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Select item 104505211.

The peroxidation-derived DNA adduct, 6-oxo-M₁dG, is a strong block to replication by human DNA polymerase η

Robyn Richie-Jannetta, Pradeep Pallan, Philip J. Kingsley, Nikhil Kamdar, Martin Egli, Lawrence J. Marnett

J Biol Chem. 2023 Aug; 299(8): 105067. Published online 2023 Jul 18. doi: 10.1016/j.jbc.2023.105067

PMCID:: PMC10450521

Abstract Article PDF–2.9M

Select item 100118342.

Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks

Anirban Chakraborty, Nisha Tapryal, Azharul Islam, Altaf H. Sarker, Kodavati Manohar, Joy Mitra, Muralidhar L. Hegde, Tapas Hazra

J Biol Chem. 2023 Mar; 299(3): 102991. Published online 2023 Feb 8. doi: 10.1016/j.jbc.2023.102991

PMCID:: PMC10011834

Abstract Article PDF–3.7M

Select item 99764653.

Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase η and reduces DNA synthesis fidelity

Caleb Chang, Christie Lee Luo, Sarah Eleraky, Aaron Lin, Grace Zhou, Yang Gao

J Biol Chem. 2023 Mar; 299(3): 102938. Published online 2023 Jan 24. doi: 10.1016/j.jbc.2023.102938

PMCID:: PMC9976465

Abstract Article PDF–3.0M

Select item 89558594.

Identification of Frameshift Variants in POLH Gene Causing Xeroderma Pigmentosum in Two Consanguineous Pakistani Families

Ghazala Y. Zamani, Ranjha Khan, Noreen Karim, Zubair M. Ahmed, Muhammad Naeem

Genes (Basel) 2022 Mar; 13(3): 543. Published online 2022 Mar 19. doi: 10.3390/genes13030543

PMCID:: PMC8955859

Abstract Article PDF–1.5M

Select item 87450645.

Manganese Is a Strong Specific Activator of the RNA Synthetic Activity of Human Polη

Eva Balint, Ildiko Unk

Int J Mol Sci. 2022 Jan; 23(1): 230. Published online 2021 Dec 26. doi: 10.3390/ijms23010230

PMCID:: PMC8745064

Abstract Article PDF–3.1M

Select item 86407886.

Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites

Shyam Twayana, Albino Bacolla, Angelica Barreto-Galvez, Ruth B. De-Paula, William C. Drosopoulos, Settapong T. Kosiyatrakul, Eric E. Bouhassira, John A. Tainer, Advaitha Madireddy, Carl L. Schildkraut

Proc Natl Acad Sci U S A. 2021 Nov 30; 118(48): e2106477118. Published online 2021 Nov 23. doi: 10.1073/pnas.2106477118

PMCID:: PMC8640788

Abstract Article PDF–2.6M

Select item 68648507.

Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η

Myong-Chul Koag, Hunmin Jung, Yi Kou, Seongmin Lee

Molecules. 2019 Nov; 24(21): 3928. Published online 2019 Oct 31. doi: 10.3390/molecules24213928

PMCID:: PMC6864850

Abstract Article PDF–5.7M

Select item 67634448.

Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η

Akira Sassa, Haruto Tada, Ayuna Takeishi, Kaho Harada, Megumi Suzuki, Masataka Tsuda, Hiroyuki Sasanuma, Shunichi Takeda, Kaoru Sugasawa, Manabu Yasui, Masamitsu Honma, Kiyoe Ura

Sci Rep. 2019; 9: 13910. Published online 2019 Sep 26. doi: 10.1038/s41598-019-50421-8

PMCID:: PMC6763444

Abstract Article PDF–1.7M

Select item 66349999.

A PolH transcript with a short 3’UTR enhances PolH expression and mediates cisplatin resistance

Jin Zhang, Wenqiang Sun, Cong Ren, Xiangmudong Kong, Wensheng Yan, Xinbin Chen

Cancer Res. Author manuscript; available in PMC 2020 Jul 15.

Published in final edited form as: Cancer Res. 2019 Jul 15; 79(14): 3714–3724. Published online 2019 May 7. doi: 10.1158/0008-5472.CAN-18-3928

PMCID:: PMC6634999

Abstract Article PDF–1.9M

Select item 639973910.

Exploring the Role of the Third Active Site Metal Ion in DNA Polymerase η with QM/MM Free Energy Simulations

David R. Stevens, Sharon Hammes-Schiffer

J Am Chem Soc. Author manuscript; available in PMC 2019 Jul 18.

Published in final edited form as: J Am Chem Soc. 2018 Jul 18; 140(28): 8965–8969. Published online 2018 Jul 9. doi: 10.1021/jacs.8b05177

PMCID:: PMC6399739

Abstract Article PDF–935K

Select item 591473411.

DNA polymerase η mutational signatures are found in a variety of different types of cancer

Igor B. Rogozin, Alexander Goncearenco, Artem G. Lada, Subhajyoti De, Vyacheslav Yurchenko, German Nudelman, Anna R. Panchenko, David N. Cooper, Youri I. Pavlov

Cell Cycle. 2018; 17(3): 348–355. Published online 2018 Feb 15. doi: 10.1080/15384101.2017.1404208

PMCID:: PMC5914734

Abstract Article PDF–627K

Select item 576619012.

Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle

Federica Bertoletti, Valentina Cea, Chih-Chao Liang, Taiba Lanati, Antonio Maffia, Mario D.M. Avarello, Lina Cipolla, Alan R. Lehmann, Martin A. Cohn, Simone Sabbioneda

Nucleic Acids Res. 2017 Sep 19; 45(16): 9441–9454. Published online 2017 Jul 24. doi: 10.1093/nar/gkx619

PMCID:: PMC5766190

Abstract Article PDF–5.3M

Select item 567203013.

Human DNA polymerase η accommodates RNA for strand extension

Yan Su, Martin Egli, F. Peter Guengerich

J Biol Chem. 2017 Nov 3; 292(44): 18044–18051. Published online 2017 Sep 26. doi: 10.1074/jbc.M117.809723

PMCID:: PMC5672030

Abstract Article PDF–1.1M

Select item 553117914.

Simulating the Fidelity And The Three Mg Mechanism of Pol η and clarifying the validity of transition state theory in enzyme catalysis

Hanwool Yoon, Arieh Warshel

Proteins. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Proteins. 2017 Aug; 85(8): 1446–1453. Published online 2017 May 4. doi: 10.1002/prot.25305

PMCID:: PMC5531179

Abstract Article PDF–698K

Select item 540601415.

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase ? in the Alternative Lengthening of Telomeres

Laura Garcia-Exposito, Elodie Bournique, Valérie Bergoglio, Arindam Bose, Jonathan Barroso-Gonzalez, Sufang Zhang, Justin L. Roncaioli, Marietta Lee, Callen T. Wallace, Simon C. Watkins, Patricia L. Opresko, Jean-Sébastien Hoffmann, Roderick J. O’Sullivan

Cell Rep. Author manuscript; available in PMC 2017 Apr 26.

Published in final edited form as: Cell Rep. 2016 Nov 8; 17(7): 1858–1871. doi: 10.1016/j.celrep.2016.10.048

PMCID:: PMC5406014

Abstract Article PDF–2.0M

Select item 538950516.

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity

Elisa Mentegari, Emmanuele Crespan, Laura Bavagnoli, Miroslava Kissova, Federica Bertoletti, Simone Sabbioneda, Ralph Imhof, Shana J. Sturla, Arman Nilforoushan, Ulrich Hübscher, Barbara van Loon, Giovanni Maga

Nucleic Acids Res. 2017 Mar 17; 45(5): 2600–2614. Published online 2016 Dec 19. doi: 10.1093/nar/gkw1275