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Items: 1 to 20 of 103

1.
Multi-omics and immunogenomics analysis revealed PFKFB3 as a targetable hallmark and mediates sunitinib resistance in papillary renal cell carcinoma: in silico study with laboratory verification
Zhongwen Lu, Yongsheng Pan, Songbo Wang, Jiajin Wu, Chenkui Miao, Zengjun Wang
Eur J Med Res. 2024; 29: 236. Published online 2024 Apr 15. doi: 10.1186/s40001-024-01808-5
PMCID:
PMC11017615
AbstractArticlePDF–12M
2.
Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers
Qingen Da, Lei Huang, Can Huang, Zee Chen, Zhitong Jiang, Fang Huang, Tao Shen, Lu Sun, Zilong Yan, Xiaoqiang Ye, Jing Yi, Yu Huang, JingJing Da, Mingming Ren, Jikui Liu, Tao Wang, Zhen Han, Kunfu Ouyang
Aging (Albany NY) 2023 May 31; 15(10): 4533–4559. Published online 2023 May 30. doi: 10.18632/aging.204758
PMCID:
PMC10258027
AbstractArticlePDF–8.3M
3.
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation
Xiao Cheng, Xiupeng Jia, Chunnian Wang, Shangyan Zhou, Jiayi Chen, Lei Chen, Jinping Chen
World J Surg Oncol. 2023; 21: 112. Published online 2023 Mar 28. doi: 10.1186/s12957-023-02990-2
PMCID:
PMC10044395
AbstractArticlePDF–2.6M
4.
PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse
Irina Larionova, Marina Patysheva, Pavel Iamshchikov, Elena Kazakova, Anna Kazakova, Militsa Rakina, Evgeniya Grigoryeva, Anna Tarasova, Sergei Afanasiev, Natalia Bezgodova, Artem Kiselev, Alexey Dobrodeev, Dmitriy Kostromitskiy, Nadezhda Cherdyntseva, Julia Kzhyshkowska
Front Immunol. 2022; 13: 1080501. Published online 2023 Jan 17. doi: 10.3389/fimmu.2022.1080501
PMCID:
PMC9887047
AbstractArticlePDF–10M
5.
Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation
Zhou Zhou, Leonie G. Plug, Thiago A. Patente, Eveline S. M. de Jonge-Muller, Amir Abou Elmagd, Andrea E. van der Meulen-de Jong, Bart Everts, Marieke C. Barnhoorn, Lukas J. A. C. Hawinkels
Front Immunol. 2022; 13: 966067. Published online 2022 Nov 2. doi: 10.3389/fimmu.2022.966067
PMCID:
PMC9670190
AbstractArticlePDF–16M
6.
PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM
Sayantani Sarkar Bhattacharya, Prabhu Thirusangu, Ling Jin, Julie Staub, Viji Shridhar, Julian R. Molina
Br J Cancer. 2022 Oct 19; 127(7): 1352–1364. Published online 2022 Jul 6. doi: 10.1038/s41416-022-01867-7
PMCID:
PMC9519537
AbstractArticlePDF–4.8M
7.
PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma
Prabhu Thirusangu, Upasana Ray, Sayantani Sarkar Bhattacharya, Derek B. Oien, Ling Jin, Julie Staub, Nagarajan Kannan, Julian R. Molina, Viji Shridhar
Oncogene. 2022; 41(33): 4003–4017. Published online 2022 Jul 8. doi: 10.1038/s41388-022-02391-x
Correction in:
Oncogene. 2023; 42(1): 79–82.
PMCID:
PMC9374593
AbstractArticlePDF–8.1M
8.
PFKFB3-mediated glycometabolism reprogramming modulates endothelial differentiation and angiogenic capacity of placenta-derived mesenchymal stem cells
Yang Zhang, Yanqi Zhong, Weifang Liu, Fanghui Zheng, Yin Zhao, Li Zou, Xiaoxia Liu
Stem Cell Res Ther. 2022; 13: 391. Published online 2022 Aug 2. doi: 10.1186/s13287-022-03089-3
PMCID:
PMC9344722
AbstractArticlePDF–6.1M
9.
A Potential Oncogenic Role for PFKFB3 Overexpression in Gastric Cancer Progression
Lan Lei, Lian-Lian Hong, Zhe-Nan Ling, Yi Zhong, Xuan-Yu Hu, Pei Li, Zhi-Qiang Ling
Clin Transl Gastroenterol. 2021 Jul; 12(7): e00377. Published online 2021 Jul 1. doi: 10.14309/ctg.0000000000000377
PMCID:
PMC8345915
AbstractArticlePDF–1.3M
10.
PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs
Nadiia Lypova, Susan M. Dougherty, Lilibeth Lanceta, Jason Chesney, Yoannis Imbert-Fernandez
Cells. 2021 Jul; 10(7): 1679. Published online 2021 Jul 3. doi: 10.3390/cells10071679
PMCID:
PMC8307619
AbstractArticlePDF–3.0M
11.
Functional diversity of PFKFB3 splice variants in glioblastomas
Ulli Heydasch, Renate Kessler, Jan-Peter Warnke, Klaus Eschrich, Nicole Scholz, Marina Bigl
PLoS One. 2021; 16(7): e0241092. Published online 2021 Jul 7. doi: 10.1371/journal.pone.0241092
PMCID:
PMC8263283
AbstractArticlePDF–3.1M
12.
Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis
Samuel M. Gonçalves, Daniela Antunes, Luis Leite, Toine Mercier, Rob ter Horst, Joana Vieira, Eduardo Espada, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, António Marques, Frank L. van de Veerdonk, Leo A. B. Joosten, Katrien Lagrou, Johan Maertens, Mihai G. Netea, João F. Lacerda, António Campos, Jr., Cristina Cunha, Agostinho Carvalho
mBio. 2021 May-Jun; 12(3): e00369-21. Published online 2021 May 28. doi: 10.1128/mBio.00369-21
PMCID:
PMC8263003
AbstractArticlePDF–1.9M
13.
PFKFB3-dependent glucose metabolism regulates 3T3-L1 adipocyte development
Beth A. Griesel, Satoshi Matsuzaki, Albert Batushansky, Timothy M. Griffin, Kenneth M. Humphries, Ann Louise Olson
FASEB J. Author manuscript; available in PMC 2022 Jul 1.
Published in final edited form as: FASEB J. 2021 Jul; 35(7): e21728. doi: 10.1096/fj.202100381RR
PMCID:
PMC8205188
AbstractArticlePDF–2.9M
14.
Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer
Yinan Xiao, Ling Jin, Chaolin Deng, Ye Guan, Eleftheria Kalogera, Upasana Ray, Prabhu Thirusangu, Julie Staub, Sayantani Sarkar Bhattacharya, Haotian Xu, Xiaoling Fang, Viji Shridhar
Oncogene. 2021; 40(8): 1409–1424. Published online 2021 Jan 8. doi: 10.1038/s41388-020-01621-4
PMCID:
PMC7906909
AbstractArticlePDF–7.4M
15.
Reactive oxygen species drive proliferation in acute myeloid leukemia via the glycolytic regulator PFKFB3
Andrew J. Robinson, Goitseone L. Hopkins, Namrata Rastogi, Marie Hodges, Michelle Doyle, Sara Davies, Paul S. Hole, Nader Omidvar, Richard L. Darley, Alex Tonks
Cancer Res. Author manuscript; available in PMC 2021 Jul 12.
Published in final edited form as: Cancer Res. 2020 Mar 1; 80(5): 937–949. Published online 2019 Dec 20. doi: 10.1158/0008-5472.CAN-19-1920
PMCID:
PMC7611211
AbstractArticlePDF–2.5M
16.
The role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 in esophageal squamous cell carcinoma
Junhui Bao, Ya Wu, Limei Wang, Yaqun Zhu
Medicine (Baltimore) 2020 Apr; 99(15): e19626. Published online 2020 Apr 10. doi: 10.1097/MD.0000000000019626
PMCID:
PMC7220331
AbstractArticlePDF–627K
17.
PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells
Siyuan Yan, Nan Zhou, Deru Zhang, Kaile Zhang, Wenao Zheng, Yonghua Bao, Wancai Yang
Int J Mol Sci. 2019 Nov; 20(21): 5415. Published online 2019 Oct 30. doi: 10.3390/ijms20215415
PMCID:
PMC6862230
AbstractArticlePDF–2.6M
18.
PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses
Sayantani Sarkar Bhattacharya, Prabhu Thirusangu, Ling Jin, Debarshi Roy, Deokbeom Jung, Yinan Xiao, Julie Staub, Bhaskar Roy, Julian R. Molina, Viji Shridhar
Cell Death Dis. 2019 Oct; 10(10): 725. Published online 2019 Sep 27. doi: 10.1038/s41419-019-1916-3
PMCID:
PMC6764980
AbstractArticlePDF–3.9M
19.
Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non–small cell lung cancer cell survival
Nadiia Lypova, Sucheta Telang, Jason Chesney, Yoannis Imbert-Fernandez
J Biol Chem. 2019 Jul 5; 294(27): 10530–10543. Published online 2019 May 24. doi: 10.1074/jbc.RA119.007784
PMCID:
PMC6615683
AbstractArticlePDF–3.7M
20.
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Nat Commun. 2018; 9: 3872. Published online 2018 Sep 24. doi: 10.1038/s41467-018-06287-x
PMCID:
PMC6155239
AbstractArticlePDF–4.5M

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