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Select item 105455061.

C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes

Cristina T. Vicente, Jolien Perneel, Sarah Wynants, Bavo Heeman, Marleen Van den Broeck, Matt Baker, Simon Cheung, Júlia Faura, Ian R A Mackenzie, Rosa Rademakers

Brain. 2023 Oct; 146(10): 4055–4064. Published online 2023 Apr 26. doi: 10.1093/brain/awad133

PMCID:: PMC10545506

Abstract Article PDF–570K

Select item 105284782.

TMEM106B Fibrils from FTLD Patients and Healthy Controls

James D. Greenwood, Wyatt C. Powell, Maciej A. Walczak

ACS Chem Neurosci. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: ACS Chem Neurosci. 2023 Aug 16; 14(16): 2827–2829. Published online 2023 Aug 2. doi: 10.1021/acschemneuro.3c00482

PMCID:: PMC10528478

Abstract Article PDF–822K

Select item 105101313.

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

Jun Yup Lee, Dylan J Harney, Jonathan D Teo, John B Kwok, Greg T. Sutherland, Mark Larance, Anthony S Don

Mol Neurodegener. 2023; 18: 63. Published online 2023 Sep 19. doi: 10.1186/s13024-023-00650-3

Correction in:: Mol Neurodegener. 2024; 19: 21.

PMCID:: PMC10510131

Abstract Article PDF–4.0M

Select item 104135484.

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function

Hai-Shan Jiao, Peng Yuan, Jin-Tai Yu

Mol Neurodegener. 2023; 18: 54. Published online 2023 Aug 10. doi: 10.1186/s13024-023-00644-1

PMCID:: PMC10413548

Abstract Article PDF–2.1M

Select item 95477995.

Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease

Jolien Perneel, Rosa Rademakers

Acta Neuropathol. 2022; 144(5): 807–819. Published online 2022 Sep 2. doi: 10.1007/s00401-022-02486-5

PMCID:: PMC9547799

Abstract Article PDF–4.5M

Select item 94088856.

TMEM106B Acts as a Modifier of Cognitive and Motor Functions in Amyotrophic Lateral Sclerosis

Arianna Manini, Antonia Ratti, Alberto Brusati, Alessio Maranzano, Isabella Fogh, Silvia Peverelli, Stefano Messina, Davide Gentilini, Federico Verde, Barbara Poletti, Claudia Morelli, Vincenzo Silani, Nicola Ticozzi

Int J Mol Sci. 2022 Aug; 23(16): 9276. Published online 2022 Aug 17. doi: 10.3390/ijms23169276

PMCID:: PMC9408885

Abstract Article PDF–772K

Select item 90954827.

Age-dependent formation of TMEM106B amyloid filaments in human brains

Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J. Garringer, Ruben Vidal, Grace I. Hallinan, Kathy L. Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G. Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G. Murzin, Michel Goedert, Sjors H. W. Scheres

Nature. 2022; 605(7909): 310–314. Published online 2022 Mar 28. doi: 10.1038/s41586-022-04650-z

PMCID:: PMC9095482

Abstract Article PDF–18M

Select item 90185638.

Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases

Andrew Chang, Xinyu Xiang, Jing Wang, Carolyn Lee, Tamta Arakhamia, Marija Simjanoska, Chi Wang, Yari Carlomagno, Guoan Zhang, Shikhar Dhingra, Manon Thierry, Jolien Perneel, Bavo Heeman, Lauren M. Forgrave, Michael DeTure, Mari L. DeMarco, Casey N. Cook, Rosa Rademakers, Dennis Dickson, Leonard Petrucelli, Michael H. B. Stowell, Ian R. A. Mackenzie, Anthony W. P. Fitzpatrick

Cell. Author manuscript; available in PMC 2023 Apr 14.

Published in final edited form as: Cell. 2022 Apr 14; 185(8): 1346–1355.e15. Published online 2022 Mar 4. doi: 10.1016/j.cell.2022.02.026

PMCID:: PMC9018563

Abstract Article PDF–2.0M

Select item 79467759.

A novel temporal‐predominant neuro‐astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS‐TDP

Jorge J. Llibre‐Guerra, Suzee E. Lee, Claudia K. Suemoto, Alexander J. Ehrenberg, Gabor G. Kovacs, Anna Karydas, Adam Staffaroni, Elisa De Paula Franca Resende, Eun‐Joo Kim, Ji‐Hye Hwang, Eliana Marisa Ramos, Kevin J. Wojta, Lorenzo Pasquini, Shirley Yin‐Yu Pang, Salvatore Spina, Isabel E. Allen, Joel Kramer, Bruce L. Miller, William W. Seeley, Lea T. Grinberg

Brain Pathol. 2021 Mar; 31(2): 267–282. Published online 2021 Feb 11. doi: 10.1111/bpa.12924

PMCID:: PMC7946775

Abstract Article PDF–1.5M

Select item 781470510.

rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues

Yang Hu, Jing-yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, Tao Wang, Zhifa Han, Longcai Wang, Bao-liang Sun, Guiyou Liu

BMC Med. 2021; 19: 11. Published online 2021 Jan 19. doi: 10.1186/s12916-020-01883-5

PMCID:: PMC7814705

Abstract Article PDF–1.5M

Select item 695317211.

TMEM106B Effect on Cognition in Parkinson’s Disease and Frontotemporal Dementia

Thomas F Tropea, Jordan Mak, Michael H Guo, Sharon X Xie, Eunran Suh, Jacqueline Rick, Andrew Siderowf, Daniel Weintraub, Murray Grossman, David Irwin, David A Wolk, John Q Trojanowski, Vivianna Van Deerlin, Alice S Chen-Plotkin

Ann Neurol. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Ann Neurol. 2019 Jun; 85(6): 801–811. doi: 10.1002/ana.25486

PMCID:: PMC6953172

Abstract Article PDF–1.7M

Select item 694264312.

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

Zeran Li, Fabiana G. Farias, Umber Dube, Jorge L. Del-Aguila, Kathie A. Mihindukulasuriya, Maria Victoria Fernandez, Laura Ibanez, John P. Budde, Fengxian Wang, Allison M. Lake, Yuetiva Deming, James Perez, Chengran Yang, Jorge A. Bahena, Wei Qin, Joseph L. Bradley, Richard Davenport, Kristy Bergmann, John C. Morris, Richard J. Perrin, Bruno A. Benitez, Joseph D. Dougherty, Oscar Harari, Carlos Cruchaga

Acta Neuropathol. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Acta Neuropathol. 2020 Jan; 139(1): 45–61. Published online 2019 Aug 27. doi: 10.1007/s00401-019-02066-0

PMCID:: PMC6942643

Abstract Article PDF–1.3M

Select item 621568613.

Variation in TMEM106B in chronic traumatic encephalopathy

Jonathan D. Cherry, Jesse Mez, John F. Crary, Yorghos Tripodis, Victor E. Alvarez, Ian Mahar, Bertrand R. Huber, Michael L. Alosco, Raymond Nicks, Bobak Abdolmohammadi, Patrick T. Kiernan, Laney Evers, Sarah Svirsky, Katharine Babcock, Hannah M. Gardner, Gaoyuan Meng, Christopher J. Nowinski, Brett M. Martin, Brigid Dwyer, Neil W. Kowall, Robert C. Cantu, Lee E. Goldstein, Douglas I. Katz, Robert A. Stern, Lindsay A. Farrer, Ann C. McKee, Thor D. Stein

Acta Neuropathol Commun. 2018; 6: 115. Published online 2018 Nov 4. doi: 10.1186/s40478-018-0619-9

PMCID:: PMC6215686

Abstract Article PDF–2.0M

Select item 619264914.

TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain

Jian Kang, Liangzhong Lim, Jianxing Song

PLoS One. 2018; 13(10): e0205856. Published online 2018 Oct 17. doi: 10.1371/journal.pone.0205856

PMCID:: PMC6192649

Abstract Article PDF–1.6M

Select item 602903615.

TMEM106B haplotypes have distinct gene expression patterns in aged brain

Yingxue Ren, Marka van Blitterswijk, Mariet Allen, Minerva M. Carrasquillo, Joseph S. Reddy, Xue Wang, Thomas G. Beach, Dennis W. Dickson, Nilüfer Ertekin-Taner, Yan W. Asmann, Rosa Rademakers

Mol Neurodegener. 2018; 13: 35. Published online 2018 Jul 3. doi: 10.1186/s13024-018-0268-2

PMCID:: PMC6029036

Abstract Article PDF–2.0M

Select item 584103816.

A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy

Cas Simons, David Dyment, Stephen J Bent, Joanna Crawford, Marc D’Hooghe, Alfried Kohlschütter, Sunita Venkateswaran, Guy Helman, Bwee-Tien Poll-The, Christine C Makowski, Yoko Ito, Kristin Kernohan, Taila Hartley, Quinten Waisfisz, Ryan J Taft, Care4Rare Consortium, Marjo S van der Knaap, Nicole I Wolf

Brain. 2017 Dec; 140(12): 3105–3111. Published online 2017 Nov 29. doi: 10.1093/brain/awx314

PMCID:: PMC5841038

Abstract Article PDF–516K

Select item 574053717.

The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort

Sophie R Harding, Martina Bocchetta, Elizabeth Gordon, David M Cash, M Jorge Cardoso, Ron Druyeh, Sebastian Ourselin, Jason D Warren, Simon Mead, Jonathan D Rohrer

J Neurol Neurosurg Psychiatry. 2017 Nov; 88(11): 997–998. Published online 2017 Apr 26. doi: 10.1136/jnnp-2017-315641

PMCID:: PMC5740537

Article PDF–364K

Select item 567361918.

A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression

Michael D. Gallagher, Marijan Posavi, Peng Huang, Travis L. Unger, Yosef Berlyand, Analise L. Gruenewald, Alessandra Chesi, Elisabetta Manduchi, Andrew D. Wells, Struan F.A. Grant, Gerd A. Blobel, Christopher D. Brown, Alice S. Chen-Plotkin

Am J Hum Genet. 2017 Nov 2; 101(5): 643–663. Published online 2017 Oct 19. doi: 10.1016/j.ajhg.2017.09.004

PMCID:: PMC5673619

Abstract Article PDF–4.4M

Select item 544525319.

Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study

Enrico Premi, Mario Grassi, John van Swieten, Daniela Galimberti, Caroline Graff, Mario Masellis, Carmela Tartaglia, Fabrizio Tagliavini, James B. Rowe, Robert Laforce Jr, Elizabeth Finger, Giovanni B. Frisoni, Alexandre de Mendonça, Sandro Sorbi, Stefano Gazzina, Maura Cosseddu, Silvana Archetti, Roberto Gasparotti, Marta Manes, Antonella Alberici, Manuel J. Cardoso, Martina Bocchetta, David M. Cash, Sebastian Ourselin, Alessandro Padovani, Jonathan D. Rohrer, Barbara Borroni, on behalf of the Genetic FTD Initiative (GENFI)

Brain. 2017 Jun; 140(6): 1784–1791. Published online 2017 Apr 27. doi: 10.1093/brain/awx103

PMCID:: PMC5445253

Abstract Article PDF–334K

Select item 527034720.

Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency

Xiaolai Zhou, Lirong Sun, Owen Adam Brady, Kira A. Murphy, Fenghua Hu

Acta Neuropathol Commun. 2017; 5: 9. Published online 2017 Jan 26. doi: 10.1186/s40478-017-0412-1

PMCID:: PMC5270347

Abstract Article PDF–5.3M

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