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Select item 110760431.

Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

Benjamin R Duewell, Naomi E Wilson, Gabriela M Bailey, Sarah E Peabody, Scott D Hansen

eLife. 2024; 12: RP88991. Published online 2024 May 7. doi: 10.7554/eLife.88991

PMCID:: PMC11076043

Abstract Article PDF–3.0M

Select item 84639252.

PIK3CB is involved in metastasis through the regulation of cell adhesion to collagen I in pancreatic cancer

Jianhua Qu, Biao Zheng, Kenoki Ohuchida, Haimin Feng, Stephen Jun Fei Chong, Xianbin Zhang, Rui Liang, Zhong Liu, Kengo Shirahane, Kazuhiro Mizumoto, Peng Gong, Masafumi Nakamura

J Adv Res. 2021 Nov; 33: 127–140. Published online 2021 Feb 17. doi: 10.1016/j.jare.2021.02.002

PMCID:: PMC8463925

Abstract Article PDF–7.6M

Select item 81338293.

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Nisha Raj, Zachary T. McEachin, William Harousseau, Ying Zhou, Feiran Zhang, Megan E. Merritt-Garza, J. Matthew Taliaferro, Magdalena Kalinowska, Samuele G. Marro, Chadwick M. Hales, Elizabeth Berry-Kravis, Marisol W. Wolf-Ochoa, Veronica Martinez-Cerdeño, Marius Wernig, Lu Chen, Eric Klann, Stephen T. Warren, Peng Jin, Zhexing Wen, Gary J. Bassell

Cell Rep. Author manuscript; available in PMC 2021 May 19.

Published in final edited form as: Cell Rep. 2021 Apr 13; 35(2): 108991. doi: 10.1016/j.celrep.2021.108991

PMCID:: PMC8133829

Abstract Article PDF–1.8M

Select item 63757094.

PI3Kβ—A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling

Anne R Bresnick, Jonathan M Backer

Endocrinology. 2019 Mar; 160(3): 536–555. Published online 2019 Jan 2. doi: 10.1210/en.2018-00843

PMCID:: PMC6375709

Abstract Article

Select item 59733845.

非小细胞肺癌PI3Kp110β高表达的临床意义及机制

熊焰, 曲琳琳, 李东, 王颖, 李挺

Zhongguo Fei Ai Za Zhi. 2017 Dec 20; 20(12): 808–816. Chinese. doi: 10.3779/j.issn.1009-3419.2017.12.03

PMCID:: PMC5973384

Abstract Article PDF–2.1M

Select item 59096646.

PIK3CB/p110β is a selective survival factor for glioblastoma

Kevin J Pridham, Lamvy Le, Sujuan Guo, Robin T Varghese, Sarah Algino, Yanping Liang, Renee Fajardin, Cara M Rodgers, Gary R Simonds, Deborah F Kelly, Zhi Sheng

Neuro Oncol. 2018 Mar; 20(4): 494–505. Published online 2017 Sep 16. doi: 10.1093/neuonc/nox181

PMCID:: PMC5909664

Abstract Article PDF–20M

Select item 49152227.

GPCR signaling mediates tumor metastasis via PI3Kβ

Bassem D. Khalil, Christine Hsueh, Yanyan Cao, Widian F. Abi Saab, Yarong Wang, John S. Condeelis, Anne R. Bresnick, Jonathan M. Backer

Cancer Res. Author manuscript; available in PMC 2017 May 15.

Published in final edited form as: Cancer Res. 2016 May 15; 76(10): 2944–2953. Published online 2016 Mar 24. doi: 10.1158/0008-5472.CAN-15-1675

PMCID:: PMC4915222

Abstract Article PDF–2.5M

Select item 46904248.

PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients

Kaspar Draaisma, Maarten M. J. Wijnenga, Bas Weenink, Ya Gao, Marcel Smid, P. Robe, Martin J. van den Bent, Pim J. French

Acta Neuropathol Commun. 2015; 3: 88. Published online 2015 Dec 23. doi: 10.1186/s40478-015-0265-4

PMCID:: PMC4690424

Abstract Article PDF–732K

Select item 39793269.

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Hashem A. Dbouk, Oscar Vadas, Aliaksei Shymanets, John E. Burke, Rachel S. Salamon, Bassem D. Khalil, Mathew O. Barrett, Gary L. Waldo, Chinmay Surve, Christine Hsueh, Olga Perisic, Christian Harteneck, Peter R. Shepherd, T. Kendall Harden, Alan V. Smrcka, Ronald Taussig, Anne R. Bresnick, Bernd Nürnberg, Roger L. Williams, Jonathan M. Backer

Sci Signal. Author manuscript; available in PMC 2014 Apr 8.

Published in final edited form as: Sci Signal. 2012 Dec 4; 5(253): ra89. Published online 2012 Dec 4. doi: 10.1126/scisignal.2003264

PMCID:: PMC3979326

Abstract Article PDF–3.1M

Select item 366718710.

Characterization of a Tumor-Associated Activating Mutation of the p110β PI 3-Kinase

Hashem A. Dbouk, Bassem D. Khalil, Haiyan Wu, Aliaksei Shymanets, Bernd Nürnberg, Jonathan M. Backer

PLoS One. 2013; 8(5): e63833. Published online 2013 May 29. doi: 10.1371/journal.pone.0063833

PMCID:: PMC3667187

Abstract Article PDF–791K

Select item 315774011.

A beta version of life: p110β takes center stage

Hashem A. Dbouk, Jonathan M. Backer

Oncotarget. 2010 Dec; 1(8): 729–733. Published online 2010 Dec 30. doi: 10.18632/oncotarget.207

PMCID:: PMC3157740

Abstract Article PDF–1.3M

Select item 299336412.

A biochemical mechanism for the oncogenic potential of the p110β catalytic subunit of phosphoinositide 3-kinase

Hashem A. Dbouk, Huan Pang, Andras Fiser, Jonathan M. Backer

Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46): 19897–19902. Published online 2010 Oct 28. doi: 10.1073/pnas.1008739107

PMCID:: PMC2993364

Abstract Article PDF–760K

Select item 284482013.

Impact of rs361072 in the Phosphoinositide 3-Kinase p110β Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle

Rasmus Ribel-Madsen, Pernille Poulsen, Johan Holmkvist, Brynjulf Mortensen, Niels Grarup, Martin Friedrichsen, Torben Jørgensen, Torsten Lauritzen, Jørgen F.P. Wojtaszewski, Oluf Pedersen, Torben Hansen, Allan Vaag

Diabetes. 2010 Apr; 59(4): 1108–1112. Published online 2010 Jan 27. doi: 10.2337/db09-1359

PMCID:: PMC2844820

Abstract Article PDF–74K

Select item 36483914.

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

P Hu, A Mondino, E Y Skolnik, J Schlessinger

Mol Cell Biol. 1993 Dec; 13(12): 7677–7688. doi: 10.1128/mcb.13.12.7677

PMCID:: PMC364839

Summary Page Browse PDF–3.0M

Select item 1107328915.

SUMOylation modulates the stability and function of PI3K-p110β

Ahmed El Motiam, Carlos F. de la Cruz-Herrera, Santiago Vidal, Rocío Seoane, Maite Baz-Martínez, Yanis H. Bouzaher, Emilio Lecona, Mariano Esteban, Manuel S. Rodríguez, Anxo Vidal, Manuel Collado, Carmen Rivas

Cell Mol Life Sci. 2021 Apr; 78(8): 4053–4065. Published online 2021 Apr 8. doi: 10.1007/s00018-021-03826-6

PMCID:: PMC11073289

Abstract Article PDF–2.7M

Select item 1048528416.

AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20)

Koung Jin Suh, Min-Hee Ryu, Dae Young Zang, Woo Kyun Bae, Hye Seung Lee, Hyeon Jeong Oh, Minsu Kang, Ji-Won Kim, Bum Jun Kim, Peter G S Mortimer, Hee Jung Kim, Keun-Wook Lee

Oncologist. 2023 Sep; 28(9): e823–e834. Published online 2023 Apr 10. doi: 10.1093/oncolo/oyad059

Correction in:: Oncologist. 2024 Apr; 29(4): e579.

PMCID:: PMC10485284

Abstract Article PDF–2.6M

Select item 888591117.

PIP₃ abundance overcomes PI3K signaling selectivity in invadopodia

Charles T. Jakubik, Claire C. Weckerly, Gerald R.V. Hammond, Anne R. Bresnick, Jonathan M. Backer

FEBS Lett. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: FEBS Lett. 2022 Feb; 596(4): 417–426. Published online 2022 Jan 12. doi: 10.1002/1873-3468.14273

PMCID:: PMC8885911

Abstract Article PDF–1.1M

Select item 730521618.

YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC

Yanwei Cui, Fengzhou Li, Qiang Xie, Shilei Zhao, Tao Guo, Ping Guo, Sheng Hu, Jiaojiao Hao, Chunfang Tian, Wendan Yu, Zhuoshi Li, Lei Fang, Lei Zhao, Manyu Chen, Taihua Wu, Chundong Gu

Cell Death Dis. 2020 Jun; 11(6): 476. Published online 2020 Jun 19. doi: 10.1038/s41419-020-2555-4

PMCID:: PMC7305216

Abstract Article PDF–2.8M

Select item 678727519.

AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells

Swati Sinha, Arun Renganathan, Prathima B. Nagendra, Vasudeva Bhat, Brian Steve Mathew, Manchanahalli R. Satyanarayana Rao

Sci Rep. 2019; 9: 14577. Published online 2019 Oct 10. doi: 10.1038/s41598-019-51068-1

PMCID:: PMC6787275

Abstract Article PDF–2.2M

Select item 673791120.

PI3Kβ is selectively required for growth factor-stimulated macropinocytosis

Gilbert Salloum, Charles T. Jakubik, Zahra Erami, Samantha D. Heitz, Anne R. Bresnick, Jonathan M. Backer

J Cell Sci. 2019 Aug 15; 132(16): jcs231639. Published online 2019 Aug 16. doi: 10.1242/jcs.231639

PMCID:: PMC6737911

Abstract Article

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