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Select item 31478021.

The RPB2 Flap Loop of Human RNA Polymerase II Is Dispensable for Transcription Initiation and Elongation

Murali Palangat, Jeffrey A. Grass, Marie-France Langelier, Benoit Coulombe, Robert Landick

Mol Cell Biol. 2011 Aug; 31(16): 3312–3325. doi: 10.1128/MCB.05318-11

PMCID:: PMC3147802

Abstract Article PDF–2.9M

Select item 30215962.

Pol II waiting in the starting gates: regulating the transition from transcription initiation into productive elongation

Sergei Nechaev, Karen Adelman

Biochim Biophys Acta. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Biochim Biophys Acta. 2011 Jan; 1809(1): 34–45. Published online 2010 Nov 13. doi: 10.1016/j.bbagrm.2010.11.001

PMCID:: PMC3021596

Abstract Article PDF–666K

Select item 10922793.

The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II

Marie-France Langelier, Dania Baali, Vincent Trinh, Jack Greenblatt, Jacques Archambault, Benoit Coulombe

Nucleic Acids Res. 2005; 33(8): 2629–2639. Published online 2005 May 10. doi: 10.1093/nar/gki570

PMCID:: PMC1092279

Abstract Article PDF–560K

Select item 36047164.

RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA

Stacey D Wagner, Petro Yakovchuk, Benjamin Gilman, Steven L Ponicsan, Linda F Drullinger, Jennifer F Kugel, James A Goodrich

EMBO J. 2013 Mar 20; 32(6): 781–790. Published online 2013 Feb 8. doi: 10.1038/emboj.2013.18

PMCID:: PMC3604716

Abstract Article PDF–752K

Select item 36723495.

The non-coding B2 RNA binds to the DNA cleft and active site region of RNA polymerase II

Steven L. Ponicsan, Stephane Houel, William M. Old, Natalie G. Ahn, James A. Goodrich, Jennifer F. Kugel

J Mol Biol. Author manuscript; available in PMC 2014 Oct 9.

Published in final edited form as: J Mol Biol. 2013 Oct 9; 425(19): 3625–3638. Published online 2013 Feb 8. doi: 10.1016/j.jmb.2013.01.035

PMCID:: PMC3672349

Abstract Article PDF–3.1M

Select item 1863166.

Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation

Anders M. Näär, Dylan J. Taatjes, Weiguo Zhai, Eva Nogales, Robert Tjian

Genes Dev. 2002 Jun 1; 16(11): 1339–1344. doi: 10.1101/gad.987602

PMCID:: PMC186316

Abstract Article PDF–185K

Select item 37026677.

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5

Susanne A. Kassube, Martin Jinek, Jie Fang, Susan Tsutakawa, Eva Nogales

Nat Struct Mol Biol. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Nat Struct Mol Biol. 2013 Jul; 20(7): 892–899. Published online 2013 Jun 9. doi: 10.1038/nsmb.2596

PMCID:: PMC3702667

Abstract Article PDF–2.7M

Select item 47427368.

Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8

Santanu Adhikary, Sulagna Sanyal, Moitri Basu, Isha Sengupta, Sabyasachi Sen, Dushyant Kumar Srivastava, Siddhartha Roy, Chandrima Das

J Biol Chem. 2016 Feb 5; 291(6): 2664–2681. Published online 2015 Dec 11. doi: 10.1074/jbc.M115.679985

PMCID:: PMC4742736

Abstract Article PDF–4.5M

Select item 49174319.

Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19

Tatiana Moiseeva, Armin M. Gamper, Brian Hood, Thomas P. Conrads, Christopher J. Bakkenist

DNA Repair (Amst) Author manuscript; available in PMC 2017 Jul 1.

Published in final edited form as: DNA Repair (Amst). 2016 Jul; 43: 9–17. Published online 2016 May 7. doi: 10.1016/j.dnarep.2016.04.007

PMCID:: PMC4917431

Abstract Article PDF–1.5M

Select item 634488110.

The OTUD5–UBR5 complex regulates FACT-mediated transcription at damaged chromatin

Angelo de Vivo, Anthony Sanchez, Jose Yegres, Jeonghyeon Kim, Sylvia Emly, Younghoon Kee

Nucleic Acids Res. 2019 Jan 25; 47(2): 729–746. Published online 2018 Dec 1. doi: 10.1093/nar/gky1219

PMCID:: PMC6344881

Abstract Article PDF–14M

Select item 267788611.

MRE11 complex links RECQ5 helicase to sites of DNA damage

Lu Zheng, Radhakrishnan Kanagaraj, Boris Mihaljevic, Sybille Schwendener, Alessandro A. Sartori, Bertran Gerrits, Igor Shevelev, Pavel Janscak

Nucleic Acids Res. 2009 May; 37(8): 2645–2657. Published online 2009 Mar 6. doi: 10.1093/nar/gkp147

PMCID:: PMC2677886

Abstract Article PDF–6.0M

Select item 3982712.

Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex.

N J Keen, M J Gait, J Karn

Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6): 2505–2510. doi: 10.1073/pnas.93.6.2505

PMCID:: PMC39827

Summary Page Browse PDF–1.6M

Select item 3809913.

Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II.

H Okamoto, C T Sheline, J L Corden, K A Jones, B M Peterlin

Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21): 11575–11579. doi: 10.1073/pnas.93.21.11575

PMCID:: PMC38099

Summary Page Browse PDF–1.1M

Select item 47974614.

RPAP1, a Novel Human RNA Polymerase II-Associated Protein Affinity Purified with Recombinant Wild-Type and Mutated Polymerase Subunits

Célia Jeronimo, Marie-France Langelier, Mahel Zeghouf, Marilena Cojocaru, Dominique Bergeron, Dania Baali, Diane Forget, Sanie Mnaimneh, Armaity P. Davierwala, Jeff Pootoolal, Mark Chandy, Veronica Canadien, Bryan K. Beattie, Dawn P. Richards, Jerry L. Workman, Timothy R. Hughes, Jack Greenblatt, Benoit Coulombe

Mol Cell Biol. 2004 Aug; 24(16): 7043–7058. doi: 10.1128/MCB.24.16.7043-7058.2004

PMCID:: PMC479746

Abstract Article PDF–701K

Select item 8427015.

Transcriptional Cofactor CA150 Regulates RNA Polymerase II Elongation in a TATA-Box-Dependent Manner

Carlos Suñé, Mariano A. Garcia-Blanco

Mol Cell Biol. 1999 Jul; 19(7): 4719–4728. doi: 10.1128/mcb.19.7.4719

PMCID:: PMC84270

Abstract Article PDF–1.1M

Select item 4129716.

Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat.

F Wu-Baer, D Sigman, R B Gaynor

Proc Natl Acad Sci U S A. 1995 Aug 1; 92(16): 7153–7157. doi: 10.1073/pnas.92.16.7153

PMCID:: PMC41297

Summary Page Browse PDF–1.5M

Select item 1620717.

BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10α in activated transcription

Brian P. Schlegel, Victoria J. Green, John A. A. Ladias, Jeffrey D. Parvin

Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7): 3148–3153. Published online 2000 Mar 21. doi: 10.1073/pnas.070452397

PMCID:: PMC16207

Abstract Article PDF–257K

Select item 751926318.

TRIM28 functions as the SUMO E3 ligase for PCNA in prevention of transcription induced DNA breaks

Min Li, Xiaohua Xu, Chou-Wei Chang, Yilun Liu

Proc Natl Acad Sci U S A. 2020 Sep 22; 117(38): 23588–23596. Published online 2020 Sep 8. doi: 10.1073/pnas.2004122117

PMCID:: PMC7519263

Abstract Article PDF–1.3M

Select item 359192119.

Identification of Novel Inhibitors of Human Immunodeficiency Virus Type 1 Replication by In Silico Screening Targeting Cyclin T1/Tat Interaction

Takayuki Hamasaki, Mika Okamoto, Masanori Baba

Antimicrob Agents Chemother. 2013 Mar; 57(3): 1323–1331. doi: 10.1128/AAC.01711-12

PMCID:: PMC3591921

Abstract Article PDF–2.2M

Select item 30563520.

TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes

Hua Xiao, Vikas Palhan, Yili Yang, Robert G. Roeder

EMBO J. 2000 Mar 1; 19(5): 956–963. doi: 10.1093/emboj/19.5.956

PMCID:: PMC305635

Abstract Article PDF–501K

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PMC Links for Gene (Select 5431) (186)
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RecName: Full=DNA-directed RNA polymerase II subunit RPB2; AltName: Full=3'-5' e...
RecName: Full=DNA-directed RNA polymerase II subunit RPB2; AltName: Full=3'-5' exoribonuclease; AltName: Full=DNA-directed RNA polymerase II 140 kDa polypeptide; AltName: Full=DNA-directed RNA polymerase II subunit B; AltName: Full=RNA polymerase II subunit 2; AltName: Full=RNA polymerase II subunit B2; AltName: Full=RNA-directed RNA polymerase II subunit RPB2
gi|401012|sp|P30876.1|RPB2_HUMAN

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