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Items: 1 to 20 of 41

1.
Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use
Monika Pawlowska, Rong Chu, Barbara Fedejko-Kap, Ewa Augustin, Zofia Mazerska, Anna Radominska-Pandya, Timothy C. Chambers
Drug Metab Dispos. 2013 Feb; 41(2): 414–421. Published online 2013 Feb. doi: 10.1124/dmd.112.047811
PMCID:
PMC3558869
AbstractArticlePDF–837K
2.
Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10
Barbara Fedejko-Kap, Stacie M. Bratton, Moshe Finel, Anna Radominska-Pandya, Zofia Mazerska
Drug Metab Dispos. 2012 Sep; 40(9): 1736–1743. doi: 10.1124/dmd.112.045401
PMCID:
PMC3422538
AbstractArticlePDF–1.3M
3.
Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens
Camilla Höglund, Nina Sneitz, Anna Radominska-Pandya, Liisa Laakonen, Moshe Finel
Steroids. Author manuscript; available in PMC 2012 Dec 11.
Published in final edited form as: Steroids. 2011 Dec 11; 76(13): 1465–1473. Published online 2011 Aug 9. doi: 10.1016/j.steroids.2011.07.017
PMCID:
PMC3188330
AbstractArticlePDF–1.9M
4.
UDP-Glucuronosyltransferase 1A10: Activity against the Tobacco-Specific Nitrosamine, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a Potential Role for a Novel UGT1A10 Promoter Deletion Polymorphism in Cancer Susceptibility
Rene M. Balliet, Gang Chen, Ryan W. Dellinger, Philip Lazarus
Drug Metab Dispos. 2010 Mar; 38(3): 484–490. doi: 10.1124/dmd.109.030569
PMCID:
PMC2835395
AbstractArticlePDF–276K
5.
Identification of Hydroxywarfarin Binding Site in Human UDP Glucuronosyltransferase 1A10: Phenylalanine90 Is Crucial for the Glucuronidation of 6- and 7-Hydroxywarfarin but Not 8-Hydroxywarfarin
Grover P. Miller, Cheryl F. Lichti, Agnieszka K. Zielinska, Anna Mazur, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Jeffery H. Moran, Anna Radominska-Pandya
Drug Metab Dispos. Author manuscript; available in PMC 2010 Jan 27.
Published in final edited form as: Drug Metab Dispos. 2008 Nov; 36(11): 2211–2218. Published online 2008 Aug 25. doi: 10.1124/dmd.108.022863
PMCID:
PMC2812427
AbstractArticlePDF–1.2M
6.
Mapping the UDP-Glucuronic Acid Binding Site in UDP-Glucuronosyltransferase-1 A10 by Homology-based Modeling: Confirmation with Biochemical Evidence
Rajat Banerjee, Matthew W. Pennington, Amanda Garza, Ida S. Owens
Biochemistry. Author manuscript; available in PMC 2009 Jul 15.
Published in final edited form as: Biochemistry. 2008 Jul 15; 47(28): 7385–7392. Published online 2008 Jun 21. doi: 10.1021/bi8006127
PMCID:
PMC2587317
AbstractArticlePDF–1.8M
7.
Human UGT1A8 and UGT1A10 mRNA Are Expressed In Primary Human Hepatocytes
Xin Li, Stacie Bratton, Anna Radominska-Pandya
Drug Metab Pharmacokinet. Author manuscript; available in PMC 2008 Mar 25.
Published in final edited form as: Drug Metab Pharmacokinet. 2007 Jun; 22(3): 152–161. doi: 10.2133/dmpk.22.152
PMCID:
PMC2275121
AbstractArticlePDF–495K
8.
Glucuronidation of Psilocin and 4-Hydroxyindole by the Human UDP-Glucuronosyltransferases
Nenad Manevski, Mika Kurkela, Camilla Höglund, Timo Mauriala, Michael H. Court, Jari Yli-Kauhaluoma, Moshe Finel
Drug Metab Dispos. 2010 Mar; 38(3): 386–395. doi: 10.1124/dmd.109.031138
PMCID:
PMC2835393
AbstractArticlePDF–263K
9.
Functional significance of UDP-glucuronosyltransferase (UGT) variants in the metabolism of active tamoxifen metabolites
Andrea S. Blevins-Primeau, Dongxiao Sun, Gang Chen, Arun K. Sharma, Carla J. Gallagher, Shantu Amin, Philip Lazarus
Cancer Res. Author manuscript; available in PMC 2010 Mar 1.
Published in final edited form as: Cancer Res. 2009 Mar 1; 69(5): 1892–1900. Published online 2009 Feb 24. doi: 10.1158/0008-5472.CAN-08-3708
PMCID:
PMC2683344
AbstractArticlePDF–1.2M
10.
Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.
C P Strassburg, A Strassburg, N Nguyen, Q Li, M P Manns, R H Tukey
Biochem J. 1999 Mar 1; 338(Pt 2): 489–498.
PMCID:
PMC1220077
SummaryPDF–320K
11.
Use of Glucuronidation Fingerprinting to Describe and Predict mono- and di-Hydroxyflavone Metabolism by Recombinant UGT Isoforms and Human Intestinal and Liver Microsomes
Lan Tang, Ling Ye, Rashim Singh, Baojian Wu, Chang Lv, Jie Zhao, Zhongqiu Liu, Ming Hu
Mol Pharm. Author manuscript; available in PMC 2011 Jun 7.
Published in final edited form as: Mol Pharm. 2010 Jun 7; 7(3): 664–679. doi: 10.1021/mp900223c
PMCID:
PMC2941766
AbstractArticlePDF–2.8M
12.
The Major Chemical-detoxifying System of UDP-glucuronosyltransferases Requires Regulated Phosphorylation Supported by Protein Kinase C
Nikhil K. Basu, Labanyamoy Kole, Mousumi Basu, Kushal Chakraborty, Partha S. Mitra, Ida S. Owens
J Biol Chem. 2008 Aug 22; 283(34): 23048–23061. doi: 10.1074/jbc.M800032200
PMCID:
PMC2516997
AbstractArticlePDF–788K
13.
Family-Based Genome-Wide Association Scan of Attention-Deficit/Hyperactivity Disorder
Dr. Eric Mick, Dr. Alexandre Todorov, Dr. Susan Smalley, Dr. Xiaolan Hu, Dr. Sandra Loo, Dr. Richard D. Todd, Dr. Joseph Biederman, Ms. Deirdre Byrne, Dr. Bryan Dechairo, Mr. Allan Guiney, Dr. James McCracken, Dr. James McGough, Dr. Stanley F. Nelson, Dr. Angela M. Reiersen, Dr. Timothy E. Wilens, Dr. Janet Wozniak, Dr. Benjamin M. Neale, Dr. Stephen V. Faraone
J Am Acad Child Adolesc Psychiatry. Author manuscript; available in PMC 2013 Aug 1.
Published in final edited form as: J Am Acad Child Adolesc Psychiatry. 2010 Sep; 49(9): 898–905.e3. Published online 2010 May 14. doi: 10.1016/j.jaac.2010.02.014
PMCID:
PMC3730251
AbstractArticlePDF–337K
14.
A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study
Juulia Jylhävä, Leo-Pekka Lyytikäinen, Mika Kähönen, Nina Hutri-Kähönen, Johannes Kettunen, Jorma Viikari, Olli T. Raitakari, Terho Lehtimäki, Mikko Hurme
PLoS One. 2012; 7(4): e35426. Published online 2012 Apr 12. doi: 10.1371/journal.pone.0035426
PMCID:
PMC3325226
AbstractArticlePDF–1.5M
15.
Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study
Amanda J Cox, Maggie C-Y Ng, Jianzhao Xu, Carl D Langefeld, Kenneth L Koch, Paul A Dawson, J Jeffrey Carr, Barry I Freedman, Fang-Chi Hsu, Donald W Bowden
Atherosclerosis. Author manuscript; available in PMC 2014 Jul 1.
Published in final edited form as: Atherosclerosis. 2013 Jul; 229(1): 155–160. Published online 2013 Apr 19. doi: 10.1016/j.atherosclerosis.2013.04.008
PMCID:
PMC3691283
AbstractArticlePDF–506K
16.
A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia
Jacqueline N. Milton, Paola Sebastiani, Nadia Solovieff, Stephen W. Hartley, Pallav Bhatnagar, Dan E. Arking, Daniel A. Dworkis, James F. Casella, Emily Barron-Casella, Christopher J. Bean, W. Craig Hooper, Michael R. DeBaun, Melanie E. Garrett, Karen Soldano, Marilyn J. Telen, Allison Ashley-Koch, Mark T. Gladwin, Clinton T. Baldwin, Martin H. Steinberg, Elizabeth S. Klings
PLoS One. 2012; 7(4): e34741. Published online 2012 Apr 27. doi: 10.1371/journal.pone.0034741
PMCID:
PMC3338756
AbstractArticlePDF–356K
17.
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
Serena Sanna, Fabio Busonero, Andrea Maschio, Patrick F. McArdle, Gianluca Usala, Mariano Dei, Sandra Lai, Antonella Mulas, Maria Grazia Piras, Lucia Perseu, Marco Masala, Mara Marongiu, Laura Crisponi, Silvia Naitza, Renzo Galanello, Gonçalo R. Abecasis, Alan R. Shuldiner, David Schlessinger, Antonio Cao, Manuela Uda
Hum Mol Genet. 2009 Jul 15; 18(14): 2711–2718. Published online 2009 May 6. doi: 10.1093/hmg/ddp203
PMCID:
PMC2701337
AbstractArticlePDF–199K
18.
Genome-wide analysis of hepatic lipid content in extreme obesity
Johanna K. DiStefano, Christopher Kingsley, G. Craig Wood, Xin Chu, George Argyropoulos, Christopher D. Still, Stefania Cotta Doné, Christophe Legendre, Waibhav Tembe, Glenn S. Gerhard
Acta Diabetol. Author manuscript; available in PMC 2016 Apr 1.
Published in final edited form as: Acta Diabetol. 2015 Apr; 52(2): 373–382. Published online 2014 Sep 23. doi: 10.1007/s00592-014-0654-3
PMCID:
PMC4370808
AbstractArticlePDF–611K
19.
UGT1A1 is a major locus influencing bilirubin levels in African Americans
Guanjie Chen, Edward Ramos, Adebowale Adeyemo, Daniel Shriner, Jie Zhou, Ayo P Doumatey, Hanxia Huang, Michael R Erdos, Norman P Gerry, Alan Herbert, Amy R Bentley, Huichun Xu, Bashira A Charles, Michael F Christman, Charles N Rotimi
Eur J Hum Genet. 2012 Apr; 20(4): 463–468. Published online 2011 Nov 16. doi: 10.1038/ejhg.2011.206
PMCID:
PMC3306855
AbstractArticlePDF–429K
20.
Disposition of Flavonoids via Enteric Recycling: Enzyme Stability Affects Characterization of Prunetin Glucuronidation across Species, Organs, and UGT Isoforms
Tiby B. Joseph, Stephen W.J. Wang, Xing Liu, Kaustubh H. Kulkarni, Jingrong Wang, Haiyan Xu, Ming Hu
Mol Pharm. Author manuscript; available in PMC 2008 Nov 1.
Published in final edited form as: Mol Pharm. 2007; 4(6): 883–894. doi: 10.1021/mp700135a
PMCID:
PMC2532587
AbstractArticlePDF–2.1M

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