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Items: 14

Select item 84968101.

Effects of ionic strength on gating and permeation of TREK-2 K2P channels

Linus J. Conrad, Peter Proks, Stephen J. Tucker

PLoS One. 2021; 16(10): e0258275. Published online 2021 Oct 7. doi: 10.1371/journal.pone.0258275

PMCID:: PMC8496810

Abstract Article PDF–1.6M

Select item 60346492.

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

Yin Yao Dong, Ashley C.W. Pike, Alexandra Mackenzie, Conor McClenaghan, Prafulla Aryal, Liang Dong, Andrew Quigley, Mariana Grieben, Solenne Goubin, Shubhashish Mukhopadhyay, Gian Filippo Ruda, Michael V. Clausen, Lishuang Cao, Paul E. Brennan, Nicola A. Burgess-Brown, Mark S. P. Sansom, Stephen J. Tucker, Elisabeth P. Carpenter

Science. Author manuscript; available in PMC 2018 Jul 6.

Published in final edited form as: Science. 2015 Mar 13; 347(6227): 1256–1259. doi: 10.1126/science.1261512

PMCID:: PMC6034649

Abstract Article PDF–2.0M

Select item 48862813.

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

Conor McClenaghan, Marcus Schewe, Prafulla Aryal, Elisabeth P. Carpenter, Thomas Baukrowitz, Stephen J. Tucker

J Gen Physiol. 2016 Jun; 147(6): 497–505. doi: 10.1085/jgp.201611601

PMCID:: PMC4886281

Abstract Article PDF–1.5M

Select item 31718804.

Alternative splicing determines mRNA translation initiation and function of human K_2P10.1 K⁺ channels

Kathrin Staudacher, Ioana Baldea, Jana Kisselbach, Ingo Staudacher, Ann-Kathrin Rahm, Patrick A Schweizer, Rüdiger Becker, Hugo A Katus, Dierk Thomas

J Physiol. 2011 Aug 1; 589(Pt 15): 3709–3720. Published online 2011 Jun 13. doi: 10.1113/jphysiol.2011.210666

PMCID:: PMC3171880

Abstract Article PDF–1.7M

Select item 42940335.

Modulation of K_2P2.1 and K_2P10.1 K⁺ channel sensitivity to carvedilol by alternative mRNA translation initiation

J Kisselbach, C Seyler, P A Schweizer, R Gerstberger, R Becker, H A Katus, D Thomas

Br J Pharmacol. 2014 Dec; 171(23): 5182–5194. Published online 2014 Aug 28. doi: 10.1111/bph.12596

PMCID:: PMC4294033

Abstract Article PDF–1.5M

Select item 41699216.

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid

Yannick Comoglio, Joshua Levitz, Michael A. Kienzler, Florian Lesage, Ehud Y. Isacoff, Guillaume Sandoz

Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37): 13547–13552. Published online 2014 Sep 2. doi: 10.1073/pnas.1407160111

PMCID:: PMC4169921

Abstract Article PDF–1.1M

Select item 22901887.

Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2

Wenli Gu, Günter Schlichthörl, Jochen R Hirsch, Hartmut Engels, Christine Karschin, Andreas Karschin, Christian Derst, Ortrud K Steinlein, Jürgen Daut

J Physiol. 2002 Mar 15; 539(Pt 3): 657–668. doi: 10.1113/jphysiol.2001.013432

PMCID:: PMC2290188

Abstract Article PDF–670K

Select item 102528898.

β-COP Suppresses the Surface Expression of the TREK2

Seong-Seop Kim, Jimin Park, Eunju Kim, Eun Mi Hwang, Jae-Yong Park

Cells. 2023 Jun; 12(11): 1500. Published online 2023 May 29. doi: 10.3390/cells12111500

PMCID:: PMC10252889

Abstract Article PDF–3.7M

Select item 46816009.

The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients

Jingyu Liu, Peter Siyahhan Julnes, Jiayu Chen, Stefan Ehrlich, Esther Walton, Vince D. Calhoun

Schizophr Res. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Schizophr Res. 2015 Dec; 169(0): 447–452. Published online 2015 Sep 14. doi: 10.1016/j.schres.2015.08.035

PMCID:: PMC4681600

Abstract Article PDF–1.1M

Select item 251846210.

Regulation of two-pore-domain (K_2P) potassium leak channels by the tyrosine kinase inhibitor genistein

J Gierten, E Ficker, R Bloehs, K Schlömer, S Kathöfer, E Scholz, E Zitron, C Kiesecker, A Bauer, R Becker, H A Katus, C A Karle, D Thomas

Br J Pharmacol. 2008 Aug; 154(8): 1680–1690. Published online 2008 Jun 2. doi: 10.1038/bjp.2008.213

PMCID:: PMC2518462

Abstract Article PDF–347K

Select item 417105311.

Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens

Rohina Rubicz, Robert Yolken, Armin Alaedini, Eugene Drigalenko, Jac C. Charlesworth, Melanie A. Carless, Emily G. Severance, Bogdana Krivogorsky, Thomas D. Dyer, Jack W. Kent, Jr., Joanne E. Curran, Matthew P. Johnson, Shelley A. Cole, Laura Almasy, Eric K. Moses, John Blangero, Harald H.H. Göring

Genet Epidemiol. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Genet Epidemiol. 2014 Jul; 38(5): 439–446. doi: 10.1002/gepi.21817

PMCID:: PMC4171053

Abstract Article PDF–398K

Select item 13914612.

Large-Scale Concatenation cDNA Sequencing

Wei Yu, Björn Andersson, Kim C. Worley, Donna M. Muzny, Yan Ding, Wen Liu, Jennifer Y. Ricafrente, Meredith A. Wentland, Greg Lennon, Richard A. Gibbs

Genome Res. 1997 Apr; 7(4): 353–358. doi: 10.1101/gr.7.4.353