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Select item 34222331.

UGT1A6 Polymorphisms Modulated Lung Cancer Risk in a Chinese Population

Ley-Fang Kua, Soo Ross, Soo-Chin Lee, Kousaku Mimura, Koji Kono, Boon-Cher Goh, Wei-Peng Yong

PLoS One. 2012; 7(8): e42873. Published online 2012 Aug 17. doi: 10.1371/journal.pone.0042873

PMCID:: PMC3422233

Abstract Article PDF–328K

Select item 33138012.

Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer

Wei Tang, Yi-Ping Fu, Jonine D. Figueroa, Núria Malats, Montserrat Garcia-Closas, Nilanjan Chatterjee, Manolis Kogevinas, Dalsu Baris, Michael Thun, Jennifer L. Hall, Immaculata De Vivo, Demetrius Albanes, Patricia Porter-Gill, Mark P. Purdue, Laurie Burdett, Luyang Liu, Amy Hutchinson, Timothy Myers, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina Garcia-Closas, Josep Lloreta, Alison Johnson, Molly Schwenn, Margaret R. Karagas, Alan Schned, Amanda Black, Eric J. Jacobs, W. Ryan Diver, Susan M. Gapstur, Jarmo Virtamo, David J. Hunter, Joseph F. Fraumeni, Jr, Stephen J. Chanock, Debra T. Silverman, Nathaniel Rothman, Ludmila Prokunina-Olsson

Hum Mol Genet. 2012 Apr 15; 21(8): 1918–1930. Published online 2012 Jan 6. doi: 10.1093/hmg/ddr619

PMCID:: PMC3313801

Abstract Article PDF–394K

Select item 32524873.

The Influence of UGT 1A6 Variants and Aspirin Use in a Randomized Trial of Celecoxib for Prevention of Colorectal Adenoma

Andrew T. Chan, Meier Hsu, Ann G. Zauber, Ernest T. Hawk, Monica M. Bertagnolli

Cancer Prev Res (Phila) Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as: Cancer Prev Res (Phila). 2012 Jan; 5(1): 61–72. Published online 2011 Oct 26. doi: 10.1158/1940-6207.CAPR-11-0337

PMCID:: PMC3252487

Abstract Article PDF–537K

Select item 31215474.

Determinants of Aspirin Metabolism in Healthy Men and Women: Effects of Dietary Inducers of UDP-Glucuronosyltransferases

Sandi L. Navarro, Misty R. Saracino, Karen W. Makar, Sushma S. Thomas, Lin Li, Yingye Zheng, Lisa Levy, Yvonne Schwarz, Jeannette Bigler, John D. Potter, Johanna W. Lampe

J Nutrigenet Nutrigenomics. 2011 Jul; 4(2): 110–118. Published online 2011 May 28. doi: 10.1159/000327782

PMCID:: PMC3121547

Abstract Article PDF–190K

Select item 25975015.

Disposition of Flavonoids via Enteric Recycling: Determination of the UDP-Glucuronosyltransferase (UGT) Isoforms Responsible for the Metabolism of Flavonoids in Intact Caco-2 TC7 Cells Using siRNA

Xing Liu, Vincent H. Tam, Ming Hu

Mol Pharm. Author manuscript; available in PMC 2008 Dec 8.

Published in final edited form as: Mol Pharm. 2007; 4(6): 873–882. Published online 2007 Oct 10. doi: 10.1021/mp0601190

PMCID:: PMC2597501

Abstract Article PDF–1.2M

Select item 24852266.

UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers

Lie Michael George Limenta, Totsapol Jirasomprasert, Jeeranut Tankanitlert, Saovaros Svasti, Prapin Wilairat, Udom Chantharaksri, Suthat Fucharoen, Noppawan Phumala Morales

Br J Clin Pharmacol. 2008 Jun; 65(6): 908–916. Published online 2008 Mar 3. doi: 10.1111/j.1365-2125.2008.03103.x

PMCID:: PMC2485226

Abstract Article PDF–754K

Select item 46163697.

Exome-Wide Association Study Identifies New Low-Frequency and Rare UGT1A1 Coding Variants and UGT1A6 Coding Variants Influencing Serum Bilirubin in Elderly Subjects: A Strobe Compliant Article

Abderrahim Oussalah, Paolo Bosco, Guido Anello, Rosario Spada, Rosa-Maria Guéant-Rodriguez, Céline Chery, Pierre Rouyer, Thomas Josse, Antonino Romano, Maurizzio Elia, Jean-Pierre Bronowicki, Jean-Louis Guéant

Medicine (Baltimore) 2015 Jun; 94(22): e925. Published online 2015 Jun 5. doi: 10.1097/MD.0000000000000925

PMCID:: PMC4616369

Abstract Article PDF–1.2M

Select item 31642748.

UGT1A6 and UGT2B15 Polymorphisms and Acetaminophen Conjugation in Response to a Randomized, Controlled Diet of Select Fruits and Vegetables

Sandi L. Navarro, Yu Chen, Lin Li, Shuying S. Li, Jyh-Lurn Chang, Yvonne Schwarz, Irena B. King, John D. Potter, Jeannette Bigler, Johanna W. Lampe

Drug Metab Dispos. 2011 Sep; 39(9): 1650–1657. doi: 10.1124/dmd.111.039149

PMCID:: PMC3164274

Abstract Article PDF–318K

Select item 30823769.

The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver

Shogo J. Miyagi, Abby C. Collier

Drug Metab Dispos. 2011 May; 39(5): 912–919. doi: 10.1124/dmd.110.037192

PMCID:: PMC3082376

Abstract Article PDF–1007K

Select item 268223910.

No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk

Cheryl L Thompson, Sarah J Plummer, Alona Merkulova, Iona Cheng, Thomas C Tucker, Graham Casey, Li Li

World J Gastroenterol. 2009 May 14; 15(18): 2240–2244. Published online 2009 May 14. doi: 10.3748/wjg.15.2240

PMCID:: PMC2682239

Abstract Article PDF–688K

Select item 188488711.

Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid

Martijn G H van Oijen, Sylvie Huybers, Wilbert H M Peters, Joost P H Drenth, Robert J F Laheij, Freek W A Verheugt, Jan B M J Jansen

Br J Clin Pharmacol. 2005 Dec; 60(6): 623–628. doi: 10.1111/j.1365-2125.2005.02495.x

PMCID:: PMC1884887

Abstract Article PDF–123K

Select item 283539312.

Glucuronidation of Psilocin and 4-Hydroxyindole by the Human UDP-Glucuronosyltransferases

Nenad Manevski, Mika Kurkela, Camilla Höglund, Timo Mauriala, Michael H. Court, Jari Yli-Kauhaluoma, Moshe Finel

Drug Metab Dispos. 2010 Mar; 38(3): 386–395. doi: 10.1124/dmd.109.031138

PMCID:: PMC2835393

Abstract Article PDF–263K

Select item 28246113.

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells.

D Harding, S Fournel-Gigleux, M R Jackson, B Burchell

Proc Natl Acad Sci U S A. 1988 Nov; 85(22): 8381–8385. doi: 10.1073/pnas.85.22.8381

PMCID:: PMC282461

Summary Page Browse PDF–1.0M

Select item 272006614.

Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma

Ellen T. Chang, Brenda M. Birmann, Julie L. Kasperzyk, David V. Conti, Peter Kraft, Richard F. Ambinder, Tongzhang Zheng, Nancy E. Mueller

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2010 Mar 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 Mar; 18(3): 976–986. Published online 2009 Feb 17. doi: 10.1158/1055-9965.EPI-08-1130

PMCID:: PMC2720066

Abstract Article PDF–346K

Select item 332522615.

A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study

Juulia Jylhävä, Leo-Pekka Lyytikäinen, Mika Kähönen, Nina Hutri-Kähönen, Johannes Kettunen, Jorma Viikari, Olli T. Raitakari, Terho Lehtimäki, Mikko Hurme

PLoS One. 2012; 7(4): e35426. Published online 2012 Apr 12. doi: 10.1371/journal.pone.0035426

PMCID:: PMC3325226

Abstract Article PDF–1.5M

Select item 369128316.

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study

Amanda J Cox, Maggie C-Y Ng, Jianzhao Xu, Carl D Langefeld, Kenneth L Koch, Paul A Dawson, J Jeffrey Carr, Barry I Freedman, Fang-Chi Hsu, Donald W Bowden

Atherosclerosis. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: Atherosclerosis. 2013 Jul; 229(1): 155–160. Published online 2013 Apr 19. doi: 10.1016/j.atherosclerosis.2013.04.008

PMCID:: PMC3691283

Abstract Article PDF–506K

Select item 333875617.

A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia

Jacqueline N. Milton, Paola Sebastiani, Nadia Solovieff, Stephen W. Hartley, Pallav Bhatnagar, Dan E. Arking, Daniel A. Dworkis, James F. Casella, Emily Barron-Casella, Christopher J. Bean, W. Craig Hooper, Michael R. DeBaun, Melanie E. Garrett, Karen Soldano, Marilyn J. Telen, Allison Ashley-Koch, Mark T. Gladwin, Clinton T. Baldwin, Martin H. Steinberg, Elizabeth S. Klings

PLoS One. 2012; 7(4): e34741. Published online 2012 Apr 27. doi: 10.1371/journal.pone.0034741

PMCID:: PMC3338756

Abstract Article PDF–356K

Select item 270133718.

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

Serena Sanna, Fabio Busonero, Andrea Maschio, Patrick F. McArdle, Gianluca Usala, Mariano Dei, Sandra Lai, Antonella Mulas, Maria Grazia Piras, Lucia Perseu, Marco Masala, Mara Marongiu, Laura Crisponi, Silvia Naitza, Renzo Galanello, Gonçalo R. Abecasis, Alan R. Shuldiner, David Schlessinger, Antonio Cao, Manuela Uda

Hum Mol Genet. 2009 Jul 15; 18(14): 2711–2718. Published online 2009 May 6. doi: 10.1093/hmg/ddp203

PMCID:: PMC2701337

Abstract Article PDF–199K

Select item 437080819.

Genome-wide analysis of hepatic lipid content in extreme obesity

Johanna K. DiStefano, Christopher Kingsley, G. Craig Wood, Xin Chu, George Argyropoulos, Christopher D. Still, Stefania Cotta Doné, Christophe Legendre, Waibhav Tembe, Glenn S. Gerhard

Acta Diabetol. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Acta Diabetol. 2015 Apr; 52(2): 373–382. Published online 2014 Sep 23. doi: 10.1007/s00592-014-0654-3

PMCID:: PMC4370808

Abstract Article PDF–611K

Select item 330685520.

UGT1A1 is a major locus influencing bilirubin levels in African Americans

Guanjie Chen, Edward Ramos, Adebowale Adeyemo, Daniel Shriner, Jie Zhou, Ayo P Doumatey, Hanxia Huang, Michael R Erdos, Norman P Gerry, Alan Herbert, Amy R Bentley, Huichun Xu, Bashira A Charles, Michael F Christman, Charles N Rotimi

Eur J Hum Genet. 2012 Apr; 20(4): 463–468. Published online 2011 Nov 16. doi: 10.1038/ejhg.2011.206

PMCID:: PMC3306855

Abstract Article PDF–429K

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