24): 3390.
PMCID:
PMC10789240
AbstractArticlePDF–3.1M
12.
miR-302a inhibits human HepG2 and SMMC-7721 cells proliferation and promotes apoptosis by targeting MAP3K2 and PBX3
Meng Wang, Guoyue Lv, Chao Jiang, Shuli Xie, Guangyi Wang
Sci Rep. 2019; 9: 2032. Published online 2019 Feb 14. doi: 10.1038/s41598-018-38435-0
PMCID:
PMC6375964
AbstractArticlePDF–2.5M
13.
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome
Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, Rae Chua, Stefan Bauernfried, Zijin Sun, Muhammad Jasrie Firdaus, Shima Bayat, Rhea Nadkarni, Zhi Sheng Poh, Khek Chian Tham, Cassandra R. Harapas, Chrissie K. Lim, Werncui Chu, Celest W. S. Tay, Kiat Yi Tan, Tianyun Zhao, Carine Bonnard, Radoslaw Sobota, John E. Connolly, John Common, Seth L. Masters, Kaiwen W. Chen, Lena Ho, Bin Wu, Veit Hornung, Franklin L. Zhong
Science. Author manuscript; available in PMC 2023 Mar 14.
Published in final edited form as: Science. 2022 Jul 15; 377(6603): 328–335. Published online 2022 Jul 14. doi: 10.1126/science.abl6324
PMCID:
PMC7614315
AbstractArticlePDF–1.8M
14.
The MLK-related Kinase (MRK) Is a Novel RhoC Effector That Mediates Lysophosphatidic Acid (LPA)-stimulated Tumor Cell Invasion
Olga Korkina, Zhiwan Dong, Allison Marullo, Gregg Warshaw, Marc Symons, Rosamaria Ruggieri
J Biol Chem. 2013 Feb 22; 288(8): 5364–5373. Published online 2013 Jan 14. doi: 10.1074/jbc.M112.414060
PMCID:
PMC3581392
AbstractArticlePDF–2.9M
15.
Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice
Malte Spielmann, Naseebullah Kakar, Naeimeh Tayebi, Catherine Leettola, Gudrun Nürnberg, Nadine Sowada, Darío G. Lupiáñez, Izabela Harabula, Ricarda Flöttmann, Denise Horn, Wing Lee Chan, Lars Wittler, Rüstem Yilmaz, Janine Altmüller, Holger Thiele, Hans van Bokhoven, Charles E. Schwartz, Peter Nürnberg, James U. Bowie, Jamil Ahmad, Christian Kubisch, Stefan Mundlos, Guntram Borck
Genome Res. 2016 Feb; 26(2): 183–191. doi: 10.1101/gr.199430.115
PMCID:
PMC4728371
AbstractArticlePDF–1.0M
16.
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays
Avinash Persaud, Philipp Alberts, Eva M Amsen, Xuejian Xiong, James Wasmuth, Zachary Saadon, Chris Fladd, John Parkinson, Daniela Rotin
Mol Syst Biol. 2009; 5: 333. Published online 2009 Dec 1. doi: 10.1038/msb.2009.85
PMCID:
PMC2824488
AbstractArticlePDF–3.1M
17.
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase
Bikash Adhikari, Jelena Bozilovic, Mathias Diebold, Jessica Denise Schwarz, Julia Hofstetter, Martin Schröder, Marek Wanior, Ashwin Narain, Markus Vogt, Nevenka Dudvarski Stankovic, Apoorva Baluapuri, Lars Schönemann, Lorenz Eing, Pranjali Bhandare, Bernhard Kuster, Andreas Schlosser, Stephanie Heinzlmeir, Christoph Sotriffer, Stefan Knapp, Elmar Wolf
Nat Chem Biol. Author manuscript; available in PMC 2021 Apr 6.
Published in final edited form as: Nat Chem Biol. 2020 Nov 1; 16(11): 1179–1188. Published online 2020 Sep 28. doi: 10.1038/s41589-020-00652-y
PMCID:
PMC7610535
AbstractArticlePDF–5.1M
18.
The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
Weimei Tang, Weijie Zhou, Li Xiang, Xiaosheng Wu, Pei Zhang, Jing Wang, Guangnan Liu, Wenjing Zhang, Ying Peng, Xiaoting Huang, Jianqun Cai, Yang Bai, Lan Bai, Wei Zhu, Hongxiang Gu, Jing Xiong, Chen Ye, Aimin Li, Side Liu, Jide Wang
Nat Commun. 2019; 10: 663. Published online 2019 Feb 8. doi: 10.1038/s41467-018-08225-3
PMCID:
PMC6368584
AbstractArticlePDF–6.8M
19.
The cell proliferation antigen Ki-67 organises heterochromatin
Michal Sobecki, Karim Mrouj, Alain Camasses, Nikolaos Parisis, Emilien Nicolas, David Llères, François Gerbe, Susana Prieto, Liliana Krasinska, Alexandre David, Manuel Eguren, Marie-Christine Birling, Serge Urbach, Sonia Hem, Jérôme Déjardin, Marcos Malumbres, Philippe Jay, Vjekoslav Dulic, Denis LJ Lafontaine, Robert Feil, Daniel Fisher
eLife. 2016; 5: e13722. Published online 2016 Mar 7. doi: 10.7554/eLife.13722
PMCID:
PMC4841783
AbstractArticlePDF–5.1M
20.
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks
Pierre Caron, Tibor Pankotai, Wouter W. Wiegant, Maxim A.X. Tollenaere, Audrey Furst, Celine Bonhomme, Angela Helfricht, Anton de Groot, Albert Pastink, Alfred C.O. Vertegaal, Martijn S. Luijsterburg, Evi Soutoglou, Haico van Attikum
Genes Dev. 2019 Jun 1; 33(11-12): 684–704. doi: 10.1101/gad.321943.118
PMCID:
PMC6546063
AbstractArticlePDF–8.4M

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