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Select item 110503611.

The Impact of SNP-Induced Amino Acid Substitutions L19P and G66R in the dRP-Lyase Domain of Human DNA Polymerase β on Enzyme Activities

Olga A. Kladova, Timofey E. Tyugashev, Denis V. Yakimov, Elena S. Mikushina, Daria S. Novopashina, Nikita A. Kuznetsov, Aleksandra A. Kuznetsova

Int J Mol Sci. 2024 Apr; 25(8): 4182. Published online 2024 Apr 10. doi: 10.3390/ijms25084182

PMCID:: PMC11050361

Abstract Article PDF–6.0M

Select item 102536262.

The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates

Artemiy S. Bakman, Stanislav S. Boichenko, Aleksandra A. Kuznetsova, Alexander A. Ishchenko, Murat Saparbaev, Nikita A. Kuznetsov

Int J Mol Sci. 2023 Jun; 24(11): 9594. Published online 2023 May 31. doi: 10.3390/ijms24119594

PMCID:: PMC10253626

Abstract Article PDF–2.4M

Select item 101770363.

The Activity of Natural Polymorphic Variants of Human DNA Polymerase β Having an Amino Acid Substitution in the Transferase Domain

Olga A. Kladova, Timofey E. Tyugashev, Elena S. Mikushina, Nikita A. Kuznetsov, Daria S. Novopashina, Aleksandra A. Kuznetsova

Cells. 2023 May; 12(9): 1300. Published online 2023 May 2. doi: 10.3390/cells12091300

PMCID:: PMC10177036

Abstract Article PDF–5.9M

Select item 100512654.

Human Polβ Natural Polymorphic Variants G118V and R149I Affects Substate Binding and Catalysis

Olga A. Kladova, Timofey E. Tyugashev, Elena S. Mikushina, Nikita O. Soloviev, Nikita A. Kuznetsov, Daria S. Novopashina, Aleksandra A. Kuznetsova

Int J Mol Sci. 2023 Mar; 24(6): 5892. Published online 2023 Mar 20. doi: 10.3390/ijms24065892

PMCID:: PMC10051265

Abstract Article PDF–4.5M

Select item 89304915.

Polymorphic mutations in the polb gene promoter and their impact on transcriptional activity

Qingjun Wu, Yuying Qi, Shuanghu Wang, Jian Liu, Peiwu Geng, Quan Zhou, Wenqian Zhang, Jianping Cai, Bin Hu, Dapeng Dai, Hui Li

Thorac Cancer. 2022 Mar; 13(6): 853–857. Published online 2022 Feb 6. doi: 10.1111/1759-7714.14337

PMCID:: PMC8930491

Abstract Article PDF–913K

Select item 79577146.

Silencing DNA Polymerase β Induces Aneuploidy as a Biomarker of Poor Prognosis in Oral Squamous Cell Cancer

Hui-Ching Wang, Leong-Perng Chan, Chun-Chieh Wu, Shu-Jyuan Chang, Sin-Hua Moi, Chi-Wen Luo, Mei-Ren Pan

Int J Mol Sci. 2021 Mar; 22(5): 2402. Published online 2021 Feb 27. doi: 10.3390/ijms22052402

PMCID:: PMC7957714

Abstract Article PDF–1.4M

Select item 79191627.

Two polymorphic mutations in promoter region of DNA polymerase β in relatively higher percentage of thymic hyperplasia patients

Qingjun Wu, Shan Zhou, Jian Liu, Hongfeng Tong, Yaoguang Sun, Wenxin Tian, Hanbo Yu, Chuan Huang, Donghang Li, Peng Jiao, Chao Ma, Jianping Cai, Dapeng Dai

Thorac Cancer. 2021 Mar; 12(5): 588–592. Published online 2020 Dec 13. doi: 10.1111/1759-7714.13773

PMCID:: PMC7919162

Abstract Article PDF–384K

Select item 76696398.

Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications

Melike Çağlayan

DNA Repair (Amst) Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: DNA Repair (Amst). 2020 Nov; 95: 102945. Published online 2020 Aug 14. doi: 10.1016/j.dnarep.2020.102945

PMCID:: PMC7669639

Abstract Article PDF–2.2M

Select item 76438119.

DNA Polymerase β: Closing the Gap between Structure and Function

William A. Beard

DNA Repair (Amst) Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2020 Sep; 93: 102910. doi: 10.1016/j.dnarep.2020.102910

PMCID:: PMC7643811

Abstract Article PDF–1.2M

Select item 744349810.

Lysines in the lyase active site of DNA polymerase β destabilize nonspecific DNA binding, facilitating searching and DNA gap recognition

Michael J. Howard, Julie K. Horton, Ming-Lang Zhao, Samuel H. Wilson

J Biol Chem. 2020 Aug 21; 295(34): 12181–12187. Published online 2020 Jul 9. doi: 10.1074/jbc.RA120.013547

PMCID:: PMC7443498

Abstract Article PDF–1.7M

Select item 714566511.

A pre-catalytic non-covalent step governs DNA polymerase β fidelity

Khadijeh S Alnajjar, Ivan S Krylov, Amirsoheil Negahbani, Pouya Haratipour, Boris A Kashemirov, Ji Huang, Mariam Mahmoud, Charles E McKenna, Myron F Goodman, Joann B Sweasy

Nucleic Acids Res. 2019 Dec 16; 47(22): 11839–11849. Published online 2019 Nov 16. doi: 10.1093/nar/gkz1076

PMCID:: PMC7145665

Abstract Article PDF–2.0M

Select item 703207012.

Optimal and Variant Metal-Ion Routes in DNA Polymerase β’s Conformational Pathways

Yunlang Li, Bret D. Freudenthal, William A. Beard, Samuel H. Wilson, Tamar Schlick

J Am Chem Soc. Author manuscript; available in PMC 2020 Feb 20.

Published in final edited form as: J Am Chem Soc. 2014 Mar 5; 136(9): 3630–3639. Published online 2014 Feb 21. doi: 10.1021/ja412701f

PMCID:: PMC7032070

Abstract Article PDF–1.9M

Select item 700836913.

Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β

Mallory R. Smith, Khadijeh S. Alnajjar, Nicole M. Hoitsma, Joann B. Sweasy, Bret D. Freudenthal

J Biol Chem. 2020 Feb 7; 295(6): 1613–1622. Published online 2019 Dec 31. doi: 10.1074/jbc.RA119.011569

PMCID:: PMC7008369

Abstract Article PDF–2.1M

Select item 695652414.

DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

Michael J. Howard, Nisha A. Cavanaugh, Vinod K. Batra, David D. Shock, William A. Beard, Samuel H. Wilson

J Biol Chem. 2020 Jan 10; 295(2): 529–538. Published online 2019 Dec 4. doi: 10.1074/jbc.RA119.010594

PMCID:: PMC6956524

Abstract Article PDF–1.6M

Select item 671226915.

肺癌组织中DNA聚合酶β基因突变的研究

吴青峻, 田文鑫, 于瀚博, 黄川, 焦鹏, 马超, 王永忠, 黄文, 孙耀光, 艾斌, 佟宏峰

Zhongguo Fei Ai Za Zhi. 2019 Jul 20; 22(7): 427–432. Chinese. doi: 10.3779/j.issn.1009-3419.2019.07.04

PMCID:: PMC6712269

Abstract Article PDF–2.0M

Select item 667465216.

DNA Polymerase-β Is Expressed Early in Neurons of Alzheimer's Disease Brain and Is Loaded into DNA Replication Forks in Neurons Challenged with β-Amyloid

Agata Copani, Jeroen J. M. Hoozemans, Filippo Caraci, Marco Calafiore, Elise S. Van Haastert, Robert Veerhuis, Annemieke J. M. Rozemuller, Eleonora Aronica, Maria Angela Sortino, Ferdinando Nicoletti

J Neurosci. 2006 Oct 25; 26(43): 10949–10957. doi: 10.1523/JNEUROSCI.2793-06.2006

PMCID:: PMC6674652

Abstract Article PDF–423K

Select item 661657117.

The Pol β variant containing exon α is deficient in DNA polymerase but has full dRP lyase activity

Da-Peng Dai, Rajendra Prasad, Phyllis R. Strauss, Samuel H. Wilson

Sci Rep. 2019; 9: 9928. Published online 2019 Jul 9. doi: 10.1038/s41598-019-45846-0

PMCID:: PMC6616571

Abstract Article PDF–2.1M

Select item 661484318.

Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress

Qingming Fang, Joel Andrews, Nidhi Sharma, Anna Wilk, Jennifer Clark, Jana Slyskova, Christopher A Koczor, Hannes Lans, Aishwarya Prakash, Robert W Sobol

Nucleic Acids Res. 2019 Jul 9; 47(12): 6269–6286. Published online 2019 Apr 26. doi: 10.1093/nar/gkz293