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Select item 93378081.

Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy

Luca Gozzelino, Gaga Kochlamazashvili, Sara Baldassari, Albert Ian Mackintosh, Laura Licchetta, Emanuela Iovino, Yu Chi Liu, Caitlin A Bennett, Mark F Bennett, John A Damiano, Gábor Zsurka, Caterina Marconi, Tania Giangregorio, Pamela Magini, Marijn Kuijpers, Tanja Maritzen, Giuseppe Danilo Norata, Stéphanie Baulac, Laura Canafoglia, Marco Seri, Paolo Tinuper, Ingrid E Scheffer, Melanie Bahlo, Samuel F Berkovic, Michael S Hildebrand, Wolfram S Kunz, Lucio Giordano, Francesca Bisulli, Miriam Martini, Volker Haucke, Emilio Hirsch, Tommaso Pippucci

Brain. 2022 Jul; 145(7): 2313–2331. Published online 2022 Jul 4. doi: 10.1093/brain/awac082

PMCID:: PMC9337808

Abstract Article PDF–1.5M

Select item 87140252.

Higher PIK3C2B gene expression of H1N1+ specific B-cells is associated with lower H1N1 immunogenicity after trivalent influenza vaccination in HIV infected children

Nicola Cotugno, Sonia Zicari, Elena Morrocchi, Lesley R. de Armas, Suresh Pallikkuth, Stefano Rinaldi, Alessandra Ruggiero, Emma Concetta Manno, Paola Zangari, Maria Chiriaco, Stefania Bernardi, Sarah F. Andrews, Alberto Cagigi, Paolo Rossi, Adrian B. McDermott, Savita Pahwa, Paolo Palma

Clin Immunol. Author manuscript; available in PMC 2021 Dec 28.

Published in final edited form as: Clin Immunol. 2020 Jun; 215: 108440. Published online 2020 Apr 21. doi: 10.1016/j.clim.2020.108440

PMCID:: PMC8714025

Abstract Article PDF–1.0M

Select item 68735613.

Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth

Ouma Cisse, Muzthahid Quraishi, Federico Gulluni, Federica Guffanti, Ioanna Mavrommati, Methushaa Suthanthirakumaran, Lara C. R. Oh, Jessica N. Schlatter, Ambisha Sarvananthan, Massimo Broggini, Emilio Hirsch, Marco Falasca, Tania Maffucci

J Exp Clin Cancer Res. 2019; 38: 472. Published online 2019 Nov 21. doi: 10.1186/s13046-019-1472-9

PMCID:: PMC6873561

Abstract Article PDF–4.5M

Select item 56634934.

Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis

Marcus Kind, Jolanta Klukowska-Rötzler, Sabina Berezowska, Alexandre Arcaro, Roch-Philippe Charles

PLoS One. 2017; 12(10): e0187308. Published online 2017 Oct 31. doi: 10.1371/journal.pone.0187308

PMCID:: PMC5663493

Abstract Article PDF–5.2M

Select item 43517445.

Phosphatidylinositol 3-kinase, Class 2 beta (PI3KC2β) isoform contributes to neuroblastoma tumorigenesis

Angela Russo, Mustafa Nazir Okur, Maarten Bosland, John P. O'Bryan

Cancer Lett. Author manuscript; available in PMC 2016 Apr 10.

Published in final edited form as: Cancer Lett. 2015 Apr 10; 359(2): 262–268. Published online 2015 Jan 23. doi: 10.1016/j.canlet.2015.01.026

PMCID:: PMC4351744

Abstract Article PDF–632K

Select item 34416336.

A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation

Katy A. Wong, Angela Russo, Xuerong Wang, Yun-Ju Chen, Arnon Lavie, John P. O'Bryan

PLoS One. 2012; 7(9): e45360. Published online 2012 Sep 13. doi: 10.1371/journal.pone.0045360

PMCID:: PMC3441633

Abstract Article PDF–1.5M

Select item 1290347.

Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation

Alexandre Arcaro, Umme K. Khanzada, Bart Vanhaesebroeck, Teresa D. Tetley, Michael D. Waterfield, Michael J. Seckl

EMBO J. 2002 Oct 1; 21(19): 5097–5108. doi: 10.1093/emboj/cdf512

PMCID:: PMC129034

Abstract Article PDF–656K

Select item 107175478.

The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells

Khin Thuzar Aung, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Noriko Takuwa, Yoh Takuwa

J Physiol Sci. 2019 Mar; 69(2): 263–280. Published online 2018 Oct 29. doi: 10.1007/s12576-018-0644-2

PMCID:: PMC10717547

Abstract Article PDF–20M

Select item 27354779.

The Class II Phosphatidylinositol 3 kinase C2β Is Required for the Activation of the K⁺ Channel KCa3.1 and CD4 T-Cells

Shekhar Srivastava, Lie Di, Olga Zhdanova, Zhai Li, Santosha Vardhana, Qi Wan, Ying Yan, Rajat Varma, Jonathan Backer, Heike Wulff, Michael L. Dustin, Edward Y. Skolnik

Mol Biol Cell. 2009 Sep 1; 20(17): 3783–3791. doi: 10.1091/mbc.E09-05-0390

PMCID:: PMC2735477

Abstract Article PDF–1.3M

Select item 159315510.

Phosphoinositide 3-Kinase C2β Regulates Cytoskeletal Organization and Cell Migration via Rac-dependent Mechanisms

Roy M. Katso, Olivier E. Pardo, Andrea Palamidessi, Clemens M. Franz, Marin Marinov, Angela De Laurentiis, Julian Downward, Giorgio Scita, Anne J. Ridley, Michael D. Waterfield, Alexandre Arcaro

Mol Biol Cell. 2006 Sep; 17(9): 3729–3744. doi: 10.1091/mbc.E05-11-1083

PMCID:: PMC1593155

Abstract Article PDF–3.5M

Select item 131698311.

The Class II Phosphoinositide 3-Kinase C2β Is Not Essential for Epidermal Differentiation

Kazutoshi Harada, Amy B. Truong, Ti Cai, Paul A. Khavari

Mol Cell Biol. 2005 Dec; 25(24): 11122–11130. doi: 10.1128/MCB.25.24.11122-11130.2005

PMCID:: PMC1316983

Abstract Article PDF–1.4M

Select item 28066012.

Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation

Soha Salama El Sheikh, Jan Domin, Prakitpunthu Tomtitchong, Paul Abel, Gordon Stamp, El-Nasir Lalani

BMC Clin Pathol. 2003; 3: 4. Published online 2003 Oct 16. doi: 10.1186/1472-6890-3-4

PMCID:: PMC280660

Abstract Article PDF–740K

Select item 353999313.

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis

Gianpaolo Tibolla, Roberto Piñeiro, Daniela Chiozzotto, Ioanna Mavrommati, Ann P. Wheeler, Giuseppe Danilo Norata, Alberico Luigi Catapano, Tania Maffucci, Marco Falasca

PLoS One. 2013; 8(1): e53808. Published online 2013 Jan 8. doi: 10.1371/journal.pone.0053808

PMCID:: PMC3539993

Abstract Article PDF–997K

Select item 9981114.

Recruitment of the Class II Phosphoinositide 3-Kinase C2β to the Epidermal Growth Factor Receptor: Role of Grb2

Matthew Wheeler, Jan Domin

Mol Cell Biol. 2001 Oct; 21(19): 6660–6667. doi: 10.1128/MCB.21.19.6660-6667.2001

PMCID:: PMC99811

Abstract Article PDF–273K

Select item 288175715.

Differential Induction of Interleukin-10 in Monocytes by HIV-1 Clade B and Clade C Tat Proteins

Justine K. Wong, Grant R. Campbell, Stephen A. Spector

J Biol Chem. 2010 Jun 11; 285(24): 18319–18325. Published online 2010 Apr 8. doi: 10.1074/jbc.M110.120840

PMCID:: PMC2881757

Abstract Article PDF–1.7M

Select item 284018416.

Pooled Analysis of Phosphatidylinositol 3-kinase Pathway Variants and Risk of Prostate Cancer

Stella Koutros, Fredrick R. Schumacher, Richard B. Hayes, Jing Ma, Wen-Yi Huang, Demetrius Albanes, Federico Canzian, Stephen J. Chanock, E. David Crawford, W. Ryan Diver, Heather Spencer Feigelson, Edward Giovanucci, Christopher A. Haiman, Brian E. Henderson, David J. Hunter, Rudolf Kaaks, Laurence N. Kolonel, Peter Kraft, Loïc Le Marchand, Elio Riboli, Afshan Siddiq, Mier J. Stampfer, Daniel O. Stram, Gilles Thomas, Ruth C. Travis, Michael J. Thun, Meredith Yeager, Sonja I. Berndt

Cancer Res. Author manuscript; available in PMC 2011 Mar 15.

Published in final edited form as: Cancer Res. 2010 Mar 15; 70(6): 2389–2396. Published online 2010 Mar 2. doi: 10.1158/0008-5472.CAN-09-3575

PMCID:: PMC2840184

Abstract Article PDF–326K

Select item 8570717.

Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors

Alexandre Arcaro, Marketa J. Zvelebil, Christian Wallasch, Axel Ullrich, Michael D. Waterfield, Jan Domin

Mol Cell Biol. 2000 Jun; 20(11): 3817–3830. doi: 10.1128/mcb.20.11.3817-3830.2000

PMCID:: PMC85707

Abstract Article PDF–4.2M

Select item 325018218.

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β

Xinjiang Cai, Shekhar Srivastava, Yi Sun, Zhai Li, Haiyan Wu, Ljiljana Zuvela-Jelaska, Jun Li, Rachel S. Salamon, Jonathan M. Backer, Edward Y. Skolnik

Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50): 20072–20077. Published online 2011 Nov 29. doi: 10.1073/pnas.1111233109

PMCID:: PMC3250182

Abstract Article PDF–720K

Select item 14974219.

Nef-Mediated Disruption of HLA-A2 Transport to the Cell Surface in T Cells

Matthew R. Kasper, Kathleen L. Collins

J Virol. 2003 Mar; 77(5): 3041–3049. doi: 10.1128/JVI.77.5.3041-3049.2003

PMCID:: PMC149742

Abstract Article PDF–829K

Select item 14110120.

Phosphatidylinositol 3-Kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4⁺ T Lymphocytes and Macrophages

Fleur François, Mary E. Klotman

J Virol. 2003 Feb; 77(4): 2539–2549. doi: 10.1128/JVI.77.4.2539-2549.2003

PMCID:: PMC141101

Abstract Article PDF–1.4M

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