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Select item 105867801.

Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity

Maria A. Voronkova, Heather L. Hansen, Madison P. Cooper, Jacob Miller, Narayanasami Sukumar, Werner J. Geldenhuys, Aaron R. Robart, Bradley A. Webb

Biochem J. 2023 Sep 13; 480(17): 1411–1427. Published online 2023 Sep 4. doi: 10.1042/BCJ20230207

PMCID:: PMC10586780

Abstract Article PDF–3.2M

Select item 100674182.

RNAi screening reveals a synthetic chemical–genetic interaction between ATP synthase and PFK1 in cancer cells

Hiroki Kobayashi, Shohei Takase, Haruna Nishimura, Ken Matsumoto, Hironori Harada, Minoru Yoshida

Cancer Sci. 2023 Apr; 114(4): 1663–1671. Published online 2023 Jan 24. doi: 10.1111/cas.15713

PMCID:: PMC10067418

Abstract Article PDF–2.4M

Select item 78891053.

RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2

Shuo Li, Peng He, Zhiwei Wang, Meng Liang, Wei Liao, Yili Huang, Mengshi Chi, Fei Liu, Nan Zen, Rongfei Su, Shulin Chen, Zhigang Liu, Haiyu Hong

Cell Cycle. 2021; 20(2): 154–165. Published online 2021 Jan 6. doi: 10.1080/15384101.2020.1866279

PMCID:: PMC7889105

Abstract Article PDF–4.3M

Select item 39313954.

Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity

Sarah Keildson, Joao Fadista, Claes Ladenvall, Åsa K. Hedman, Targ Elgzyri, Kerrin S. Small, Elin Grundberg, Alexandra C. Nica, Daniel Glass, J. Brent Richards, Amy Barrett, James Nisbet, Hou-Feng Zheng, Tina Rönn, Kristoffer Ström, Karl-Fredrik Eriksson, Inga Prokopenko, MAGIC Consortium, DIAGRAM Consortium, MuTHER Consortium, Timothy D. Spector, Emmanouil T. Dermitzakis, Panos Deloukas, Mark I. McCarthy, Johan Rung, Leif Groop, Paul W. Franks, Cecilia M. Lindgren, Ola Hansson

Diabetes. 2014 Mar; 63(3): 1154–1165. Published online 2014 Feb 13. doi: 10.2337/db13-1301

PMCID:: PMC3931395

Abstract Article PDF–864K

Select item 33668545.

Functional Linkage of Adenine Nucleotide Binding Sites in Mammalian Muscle 6-Phosphofructokinase

Antje Brüser, Jürgen Kirchberger, Marco Kloos, Norbert Sträter, Torsten Schöneberg

J Biol Chem. 2012 May 18; 287(21): 17546–17553. Published online 2012 Apr 3. doi: 10.1074/jbc.M112.347153

PMCID:: PMC3366854

Abstract Article PDF–1.0M

Select item 29907646.

Evolution of Allosteric Citrate Binding Sites on 6-phosphofructo-1-kinase

Aleksandra Usenik, Matic Legiša

PLoS One. 2010; 5(11): e15447. Published online 2010 Nov 23. doi: 10.1371/journal.pone.0015447

PMCID:: PMC2990764

Abstract Article PDF–544K

Select item 19183807.

Common mutations in the phosphofructokinase-M gene in Ashkenazi Jewish patients with glycogenesis VII--and their population frequency.

J. B. Sherman, N. Raben, C. Nicastri, Z. Argov, H. Nakajima, E. M. Adams, C. M. Eng, T. M. Cowan, P. H. Plotz

Am J Hum Genet. 1994 Aug; 55(2): 305–313.

PMCID:: PMC1918380

Summary Page Browse PDF–1.6M

Select item 19182468.

Identification of three novel mutations in non-Ashkenazi Italian patients with muscle phosphofructokinase deficiency.

S. Tsujino, S. Servidei, P. Tonin, S. Shanske, G. Azan, S. DiMauro

Am J Hum Genet. 1994 May; 54(5): 812–819.

PMCID:: PMC1918246

Summary Page Browse PDF–1.4M

Select item 5084899.

Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance.

M Ristow, M Vorgerd, M Möhlig, H Schatz, A Pfeiffer

J Clin Invest. 1997 Dec 1; 100(11): 2833–2841. doi: 10.1172/JCI119831

PMCID:: PMC508489

Summary PDF–342K

Select item 4078810.

Nonsense mutation in the phosphofructokinase muscle subunit gene associated with retention of intron 10 in one of the isolated transcripts in Ashkenazi Jewish patients with Tarui disease.

O Vasconcelos, K Sivakumar, M C Dalakas, M Quezado, J Nagle, M Leon-Monzon, M Dubnick, D C Gajdusek, L G Goldfarb

Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22): 10322–10326. doi: 10.1073/pnas.92.22.10322

PMCID:: PMC40788

Summary Page Browse PDF–1.2M

Select item 957672611.

Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM

Shihao Xu, Yin Celeste Cheuk, Yichen Jia, Tian Chen, Juntao Chen, Yongsheng Luo, Yirui Cao, Jingjing Guo, Lijun Dong, Yi Zhang, Yi Shi, Ruiming Rong

Cell Death Dis. 2022 Oct; 13(10): 876. Published online 2022 Oct 17. doi: 10.1038/s41419-022-05305-7

PMCID:: PMC9576726

Abstract Article PDF–5.4M

Select item 805873712.

ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM

Yanming Zhou, Furong Lin, Tao Wan, Ai Chen, Huihui Wang, Bin Jiang, Wentao Zhao, Shan Liao, Shijie Wang, Guannan Li, Zhenzhen Xu, Jinyang Wang, Jia Zhang, Huanhuan Ma, Donghai Lin, Qinxi Li

Theranostics. 2021; 11(12): 5926–5938. Published online 2021 Apr 3. doi: 10.7150/thno.56490

PMCID:: PMC8058737

Abstract Article PDF–2.8M

Select item 771894513.

TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas

Francesca Maddalena, Valentina Condelli, Danilo Swann Matassa, Consiglia Pacelli, Rosella Scrima, Giacomo Lettini, Valeria Li Bergolis, Michele Pietrafesa, Fabiana Crispo, Annamaria Piscazzi, Giovanni Storto, Nazzareno Capitanio, Franca Esposito, Matteo Landriscina

Mol Oncol. 2020 Dec; 14(12): 3030–3047. Published online 2020 Oct 30. doi: 10.1002/1878-0261.12814

PMCID:: PMC7718945

Abstract Article PDF–2.4M

Select item 555171314.

The glycolytic enzyme phosphofructokinase-1 assembles into filaments

Bradley A. Webb, Anne M. Dosey, Torsten Wittmann, Justin M. Kollman, Diane L. Barber

J Cell Biol. 2017 Aug 7; 216(8): 2305–2313. doi: 10.1083/jcb.201701084

PMCID:: PMC5551713

Abstract Article PDF–2.0M

Select item 474576015.

The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells

Artur Cieślar-Pobuda, Mayur Vilas Jain, Gunnar Kratz, Joanna Rzeszowska-Wolny, Saeid Ghavami, Emilia Wiechec

Oncotarget. 2015 Oct 6; 6(30): 29753–29770. Published online 2015 Aug 13. doi: 10.18632/oncotarget.4995

PMCID:: PMC4745760

Abstract Article PDF–4.3M

Select item 895564816.

Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients

Mehreen Ishfaq, Nabiha Bashir, Syeda Kiran Riaz, Shumaila Manzoor, Jahangir Sarwar Khan, Yamin Bibi, Rokayya Sami, Amani H. Aljahani, Saif A. Alharthy, Ramla Shahid

Genes (Basel) 2022 Mar; 13(3): 549. Published online 2022 Mar 20. doi: 10.3390/genes13030549